메뉴 건너뛰기




Volumn 17, Issue 1, 2012, Pages 281-299

Hepatitis C Virus' initial encounters: Mechanisms of innate immunity

Author keywords

Dendritic Cells; HCV; Innate Immunity; Interferon Response; Review; RIG I; TLR3

Indexed keywords

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 84860283422     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3927     Document Type: Article
Times cited : (1)

References (173)
  • 2
    • 0033060563 scopus 로고    scopus 로고
    • Global survillence and control of hepatitis C
    • Anonymous
    • Anonymous: Global survillence and control of hepatitis C. J. Viral Hepat., 6, 35-47 (1999)
    • (1999) J. Viral Hepat. , vol.6 , pp. 35-47
  • 3
    • 0032841846 scopus 로고    scopus 로고
    • Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence
    • DOI 10.1002/hep.510300312
    • Cerny, A. & F. V. Chisari: Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence. Hepatology, 30, 595-601 (1999) (Pubitemid 29409400)
    • (1999) Hepatology , vol.30 , Issue.3 , pp. 595-601
    • Cerny, A.1    Chisari, F.V.2
  • 4
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • DOI 10.1016/S1473-3099(05)70216-4, PII S1473309905702164
    • Shepard, C. W., L. Finelli & M. J. Alter: Global epidemiology of hepatitis C virus infection. Lancet Infect Dis, 5, 558-67 (2005) (Pubitemid 41196755)
    • (2005) Lancet Infectious Diseases , vol.5 , Issue.9 , pp. 558-567
    • Shepard, C.W.1    Finelli, L.2    Alter, M.J.3
  • 5
    • 0033224570 scopus 로고    scopus 로고
    • Combination treatment with interferon and ribavirin for chronic hepatitis C
    • Davis, G. L.: Combination treatment with interferon and ribavirin for chronic hepatitis C. Clin Liver Dis, 3, 811-26 (1999)
    • (1999) Clin Liver Dis , vol.3 , pp. 811-826
    • Davis, G.L.1
  • 6
    • 4444304792 scopus 로고    scopus 로고
    • Past, present, and future hepatitis C treatments
    • DOI 10.1055/s-2004-832934
    • Foster, G. R.: Past, present, and future hepatitis C treatments. Semin Liver Dis, 24 Suppl 2, 97-104 (2004) (Pubitemid 39180712)
    • (2004) Seminars in Liver Disease , vol.24 , Issue.SUPPL. 2 , pp. 97-104
    • Foster, G.R.1
  • 7
    • 0033760016 scopus 로고    scopus 로고
    • Hepatitis C virus resistance to antiviral therapy
    • Pawlotsky, J. M.: Hepatitis C virus resistance to antiviral therapy. Hepatology, 32, 889-96 (2000)
    • (2000) Hepatology , vol.32 , pp. 889-896
    • Pawlotsky, J.M.1
  • 8
    • 34249994583 scopus 로고    scopus 로고
    • Interleukin-10 and viral clearance: Translation to viral hepatitis
    • DOI 10.1053/j.gastro.2007.04.049, PII S0016508507008359
    • Thimme, R. & O. G. Opitz: Interleukin-10 and viral clearance: translation to viral hepatitis. Gastroenterology, 132, 2611-3 (2007) (Pubitemid 46890883)
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2611-2613
    • Thimme, R.1    Opitz, O.G.2
  • 11
    • 23944467250 scopus 로고    scopus 로고
    • Adaptive immune responses in acute and chronic hepatitis C virus infection
    • DOI 10.1038/nature04079
    • Bowen, D. G. & C. M. Walker: Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature, 436, 946-52 (2005) (Pubitemid 41191670)
    • (2005) Nature , vol.436 , Issue.7053 , pp. 946-952
    • Bowen, D.G.1    Walker, C.M.2
  • 12
    • 0347382454 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes
    • DOI 10.1002/eji.200324251
    • Brady, M. T., A. J. MacDonald, A. G. Rowan & K. H. Mills: Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. Eur J Immunol, 33, 3448-57 (2003) (Pubitemid 37541123)
    • (2003) European Journal of Immunology , vol.33 , Issue.12 , pp. 3448-3457
    • Brady, M.T.1    MacDonald, A.J.2    Rowan, A.G.3    Mills, K.H.G.4
  • 14
    • 37648998728 scopus 로고    scopus 로고
    • Defective response to Toll-like receptor 3 and 4 ligands by activated monocytes in chronic hepatitis C virus infection
    • Villacres, M. C., O. Literat, M. DeGiacomo, W. Du, T. Frederick & A. Kovacs: Defective response to Toll-like receptor 3 and 4 ligands by activated monocytes in chronic hepatitis C virus infection. J Viral Hepat, 15, 137-44 (2008)
    • (2008) J Viral Hepat , vol.15 , pp. 137-144
    • Villacres, M.C.1    Literat, O.2    Degiacomo, M.3    Du, W.4    Frederick, T.5    Kovacs, A.6
  • 15
    • 24944452287 scopus 로고    scopus 로고
    • Impaired function of dendritic cells circulating in patients infected with hepatitis C virus who have persistently normal alanine aminotransferase levels
    • DOI 10.1159/000087264
    • Kanto, T., M. Inoue, M. Miyazaki, I. Itose, H. Miyatake, M. Sakakibara, T. Yakushijin, A. Kaimori, C. Oki, N. Hiramatsu, A. Kasahara & N. Hayashi: Impaired function of dendritic cells circulating in patients infected with hepatitis C virus who have persistently normal alanine aminotransferase levels. Intervirology, 49, 58-63 (2006) (Pubitemid 41318177)
    • (2006) Intervirology , vol.49 , Issue.1-2 , pp. 58-63
    • Kanto, T.1    Inoue, M.2    Miyazaki, M.3    Itose, I.4    Miyatake, H.5    Sakakibara, M.6    Yakushijin, T.7    Kaimori, A.8    Oki, C.9    Hiramatsu, N.10    Kasahara, A.11    Hayashi, N.12
  • 16
    • 22544450461 scopus 로고    scopus 로고
    • Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C
    • DOI 10.1086/431523
    • Longman, R. S., A. H. Talal, I. M. Jacobson, C. M. Rice & M. L. Albert: Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C. J Infect Dis, 192, 497-503 (2005) (Pubitemid 41023130)
    • (2005) Journal of Infectious Diseases , vol.192 , Issue.3 , pp. 497-503
    • Longman, R.S.1    Talal, A.H.2    Jacobson, I.M.3    Rice, C.M.4    Albert, M.L.5
  • 18
    • 4043179185 scopus 로고    scopus 로고
    • Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease
    • DOI 10.1002/hep.20306
    • Wertheimer, A. M., A. Bakke & H. R. Rosen: Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease. Hepatology, 40, 335-45 (2004) (Pubitemid 39062851)
    • (2004) Hepatology , vol.40 , Issue.2 , pp. 335-345
    • Wertheimer, A.M.1    Bakke, A.2    Rosen, H.R.3
  • 19
    • 4344713084 scopus 로고    scopus 로고
    • Decreased interferon-α production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C
    • DOI 10.1111/j.1365-2249.2004.02550.x
    • Murakami, H., S. M. Akbar, H. Matsui, N. Horiike & M. Onji: Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C. Clin Exp Immunol, 137, 559-65 (2004) (Pubitemid 39128083)
    • (2004) Clinical and Experimental Immunology , vol.137 , Issue.3 , pp. 559-565
    • Murakami, H.1    Akbar, S.M.F.2    Matsui, H.3    Horiike, N.4    Onji, M.5
  • 20
    • 0034100047 scopus 로고    scopus 로고
    • Decreased function of peripheral blood dendritic cells in patients with hepatocellular carcinoma with hepatitis B and C virus infection
    • DOI 10.1046/j.1440-1746.2000.02161.x
    • Kakumu, S., S. Ito, T. Ishikawa, Y. Mita, T. Tagaya, Y. Fukuzawa & K. Yoshioka: Decreased function of peripheral blood dendritic cells in patients with hepatocellular carcinoma with hepatitis B and C virus infection. J Gastroenterol Hepatol, 15, 431-6 (2000) (Pubitemid 30262212)
    • (2000) Journal of Gastroenterology and Hepatology , vol.15 , Issue.4 , pp. 431-436
    • Kakumu, S.1    Ito, S.2    Ishikawa, T.3    Mita, Y.4    Tagaya, T.5    Fukuzawa, Y.6    Yoshioka, K.7
  • 22
    • 3543001125 scopus 로고    scopus 로고
    • Isolation and functional analysis of circulating dendritic cells from hepatitis C virus (HCV) RNA-positive and HCV RNA-negative patients with chronic hepatitis C: Role of antiviral therapy
    • DOI 10.1111/j.1365-2249.2004.02544.x
    • Tsubouchi, E., S. M. Akbar, H. Murakami, N. Horiike & M. Onji: Isolation and functional analysis of circulating dendritic cells from hepatitis C virus (HCV) RNA-positive and HCV RNA-negative patients with chronic hepatitis C: role of antiviral therapy. Clin Exp Immunol, 137, 417-23 (2004) (Pubitemid 39013090)
    • (2004) Clinical and Experimental Immunology , vol.137 , Issue.2 , pp. 417-423
    • Tsubouchi, E.1    Akbar, S.M.F.2    Murakami, H.3    Horiike, N.4    Onji, M.5
  • 23
    • 0141532301 scopus 로고    scopus 로고
    • Chronic hepatitis C virus infection established and maintained in chimpanzees independent of dendritic cell impairment
    • DOI 10.1053/jhep.2003.50426
    • Rollier, C., J. A. Drexhage, B. E. Verstrepen, E. J. Verschoor, R. E. Bontrop, G. Koopman & J. L. Heeney: Chronic hepatitis C virus infection established and maintained in chimpanzees independent of dendritic cell impairment. Hepatology, 38, 851-8 (2003) (Pubitemid 37221668)
    • (2003) Hepatology , vol.38 , Issue.4 , pp. 851-858
    • Rollier, C.1    Drexhage, J.A.R.2    Verstrepen, B.E.3    Verschoor, E.J.4    Bontrop, R.E.5    Koopman, G.6    Heeney, J.L.7
  • 24
    • 0035121503 scopus 로고    scopus 로고
    • Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection
    • Bain, C., A. Fatmi, F. Zoulim, J. P. Zarski, C. Trepo & G. Inchauspe: Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology, 120, 512-24 (2001) (Pubitemid 32147649)
    • (2001) Gastroenterology , vol.120 , Issue.2 , pp. 512-524
    • Bain, C.1    Fatmi, A.2    Zoulim, F.3    Zarski, J.-P.4    Trepo, C.5    Inchauspe, G.6
  • 25
    • 0035874506 scopus 로고    scopus 로고
    • Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection
    • Auffermann-Gretzinger, S., E. B. Keeffe & S. Levy: Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection. Blood, 97, 3171-6 (2001)
    • (2001) Blood , vol.97 , pp. 3171-3176
    • Auffermann-Gretzinger, S.1    Keeffe, E.B.2    Levy, S.3
  • 26
    • 0033136306 scopus 로고    scopus 로고
    • Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals
    • Kanto, T., N. Hayashi, T. Takehara, T. Tatsumi, N. Kuzushita, A. Ito, Y. Sasaki, A. Kasahara & M. Hori: Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol, 162, 5584-91 (1999) (Pubitemid 29307172)
    • (1999) Journal of Immunology , vol.162 , Issue.9 , pp. 5584-5591
    • Kanto, T.1    Hayashi, N.2    Takehara, T.3    Tatsumi, T.4    Kuzushita, N.5    Ito, A.6    Sasaki, Y.7    Kasahara, A.8    Hori, M.9
  • 29
    • 1642581676 scopus 로고    scopus 로고
    • Presence of functional dendritic cells in patients chronically infected with hepatitis C virus
    • DOI 10.1182/blood-2003-04-1339
    • Longman, R. S., A. H. Talal, I. M. Jacobson, M. L. Albert & C. M. Rice: Presence of functional dendritic cells in patients chronically infected with hepatitis C virus. Blood, 103, 1026-9 (2004) (Pubitemid 38129566)
    • (2004) Blood , vol.103 , Issue.3 , pp. 1026-1029
    • Longman, R.S.1    Talal, A.H.2    Jacobson, I.M.3    Albert, M.L.4    Rice, C.M.5
  • 30
    • 0037851770 scopus 로고    scopus 로고
    • Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation
    • Dolganiuc, A., K. Kodys, A. Kopasz, C. Marshall, T. Do, L. Romics, Jr., P. Mandrekar, M. Zapp & G. Szabo: Hepatitis C virus core and nonstructural protein 3 proteins induce pro-and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J Immunol, 170, 5615-24 (2003) (Pubitemid 36617852)
    • (2003) Journal of Immunology , vol.170 , Issue.11 , pp. 5615-5624
    • Dolganiuc, A.1    Kodys, K.2    Kopasz, A.3    Marshall, C.4    Do, T.5    Romics Jr., L.6    Mandrekar, P.7    Zapp, M.8    Szabo, G.9
  • 31
    • 41149145956 scopus 로고    scopus 로고
    • Hepatitis C virus inhibits cell surface expression of HLA-DR, prevents dendritic cell maturation, and induces interleukin-10 production
    • DOI 10.1128/JVI.02547-07
    • Saito, K., M. Ait-Goughoulte, S. M. Truscott, K. Meyer, A. Blazevic, G. Abate, R. B. Ray, D. F. Hoft & R. Ray: Hepatitis C virus inhibits cell surface expression of HLA-DR, prevents dendritic cell maturation, and induces interleukin-10 production. J Virol, 82, 3320-8 (2008) (Pubitemid 351429910)
    • (2008) Journal of Virology , vol.82 , Issue.7 , pp. 3320-3328
    • Saito, K.1    Ait-Goughoulte, M.2    Truscott, S.M.3    Meyer, K.4    Blazevic, A.5    Abate, G.6    Ray, R.B.7    Hoft, D.F.8    Ray, R.9
  • 36
    • 73449145993 scopus 로고    scopus 로고
    • Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells
    • Chang, S., K. Kodys & G. Szabo: Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells. Hepatology, 51, 35-42
    • Hepatology , vol.51 , pp. 35-42
    • Chang, S.1    Kodys, K.2    Szabo, G.3
  • 37
    • 33745728738 scopus 로고    scopus 로고
    • Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: A role for capturing hepatitis C virus particles
    • Lai, W. K., P. J. Sun, J. Zhang, A. Jennings, P. F. Lalor, S. Hubscher, J. A. McKeating & D. H. Adams: Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Am J Pathol, 169, 200-8 (2006)
    • (2006) Am J Pathol , vol.169 , pp. 200-208
    • Lai, W.K.1    Sun, P.J.2    Zhang, J.3    Jennings, A.4    Lalor, P.F.5    Hubscher, S.6    McKeating, J.A.7    Adams, D.H.8
  • 38
    • 0345223476 scopus 로고    scopus 로고
    • Efficient Replication of the Genotype 2a Hepatitis C Virus Subgenomic Replicon
    • DOI 10.1053/j.gastro.2003.09.023
    • Kato, T., T. Date, M. Miyamoto, A. Furusaka, K. Tokushige, M. Mizokami & T. Wakita: Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon. Gastroenterology, 125, 1808-17 (2003) (Pubitemid 37500445)
    • (2003) Gastroenterology , vol.125 , Issue.6 , pp. 1808-1817
    • Kato, T.1    Date, T.2    Miyamoto, M.3    Furusaka, A.4    Tokushige, K.5    Mizokami, M.6    Wakita, T.7
  • 40
  • 41
    • 33244461743 scopus 로고    scopus 로고
    • Aberrant composition of the dendritic cell population in hepatic lymph nodes of patients with hepatocellular carcinoma
    • DOI 10.1016/j.humpath.2005.11.007, PII S0046817705006386
    • Tang, T. J., D. Vukosavljevic, H. L. Janssen, R. S. Binda, S. Mancham, H. W. Tilanus, J. N. Ijzermans, H. Drexhage & J. Kwekkeboom: Aberrant composition of the dendritic cell population in hepatic lymph nodes of patients with hepatocellular carcinoma. Hum Pathol, 37, 332-8 (2006) (Pubitemid 43277521)
    • (2006) Human Pathology , vol.37 , Issue.3 , pp. 332-338
    • Tang, T.J.1    Vukosavljevic, D.2    Janssen, H.L.A.3    Binda, R.S.4    Mancham, S.5    Tilanus, H.W.6    Ijzermans, J.N.M.7    Drexhage, H.8    Kwekkeboom, J.9
  • 42
    • 33749013592 scopus 로고    scopus 로고
    • Dynamics of immature subsets of dendritic cells during antiviral therapy in HLA-A24-positive chronic hepatitis C patients
    • DOI 10.1007/s00535-006-1843-9
    • Shiina, M., K. Kobayashi, T. Kobayashi, Y. Kondo, Y. Ueno & T. Shimosegawa: Dynamics of immature subsets of dendritic cells during antiviral therapy in HLA-A24-positive chronic hepatitis C patients. J Gastroenterol, 41, 758-64 (2006) (Pubitemid 44446129)
    • (2006) Journal of Gastroenterology , vol.41 , Issue.8 , pp. 758-764
    • Shiina, M.1    Kobayashi, K.2    Kobayashi, T.3    Kondo, Y.4    Ueno, Y.5    Shimosegawa, T.6
  • 43
    • 0347755433 scopus 로고    scopus 로고
    • Neutralising antibody, CTL and dendritic cell responses to hepatitis C virus: A preventive vaccine strategy
    • DOI 10.2174/1389450043490677
    • Torresi, J., M. Bharadwaj, D. C. Jackson & E. J. Gowans: Neutralising antibody, CTL and dendritic cell responses to hepatitis C virus: a preventative vaccine strategy. Curr Drug Targets, 5, 41-56 (2004) (Pubitemid 38081741)
    • (2004) Current Drug Targets , vol.5 , Issue.1 , pp. 41-56
    • Torresi, J.1    Bharadwaj, M.2    Jackson, D.C.3    Gowans, E.J.4
  • 44
    • 18044395172 scopus 로고    scopus 로고
    • Is hepatitis C virus infection of dendritic cells a mechanism facilitating viral persistence?
    • DOI 10.1016/S1473-3099(05)70114-6
    • Pachiadakis, I., G. Pollara, B. M. Chain & N. V. Naoumov: Is hepatitis C virus infection of dendritic cells a mechanism facilitating viral persistence? Lancet Infect Dis, 5, 296-304 (2005) (Pubitemid 40602249)
    • (2005) Lancet Infectious Diseases , vol.5 , Issue.5 , pp. 296-304
    • Pachiadakis, I.1    Pollara, G.2    Chain, B.M.3    Naoumov, N.V.4
  • 45
    • 39549097752 scopus 로고    scopus 로고
    • Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function
    • DOI 10.1002/hep.21996
    • Shiina, M. & B. Rehermann: Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function. Hepatology, 47, 385-95 (2008) (Pubitemid 351280706)
    • (2008) Hepatology , vol.47 , Issue.2 , pp. 385-395
    • Shiina, M.1    Rehermann, B.2
  • 47
    • 0141566336 scopus 로고    scopus 로고
    • Hepatitis C virus structural proteins impair dendritic cell maturation and inhibit in vivo induction of cellular immune responses
    • DOI 10.1128/JVI.77.20.10862-10871.2003
    • Sarobe, P., J. J. Lasarte, A. Zabaleta, L. Arribillaga, A. Arina, I. Melero, F. Borras-Cuesta & J. Prieto: Hepatitis C virus structural proteins impair dendritic cell maturation and inhibit in vivo induction of cellular immune responses. J Virol, 77, 10862-71 (2003) (Pubitemid 37204279)
    • (2003) Journal of Virology , vol.77 , Issue.20 , pp. 10862-10871
    • Sarobe, P.1    Lasarte, J.J.2    Zabaleta, A.3    Arribillaga, L.4    Arina, A.5    Melero, I.6    Borras-Cuesta, F.7    Prieto, J.8
  • 48
    • 22644432777 scopus 로고    scopus 로고
    • Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection
    • DOI 10.1016/j.imbio.2005.05.018, PII S0171298505000914
    • Szabo, G. & A. Dolganiuc: Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection. Immunobiology, 210, 237-47 (2005) (Pubitemid 41025165)
    • (2005) Immunobiology , vol.210 , Issue.2-4 , pp. 237-247
    • Szabo, G.1    Dolganiuc, A.2
  • 49
    • 30344446364 scopus 로고    scopus 로고
    • Dendritic cells pulsed with hepatitis C virus NS3 protein induce immune responses and protection from infection with recombinant vaccinia virus expressing NS3
    • DOI 10.1099/vir.0.81423-0
    • Yu, H., H. Huang, J. Xiang, L. A. Babiuk & S. van Drunen Littel-van den Hurk: Dendritic cells pulsed with hepatitis C virus NS3 protein induce immune responses and protection from infection with recombinant vaccinia virus expressing NS3. J Gen Virol, 87, 1-10 (2006) (Pubitemid 43056938)
    • (2006) Journal of General Virology , vol.87 , Issue.1 , pp. 1-10
    • Yu, H.1    Huang, H.2    Xiang, J.3    Babiuk, L.A.4    Van Drunen Littel-Van Den Hurk, S.5
  • 50
    • 27644535720 scopus 로고    scopus 로고
    • Prophylactic and therapeutic vaccination with dendritic cells against hepatitis C virus infection
    • DOI 10.1111/j.1365-2249.2005.02919.x
    • Encke, J., J. Findeklee, J. Geib, E. Pfaff & W. Stremmel: Prophylactic and therapeutic vaccination with dendritic cells against hepatitis C virus infection. Clin Exp Immunol, 142, 362-9 (2005) (Pubitemid 41565254)
    • (2005) Clinical and Experimental Immunology , vol.142 , Issue.2 , pp. 362-369
    • Encke, J.1    Findeklee, J.2    Geib, J.3    Pfaff, E.4    Stremmel, W.5
  • 51
    • 13244262918 scopus 로고    scopus 로고
    • Induction of hepatitis C virus-specific cytotoxic T and B cell responses by dendritic cells expressing a modified antigen targeting receptor
    • Wang, Q. C., Z. H. Feng, Y. X. Zhou & Q. H. Nie: Induction of hepatitis C virus-specific cytotoxic T and B cell responses by dendritic cells expressing a modified antigen targeting receptor. World J Gastroenterol, 11, 557-60 (2005)
    • (2005) World J Gastroenterol , vol.11 , pp. 557-560
    • Wang, Q.C.1    Feng, Z.H.2    Zhou, Y.X.3    Nie, Q.H.4
  • 52
    • 1642538454 scopus 로고    scopus 로고
    • Dendritic cells transfected with cytopathic self-replicating RNA induce crosspriming of CD8+ T cells and antiviral immunity
    • DOI 10.1016/S1074-7613(03)00353-4
    • Racanelli, V., S. E. Behrens, J. Aliberti & B. Rehermann: Dendritic cells transfected with cytopathic self-replicating RNA induce crosspriming of CD8+ T cells and antiviral immunity. Immunity, 20, 47-58 (2004) (Pubitemid 38134293)
    • (2004) Immunity , vol.20 , Issue.1 , pp. 47-58
    • Racanelli, V.1    Behrens, S.-E.2    Aliberti, J.3    Rehermann, B.4
  • 53
    • 30344458832 scopus 로고    scopus 로고
    • Expression of hepatitic C virus-derived core or NS3 antigens in human dendritic cells leads to induction of pro-inflammatory cytokines and normal T-cell stimulation capabilities
    • DOI 10.1099/vir.0.81364-0
    • Li, W., J. Li, D. L. Tyrrell & B. Agrawal: Expression of hepatitis C virus-derived core or NS3 antigens in human dendritic cells leads to induction of pro-inflammatory cytokines and normal T-cell stimulation capabilities. J Gen Virol, 87, 61-72 (2006) (Pubitemid 43056944)
    • (2006) Journal of General Virology , vol.87 , Issue.1 , pp. 61-72
    • Li, W.1    Li, J.2    Tyrrell, D.L.J.3    Agrawal, B.4
  • 56
    • 31344453421 scopus 로고    scopus 로고
    • Dendritic cells at the host-pathogen interface
    • DOI 10.1038/ni0206-117, PII N0206117
    • Colonna, M., B. Pulendran & A. Iwasaki: Dendritic cells at the host-pathogen interface. Nat Immunol, 7, 117-20 (2006) (Pubitemid 43135873)
    • (2006) Nature Immunology , vol.7 , Issue.2 , pp. 117-120
    • Colonna, M.1    Pulendran, B.2    Iwasaki, A.3
  • 57
    • 33845911460 scopus 로고    scopus 로고
    • TLR7/8 agonists impair monocyte-derived dendritic cell differentiation and maturation
    • DOI 10.1189/jlb.0705385
    • Assier, E., V. Marin-Esteban, A. Haziot, E. Maggi, D. Charron & N. Mooney: TLR7/8 agonists impair monocytederived dendritic cell differentiation and maturation. J Leukoc Biol, 81, 221-8 (2007) (Pubitemid 46021272)
    • (2007) Journal of Leukocyte Biology , vol.81 , Issue.1 , pp. 221-228
    • Assier, E.1    Marin-Esteban, V.2    Haziot, A.3    Maggi, E.4    Charron, D.5    Mooney, N.6
  • 58
    • 17644372733 scopus 로고    scopus 로고
    • IPC: Professional type 1 interferonproducing cells and plasmacytoid dendritic cell precursors
    • Liu, Y. J.: IPC: professional type 1 interferonproducing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol, 23, 275-306 (2005)
    • (2005) Annu Rev Immunol , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 61
    • 46749128497 scopus 로고    scopus 로고
    • Hepatitis C and innate immunity: Recent advances
    • DOI 10.1016/j.cld.2008.03.003, PII S1089326108000408
    • Szabo, G. & A. Dolganiuc: Hepatitis C and innate immunity: recent advances. Clin Liver Dis, 12, 675-92, x (2008) (Pubitemid 351952475)
    • (2008) Clinics in Liver Disease , vol.12 , Issue.3 , pp. 675-692
    • Szabo, G.1    Dolganiuc, A.2
  • 62
    • 33947380550 scopus 로고    scopus 로고
    • Changes in gene expression during pegylated interferon and ribavirin therapy of chronic hepatitis C virus distinguish responders from nonresponders to antiviral therapy
    • DOI 10.1128/JVI.02640-06
    • Taylor, M. W., T. Tsukahara, L. Brodsky, J. Schaley, C. Sanda, M. J. Stephens, J. N. McClintick, H. J. Edenberg, L. Li, J. E. Tavis, C. Howell & S. H. Belle: Changes in gene expression during pegylated interferon and ribavirin therapy of chronic hepatitis C virus distinguish responders from nonresponders to antiviral therapy. J Virol, 81, 3391-401 (2007) (Pubitemid 46456648)
    • (2007) Journal of Virology , vol.81 , Issue.7 , pp. 3391-3401
    • Taylor, M.W.1    Tsukahara, T.2    Brodsky, L.3    Schaley, J.4    Sanda, C.5    Stephens, M.J.6    McClintick, J.N.7    Edenberg, H.J.8    Li, L.9    Tavis, J.E.10    Howell, C.11    Belle, S.H.12
  • 63
    • 33947661034 scopus 로고    scopus 로고
    • TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection
    • Yonkers, N. L., B. Rodriguez, K. A. Milkovich, R. Asaad, M. M. Lederman, P. S. Heeger & D. D. Anthony: TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection. J Immunol, 178, 4436-44 (2007) (Pubitemid 46492395)
    • (2007) Journal of Immunology , vol.178 , Issue.7 , pp. 4436-4444
    • Yonkers, N.L.1    Rodriguez, B.2    Milkovich, K.A.3    Asaad, R.4    Lederman, M.M.5    Heeger, P.S.6    Anthony, D.D.7
  • 64
    • 33750826035 scopus 로고    scopus 로고
    • Hepatitis C Virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-α and plasmacytoid dendritic cell loss in chronic HCV infection
    • Dolganiuc, A., S. Chang, K. Kodys, P. Mandrekar, G. Bakis, M. Cormier & G. Szabo: Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection. J Immunol, 177, 6758-68 (2006) (Pubitemid 44715040)
    • (2006) Journal of Immunology , vol.177 , Issue.10 , pp. 6758-6768
    • Dolganiuc, A.1    Chang, S.2    Kodys, K.3    Mandrekar, P.4    Bakis, G.5    Cormier, M.6    Szabo, G.7
  • 66
    • 0036376644 scopus 로고    scopus 로고
    • Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines
    • DOI 10.1089/10799900260100132
    • Gary-Gouy, H., P. Lebon & A. H. Dalloul: Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines. J Interferon Cytokine Res, 22, 653-9 (2002) (Pubitemid 35034523)
    • (2002) Journal of Interferon and Cytokine Research , vol.22 , Issue.6 , pp. 653-659
    • Gary-Gouy, H.1    Lebon, P.2    Dalloul, A.H.3
  • 67
    • 0034087136 scopus 로고    scopus 로고
    • Relationship between interferon-γ, interleukin-10, and interleukin-12 production in chronic hepatitis C and in vitro effects of interferon-α
    • DOI 10.1023/A:1006694627907
    • Piazzolla, G., C. Tortorella, O. Schiraldi & S. Antonaci: Relationship between interferon-gamma, interleukin-10, and interleukin-12 production in chronic hepatitis C and in vitro effects of interferon-alpha. J Clin Immunol, 20, 54-61 (2000) (Pubitemid 30210107)
    • (2000) Journal of Clinical Immunology , vol.20 , Issue.1 , pp. 54-61
    • Piazzolla, G.1    Tortorella, C.2    Schiraldi, O.3    Antonaci, S.4
  • 69
    • 47149116458 scopus 로고    scopus 로고
    • Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells
    • DOI 10.1002/hep.22337
    • Ebihara, T., M. Shingai, M. Matsumoto, T. Wakita & T. Seya: Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells. Hepatology, 48, 48-58 (2008) (Pubitemid 351975530)
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 48-58
    • Ebihara, T.1    Shingai, M.2    Matsumoto, M.3    Wakita, T.4    Seya, T.5
  • 70
    • 0242410962 scopus 로고    scopus 로고
    • Autocrine/paracrine IL-15 that is required for type I IFNmediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection
    • Jinushi, M., T. Takehara, T. Tatsumi, T. Kanto, V. Groh, T. Spies, T. Suzuki, T. Miyagi & N. Hayashi: Autocrine/paracrine IL-15 that is required for type I IFNmediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection. J Immunol, 171, 5423-9 (2003) (Pubitemid 37432829)
    • (2003) Journal of Immunology , vol.171 , Issue.10 , pp. 5423-5429
    • Jinushi, M.1    Takehara, T.2    Tatsumi, T.3    Kanto, T.4    Groh, V.5    Spies, T.6    Suzuki, T.7    Miyagi, T.8    Hayashi, N.9
  • 71
    • 33645713385 scopus 로고    scopus 로고
    • Significance of alterations in PBMC immunophenotype of children with chronic viral hepatitis C-The role of dendritic cells
    • Mozer-Lisewska, I., G. Dworacki, E. Kaczmarek, W. Sluzewski, M. Kaczmarek, A. Wozniak & J. Zeromski: Significance of alterations in PBMC immunophenotype of children with chronic viral hepatitis C-the role of dendritic cells. Scand J Immunol, 63, 311-9 (2006)
    • (2006) Scand J Immunol , vol.63 , pp. 311-319
    • Mozer-Lisewska, I.1    Dworacki, G.2    Kaczmarek, E.3    Sluzewski, W.4    Kaczmarek, M.5    Wozniak, A.6    Zeromski, J.7
  • 72
    • 0031830974 scopus 로고    scopus 로고
    • Are all Type I human interferons equivalent?
    • DOI 10.1046/j.1365-2893.1998.00103.x
    • Foster, G. R. & N. B. Finter: Are all type I human interferons equivalent? J Viral Hepat, 5, 143-52 (1998) (Pubitemid 28374722)
    • (1998) Journal of Viral Hepatitis , vol.5 , Issue.3 , pp. 143-152
    • Foster, G.R.1    Finter, N.B.2
  • 73
    • 0031895778 scopus 로고    scopus 로고
    • CD81 (TAPA-1): A molecule involved in signal transduction and cell adhesion in the immune system
    • DOI 10.1146/annurev.immunol.16.1.89
    • Levy, S., S. C. Todd & H. T. Maecker: CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol, 16, 89-109 (1998) (Pubitemid 28183360)
    • (1998) Annual Review of Immunology , vol.16 , pp. 89-109
    • Levy, S.1    Todd, S.C.2    Maecker, H.T.3
  • 75
    • 33644816016 scopus 로고    scopus 로고
    • Hepatitis C virus NS5B delays cell cycle progression by inducing interferon-β via Toll-like receptor 3 signaling pathway without replicating viral genomes
    • DOI 10.1016/j.virol.2005.10.023, PII S0042682205006732
    • Naka, K., H. Dansako, N. Kobayashi, M. Ikeda & N. Kato: Hepatitis C virus NS5B delays cell cycle progression by inducing interferon-beta via Toll-like receptor 3 signaling pathway without replicating viral genomes. Virology, 346, 348-62 (2006) (Pubitemid 43357878)
    • (2006) Virology , vol.346 , Issue.2 , pp. 348-362
    • Naka, K.1    Dansako, H.2    Kobayashi, N.3    Ikeda, M.4    Kato, N.5
  • 77
    • 23944485662 scopus 로고    scopus 로고
    • Evasion of intracellular host defence by hepatitis C virus
    • DOI 10.1038/nature04078
    • Gale, M., Jr. & E. M. Foy: Evasion of intracellular host defence by hepatitis C virus. Nature, 436, 939-45 (2005) (Pubitemid 41191669)
    • (2005) Nature , vol.436 , Issue.7053 , pp. 939-945
    • Gale Jr., M.1    Foy, E.M.2
  • 80
    • 36048975791 scopus 로고    scopus 로고
    • Hepatitis C virus infection induces the beta interferon signaling pathway in immortalized human hepatocytes
    • DOI 10.1128/JVI.01695-07
    • Kanda, T., R. Steele, R. Ray & R. B. Ray: Hepatitis C virus infection induces the beta interferon signaling pathway in immortalized human hepatocytes. J Virol, 81, 12375-81 (2007) (Pubitemid 350085851)
    • (2007) Journal of Virology , vol.81 , Issue.22 , pp. 12375-12381
    • Kanda, T.1    Steele, R.2    Ray, R.3    Ray, R.B.4
  • 81
  • 82
    • 13944253573 scopus 로고    scopus 로고
    • Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I
    • DOI 10.1128/JVI.79.5.2689-2699.2005
    • Sumpter, R., Jr., Y. M. Loo, E. Foy, K. Li, M. Yoneyama, T. Fujita, S. M. Lemon & M. Gale, Jr.: Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol, 79, 2689-99 (2005) (Pubitemid 40270547)
    • (2005) Journal of Virology , vol.79 , Issue.5 , pp. 2689-2699
    • Sumpter Jr., R.1    Loo, Y.-M.2    Foy, E.3    Li, K.4    Yoneyama, M.5    Fujita, T.6    Lemon, S.M.7    Gale Jr., M.8
  • 83
    • 36348936640 scopus 로고    scopus 로고
    • Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy
    • DOI 10.1002/hep.21829
    • Binder, M., G. Kochs, R. Bartenschlager & V. Lohmann: Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy. Hepatology, 46, 1365-74 (2007) (Pubitemid 350155518)
    • (2007) Hepatology , vol.46 , Issue.5 , pp. 1365-1374
    • Binder, M.1    Kochs, G.2    Bartenschlager, R.3    Lohmann, V.4
  • 86
    • 33645897032 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons
    • Hamazaki, H., S. Ujino, N. Miyano-Kurosaki, K. Shimotohno & H. Takaku: Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons. Biochem Biophys Res Commun, 343, 988-94 (2006)
    • (2006) Biochem Biophys Res Commun , vol.343 , pp. 988-994
    • Hamazaki, H.1    Ujino, S.2    Miyano-Kurosaki, N.3    Shimotohno, K.4    Takaku, H.5
  • 87
    • 35648957775 scopus 로고    scopus 로고
    • Hepatitis C Virus Triggers Apoptosis of a Newly Developed Hepatoma Cell Line Through Antiviral Defense System
    • DOI 10.1053/j.gastro.2007.09.017, PII S0016508507016587
    • Zhu, H., H. Dong, E. Eksioglu, A. Hemming, M. Cao, J. M. Crawford, D. R. Nelson & C. Liu: Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system. Gastroenterology, 133, 1649-59 (2007) (Pubitemid 350029762)
    • (2007) Gastroenterology , vol.133 , Issue.5 , pp. 1649-1659
    • Zhu, H.1    Dong, H.2    Eksioglu, E.3    Hemming, A.4    Cao, M.5    Crawford, J.M.6    Nelson, D.R.7    Liu, C.8
  • 89
    • 33845775795 scopus 로고    scopus 로고
    • The protein kinase IKKε can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers
    • DOI 10.1002/hep.21432
    • Vilasco, M., E. Larrea, D. Vitour, S. Dabo, A. Breiman, B. Regnault, J. I. Riezu, P. Eid, J. Prieto & E. F. Meurs: The protein kinase IKKepsilon can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers. Hepatology, 44, 1635-47 (2006) (Pubitemid 44970358)
    • (2006) Hepatology , vol.44 , Issue.6 , pp. 1635-1647
    • Vilasco, M.1    Larrea, E.2    Vitour, D.3    Dabo, S.4    Breiman, A.5    Regnault, B.6    Riezu, J.-I.7    Eid, P.8    Prieto, J.9    Meurs, E.F.10
  • 90
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • DOI 10.1038/ni1112
    • Iwasaki, A. & R. Medzhitov: Toll-like receptor control of the adaptive immune responses. Nat Immunol, 5, 987-95 (2004) (Pubitemid 41057715)
    • (2004) Nature Immunology , vol.5 , Issue.10 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 91
    • 33748741785 scopus 로고    scopus 로고
    • Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    • Kaukinen, P., M. Sillanpaa, S. Kotenko, R. Lin, J. Hiscott, K. Melen & I. Julkunen: Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression. Virol J, 3, 66 (2006)
    • (2006) Virol J , vol.3 , pp. 66
    • Kaukinen, P.1    Sillanpaa, M.2    Kotenko, S.3    Lin, R.4    Hiscott, J.5    Melen, K.6    Julkunen, I.7
  • 92
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • DOI 10.1126/science.1093616
    • Diebold, S. S., T. Kaisho, H. Hemmi, S. Akira & C. Reis e Sousa: Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science, 303, 1529-31 (2004) (Pubitemid 38314425)
    • (2004) Science , vol.303 , Issue.5663 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis E Sousa, C.5
  • 93
    • 14044260466 scopus 로고    scopus 로고
    • Transcriptional signaling by double-stranded RNA: Role of TLR3
    • DOI 10.1016/j.cytogfr.2005.01.006
    • Sen, G. C. & S. N. Sarkar: Transcriptional signaling by double-stranded RNA: role of TLR3. Cytokine Growth Factor Rev, 16, 1-14 (2005) (Pubitemid 40279114)
    • (2005) Cytokine and Growth Factor Reviews , vol.16 , Issue.1 , pp. 1-14
    • Sen, G.C.1    Sarkar, S.N.2
  • 94
    • 34250643546 scopus 로고    scopus 로고
    • The interferon inducing pathways and the hepatitis C virus
    • Meurs, E. F. & A. Breiman: The interferon inducing pathways and the hepatitis C virus. World J Gastroenterol, 13, 2446-54 (2007) (Pubitemid 46929500)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.17 , pp. 2446-2454
    • Meurs, E.F.1    Breiman, A.2
  • 95
    • 23044445303 scopus 로고    scopus 로고
    • Structural biology: Crystal structure of human toll-like receptor 3 (TLR3) ectodomain
    • DOI 10.1126/science.1115253
    • Choe, J., M. S. Kelker & I. A. Wilson: Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science, 309, 581-5 (2005) (Pubitemid 41033635)
    • (2005) Science , vol.309 , Issue.5734 , pp. 581-585
    • Choe, J.1    Kelker, M.S.2    Wilson, I.A.3
  • 96
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • DOI 10.1038/ni1303, PII N1303
    • Kawai, T. & S. Akira: Innate immune recognition of viral infection. Nat Immunol, 7, 131-7 (2006) (Pubitemid 43135878)
    • (2006) Nature Immunology , vol.7 , Issue.2 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 97
    • 32044457700 scopus 로고    scopus 로고
    • MasterCARD: A priceless link to innate immunity
    • DOI 10.1016/j.molmed.2005.12.003, PII S1471491405002704
    • Hiscott, J., R. Lin, P. Nakhaei & S. Paz: MasterCARD: a priceless link to innate immunity. Trends Mol Med, 12, 53-6 (2006) (Pubitemid 43202122)
    • (2006) Trends in Molecular Medicine , vol.12 , Issue.2 , pp. 53-56
    • Hiscott, J.1    Lin, R.2    Nakhaei, P.3    Paz, S.4
  • 98
    • 24144461689 scopus 로고    scopus 로고
    • Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3
    • DOI 10.1016/j.cell.2005.08.012, PII S0092867405008160
    • Seth, R. B., L. Sun, C. K. Ea & Z. J. Chen: Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NFkappaB and IRF 3. Cell, 122, 669-82 (2005) (Pubitemid 41242633)
    • (2005) Cell , vol.122 , Issue.5 , pp. 669-682
    • Seth, R.B.1    Sun, L.2    Ea, C.-K.3    Chen, Z.J.4
  • 99
    • 33750508963 scopus 로고    scopus 로고
    • Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: Disruption by hepatitis C virus NS3-4A protease
    • DOI 10.1016/j.bcp.2006.06.030, PII S000629520600390X, Cell Signalling, Transcription and Translation as Therapeutic Tergets
    • Hiscott, J., J. Lacoste & R. Lin: Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease. Biochem Pharmacol, 72, 1477-84 (2006) (Pubitemid 44666740)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.11 , pp. 1477-1484
    • Hiscott, J.1    Lacoste, J.2    Lin, R.3
  • 100
    • 0032538891 scopus 로고    scopus 로고
    • Differential viral induction of distinct interferon-α genes by positive feedback through interferon regulatory factor-7
    • Marie, I., J. E. Durbin & D. E. Levy: Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. Embo J, 17, 6660-9 (1998) (Pubitemid 28521799)
    • (1998) EMBO Journal , vol.17 , Issue.22 , pp. 6660-6669
    • Marie, I.1    Durbin, J.E.2    Levy, D.E.3
  • 101
    • 0032549658 scopus 로고    scopus 로고
    • Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-β gene
    • DOI 10.1016/S0014-5793(98)00210-5, PII S0014579398002105
    • Sato, M., N. Tanaka, N. Hata, E. Oda & T. Taniguchi: Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene. FEBS Lett, 425, 112-6 (1998) (Pubitemid 28149751)
    • (1998) FEBS Letters , vol.425 , Issue.1 , pp. 112-116
    • Sato, M.1    Tanaka, N.2    Hata, N.3    Oda, E.4    Taniguchi, T.5
  • 102
    • 34548418935 scopus 로고    scopus 로고
    • Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response
    • DOI 10.1038/sj.icb.7100100, PII 7100100
    • Thompson, A. J. & S. A. Locarnini: Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response. Immunol Cell Biol, 85, 435-45 (2007) (Pubitemid 47367510)
    • (2007) Immunology and Cell Biology , vol.85 , Issue.6 , pp. 435-445
    • Thompson, A.J.V.1    Locarnini, S.A.2
  • 103
    • 0033623848 scopus 로고    scopus 로고
    • IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex
    • Peters, R. T., S. M. Liao & T. Maniatis: IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. Mol Cell, 5, 513-22 (2000)
    • (2000) Mol Cell , vol.5 , pp. 513-522
    • Peters, R.T.1    Liao, S.M.2    Maniatis, T.3
  • 105
    • 56749133272 scopus 로고    scopus 로고
    • Viral evasion and subversion of pattern-recognition receptor signalling
    • Bowie, A. G. & L. Unterholzner: Viral evasion and subversion of pattern-recognition receptor signalling. Nat Rev Immunol, 8, 911-22 (2008)
    • (2008) Nat Rev Immunol , vol.8 , pp. 911-922
    • Bowie, A.G.1    Unterholzner, L.2
  • 106
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • DOI 10.1038/nature04193, PII N04193
    • Meylan, E., J. Curran, K. Hofmann, D. Moradpour, M. Binder, R. Bartenschlager & J. Tschopp: Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature, 437, 1167-72 (2005) (Pubitemid 41509355)
    • (2005) Nature , vol.437 , Issue.7062 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 109
    • 0036829988 scopus 로고    scopus 로고
    • Cell activation by synthetic lipopeptides of the hepatitis C virus (HCV) - Core protein is mediated by toll like receptors (TLRs) 2 and 4
    • DOI 10.1016/S0165-2478(02)00178-5, PII S0165247802001785
    • Duesberg, U., A. von dem Bussche, C. Kirschning, K. Miyake, T. Sauerbruch & U. Spengler: Cell activation by synthetic lipopeptides of the hepatitis C virus (HCV)-core protein is mediated by toll like receptors (TLRs) 2 and 4. Immunol Lett, 84, 89-95 (2002) (Pubitemid 35248001)
    • (2002) Immunology Letters , vol.84 , Issue.2 , pp. 89-95
    • Duesberg, U.1    Von Dem Bussche, A.2    Kirschning, C.J.3    Miyake, K.4    Sauerbruch, T.5    Spengler, U.6
  • 110
    • 54149102851 scopus 로고    scopus 로고
    • TLRs antiviral effect on hepatitis B virus in HepG2 cells
    • Xia, C., M. Lu, Z. Zhang, Z. Meng & C. Shi: TLRs antiviral effect on hepatitis B virus in HepG2 cells. J Appl Microbiol, 105, 1720-7 (2008)
    • (2008) J Appl Microbiol , vol.105 , pp. 1720-1727
    • Xia, C.1    Lu, M.2    Zhang, Z.3    Meng, Z.4    Shi, C.5
  • 111
    • 0037379437 scopus 로고    scopus 로고
    • Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication
    • DOI 10.1128/JVI.77.7.3898-3912.2003
    • Wang, C., J. Pflugheber, R. Sumpter, Jr., D. L. Sodora, D. Hui, G. C. Sen & M. Gale, Jr.: Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication. J Virol, 77, 3898-912 (2003) (Pubitemid 36350931)
    • (2003) Journal of Virology , vol.77 , Issue.7 , pp. 3898-3912
    • Wang, C.1    Pflugheber, J.2    Sumpter Jr., R.3    Sodora, D.L.4    Hui, D.5    Sen, G.C.6    Gale Jr., M.7
  • 112
    • 41649113404 scopus 로고    scopus 로고
    • Hepatitis C virus proteins interfere with the activation of chemokine gene promoters and downregulate chemokine gene expression
    • DOI 10.1099/vir.0.83316-0
    • Sillanpaa, M., P. Kaukinen, K. Melen & I. Julkunen: Hepatitis C virus proteins interfere with the activation of chemokine gene promoters and downregulate chemokine gene expression. J Gen Virol, 89, 432-43 (2008) (Pubitemid 351622440)
    • (2008) Journal of General Virology , vol.89 , Issue.2 , pp. 432-443
    • Sillanpaa, M.1    Kaukinen, P.2    Melen, K.3    Julkunen, I.4
  • 113
    • 42949149154 scopus 로고    scopus 로고
    • GB virus type Cdriven protection in HIV/HCV coinfection: Psssssossible role of interferon gamma and dendritic cell activation
    • DOI 10.1053/j.gastro.2008.03.070, PII S0016508508005659
    • Martini, F., A. Sacchi, E. Lalle, C. Castilletti, G. D'Offizi, I. Abbate & M. R. Capobianchi: GB virus type Cdriven protection in HIV/HCV coinfection: possible role of interferon gamma and dendritic cell activation. Gastroenterology, 134, 1631-3; author reply 1633 (2008) (Pubitemid 351615405)
    • (2008) Gastroenterology , vol.134 , Issue.5 , pp. 1631-1633
    • Martini, F.1    Sacchi, A.2    Lalle, E.3    Castilletti, C.4    D'Offizi, G.5    Abbate, I.6    Capobianchi, M.R.7
  • 114
    • 33749633453 scopus 로고    scopus 로고
    • Differential expression of toll-like receptor mRNA in treatment non-responders and sustained virologic responders at baseline in patients with chronic hepatitis C
    • DOI 10.1111/j.1478-3231.2006.01357.x
    • He, Q., C. S. Graham, E. Durante Mangoni & M. J. Koziel: Differential expression of toll-like receptor mRNA in treatment non-responders and sustained virologic responders at baseline in patients with chronic hepatitis C. Liver Int, 26, 1100-10 (2006) (Pubitemid 44541751)
    • (2006) Liver International , vol.26 , Issue.9 , pp. 1100-1110
    • He, Q.1    Graham, C.S.2    Mangoni, E.D.3    Koziel, M.J.4
  • 116
    • 38149077342 scopus 로고    scopus 로고
    • Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection
    • Atencia, R., F. J. Bustamante, A. Valdivieso, A. Arrieta, M. Rinon, A. Prada & N. Maruri: Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection. BMC Infect Dis, 7, 136 (2007)
    • (2007) BMC Infect Dis , vol.7 , pp. 136
    • Atencia, R.1    Bustamante, F.J.2    Valdivieso, A.3    Arrieta, A.4    Rinon, M.5    Prada, A.6    Maruri, N.7
  • 118
    • 1542317578 scopus 로고    scopus 로고
    • Species-Specific Recognition of Single-Stranded RNA via Till-like Receptor 7 and 8
    • DOI 10.1126/science.1093620
    • Heil, F., H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner & S. Bauer: Species-specific recognition of single-stranded RNA via tolllike receptor 7 and 8. Science, 303, 1526-9 (2004) (Pubitemid 38314424)
    • (2004) Science , vol.303 , Issue.5663 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3    Ampenberger, F.4    Kirschning, C.5    Akira, S.6    Lipford, G.7    Wagner, H.8    Bauer, S.9
  • 120
    • 19644362276 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
    • DOI 10.1248/bpb.28.886
    • Nishimura, M. & S. Naito: Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull, 28, 886-92 (2005) (Pubitemid 40740661)
    • (2005) Biological and Pharmaceutical Bulletin , vol.28 , Issue.5 , pp. 886-892
    • Nishimura, M.1    Naito, S.2
  • 123
    • 34250359469 scopus 로고    scopus 로고
    • Engulfment of apoptotic Cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells
    • DOI 10.1002/hep.21637
    • Wertheimer, A. M., S. J. Polyak, R. Leistikow & H. R. Rosen: Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells. Hepatology, 45, 1422-32 (2007) (Pubitemid 46918326)
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1422-1432
    • Wertheimer, A.M.1    Polyak, S.J.2    Leistikow, R.3    Rosen, H.R.4
  • 124
    • 67649818408 scopus 로고    scopus 로고
    • Functionally active toll-like receptor 3 on human primary and metastatic cancer cells
    • Matijevic, T., M. Marjanovic & J. Pavelic: Functionally active toll-like receptor 3 on human primary and metastatic cancer cells. Scand J Immunol, 70, 18-24 (2009)
    • (2009) Scand J Immunol , vol.70 , pp. 18-24
    • Matijevic, T.1    Marjanovic, M.2    Pavelic, J.3
  • 125
    • 2442712643 scopus 로고    scopus 로고
    • Toll signaling: RIPping off the TNF pathway
    • DOI 10.1038/ni0504-472
    • Barton, G. M. & R. Medzhitov: Toll signaling: RIPping off the TNF pathway. Nat Immunol, 5, 472-4 (2004) (Pubitemid 38660456)
    • (2004) Nature Immunology , vol.5 , Issue.5 , pp. 472-474
    • Barton, G.M.1    Medzhitov, R.2
  • 126
    • 0032582712 scopus 로고    scopus 로고
    • Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes
    • DOI 10.1074/jbc.273.44.29210
    • Au, W. C., P. A. Moore, D. W. LaFleur, B. Tombal & P. M. Pitha: Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. J Biol Chem, 273, 29210-7 (1998) (Pubitemid 28507622)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.44 , pp. 29210-29217
    • Au, W.-C.1    Moore, P.A.2    LaFleur, D.W.3    Tombal, B.4    Pitha, P.M.5
  • 127
    • 0032926882 scopus 로고    scopus 로고
    • Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription
    • Lin, R., C. Heylbroeck, P. Genin, P. M. Pitha & J. Hiscott: Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription. Mol Cell Biol, 19, 959-66 (1999) (Pubitemid 29046840)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.2 , pp. 959-966
    • Lin, R.1    Heylbroeck, C.2    Genin, P.3    Pitha, P.M.4    Hiscott, J.5
  • 128
    • 0031893220 scopus 로고    scopus 로고
    • Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome- mediated degradation
    • Lin, R., C. Heylbroeck, P. M. Pitha & J. Hiscott: Virusdependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol, 18, 2986-96 (1998) (Pubitemid 28183468)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.5 , pp. 2986-2996
    • Lin, R.1    Heylbroeck, C.2    Pitha, P.M.3    Hiscott, J.4
  • 129
    • 0032915860 scopus 로고    scopus 로고
    • Structural and functional analysis of interferon regulatory factor 3: Localization of the transactivation and autoinhibitory domains
    • Lin, R., Y. Mamane & J. Hiscott: Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains. Mol Cell Biol, 19, 2465-74 (1999) (Pubitemid 29144490)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.4 , pp. 2465-2474
    • Lin, R.1    Mamane, Y.2    Hiscott, J.3
  • 131
    • 0032434924 scopus 로고    scopus 로고
    • Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
    • DOI 10.1016/S0014-5793(98)01514-2, PII S0014579398015142
    • Sato, M., N. Hata, M. Asagiri, T. Nakaya, T. Taniguchi & N. Tanaka: Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7. FEBS Lett, 441, 106-10 (1998) (Pubitemid 29012382)
    • (1998) FEBS Letters , vol.441 , Issue.1 , pp. 106-110
    • Sato, M.1    Hata, N.2    Asagiri, M.3    Nakaya, T.4    Taniguchi, T.5    Tanaka, N.6
  • 132
    • 0032481352 scopus 로고    scopus 로고
    • Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF-3 and CBP/p300
    • DOI 10.1093/emboj/17.4.1087
    • Yoneyama, M., W. Suhara, Y. Fukuhara, M. Fukuda, E. Nishida & T. Fujita: Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. Embo J, 17, 1087-95 (1998) (Pubitemid 28077662)
    • (1998) EMBO Journal , vol.17 , Issue.4 , pp. 1087-1095
    • Yoneyama, M.1    Suhara, W.2    Fukuhara, Y.3    Fukuda, M.4    Nishida, E.5    Fujita, T.6
  • 134
    • 15244346528 scopus 로고    scopus 로고
    • Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKε
    • DOI 10.1128/JVI.79.7.3969-3978.2005
    • Breiman, A., N. Grandvaux, R. Lin, C. Ottone, S. Akira, M. Yoneyama, T. Fujita, J. Hiscott & E. F. Meurs: Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. J Virol, 79, 3969-78 (2005) (Pubitemid 40388337)
    • (2005) Journal of Virology , vol.79 , Issue.7 , pp. 3969-3978
    • Breiman, A.1    Grandvaux, N.2    Lin, R.3    Ottone, C.4    Akira, S.5    Yoneyama, M.6    Fujita, T.7    Hiscott, J.8    Meurs, E.F.9
  • 138
    • 34447560071 scopus 로고    scopus 로고
    • Function of RIG-I-like receptors in antiviral innate immunity
    • DOI 10.1074/jbc.R700007200
    • Yoneyama, M. & T. Fujita: Function of RIG-I-like receptors in antiviral innate immunity. J Biol Chem, 282, 15315-8 (2007) (Pubitemid 47093255)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.21 , pp. 15315-15318
    • Yoneyama, M.1    Fujita, T.2
  • 139
    • 20444442721 scopus 로고    scopus 로고
    • Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-β production in hepatocytes
    • DOI 10.1074/jbc.M414139200
    • Li, K., Z. Chen, N. Kato, M. Gale, Jr. & S. M. Lemon: Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes. J Biol Chem, 280, 16739-47 (2005) (Pubitemid 41389131)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.17 , pp. 16739-16747
    • Li, K.1    Chen, Z.2    Kato, N.3    Gale Jr., M.4    Lemon, S.M.5
  • 140
    • 34547796858 scopus 로고    scopus 로고
    • Limited suppression of the interferon-β production by hepatitis C virus serine protease in cultured human hepatocytes
    • DOI 10.1111/j.1742-4658.2007.05942.x
    • Dansako, H., M. Ikeda & N. Kato: Limited suppression of the interferon-beta production by hepatitis C virus serine protease in cultured human hepatocytes. FEBS J, 274, 4161-76 (2007) (Pubitemid 47228632)
    • (2007) FEBS Journal , vol.274 , Issue.16 , pp. 4161-4176
    • Dansako, H.1    Ikeda, M.2    Kato, N.3
  • 143
    • 3042740355 scopus 로고    scopus 로고
    • Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs
    • DOI 10.1002/jmv.20123
    • Melen, K., R. Fagerlund, M. Nyqvist, P. Keskinen & I. Julkunen: Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs. J Med Virol, 73, 536-47 (2004) (Pubitemid 38857203)
    • (2004) Journal of Medical Virology , vol.73 , Issue.4 , pp. 536-547
    • Melen, K.1    Fagerlund, R.2    Nyqvist, M.3    Keskinen, P.4    Julkunen, I.5
  • 145
    • 3242673323 scopus 로고    scopus 로고
    • Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif
    • DOI 10.1128/JVI.78.15.7958-7968.2004
    • Schwer, B., S. Ren, T. Pietschmann, J. Kartenbeck, K. Kaehlcke, R. Bartenschlager, T. S. Yen & M. Ott: Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol, 78, 7958-68 (2004) (Pubitemid 38944281)
    • (2004) Journal of Virology , vol.78 , Issue.15 , pp. 7958-7968
    • Schwer, B.1    Ren, S.2    Pietschmann, T.3    Kartenbeck, J.4    Kaehlcke, K.5    Bartenschlager, R.6    Yen, T.S.B.7    Ott, M.8
  • 147
    • 34249845169 scopus 로고    scopus 로고
    • Functional and therapeutic analysis of hepatitis C virus NS3·4A protease control of antiviral immune defense
    • DOI 10.1074/jbc.M610361200
    • Johnson, C. L., D. M. Owen & M. Gale, Jr.: Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense. J Biol Chem, 282, 10792-803 (2007) (Pubitemid 47093463)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.14 , pp. 10792-10803
    • Johnson, C.L.1    Owen, D.M.2    Gale Jr., M.3
  • 148
    • 33745624260 scopus 로고    scopus 로고
    • Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis
    • DOI 10.1099/vir.0.81701-0
    • Nomura-Takigawa, Y., M. Nagano-Fujii, L. Deng, S. Kitazawa, S. Ishido, K. Sada & H. Hotta: Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis. J Gen Virol, 87, 1935-45 (2006) (Pubitemid 43985876)
    • (2006) Journal of General Virology , vol.87 , Issue.7 , pp. 1935-1945
    • Nomura-Takigawa, Y.1    Nagano-Fujii, M.2    Deng, L.3    Kitazawa, S.4    Ishido, S.5    Sada, K.6    Hotta, H.7
  • 149
    • 0343446139 scopus 로고    scopus 로고
    • Viral inhibition of interferon signal transduction
    • Cebulla, C. M., D. M. Miller & D. D. Sedmak: Viral inhibition of interferon signal transduction. Intervirology, 42, 325-30 (1999) (Pubitemid 30122067)
    • (1999) Intervirology , vol.42 , Issue.5-6 , pp. 325-330
    • Cebulla, C.M.1    Miller, D.M.2    Sedmak, D.D.3
  • 150
    • 0033998608 scopus 로고    scopus 로고
    • Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31
    • DOI 10.1128/JVI.74.9.4174-4182.2000
    • Chang, Y. E. & L. A. Laimins: Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31. J Virol, 74, 4174-82 (2000) (Pubitemid 30214423)
    • (2000) Journal of Virology , vol.74 , Issue.9 , pp. 4174-4182
    • Chang, Y.E.1    Laimins, L.A.2
  • 151
    • 0035947270 scopus 로고    scopus 로고
    • How hepatitis C virus counteracts the interferon response: The jury is still out on NS5A
    • DOI 10.1006/viro.2001.0885
    • Tan, S. L. & M. G. Katze: How hepatitis C virus counteracts the interferon response: the jury is still out on NS5A. Virology, 284, 1-12 (2001) (Pubitemid 32476690)
    • (2001) Virology , vol.284 , Issue.1 , pp. 1-12
    • Tan, S.-L.1    Katze, M.G.2
  • 153
    • 0033516497 scopus 로고    scopus 로고
    • Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
    • DOI 10.1126/science.285.5424.107
    • Taylor, D. R., S. T. Shi, P. R. Romano, G. N. Barber & M. M. Lai: Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science, 285, 107-10 (1999) (Pubitemid 29307576)
    • (1999) Science , vol.285 , Issue.5424 , pp. 107-110
    • Taylor, D.R.1    Shi, S.T.2    Romano, P.R.3    Barber, G.N.4    Lai, M.M.C.5
  • 154
    • 0345004984 scopus 로고    scopus 로고
    • Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase
    • Gale, M., Jr., B. Kwieciszewski, M. Dossett, H. Nakao & M. G. Katze: Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase. J Virol, 73, 6506-16 (1999) (Pubitemid 29327831)
    • (1999) Journal of Virology , vol.73 , Issue.8 , pp. 6506-6516
    • Gale Jr., M.1    Kwieciszewski, B.2    Dossett, M.3    Nakao, H.4    Katze, M.G.5
  • 156
    • 0025298202 scopus 로고
    • Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
    • Meurs, E., K. Chong, J. Galabru, N. S. Thomas, I. M. Kerr, B. R. Williams & A. G. Hovanessian: Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell, 62, 379-90 (1990)
    • (1990) Cell , vol.62 , pp. 379-390
    • Meurs, E.1    Chong, K.2    Galabru, J.3    Thomas, N.S.4    Kerr, I.M.5    Williams, B.R.6    Hovanessian, A.G.7
  • 157
    • 0030725442 scopus 로고    scopus 로고
    • The double-stranded RNA-dependent protein kinase PKR: Structure and function
    • Clemens, M. J. & A. Elia: The double-stranded RNAdependent protein kinase PKR: structure and function. J Interferon Cytokine Res, 17, 503-24 (1997) (Pubitemid 27475916)
    • (1997) Journal of Interferon and Cytokine Research , vol.17 , Issue.9 , pp. 503-524
    • Clemens, M.J.1    Elia, A.2
  • 159
    • 0141566358 scopus 로고    scopus 로고
    • Cytopathic and noncytopathic interferon responses in cells expressing hepatitis C virus subgenomic replicons
    • DOI 10.1128/JVI.77.20.10769-10779.2003
    • Guo, J. T., Q. Zhu & C. Seeger: Cytopathic and noncytopathic interferon responses in cells expressing hepatitis C virus subgenomic replicons. J Virol, 77, 10769-79 (2003) (Pubitemid 37204270)
    • (2003) Journal of Virology , vol.77 , Issue.20 , pp. 10769-10779
    • Guo, J.-T.1    Zhu, Q.2    Seeger, C.3
  • 160
    • 34848845288 scopus 로고    scopus 로고
    • Interaction of hepatitis C virus with the type I interferon system
    • Weber, F.: Interaction of hepatitis C virus with the type I interferon system. World J Gastroenterol, 13, 4818-23 (2007) (Pubitemid 47496746)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.36 , pp. 4818-4823
    • Weber, F.1
  • 162
    • 16044365493 scopus 로고    scopus 로고
    • Severity of liver disease in liver transplantation recipients with hepatitis C virus infection: Relationship to genotype and level of viremia
    • DOI 10.1053/jhep.1996.v24.pm0008903372
    • Zhou, S., N. A. Terrault, L. Ferrell, J. A. Hahn, J. Y. Lau, P. Simmonds, J. P. Roberts, J. R. Lake, N. L. Ascher & T. L. Wright: Severity of liver disease in liver transplantation recipients with hepatitis C virus infection: relationship to genotype and level of viremia. Hepatology, 24, 1041-6 (1996) (Pubitemid 26365900)
    • (1996) Hepatology , vol.24 , Issue.5 , pp. 1041-1046
    • Zhou, S.1    Terrault, N.A.2    Ferrell, L.3    Hahn, J.A.4    Lau, J.Y.N.5    Simmonds, P.6    Roberts, J.P.7    Lake, J.R.8    Ascher, N.L.9    Wright, T.L.10
  • 163
    • 0032994280 scopus 로고    scopus 로고
    • Serum HCV RNA titer does not predict the severity of liver damage in HCV carriers with normal aminotransferase levels
    • Puoti, C., T. Stati & A. Magrini: Serum HCV RNA titer does not predict the severity of liver damage in HCV carriers with normal aminotransferase levels. Liver, 19, 104-9 (1999) (Pubitemid 29139762)
    • (1999) Liver , vol.19 , Issue.2 , pp. 104-109
    • Puoti, C.1    Stati, T.2    Magrini, A.3
  • 165
    • 67449096851 scopus 로고    scopus 로고
    • Multiple antigen-targeted immunotherapy with alpha-galactosylceramide- loaded and genetically engineered dendritic cells derived from embryonic stem cells
    • Fukushima, S., S. Hirata, Y. Motomura, D. Fukuma, Y. Matsunaga, Y. Ikuta, T. Ikeda, T. Kageshita, H. Ihn, Y. Nishimura & S. Senju: Multiple antigen-targeted immunotherapy with alpha-galactosylceramide-loaded and genetically engineered dendritic cells derived from embryonic stem cells. J Immunother, 32, 219-31 (2009)
    • (2009) J Immunother , vol.32 , pp. 219-231
    • Fukushima, S.1    Hirata, S.2    Motomura, Y.3    Fukuma, D.4    Matsunaga, Y.5    Ikuta, Y.6    Ikeda, T.7    Kageshita, T.8    Ihn, H.9    Nishimura, Y.10    Senju, S.11
  • 166
    • 50149090526 scopus 로고    scopus 로고
    • A birthday gift for TRADD
    • Natoli, G. & L. M. Austenaa: A birthday gift for TRADD. Nat Immunol, 9, 1015-6 (2008)
    • (2008) Nat Immunol , vol.9 , pp. 1015-1016
    • Natoli, G.1    Austenaa, L.M.2
  • 167
    • 0030589563 scopus 로고    scopus 로고
    • Suppression of apoptotic cell death by hepatitis C virus core protein
    • DOI 10.1006/viro.1996.0644
    • Ray, R. B., K. Meyer & R. Ray: Suppression of apoptotic cell death by hepatitis C virus core protein. Virology, 226, 176-82 (1996) (Pubitemid 27025796)
    • (1996) Virology , vol.226 , Issue.2 , pp. 176-182
    • Ray, R.B.1    Meyer, K.2    Ray, R.3
  • 168
    • 0031957325 scopus 로고    scopus 로고
    • Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis
    • Zhu, N., A. Khoshnan, R. Schneider, M. Matsumoto, G. Dennert, C. Ware & M. M. Lai: Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J Virol, 72, 3691-7 (1998) (Pubitemid 28188666)
    • (1998) Journal of Virology , vol.72 , Issue.5 , pp. 3691-3697
    • Zhu, N.1    Khoshnan, A.2    Schneider, R.3    Matsumoto, M.4    Dennert, G.5    Ware, C.6    Lai, M.M.C.7
  • 171
    • 33749039973 scopus 로고    scopus 로고
    • Do DCs influence the antiviral effect of interferon/ribavirin by changing their profile during the therapy?
    • DOI 10.1007/s00535-006-1863-5
    • Takahashi, H. & M. Zeniya: Do DCs influence the antiviral effect of interferon/ribavirin by changing their profile during the therapy? J Gastroenterol, 41, 816-7 (2006) (Pubitemid 44446141)
    • (2006) Journal of Gastroenterology , vol.41 , Issue.8 , pp. 816-817
    • Takahashi, H.1    Zeniya, M.2
  • 172
    • 13944275171 scopus 로고    scopus 로고
    • Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted for degradation to the proteasome
    • DOI 10.1128/JVI.79.5.2700-2708.2005
    • Franck, N., J. Le Seyec, C. Guguen-Guillouzo & L. Erdtmann: Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted for degradation to the proteasome. J Virol, 79, 2700-8 (2005) (Pubitemid 40270548)
    • (2005) Journal of Virology , vol.79 , Issue.5 , pp. 2700-2708
    • Franck, N.1    Le Seyec, J.2    Guguen-Guillouzo, C.3    Erdtmann, L.4
  • 173
    • 5144227738 scopus 로고    scopus 로고
    • The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities
    • DOI 10.1016/j.virol.2004.08.012, PII S0042682204005367
    • Prikhod'ko, E. A., G. G. Prikhod'ko, R. M. Siegel, P. Thompson, M. E. Major & J. I. Cohen: The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities. Virology, 329, 53-67 (2004) (Pubitemid 39346028)
    • (2004) Virology , vol.329 , Issue.1 , pp. 53-67
    • Prikhod'Ko, E.A.1    Prikhod'Ko, G.G.2    Siegel, R.M.3    Thompson, P.4    Major, M.E.5    Cohen, J.I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.