Serum HCV RNA titer does not predict the severity of liver damage in HCV carriers with normal aminotransferase levels

Liver

Volumn 19, Issue 2, 1999, Pages 104-109

  Puoti, Claudio ^a   Stati, Tonino ^a   Magrini, Andrea ^a  

^a E De Santis Hospital   (Italy)

Author keywords

Aminotransferase; HCV carriers histological; Liver biopsy; Scores; Viraemia

Indexed keywords

AMINOTRANSFERASE; VIRUS RNA;

ADULT; ARTICLE; BIOCHEMISTRY; CLINICAL PRACTICE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEVICE; DISEASE COURSE; FEMALE; FIBROSIS; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; PREDICTION; STAGING; VIREMIA; VIRUS CARRIER; VIRUS REPLICATION;

EID: 0032994280     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1478-3231.1999.tb00018.x     Document Type: Article

References (59)

1. HOOFNAGLE J H. Hepatitis C: the clinical spectrum of disease. Hepatology 1997; 26 (suppl 1): 15S-20S.
2. MARCELLIN P, LÉVY S, ERLINGER S. Therapy of hepatitis C: patients with normal aminotransferase levels. Hepatology 1997; 26 (suppl 1): 133S-6S.
3. BRILLANTI S, FOLI M, GAIANI S, MASCI C, MIGLIOLI M, BARBARA L. Persistent hepatitis C viremia without liver injury. Lancet 1993; 341: 464-5.
4. PUOTI C, MAGRINI A, STATI T, RIGATO P, MONTAGNESE F, ROSSI P. Clinical, histological and viroiogical features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels. Hepatology 1997; 26: 1393-8.
5. PUOTI C, MAGRINI A, STATI T, ROSSI P, MONTAGNESE F, RESTA S. Interferon for hepatitis C. Lancet 1997; 349: 398-9.
6. PUOTI C, STATI T, MAGRINI A, RIGATO P, ROMAGNOLI G C, ROSSI P. Liver histology in anti-HCV positive subjects with normal ALT levels. Ital J Gastroenterol Hepatol 1997; 29: 383-4.
7. ALBERTI A, MORSICA G, CHEMELLO L, CAVALLETTO D, NOVENTA F, PONTISSO P. Hepatitis C viremia and liver disease in symptom-free individuals with anti-HCV. Lancet 1992; 340: 697-8.
8. HEALEY C J, CHAPMAN R W G, FLEMING K A. Liver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases. Gut 1993; 37: 274-8.
9. PRIETO M, OLASO V, VERDU C, CORDOBA J, GISBERT C, RAYON M. Does the healthy hepatitis C virus carrier state really exist? An analysis using Polymerase Chain Reaction. Hepatology 1995; 22: 413-7.
10. MCLINDON J P, PAVER M K, BABBS C, YATES A D, MCMAHON 1 F T, LOVE E M. Hepatitis C-related chronic liver disease among asymptomatic blood donors in the North West of England. J Infect 1995; 30: 253-9.
11. SHAKIL A O, CONRY-CANTILENA C, ALTER H J, HAYASHI P, KLEINER D E, TEDESCHI V. Volunteer blood donors with antibody to hepatitis C virus: clinical, biochemical, virologic, and histologic features. Ann Intern Med 1995; 123: 330-7.
12. CAHEN D L, VAN LEEUWEN D J, TEN KATE F J W, BLOK A P R, OOSTING J, CHAMULEAU R A F M. Do serum ALT values reflect the inflammatory activity in the liver of patients with chronic hepatitis? Liver 1996; 16: 105-9.
13. MCCORMICK S E, GOODMAN Z D, MAYDONOVITCH C L, SJOGREN M H. Evaluation of liver histology, ALT elevation and HCV RNA titer in patients with chronic hepatitis. Am J Gastroenterol 1996; 91: 1516-22.
14. SEYMOUR C. Asymptomatic infection with hepatitis C virus. BMJ 1994; 308: 670-1.
15. VALORI R, CHRISTIE J. Be cautious with liver biopsy. BMJ 1994; 308: 1235.
16. PERRILLO R. The role of liver biopsy in hepatitis C. Hepatology 1997; 26 (suppl 1): 57S-61S.
17. KATO N, YOKOSUKA O, HOSODA K, ITO Y, OHTO M, OMATA M. Quantification of hepatitis C virus by competitive reverse transcription-polymerase chain reaction: increase of the virus in advanced liver disease. Hepatology 1993; 18: 16-20.
18. LAU J Y N, DAVIS G L, KNIFFEN J, QIAN Q P, URDEA M S, CHAN C S. Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet 1993; 341: 1501-4.
19. GRETCH D, COREY L, WILSON J, DELA ROSA C, WILLSON R, CARITHERS R. Assessment of hepatitis C virus RNA levels by quantitative competitive RNA polymerase chain reaction: high-titer viremia correlates with advanced stage of disease. J Infect Dis 1994; 169: 1219-23.
20. GORDON S C, KODALI V P, SILVERMAN A L, DMUCHOWSKI C F, URDEA M S, CHAN C S. Levels of hepatitis C virus RNA and liver histology in chronic type C hepatitis. Am J Gastroenterol 1994; 89: 1458-61.
21. MAGRIN S, CRAXÌ A, FABIANO C, SIMONETTI R G, FIORENTINO G, MARINO L. Hepatitis C viremia in chronic liver disease: relationship to interferon alpha or corticosteroid treatment. Hepatology 1994; 19: 273-9.
22. ZEUZEM S, FRANKE A, LEE J-H, HERRMANN G, RUSTER B, ROTH W K. Phylogenetic analysis of hepatitis C virus isolates and their correlation to viremia, liver function tests, and histology. Hepatology 1996; 24: 1003-9.
23. HOLLINGSWORTH R C, SILLEKENS P, VAN DEURSEN P, NEAL K R, IRVING W L, TRENT HCV STUDY GROUP. Serum HCV RNA levels assessed by quantitative NASBA®: stability of viral load over time, and lack of correlation with liver disease. J Hepatol 1996; 25: 301-6.
24. YUKI N, HAYASHI N, KAMADA T. HCV viremia and liver injury in symptom-free blood donors. Lancet 1993; 342: 444.
25. HAGIWARA H, HAYASHI N, MITA E, NAITO M, KASAHARA A, FUSAMOTO H. Quantitation of Hepatitis C Virus RNA in serum of asymptomatic blood donors and patients with type C chronic liver disease. Hepatology 1993; 17: 545-50.
26. NAITO M, HAYASHI N, HAGIWARA H, HIRAMATSU N, KASAHARA A, FUSAMOTO H. Serum hepatitis C virus RNA quantity and histological features of hepatitis C virus carriers with persistently normal ALT levels. Hepatology 1994; 19: 871-5.
27. SHINDO M, ARAI K, SOKAWA Y, OKUNO T. The virological and histological states of anti-hepatitis C virus-positive subjects with normal liver biochemical values. Hepatology 1995; 22: 418-25.
28. OKANOUE T, YASUI K, SAKAMOTO S, MINAMI M, NAGAO Y, ITOH Y. Circulating HCV-RNA, HCV genotypes, and liver histology in asymptomatic individuals reactive for anti-HCV antibody and their follow-up study. Liver 1996; 16: 241-7.
29. ROSSINI A, RAVAGGI A, AGOSTINELLI E, BERCICH L, GAZZOLA G B, RADAELI E. Virological characterization and liver histology in HCV positive subjects with normal and elevated ALT levels. Liver 1997; 17: 133-6.
30. DESMET V J, GERBER M, HOOFNAGLE J H, MANNS M, SCHEUER P J. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994; 19: 1513-20.
31. ISHAK K, BAPTISTA L, BIANCHI L, CALLEA F, DE GROOTE J, GUDAT F. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696-9.
32. STANLEY A J, HAYDON G H, PIRIS J, JARVIS L M, HAYES P C. Assessment of liver function in patients with hepatitis C and normal transaminase levels. Eur J Gastroenterol Hepatol 1996; 8: 869-72.
33. MARCELLIN P, LÉVY S, BENHAMOU J P, ERLINGER S. Management of the asymptomatic HCV carrier of normal ALT levels. Viral Hepatitis Rev 1996; 2: 277-83.
34. VAN THIEL D H, CARACENI P, MOLLOY P J, HASSANEIN T, KANIA R J, GURAKAR A. Chronic hepatitis C in patients with normal or near normal alanine aminotransferase levels: the role of interferon alfa2b therapy. J Hepatol 1995; 23: 503-8.
35. SERFATY L, CHAZOUILLÈRES O, PAWLOTSKI J M, ANDREANI T, PELLET C, POUPON R. Interferon alfa therapy in patients with chronic hepatitis C and persistently normal aminotransferase activity. Gastroenterology 1996; 110: 291-5.
36. ROSSINI A, RAVAGGI A, BIASI L, AGOSTINELLI E, BERCICH L, GAZZOLA G B. Virological response to Interferon treatment in Hepatitis C Virus carriers with normal aminotransferase levels and chronic hepatitis. Hepatology 1997; 26: 1012-7.
37. GRASSI G, POZZATO G, MORETTI M, GIACCA M. Quantitative analysis of hepatitis C virus RNA in liver biopsies by competitive reverse transcription and polymerase chain reaction. J Hepatol 1995; 23: 403-11.
38. NOUSBAUM J B, POL S, NALPAS B, LANDAIS P, BERTHELOT P, BRECHOT C. Hepatitis C virus type 1b (II) infection in France and Italy. Ann Intern Med 1995; 122: 161-8.
39. ROMEO R, COLOMBO M, RUMI M G, SOFFREDINI R, DEL NINNO E, DONATO M F. Lack of association between type of hepatitis C virus, serum load and severity of liver disease. J Viral Hepat 1996; 3: 183-90.
40. YAMADA G, TAKATANI M, KISHI F, TAKAHASHI M, DOI T, TSUJI T. Efficacy of interferon alfa therapy in chronic hepatitis C patients depends primarily on hepatitis C virus RNA level. Hepatology 1995; 22: 1351-4.
41. MITA E, HAYASHI N, KANAZAWA Y, HAGIWARA H, UEDA K, KASAHARA A. Hepatitis C virus genotype and RNA titer in the progression of type C chronic liver disease. J Hepatol 1994; 21: 468-73.
42. ZEUZEM S, SCHMIDT J M, LEE J H, RUSTER B, ROTH W K. Effect of interferon alfa on the dynamics of hepatitis C virus turnover in vivo. Hepatology 1996; 23: 366-71.
43. SHINDO M, ARAI K, SOKAWA Y, OKUNO T. Hepatic hepatitis C virus RNA as a predictor of a long-term response to interferon-α therapy. Ann Intern Med 1995; 122: 586-91.
44. GARSON G A, TUKE P W, MAKRIS M, BRIGGS M, MACHIN J J, PRESTON P E. Demonstration of viremia patterns in hemophiliacs treated with hepatitis C contaminates factor VIII concentrates. Lancet 1990; 336: 1015-22.
45. ALTER M J, MARGOLIS H S, KRAWCZYNSKI K, JUDSON F N, MARES A, ALEXANDER W J. The natural history of community-acquired hepatitis C in the United States. N Engl J Med 1992; 327: 1899-1905.
46. NGUYEN T T, SEDGHI-VAZIRI A, WILKS L B, MONDALA T, POCKROS P J, LINDSAY K L. Fluctuations in viral load (HCV RNA) are relatively insignificant in untreated patients with chronic HCV infection. J Viral Hepat 1996; 3: 75-8.
47. WANG J T, SHEU J C, LIN J T, WANG T H, CHEN D S. Detection of replicative form of hepatitis C virus RNA in peripheral blood mononuclear cells. J Infect Dis 1992; 166: 1167-9.
48. ZIGNEGO A L, MACCHIA D, MONTI M, THIERS V, MAZETTI M, FOSCHI M. Infection of peripheral blood mononuclear cells by hepatitis C virus. J Hepatol 1992; 15: 382-6.
49. MULLER H M, PFAFF E, GOESER T, KALLINOWSKI B, SOLBACH C, THEILMANN L. Peripheral blood leukocytes serve as a possible extrahepatic site for hepatitis C virus replication. J Gen Virol 1993; 74: 669-76.
50. SAKAMOTO N, ENOMOTO N, KUROSAKI M, MARUMO F, SATO C. Detection and quantitation of hepatitis C virus RNA replication in the liver. J Hepatol 1994; 20: 593-7.
51. BALLARDINI G, MANZIN A, GIOSTRA F, FRANCESCONI R, GROFF P, GRASSI A. Quantitative parameters of HCV infection: relation to HCV genotypes, viremia and response to interferon treatment. J Hepatol 1997; 26: 779-86.
52. FONG T L, LEE S R, BRIGGS W K, VALINLUCK B, GOVINDARAJAN S, HUFFMAN A. Clinical significance of hepatitis C viral RNA status and its correlation to antibodies to structural HCV antigens in anti-HCV reactive patients with normal liver tests. J Med Virol 1996; 49: 253-8.
53. IDROVO V, DAILEY P J, JEFFERS L J, COELHO-LITTLE E, BERNSTEIN D, BARTHOLOMEW M. Hepatitis C virus RNA quantitation in right and left lobes of the liver in patients with chronic hepatitis C. J Viral Hepat 1996; 3: 239-46.
54. MCGUINNESS P H, BISHOP A G, PAINTER D M, CHAN D, MCCAUGHAN G W. Intrahepatic C RNA levels do not correlate with degree of liver injury in patients with chronic hepatitis C. Hepatology 1996; 23: 676-87.
55. KAGE M, SHIMAMATSU K, NAKASHIMA E, KOJIRO M, INOUE O, YANO M. Long-term evolution of fibrosis from chronic hepatitis to cirrhosis in patients with hepatitis C: morphometric analysis of repeated biopsies. Hepatology 1997; 25: 1027-31.
56. SHINDO M, ARAI K, OKUNO T. The clinical value of grading and staging score for predicting a long-term response and evaluating the efficacy of interferon therapy in chronic hepatitis C. J Hepatol 1997; 26: 492-7.
57. SHEV S, DHILLON A P, LINDH M, et al. The importance of cofactors in the histologic progression of minimal and mild chronic hepatitis C. Liver 1997; 17: 215-23.
58. YANO M, KUMADA H, KAGE M, et al. The long-term pathological evolution of chronic hepatitis C. Hepatology 1996; 23: 1334-40.
59. ISAACSON A H, DAVIS G L, LAU J Y N. Should we test hepatitis C virus genotype and viremia in patients with chronic hepatitis C? J Viral Hepat 1997; 4: 285-92.