Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication

Journal of Hepatology

Volumn 48, Issue 6, 2008, Pages 914-922

  Broering, Ruth ^a   Wu, Jun ^a   Meng, Zhongji ^a   Hilgard, Philip ^a   Lu, Mengji ^a   Trippler, Martin ^a   Szczeponek, Agnes ^a   Gerken, Guido ^a   Schlaak, Joerg F ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Hepatitis C virus; Interferon response; Kupffer cells; Liver sinusoid endothelial cells; Poly I:C; Replicon

Indexed keywords

CYTOKINE; INTERFERON; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; HEPATITIS C VIRUS; INNATE IMMUNITY; LIVER CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRUS REPLICATION;

ANIMALS; CELL LINE; DENDRITIC CELLS; ENDOTHELIAL CELLS; HEPACIVIRUS; IMMUNE SYSTEM; INTERFERON-BETA; KUPFFER CELLS; LIVER; MICE; MICE, INBRED C57BL; RNA, MESSENGER; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS; VIRUS REPLICATION;

EID: 43049183612     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.01.028     Document Type: Article

References (26)

1. Alter H.J., and Seeff L.B. Recovery, persistence, and sequelae in hepatitis C virus infection: a perspective on long-term outcome. Semin Liver Dis 20 (2000) 17-35
2. McHutchison J.G., and Fried M.W. Current therapy for hepatitis C: pegylated interferon and ribavirin. Clin Liver Dis 7 (2003) 149-161
3. Gorczynski R.M., Hozumi N., Wolf S., and Chen Z. Interleukin 12 in combination with anti-interleukin 10 reverses graft prolongation after portal venous immunization. Transplantation 60 (1995) 1337-1341
4. Groux H., O'Garra A., Bigler M., Rouleau M., Antonenko S., de Vries J.E., et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389 (1997) 737-742
5. Knolle P.A., and Gerken G. Local control of the immune response in the liver. Immunol Rev 174 (2000) 21-34
6. Steinbrink K., Wolfl M., Jonuleit H., Knop J., and Enk A.H. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159 (1997) 4772-4780
7. McCormick C.J., Challinor L., Macdonald A., Rowlands D.J., and Harris M. Introduction of replication-competent hepatitis C virus transcripts using a tetracycline-regulable baculovirus delivery system. J Gen Virol 85 (2004) 429-439
8. Sumpter Jr. R., Loo Y.M., Foy E., Li K., Yoneyama M., Fujita T., et al. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol 79 (2005) 2689-2699
9. Bigger C.B., Guerra B., Brasky K.M., Hubbard G., Beard M.R., Luxon B.A., et al. Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees. J Virol 78 (2004) 13779-13792
10. Helbig K.J., Lau D.T., Semendric L., Harley H.A., and Beard M.R. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology 42 (2005) 702-710
11. Foy E., Li K., Sumpter Jr. R., Loo Y.M., Johnson C.L., Wang C., et al. Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci USA 102 (2005) 2986-2991
12. Li K., Foy E., Ferreon J.C., Nakamura M., Ferreon A.C., Ikeda M., et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci USA 102 (2005) 2992-2997
13. Wu J., Lu M., Meng Z., Trippler M., Broering R., Szczeponek A., et al. Toll-like receptor-mediated control of HBV replication by non-parenchymal liver cells in mice. Hepatology 46 (2007) 1769-1778
14. Inaba K., Inaba M., Romani N., Aya H., Deguchi M., Ikehara S., et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 176 (1992) 1693-1702
15. Guo J.T., Bichko V.V., and Seeger C. Effect of alpha interferon on the hepatitis C virus replicon. J Virol 75 (2001) 8516-8523
16. Zhu Q., Guo J.T., and Seeger C. Replication of hepatitis C virus subgenomes in nonhepatic epithelial and mouse hepatoma cells. J Virol 77 (2003) 9204-9210
17. Hilkens C.M., Schlaak J.F., and Kerr I.M. Differential responses to IFN-alpha subtypes in human T cells and dendritic cells. J Immunol 171 (2003) 5255-5263
18. Pietschmann T., Lohmann V., Rutter G., Kurpanek K., and Bartenschlager R. Characterization of cell lines carrying self-replicating hepatitis C virus RNAs. J Virol 75 (2001) 1252-1264
19. aus dem Siepen M., Lohmann V., Wiese M., Ross S., Roggendorf M., Viazov S., et al. Nonstructural protein 5A does not contribute to the resistance of hepatitis C virus replication to interferon alpha in cell culture. Virology 336 (2005) 131-136
20. Gu B., Gates A.T., Isken O., Behrens S.E., and Sarisky R.T. Replication studies using genotype 1a subgenomic hepatitis C virus replicons. J Virol 77 (2003) 5352-5359
21. Liew F.Y., Patel M., and Xu D. Toll-like receptor 2 signalling and inflammation. Ann Rheum Dis 64 (2005) iv104-iv105
22. O'Neill L.A. How Toll-like receptors signal: what we know and what we don't know. Curr Opin Immunol 18 (2006) 3-9
23. Zhang Z., and Schluesener H.J. Mammalian toll-like receptors: from endogenous ligands to tissue regeneration. Cell Mol Life Sci 63 (2006) 2901-2907
24. Akira S., and Takeda K. Toll-like receptor signalling. Nat Rev Immunol 4 (2004) 499-511
25. Takeda K., and Akira S. TLR signaling pathways. Semin Immunol 16 (2004) 3-9
26. Takeda K., and Akira S. Toll-like receptors in innate immunity. Int Immunol 17 (2005) 1-14