Expression of hepatitic C virus-derived core or NS3 antigens in human dendritic cells leads to induction of pro-inflammatory cytokines and normal T-cell stimulation capabilities

Journal of General Virology

Volumn 87, Issue 1, 2006, Pages 61-72

  Li, Wen ^a   Li, Jie ^a   Tyrrell, D Lorne J ^a   Agrawal, Babita ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CORE PROTEIN; CYTOKINE; DENDRITIC CELL VACCINE; MESSENGER RNA; NONSTRUCTURAL PROTEIN 3; TETANUS TOXOID; VIRUS PROTEIN; VIRUS RNA; NS3 PROTEIN, HEPATITIS C VIRUS; VIRUS ANTIGEN;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DENDRITIC CELL; DRUG TARGETING; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOSTIMULATION; LYMPHOCYTE ACTIVATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN TARGETING; T LYMPHOCYTE; WESTERN BLOTTING; BIOSYNTHESIS; CELL LINE; CHEMISTRY; CYTOLOGY; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; VIROLOGY;

ADENOVIRIDAE; HEPATITIS C VIRUS;

ANTIGENS, VIRAL; CELL LINE; CYTOKINES; DENDRITIC CELLS; GENE EXPRESSION; HEPACIVIRUS; HUMANS; T-LYMPHOCYTES; VIRAL CORE PROTEINS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 30344458832     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.81364-0     Document Type: Article

References (42)

1. Auffermann-Gretzinger, S., Keeffe, E. B. & Levy, S. (2001). Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection. Blood 97, 3171-3176.
2. Bain, C., Fatmi, A., Zoulim, F., Zarski, J.-P., Trépo, C. & Inchauspé, G. (2001). Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology 120, 512-524.
3. Battegay, M., Fikes, J., Di Bisceglie, A. M. & 11 other authors (1995). Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules. J Virol 69, 2462-2470.
4. Bronte, V., Carroll, M. W., Goletz, T. J., Wang, M., Overwijk, W. W., Marincola, F., Rosenberg, S. A., Moss, B. & Restifo, N. P. (1997). Related antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine. Proc Natl Acad Sci U S A 94, 3183-3188.
5. Brossart, P., Goldrath, A. W., Butz, E. A., Martin, S. & Bevan, M. J. (1997). Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL. J Immunol 158, 3270-3276.
6. Butterfield, L. H., Jilani, S. M., Chakraborty, N. G. & 9 other authors (1998). Generation of melanoma-specific cytotoxic T lymphocytes by dendritic cells transduced with a MART-1 adenovirus. J Immunol 161, 5607-5613.
7. Cerny, A., McHutchison, J. G., Pasquinelli, C., Brown, M. E., Brothers, M. A., Grabscheid, B., Fowler, P., Houghton, M. & Chisari, F. V. (1995). Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J Clin Invest 95, 521-530.
8. Chiriva-Internati, M., Liu, Y., Salati, E., Zhou, W., Wang, Z., Grizzi, F., Roman, J. J., Lim, S. H. & Hermonat, P. L. (2002). Efficient generation of cytotoxic T lymphocytes against cervical cancer cells by adeno-associated virus/human papillomavirus type 16 E7 antigen gene transduction into dendritic cells. Eur J Immunol 32, 30-38.
9. Diepolder, H. M., Zachoval, R., Hoffmann, R. M., Wierenga, E. A., Santantonio, T., Jung, M.-C., Eichenlaub, D. & Pape, G. R. (1995). Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346, 1006-1007.
10. + T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection. J Virol 71, 6011-6019.
11. Dolganiuc, A., Kodys, K., Kopasz, A., Marshall, C., Do, T., Romics, L., Jr, Mandrekar, P., Zapp, M. & Szabo, G. (2003). Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J Immunol 170, 5615-5624.
12. Gahn, B., Siller-Lopez, F., Pirooz, A. D. & 7 other authors (2001). Adenoviral gene transfer into dendritic cells efficiently amplifies the immune response to LMP2A antigen: a potential treatment strategy for Epstein-Barr virus-positive Hodgkin's lymphoma. Int J Cancer 93, 706-713.
13. Hahn, C. S., Cho, Y. G., Kang, B.-S., Lester, I. M. & Hahn, Y. S. (2000). The HCV core protein acts as a positive regulator of Fas-mediated apoptosis in a human lymphoblastoid T cell line. Virology 276, 127-137.
14. Hiasa, Y., Horiike, N., Akbar, S. M. F., Saito, I., Miyamura, T., Matsuura, Y. & Onji, M. (1998). Low stimulatory capacity of lymphoid dendritic cells expressing hepatitis C virus genes. Biochem Biophys Res Commun 249, 90-95.
15. Iwatani, Y., Amino, N., Mori, H., Asari, S., Ina, K., Ennyu, K. & Miyai, K. (1982). Effects of various isolation methods for human peripheral lymphocytes on T cell subsets determined in a fluorescence activated cell sorter (FACS), and demonstration of a sex difference of suppressor/cytotoxic T cells. J Immunol Methods 54, 31-42.
16. Kakumu, S., Ito, S., Ishikawa, T., Mita, Y., Tagaya, T., Fukuzawa, Y. & Yoshioka, K. (2000). Decreased function of peripheral blood dendritic cells in patients with hepatocellular carcinoma with hepatitis B and C virus infection. J Gastroenterol Hepatol 15, 431-436.
17. Kanto, T., Hayashi, N., Takehara, T., Tatsumi, T., Kuzushita, N., Ito, A., Sasaki, Y., Kasahara, A. & Hori, M. (1999). Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol 162, 5584-5591.
18. Kaplan, J. M., Yu, Q., Piraino, S. T., Pennington, S. E., Shankara, S., Woodworth, L. A. & Roberts, B. L. (1999). Induction of antitumor immunity with dendritic cells transduced with adenovirus vector-encoding endogenous tumor-associated antigens. J Immunol 163, 699-707.
19. Koziel, M. J., Dudley, D., Wong, J. T., Dienstag, J., Houghton, M., Ralston, R. & Walker, B. D. (1992). Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J Immunol 149, 3339-3344.
20. Langhans, B., Lechmann, M., Ihlenfeldt, H., Jung, G., Giers, G., Schweitzer, S., El Bakri, M., Sauerbruch, T. & Spengler, U. (2000). A hepatitis C virus (HCV) core protein derived peptide inhibits HCV specific lymphocyte proliferation. Eur J Med Res 5, 115-120.
21. Large, M. K., Kittlesen, D. J. & Hahn, Y. S. (1999). Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus persistence. J Immunol 162, 931-938.
22. Larsson, M., Babcock, E., Grakoui, A., Shoukry, N., Lauer, G., Rice, C., Walker, C. & Bhardwaj, N. (2004). Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus. J Virol 78, 6151-6161.
23. +-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol 76, 6104-6113.
24. Lechner, F., Wong, D. K. H., Dunbar, P. R. & 7 other authors (2000). Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 191, 1499-1512.
25. + Tr cells. Blood 105, 1162-1169.
26. Longman, R. S., Talal, A. H., Jacobson, I. M., Albert, M. L. & Rice, C. M. (2004). Presence of functional dendritic cells in patients chronically infected with hepatitis C virus. Blood 103, 1026-1029.
27. Motta, I., André, F., Lim, A., Tartaglia, J., Cox, W. I., Zitvogel, L., Angevin, E. & Kourilsky, P. (2001). Cross-presentation by dendritic cells of tumor antigen expressed in apoptotic recombinant canarypox virus-infected dendritic cells. J Immunol 167, 1795-1802.
28. Neumann-Haefelin, C., Blum, H. E., Chisari, F. V. & Thimme, R. (2005). T cell responses in hepatitis C virus infection. J Clin Virol 32, 75-85.
29. Pape, G. R., Gerlach, T. J., Diepolder, H. M., Gruner, N., Jung, M. & Santantonio, T. (1999). Role of the specific T-cell response for clearance and control of hepatitis C virus. J Viral Hepat 6 (Suppl. 1), 36-40.
30. Radstake, T. R. D. J., van Lent, P. L. E. M., Pesman, G. J., Blom, A. B., Sweep, F. G. J., Rönnelid, J., Adema, G. J., Barrera, P. & van den Berg, W. B. (2004). High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcγR triggering. Ann Rheum Dis 63, 696-702.
31. Rehermann, B., Chang, K.-M., McHutchison, J. G., Kokka, R., Houghton, M. & Chisari, F. V. (1996). Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J Clin Invest 98, 1432-1440.
32. + T cells by dendritic cells expressing hepatitis C virus core and E1 proteins. J Virol 76, 5062-5070.
33. Sarobe, P., Lasarte, J. J., Zabaleta, A., Arribillaga, L., Arina, A., Melero, I., Borrás-Cuesta, F. & Prieto, J. (2003). Hepatitis C virus structural proteins impair dendritic cell maturation and inhibit in vivo induction of cellular immune responses. J Virol 77, 10862-10871.
34. Shirai, M., Okada, H., Nishioka, M., Akatsuka, T., Wychowski, C., Houghten, R., Pendleton, C. D., Feinstone, S. M. & Berzofsky, J. A. (1994). An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans. J Virol 68, 3334-3342.
35. + T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 197, 1645-1655.
36. Song, W., Kong, H.-L., Carpenter, H., Torii, H., Granstein, R., Rafii, S., Moore, M. A. S. & Crystal, R. G. (1997). Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity. J Exp Med 186, 1247-1256.
37. Specht, J. M., Wang, G., Do, M. T., Lam, J. S., Royal, R. E., Reeves, M. E., Rosenberg, S. A. & Hwu, P. (1997). Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases. J Exp Med 186, 1213-1221.
38. Thimme, R., Oldach, D., Chang, K.-M., Steiger, C., Ray, S. C. & Chisari, F. V. (2001). Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 194, 1395-1406.
39. Tsubouchi, E., Akbar, S. M. F., Horiike, N. & Onji, M. (2004). Infection and dysfunction of circulating blood dendritic cells and their subsets in chronic hepatitis C virus infection. J Gastroenterol 39, 754-762.
40. + lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C. J Virol 76, 12423-12434.
41. Wan, Y. & Bramson, J. (2001). Role of dendritic cell-derived cytokines in immune regulation. Curr Pharm Des 7, 977-992.
42. Yanagi, M., Purcell, R. H., Emerson, S. U. & Bukh, J. (1997). Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Proc Natl Acad Sci U S A 94, 8738-8743.