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Volumn 18, Issue 16, 2012, Pages 2305-2313

The mechanism of adjuvanticity of aluminium-containing formulas

Author keywords

Adjuvant; Aluminium hydroxide; Dendritic cell; NLRP3; Syk; Uric acid and dsDNA

Indexed keywords

ADJUVANT; ALUMINUM DERIVATIVE; ALUMINUM HYDROXIDE; ALUMINUM POTASSIUM SULFATE; CRYOPYRIN; DOUBLE STRANDED DNA; MIFAMURTIDE; PROTEIN KINASE SYK; URIC ACID; VACCINE;

EID: 84860170373     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212800166004     Document Type: Review
Times cited : (10)

References (119)
  • 1
    • 27744440480 scopus 로고    scopus 로고
    • How) do aluminium adjuvants work?
    • Brewer JM (2006). (How) do aluminium adjuvants work? Immunol Lett 102 (1): 10-15.
    • (2006) Immunol Lett , vol.102 , Issue.1 , pp. 10-15
    • Brewer, J.M.1
  • 4
    • 79952704589 scopus 로고    scopus 로고
    • Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes
    • Calabro S, Tortoli M, Baudner BC, Pacitto A, Cortese M, O'Hagan DT, De Gregorio E, Seubert A, Wack A (2011). Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes. Vaccine 29 (9): 1812-1823.
    • (2011) Vaccine , vol.29 , Issue.9 , pp. 1812-1823
    • Calabro, S.1    Tortoli, M.2    Baudner, B.C.3    Pacitto, A.4    Cortese, M.5    O'Hagan, D.T.6    de Gregorio, E.7    Seubert, A.8    Wack, A.9
  • 5
    • 68949086546 scopus 로고    scopus 로고
    • Novel cellular and molecular mechanisms of induction of immune responses by aluminumadjuvants
    • Aimanianda V, Haensler J, Lacroix-Desmazes S, Kaveri SV, Bayry J (2009). Novel cellular and molecular mechanisms of induction of immune responses by aluminumadjuvants. Trends Pharmacol Sci 30 (6): 287-295.
    • (2009) Trends Pharmacol Sci , vol.30 , Issue.6 , pp. 287-295
    • Aimanianda, V.1    Haensler, J.2    Lacroix-Desmazes, S.3    Kaveri, S.V.4    Bayry, J.5
  • 7
    • 34250331531 scopus 로고    scopus 로고
    • The perfect mix: Recent progress in adjuvant research
    • Guy B (2007). The perfect mix: recent progress in adjuvant research. Nat Rev Microbiol 2007 5 (7): 505-517.
    • (2007) Nat Rev Microbiol 2007 , vol.5 , Issue.7 , pp. 505-517
    • Guy, B.1
  • 8
    • 17644416719 scopus 로고    scopus 로고
    • Targeting the innate immune response with improved vaccine adjuvants
    • Pashine A, Valiante NM, Ulmer JB (2005). Targeting the innate immune response with improved vaccine adjuvants. Nat Med 11(4): 63-68.
    • (2005) Nat Med , vol.11 , Issue.4 , pp. 63-68
    • Pashine, A.1    Valiante, N.M.2    Ulmer, J.B.3
  • 9
    • 33845905223 scopus 로고    scopus 로고
    • Adjuvant-enhanced antibody responses in the absence of toll-like receptor signalling
    • Gavin AL, Hoebe K, Duong B, Ota T, Martin C, Beutler B, Nemazee D (2006). Adjuvant-enhanced antibody responses in the absence of toll-like receptor signalling. Science 314 (5807): 1936-1938.
    • (2006) Science , vol.314 , Issue.5807 , pp. 1936-1938
    • Gavin, A.L.1    Hoebe, K.2    Duong, B.3    Ota, T.4    Martin, C.5    Beutler, B.6    Nemazee, D.7
  • 10
    • 33744999388 scopus 로고    scopus 로고
    • Immunology: Toll-like receptors and antibody responses
    • discussion E4
    • Nemazee D, Gavin A, Hoebe K, Beutler B (2006). Immunology: Toll-like receptors and antibody responses. Nature 441 (7091): discussion E4.
    • (2006) Nature , vol.441 , pp. 7091
    • Nemazee, D.1    Gavin, A.2    Hoebe, K.3    Beutler, B.4
  • 11
    • 0029987839 scopus 로고    scopus 로고
    • The instructive role of innate immunity in the acquired immune response
    • Fearon DT, Locksley RM (1996). The instructive role of innate immunity in the acquired immune response. Science 272 (5258): 50-53.
    • (1996) Science , vol.272 , Issue.5258 , pp. 50-53
    • Fearon, D.T.1    Locksley, R.M.2
  • 12
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: The virtues of a nonclonal system of recognition
    • Medzhitov R, Janeway CA Jr (1997). Innate immunity: the virtues of a nonclonal system of recognition. Cell 91 (3): 295-298.
    • (1997) Cell , vol.91 , Issue.3 , pp. 295-298
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 14
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S (2005). Toll-like receptors in innate immunity. Int Immunol 17 (1):1-14.
    • (2005) Int Immunol , vol.17 , Issue.1 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 16
    • 0037205089 scopus 로고    scopus 로고
    • Overview of vaccine adjuvants: Present and future
    • Hunter RL (2002). Overview of vaccine adjuvants: present and future. Vaccine 20 (3): S7-12.
    • (2002) Vaccine , vol.20 , Issue.3
    • Hunter, R.L.1
  • 17
    • 2942701975 scopus 로고    scopus 로고
    • Promotion of B cell immune responses via an alum-induced myeloid cell population
    • Jordan MB, Mills DM, Kappler J, Marrack P, Cambier JC (2004). Promotion of B cell immune responses via an alum-induced myeloid cell population. Science 304(5678): 1808-1810.
    • (2004) Science , vol.304 , Issue.5678 , pp. 1808-1810
    • Jordan, M.B.1    Mills, D.M.2    Kappler, J.3    Marrack, P.4    Cambier, J.C.5
  • 18
    • 44449159510 scopus 로고    scopus 로고
    • Pivotal advance: Eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production
    • Wang HB, Weller PF (2008). Pivotal advance: eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production. J Leukoc Biol 83 (4): 817-821.
    • (2008) J Leukoc Biol , vol.83 , Issue.4 , pp. 817-821
    • Wang, H.B.1    Weller, P.F.2
  • 19
    • 0030769938 scopus 로고    scopus 로고
    • Mechanisms of adjuvancy: I--Metal oxides as adjuvants
    • Naim JO, van Oss CJ, Wu W, Giese RF, Nickerson PA (1997). Mechanisms of adjuvancy: I--Metal oxides as adjuvants. Vaccine 15 (11): 1183-1193.
    • (1997) Vaccine , vol.15 , Issue.11 , pp. 1183-1193
    • Naim, J.O.1    van Oss, C.J.2    Wu, W.3    Giese, R.F.4    Nickerson, P.A.5
  • 21
    • 0018817401 scopus 로고
    • The comparative selectivity of adjuvants for humoral and cell-mediated immunity. II. Effect on delayed-type hypersensitivity in the mouse and guinea pig, and cell-mediated immunity to tumour antigens in the mouse of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacteriumparvum, Bordetella pertussis, muramyl dipeptide and saponin
    • Bomford R (1980). The comparative selectivity of adjuvants for humoral and cell-mediated immunity. II. Effect on delayed-type hypersensitivity in the mouse and guinea pig, and cell-mediated immunity to tumour antigens in the mouse of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacteriumparvum, Bordetella pertussis, muramyl dipeptide and saponin. Clin Exp Immunol 39 (2): 435-441.
    • (1980) Clin Exp Immunol , vol.39 , Issue.2 , pp. 435-441
    • Bomford, R.1
  • 22
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • Shi Y, Evans JE, Rock KL (2003). Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425 (6957): 516-621.
    • (2003) Nature , vol.425 , Issue.6957 , pp. 516-621
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 23
    • 73249127767 scopus 로고    scopus 로고
    • Monosodium urate crystals in inflammation and immunity
    • Shi Y, Mucsi AD, Ng G (2010). Monosodium urate crystals in inflammation and immunity. Immunol Rev 233 (1): 203-217.
    • (2010) Immunol Rev , vol.233 , Issue.1 , pp. 203-217
    • Shi, Y.1    Mucsi, A.D.2    Ng, G.3
  • 24
    • 79960758984 scopus 로고    scopus 로고
    • The inflammasome and alummediated adjuvanticity
    • Kang SJ, Locksley RM (2009). The inflammasome and alummediated adjuvanticity. Biol Rep 1.p: 15.
    • (2009) Biol Rep , vol.1 , pp. 15
    • Kang, S.J.1    Locksley, R.M.2
  • 25
    • 36849045915 scopus 로고    scopus 로고
    • The inflammasome: A danger sensing complex triggering innate immunity
    • Pétrilli V, Dostert C, Muruve DA, Tschopp J (2007). The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 19 (6): 615-622.
    • (2007) Curr Opin Immunol , vol.19 , Issue.6 , pp. 615-622
    • Pétrilli, V.1    Dostert, C.2    Muruve, D.A.3    Tschopp, J.4
  • 26
    • 77957701029 scopus 로고    scopus 로고
    • Immunogenicity and safety of MF59-adjuvanted H5N1 influenza vaccine from infancy to adolescence
    • Vesikari T, Karvonen A, Tilman S, Borkowski A, Montomoli E, Banzhoff A, Clemens R (2010). Immunogenicity and safety of MF59-adjuvanted H5N1 influenza vaccine from infancy to adolescence. Pediatrics 126 (4): 762-770.
    • (2010) Pediatrics , vol.126 , Issue.4 , pp. 762-770
    • Vesikari, T.1    Karvonen, A.2    Tilman, S.3    Borkowski, A.4    Montomoli, E.5    Banzhoff, A.6    Clemens, R.7
  • 28
    • 67349269509 scopus 로고    scopus 로고
    • Mechanism of action of licensed vaccine adjuvants
    • Tritto E, Mosca F, De Gregorio E (2009). Mechanism of action of licensed vaccine adjuvants. Vaccine 27 (25-26): 3331-3334.
    • (2009) Vaccine , vol.27 , Issue.25-26 , pp. 3331-3334
    • Tritto, E.1    Mosca, F.2    de Gregorio, E.3
  • 29
    • 77949500672 scopus 로고    scopus 로고
    • Cervarix: A vaccine for the prevention of HPV 16, 18-associated cervical cancer
    • Monie A, Hung CF, Roden R, Wu TC (2008). Cervarix: a vaccine for the prevention of HPV 16, 18-associated cervical cancer. Biologics 2 (1): 97-105.
    • (2008) Biologics , vol.2 , Issue.1 , pp. 97-105
    • Monie, A.1    Hung, C.F.2    Roden, R.3    Wu, T.C.4
  • 30
    • 0030687891 scopus 로고    scopus 로고
    • Cytokines and the mechanisms of action of vaccine adjuvants
    • Brewer JM, Alexander J (1997). Cytokines and the mechanisms of action of vaccine adjuvants. Cytokines Cell Mol Ther 3 (4):233-246.
    • (1997) Cytokines Cell Mol Ther , vol.3 , Issue.4 , pp. 233-246
    • Brewer, J.M.1    Alexander, J.2
  • 31
    • 40049088465 scopus 로고    scopus 로고
    • Dendritic cells and epithelial cells: Linking innate and adaptive immunity in asthma
    • Hammad H, Lambrecht BN (2008). Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat Rev Immunol 8 (3): 193-204.
    • (2008) Nat Rev Immunol , vol.8 , Issue.3 , pp. 193-204
    • Hammad, H.1    Lambrecht, B.N.2
  • 32
    • 0036083905 scopus 로고    scopus 로고
    • Exploiting dendritic cells to improve vaccine efficiency
    • Steinman RM, Pope M (2002). Exploiting dendritic cells to improve vaccine efficiency. J ClinInvest 109 (12): 1519-1526.
    • (2002) J ClinInvest , vol.109 , Issue.12 , pp. 1519-1526
    • Steinman, R.M.1    Pope, M.2
  • 33
    • 0037018097 scopus 로고    scopus 로고
    • Adjuvants of immunity: Harnessing innate immunity to promote adaptive immunity
    • Bendelac A, Medzhitov R (2002). Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med 195 (5): F19-23.
    • (2002) J Exp Med , vol.195 , Issue.5
    • Bendelac, A.1    Medzhitov, R.2
  • 34
    • 33644788087 scopus 로고    scopus 로고
    • Dendritic cells in asthma: A function beyond sensitization
    • van Rijt LS, Lambrecht BN (2005). Dendritic cells in asthma: a function beyond sensitization. Clin Exp Allergy 2005 35 (9): 1125-1134.
    • (2005) Clin Exp Allergy 2005 , vol.35 , Issue.9 , pp. 1125-1134
    • van Rijt, L.S.1    Lambrecht, B.N.2
  • 35
    • 34248400446 scopus 로고    scopus 로고
    • Activation of dendritic cells and induction of CD4(+) T cell differentiation by aluminum-containing adjuvants
    • Sokolovska A, Hem SL, HogenEsch H (2007). Activation of dendritic cells and induction of CD4(+) T cell differentiation by aluminum-containing adjuvants. Vaccine 25 (23): 4575-4585.
    • (2007) Vaccine , vol.25 , Issue.23 , pp. 4575-4585
    • Sokolovska, A.1    Hem, S.L.2    Hogenesch, H.3
  • 36
    • 0029148878 scopus 로고
    • Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
    • Sallusto F, Cella M, Danieli C, Lanzavecchia A (1995). Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med 182 (2): 389-400.
    • (1995) J Exp Med , vol.182 , Issue.2 , pp. 389-400
    • Sallusto, F.1    Cella, M.2    Danieli, C.3    Lanzavecchia, A.4
  • 38
    • 0030175501 scopus 로고    scopus 로고
    • Mechanisms of antigen uptake for presentation
    • Lanzavecchia A (1996). Mechanisms of antigen uptake for presentation. Curr Opin Immunol 3: 348-354.
    • (1996) Curr Opin Immunol , vol.3 , pp. 348-354
    • Lanzavecchia, A.1
  • 40
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel TR, Henrickson SE, Von Andrian UH (2004). T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427 (6970): 154-159.
    • (2004) Nature , vol.427 , Issue.6970 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    von Andrian, U.H.3
  • 41
    • 0017603174 scopus 로고
    • A simple conservative explanation of the H-2 restriction of interactions between lymphocytes
    • Cunningham AJ, Lafferty KJ (1977). A simple conservative explanation of the H-2 restriction of interactions between lymphocytes. Scand J Immunol 6 (1-2): 1-6.
    • (1977) Scand J Immunol , vol.6 , Issue.1-2 , pp. 1-6
    • Cunningham, A.J.1    Lafferty, K.J.2
  • 43
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: A costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy
    • Mueller DL, Jenkins MK, Schwartz RH (1989). Clonal expansion versus functional clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol 7: 445-480.
    • (1989) Annu Rev Immunol , vol.7 , pp. 445-480
    • Mueller, D.L.1    Jenkins, M.K.2    Schwartz, R.H.3
  • 44
    • 0033486007 scopus 로고    scopus 로고
    • Tcell priming by type-1 and type-2 polarized dendritic cells: The concept of a third signal
    • Kaliński P, Hilkens CM, Wierenga EA, Kapsenberg ML (1999). Tcell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today 20 (12): 561-567.
    • (1999) Immunol Today , vol.20 , Issue.12 , pp. 561-567
    • Kaliński, P.1    Hilkens, C.M.2    Wierenga, E.A.3    Kapsenberg, M.L.4
  • 45
    • 0026580529 scopus 로고
    • Antigen pulsed dendritic cells can efficiently induce an antibody response et al. Antigen pulsed dendritic cells can efficiently induce an antibody response in vivo
    • Sornasse T, Flamand V, De Becker G, Bazin H, Tielemans F, Thielemans K, Urbain J, Leo O, Moser M (1992). Antigen pulsed dendritic cells can efficiently induce an antibody response et al. Antigen pulsed dendritic cells can efficiently induce an antibody response in vivo. J Exp Med 175: 15-21.
    • (1992) J Exp Med , vol.175 , pp. 15-21
    • Sornasse, T.1    Flamand, V.2    de Becker, G.3    Bazin, H.4    Tielemans, F.5    Thielemans, K.6    Urbain, J.7    Leo, O.8    Moser, M.9
  • 46
    • 34047261260 scopus 로고    scopus 로고
    • ATP activates a oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages
    • Cruz CM, Rinna A, Forman HJ, Ventura AL, Persechini PM, Ojcius DM (2007). ATP activates a oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem 282 (5): 2871-2879.
    • (2007) J Biol Chem , vol.282 , Issue.5 , pp. 2871-2879
    • Cruz, C.M.1    Rinna, A.2    Forman, H.J.3    Ventura, A.L.4    Persechini, P.M.5    Ojcius, D.M.6
  • 47
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • Lotze MT, Tracey KJ (2005). High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 5 (4): 331-342.
    • (2005) Nat Rev Immunol , vol.5 , Issue.4 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 48
    • 0032756730 scopus 로고    scopus 로고
    • Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling
    • Brewer JM, Conacher M, Hunter CA, Mohrs M, Brombacher F, Alexander J (1999). Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling. J Immunol 163 (12): 6448-6454.
    • (1999) J Immunol , vol.163 , Issue.12 , pp. 6448-6454
    • Brewer, J.M.1    Conacher, M.2    Hunter, C.A.3    Mohrs, M.4    Brombacher, F.5    Alexander, J.6
  • 49
    • 0031914326 scopus 로고    scopus 로고
    • Neither interleukin-6 nor signalling via tumour necrosis factor receptor-1 contribute to the adjuvant activity of Alum and Freund's adjuvant
    • Brewer JM, Conacher M, Gaffney M, Douglas M, Bluethmann H, Alexander J (1998). Neither interleukin-6 nor signalling via tumour necrosis factor receptor-1 contribute to the adjuvant activity of Alum and Freund's adjuvant. Immunology 93 (1): 41-48.
    • (1998) Immunology , vol.93 , Issue.1 , pp. 41-48
    • Brewer, J.M.1    Conacher, M.2    Gaffney, M.3    Douglas, M.4    Bluethmann, H.5    Alexander, J.6
  • 50
    • 0029796717 scopus 로고    scopus 로고
    • In interleukin-4 deficient mice, alum not only generates T helper 1 responses equivalent to Freund's complete adjuvant, but continues to induce T helper 2 cytokine production
    • Brewer JM, Conacher M, Satoskar A, Bluethmann H, Alexander J (1996). In interleukin-4 deficient mice, alum not only generates T helper 1 responses equivalent to Freund's complete adjuvant, but continues to induce T helper 2 cytokine production. Eur J Immunol 26: 2062-2066.
    • (1996) Eur J Immunol , vol.26 , pp. 2062-2066
    • Brewer, J.M.1    Conacher, M.2    Satoskar, A.3    Bluethmann, H.4    Alexander, J.5
  • 51
    • 0030460025 scopus 로고    scopus 로고
    • In vivo distribution of radioactivity in mice after injection of biodegradable polymer microspheres containing 14C-labeled tetanus toxoid
    • Gupta RK, Chang AC, Griffin P, Rivera R, Siber GR (1996). In vivo distribution of radioactivity in mice after injection of biodegradable polymer microspheres containing 14C-labeled tetanus toxoid. Vaccine 14 (15): 1412-1416.
    • (1996) Vaccine , vol.14 , Issue.15 , pp. 1412-1416
    • Gupta, R.K.1    Chang, A.C.2    Griffin, P.3    Rivera, R.4    Siber, G.R.5
  • 52
    • 4243187214 scopus 로고    scopus 로고
    • Aluminium adjuvants--in retrospect and prospect
    • Lindblad EB (2004). Aluminium adjuvants--in retrospect and prospect. Vaccine 22 (27-28): 3658-3668.
    • (2004) Vaccine , vol.22 , Issue.27-28 , pp. 3658-3668
    • Lindblad, E.B.1
  • 53
    • 0037205174 scopus 로고    scopus 로고
    • Mechanism of stimulation of the immune response of aluminium adjuvants
    • HogenEsch H (2002). Mechanism of stimulation of the immune response of aluminium adjuvants. Vaccine 20 (3): S34-39.
    • (2002) Vaccine , vol.20 , Issue.3
    • Hogenesch, H.1
  • 55
    • 45949083618 scopus 로고    scopus 로고
    • The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells
    • Seubert A, Monaci E, Pizza M, O'Hagan DT, Wack A (2008). The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells. J Immunol 180 (8): 5402-5412.
    • (2008) J Immunol , vol.180 , Issue.8 , pp. 5402-5412
    • Seubert, A.1    Monaci, E.2    Pizza, M.3    O'Hagan, D.T.4    Wack, A.5
  • 56
    • 70449713915 scopus 로고    scopus 로고
    • Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
    • McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, et al (2009). Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol 183 (7): 4403-4414.
    • (2009) J Immunol , vol.183 , Issue.7 , pp. 4403-4414
    • McKee, A.S.1    Munks, M.W.2    Macleod, M.K.3    Fleenor, C.J.4    van Rooijen, N.5    Kappler, J.W.6
  • 58
    • 78049413094 scopus 로고    scopus 로고
    • Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants
    • Yang CW, Strong BS, Miller MJ, Unanue ER (2010). Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants. J Immunol 185 (5): 2927-2934.
    • (2010) J Immunol , vol.185 , Issue.5 , pp. 2927-2934
    • Yang, C.W.1    Strong, B.S.2    Miller, M.J.3    Unanue, E.R.4
  • 59
    • 0002897532 scopus 로고
    • Studies on antibody production. III. The alum granuloma
    • White RG, Coons AH, Connolly JM (1955). Studies on antibody production. III. The alum granuloma. J Exp Med 102: 73-82.
    • (1955) J Exp Med , vol.102 , pp. 73-82
    • White, R.G.1    Coons, A.H.2    Connolly, J.M.3
  • 60
    • 0033889651 scopus 로고    scopus 로고
    • Aluminium-induced granulomas after inaccurate intradermal hyposensitization injections of aluminium-adsorbed depot preparations
    • Vogelbruch M, Nuss B, Körner M, Kapp A, Kiehl P, Bohm W (2000). Aluminium-induced granulomas after inaccurate intradermal hyposensitization injections of aluminium-adsorbed depot preparations. Allergy 55(9): 883-887.
    • (2000) Allergy , vol.55 , Issue.9 , pp. 883-887
    • Vogelbruch, M.1    Nuss, B.2    Körner, M.3    Kapp, A.4    Kiehl, P.5    Bohm, W.6
  • 61
    • 43249112858 scopus 로고    scopus 로고
    • Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses
    • McKee AS, MacLeod M, White J, Crawford F, Kappler JW, Marrack P (2008). Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses. Int Immunol 20 (5): 659-669.
    • (2008) Int Immunol , vol.20 , Issue.5 , pp. 659-669
    • McKee, A.S.1    Macleod, M.2    White, J.3    Crawford, F.4    Kappler, J.W.5    Marrack, P.6
  • 62
    • 0018292652 scopus 로고
    • Complement activation by aluminum and zirconium compounds
    • Ramanathan VD, Badenoch-Jones P, Turk JL (1979). Complement activation by aluminum and zirconium compounds. Immunology 37: 881-888.
    • (1979) Immunology , vol.37 , pp. 881-888
    • Ramanathan, V.D.1    Badenoch-Jones, P.2    Turk, J.L.3
  • 63
    • 0034283681 scopus 로고    scopus 로고
    • Antibody production in mice deficient for complement receptors 1 and 2 can be induced by IgG/Ag and IgE/Ag, but not IgM/Ag complexes
    • Applequist SE, Dahlström J, Jiang N, Molina H, Heyman B (2000). Antibody production in mice deficient for complement receptors 1 and 2 can be induced by IgG/Ag and IgE/Ag, but not IgM/Ag complexes. J Immunol 165 (5): 2398-2403.
    • (2000) J Immunol , vol.165 , Issue.5 , pp. 2398-2403
    • Applequist, S.E.1    Dahlström, J.2    Jiang, N.3    Molina, H.4    Heyman, B.5
  • 64
    • 0034665297 scopus 로고    scopus 로고
    • Impaired affinity maturation in Cr2-/- mice is rescued by adjuvants without improvement in germinal center development
    • Wu X, Jiang N, Fang YF, Xu C, Mao D, Singh J, Fu YX, Molina H (2000). Impaired affinity maturation in Cr2-/- mice is rescued by adjuvants without improvement in germinal center development. J Immunol 165 (6): 3119-3127.
    • (2000) J Immunol , vol.165 , Issue.6 , pp. 3119-3127
    • Wu, X.1    Jiang, N.2    Fang, Y.F.3    Xu, C.4    Mao, D.5    Singh, J.6    Fu, Y.X.7    Molina, H.8
  • 66
    • 0035144140 scopus 로고    scopus 로고
    • The Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism
    • Ulanova M, Tarkowski A, Hahn-Zoric M, Hanson LA (2001). The Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism. Infect Immun 69 (2): 1151-1159.
    • (2001) Infect Immun , vol.69 , Issue.2 , pp. 1151-1159
    • Ulanova, M.1    Tarkowski, A.2    Hahn-Zoric, M.3    Hanson, L.A.4
  • 67
    • 0037435833 scopus 로고    scopus 로고
    • Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro
    • Sun H, Pollock KG, Brewer JM (2003). Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro. Vaccine 21(9-10): 849-855.
    • (2003) Vaccine , vol.21 , Issue.9-10 , pp. 849-855
    • Sun, H.1    Pollock, K.G.2    Brewer, J.M.3
  • 68
    • 31944440061 scopus 로고    scopus 로고
    • Are mineral adjuvants triggering TLR2/TLR4 on dendritic cells by a secondary cascade reaction in vivo through the action of heat shock proteins and danger signals?
    • Lindblad EB (2006). Are mineral adjuvants triggering TLR2/TLR4 on dendritic cells by a secondary cascade reaction in vivo through the action of heat shock proteins and danger signals? Vaccine 24 (6): 697-698.
    • (2006) Vaccine , vol.24 , Issue.6 , pp. 697-698
    • Lindblad, E.B.1
  • 69
    • 13444292001 scopus 로고    scopus 로고
    • Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro
    • Morefield GL, Sokolovska A, Jiang D, HogenEsch H, Robinson JP, Hem SL (2005). Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro. Vaccine 23(13): 1588-1595.
    • (2005) Vaccine , vol.23 , Issue.13 , pp. 1588-1595
    • Morefield, G.L.1    Sokolovska, A.2    Jiang, D.3    Hogenesch, H.4    Robinson, J.P.5    Hem, S.L.6
  • 70
    • 0021828474 scopus 로고
    • Modulation of the human immune response by the nontoxic and non-pyrogenic adjuvant aluminium hydroxide: Effect on antigen uptake and antigen presentation
    • Mannhalter JW, Neychev HO, Zlabinger GJ, Ahmad R, Eibl MM (1985). Modulation of the human immune response by the nontoxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation. Clin Exp Immunol 61(1): 143-151.
    • (1985) Clin Exp Immunol , vol.61 , Issue.1 , pp. 143-151
    • Mannhalter, J.W.1    Neychev, H.O.2    Zlabinger, G.J.3    Ahmad, R.4    Eibl, M.M.5
  • 72
    • 34547699645 scopus 로고    scopus 로고
    • Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response
    • Hansen B, Sokolovska A, HogenEsch H, Hem SL (2007). Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response. Vaccine 25 (36): 6618-6624.
    • (2007) Vaccine , vol.25 , Issue.36 , pp. 6618-6624
    • Hansen, B.1    Sokolovska, A.2    Hogenesch, H.3    Hem, S.L.4
  • 73
    • 45749111446 scopus 로고    scopus 로고
    • Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    • Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA (2008). Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453 (7198): 1122-1126.
    • (2008) Nature , vol.453 , Issue.7198 , pp. 1122-1126
    • Eisenbarth, S.C.1    Colegio, O.R.2    O'Connor, W.3    Sutterwala, F.S.4    Flavell, R.A.5
  • 74
    • 35348968868 scopus 로고    scopus 로고
    • Relationship between physical and chemical properties of aluminium containing adjuvants and immunopotentiation
    • Hem SL, Hogenesch H (2007). Relationship between physical and chemical properties of aluminium containing adjuvants and immunopotentiation. Vaccine 20 (3): 685-698.
    • (2007) Vaccine , vol.20 , Issue.3 , pp. 685-698
    • Hem, S.L.1    Hogenesch, H.2
  • 77
    • 22444433175 scopus 로고    scopus 로고
    • NLRs join TLRs as innate sensors of pathogens
    • Martinon F, Tschopp J (2005). NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26 (8): 447-454.
    • (2005) Trends Immunol , vol.26 , Issue.8 , pp. 447-454
    • Martinon, F.1    Tschopp, J.2
  • 78
    • 48549102504 scopus 로고    scopus 로고
    • NOD-like receptors (NLRs): Bona fide intracellular microbial sensors
    • Shaw MH, Reimer T, Kim YG, Nunez G (2008). NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr Opin Immunol 20 (4): 377-382.
    • (2008) Curr Opin Immunol , vol.20 , Issue.4 , pp. 377-382
    • Shaw, M.H.1    Reimer, T.2    Kim, Y.G.3    Nunez, G.4
  • 79
    • 33845890803 scopus 로고    scopus 로고
    • Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation
    • Mariathasan S, Monack DM (2007). Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7 (1): 31-40.
    • (2007) Nat Rev Immunol , vol.7 , Issue.1 , pp. 31-40
    • Mariathasan, S.1    Monack, D.M.2
  • 80
    • 34547743231 scopus 로고    scopus 로고
    • The inflammasome in pathogen recognition and inflammation
    • Sutterwala FS, Ogura Y, Flavell RA (2007). The inflammasome in pathogen recognition and inflammation. J Leukoc Biol 82 (2): 259-264.
    • (2007) J Leukoc Biol , vol.82 , Issue.2 , pp. 259-264
    • Sutterwala, F.S.1    Ogura, Y.2    Flavell, R.A.3
  • 81
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger P (2002). The danger model: a renewed sense of self. Science 296 (5566): 301-305.
    • (2002) Science , vol.296 , Issue.5566 , pp. 301-305
    • Matzinger, P.1
  • 83
    • 2542457495 scopus 로고    scopus 로고
    • Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases
    • Martinon F, Tschopp J (2004). Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117 (5): 561-574.
    • (2004) Cell , vol.117 , Issue.5 , pp. 561-574
    • Martinon, F.1    Tschopp, J.2
  • 85
    • 0037312509 scopus 로고    scopus 로고
    • NALPs: A novel protein family involved in inflammation
    • Tschopp J, Martinon F, Burns K (2003). NALPs: a novel protein family involved in inflammation. Nat Rev Mol Cell Biol 4 (2): 95-104.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.2 , pp. 95-104
    • Tschopp, J.1    Martinon, F.2    Burns, K.3
  • 86
    • 47849087075 scopus 로고    scopus 로고
    • Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
    • Li H, Willingham SB, Ting JP, Re F (2008). Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol 181 (1): 17-21.
    • (2008) J Immunol , vol.181 , Issue.1 , pp. 17-21
    • Li, H.1    Willingham, S.B.2    Ting, J.P.3    Re, F.4
  • 87
    • 0037290856 scopus 로고    scopus 로고
    • New insights into the mechanism of IL-1beta maturation
    • Burns K, Martinon F, Tschopp J (2003). New insights into the mechanism of IL-1beta maturation. Curr Opin Immunol 15 (1): 26-30.
    • (2003) Curr Opin Immunol , vol.15 , Issue.1 , pp. 26-30
    • Burns, K.1    Martinon, F.2    Tschopp, J.3
  • 88
    • 0021175756 scopus 로고
    • Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: Interleukin 1 is required for the expression of receptors for interleukin 2
    • Kaye J, Gillis S, Mizel SB, Shevach EM, Malek TR, Dinarello CA, Lachman LB, Janeway CA Jr (1984). Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2. J Immunol 133 (3): 1339-1345.
    • (1984) J Immunol , vol.133 , Issue.3 , pp. 1339-1345
    • Kaye, J.1    Gillis, S.2    Mizel, S.B.3    Shevach, E.M.4    Malek, T.R.5    Dinarello, C.A.6    Lachman, L.B.7    Janeway Jr., C.A.8
  • 89
    • 0037465251 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense
    • Dunne A, O'Neill LA (2003). The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE (171): 53.
    • (2003) Sci STKE , vol.171 , pp. 53
    • Dunne, A.1    O'Neill, L.A.2
  • 90
    • 66949175347 scopus 로고    scopus 로고
    • A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses
    • Meng G, Zhang F, Fuss I, Kitani A, Strober W (2009). A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity 30 (6): 860-874.
    • (2009) Immunity , vol.30 , Issue.6 , pp. 860-874
    • Meng, G.1    Zhang, F.2    Fuss, I.3    Kitani, A.4    Strober, W.5
  • 91
    • 0032080345 scopus 로고    scopus 로고
    • Costimulation via TCR and IL-1 receptor reveals a novel IL-1alpha-mediated autocrine pathway of Th2 cell proliferation
    • Huber M, Beuscher HU, Rohwer P, Kurrle R, Röllinghoff M, Lohoff M (1998). Costimulation via TCR and IL-1 receptor reveals a novel IL-1alpha-mediated autocrine pathway of Th2 cell proliferation. J Immunol 160 (9): 4242-4247.
    • (1998) J Immunol , vol.160 , Issue.9 , pp. 4242-4247
    • Huber, M.1    Beuscher, H.U.2    Rohwer, P.3    Kurrle, R.4    Röllinghoff, M.5    Lohoff, M.6
  • 93
    • 34548027736 scopus 로고    scopus 로고
    • Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
    • Pétrilli V, Papin S, Dostert C, Mayor A, Martinon F, Tschopp J (2007). Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14 (9): 1583-1589.
    • (2007) Cell Death Differ , vol.14 , Issue.9 , pp. 1583-1589
    • Pétrilli, V.1    Papin, S.2    Dostert, C.3    Mayor, A.4    Martinon, F.5    Tschopp, J.6
  • 94
    • 34547101484 scopus 로고    scopus 로고
    • Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria
    • Franchi L, Kanneganti TD, Dubyak GR, Núñez G (2007). Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J Biol Chem 282 (26): 18810-18818.
    • (2007) J Biol Chem , vol.282 , Issue.26 , pp. 18810-18818
    • Franchi, L.1    Kanneganti, T.D.2    Dubyak, G.R.3    Núñez, G.4
  • 96
    • 3042800587 scopus 로고    scopus 로고
    • Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes
    • Andrei C, Margiocco P, Poggi A, Lotti LV, Torrisi MR, Rubartelli A (2004). Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes. Proc Natl Acad Sci USA 101 (26): 9745-9750.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.26 , pp. 9745-9750
    • Andrei, C.1    Margiocco, P.2    Poggi, A.3    Lotti, L.V.4    Torrisi, M.R.5    Rubartelli, A.6
  • 97
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin- interacting protein links oxidative stress to inflammasome activation
    • Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J (2010). Thioredoxin- interacting protein links oxidative stress to inflammasome activation. Nat Immunol 11(2): 136-140.
    • (2010) Nat Immunol , vol.11 , Issue.2 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 100
    • 0042914359 scopus 로고    scopus 로고
    • Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin
    • Hentze H, Lin XY, Choi MS, Porter AG (2003). Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. Cell Death Differ 10 (9): 956-968.
    • (2003) Cell Death Differ , vol.10 , Issue.9 , pp. 956-968
    • Hentze, H.1    Lin, X.Y.2    Choi, M.S.3    Porter, A.G.4
  • 101
    • 34247106805 scopus 로고    scopus 로고
    • Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release
    • Li H, Nookala S, Re F (2007). Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. J Immunol 178 (8): 5271-5276.
    • (2007) J Immunol , vol.178 , Issue.8 , pp. 5271-5276
    • Li, H.1    Nookala, S.2    Re, F.3
  • 102
    • 56149119563 scopus 로고    scopus 로고
    • Cutting Edge: Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
    • Kool M, Petrilli V, De Smedt T, Rolaz A, Hammad H, van Nimwegen M, et al. (2008). Cutting Edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol 181 (6): 3755-3759.
    • (2008) J Immunol , vol.181 , Issue.6 , pp. 3755-3759
    • Kool, M.1    Petrilli, V.2    de Smedt, T.3    Rolaz, A.4    Hammad, H.5    van Nimwegen, M.6
  • 103
    • 50849112477 scopus 로고    scopus 로고
    • The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity
    • Franchi L, Nunez G (2008). The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur J Immunol 38 (8): 2085-2089.
    • (2008) Eur J Immunol , vol.38 , Issue.8 , pp. 2085-2089
    • Franchi, L.1    Nunez, G.2
  • 104
    • 0031987322 scopus 로고    scopus 로고
    • Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells
    • Puren AJ, Fantuzzi G, Gu Y, Su MS, Dinarello CA (1998). Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. J Clin Invest 101 (3): 711-721.
    • (1998) J Clin Invest , vol.101 , Issue.3 , pp. 711-721
    • Puren, A.J.1    Fantuzzi, G.2    Gu, Y.3    Su, M.S.4    Dinarello, C.A.5
  • 107
    • 8844222731 scopus 로고    scopus 로고
    • A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells
    • Nakashima K, Kokubo T, Shichijo M, Li YF, Yura T, Yamamoto N (2004). A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells. Eur J Pharmacol 505 (1-3): 223-228.
    • (2004) Eur J Pharmacol , vol.505 , Issue.1-3 , pp. 223-228
    • Nakashima, K.1    Kokubo, T.2    Shichijo, M.3    Li, Y.F.4    Yura, T.5    Yamamoto, N.6
  • 109
    • 0036034183 scopus 로고    scopus 로고
    • Protein tyrosine kinase Syk in mast cell signaling
    • Siraganian RP, Zhang J, Suzuki K, Sada K (2002). Protein tyrosine kinase Syk in mast cell signaling. Mol Immunol 38 (16-18): 1229-1233.
    • (2002) Mol Immunol , vol.38 , Issue.16-18 , pp. 1229-1233
    • Siraganian, R.P.1    Zhang, J.2    Suzuki, K.3    Sada, K.4
  • 111
    • 68149160812 scopus 로고    scopus 로고
    • Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C
    • Popa-Nita O, Proulx S, Paré G, Rollet-Labelle E, Naccache PH (2009). Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C. J Immunol 183 (3): 2104-2114
    • (2009) J Immunol , vol.183 , Issue.3 , pp. 2104-2114
    • Popa-Nita, O.1    Proulx, S.2    Paré, G.3    Rollet-Labelle, E.4    Naccache, P.H.5
  • 112
    • 79954587515 scopus 로고    scopus 로고
    • Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms
    • Kuroda E, Ishii KJ, Uematsu S, Ohata K, Coban C, Akira S, Aritake K, Urade Y, Morimoto Y (2011). Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms. Immunity 34 (4): 514-526.
    • (2011) Immunity , vol.34 , Issue.4 , pp. 514-526
    • Kuroda, E.1    Ishii, K.J.2    Uematsu, S.3    Ohata, K.4    Coban, C.5    Akira, S.6    Aritake, K.7    Urade, Y.8    Morimoto, Y.9
  • 113
    • 0027250010 scopus 로고
    • Studies on the toxicities of aluminium hydroxide and calcium phosphate as immunological adjuvants for vaccines
    • Goto N, Kato H, Maeyama J, Eto K, Yoshihara S (1993). Studies on the toxicities of aluminium hydroxide and calcium phosphate as immunological adjuvants for vaccines. Vaccine 11 (9): 914-918.
    • (1993) Vaccine , vol.11 , Issue.9 , pp. 914-918
    • Goto, N.1    Kato, H.2    Maeyama, J.3    Eto, K.4    Yoshihara, S.5
  • 114
    • 0021269182 scopus 로고
    • Local histopathological reactions to aluminum-adsorbed tetanus toxoid
    • Goto N, Akama K (1984). Local histopathological reactions to aluminum-adsorbed tetanus toxoid. Naturwissenschaften 71 (8): 427-428.
    • (1984) Naturwissenschaften , vol.71 , Issue.8 , pp. 427-428
    • Goto, N.1    Akama, K.2
  • 115
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J (2006). Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 (7081): 237-241.
    • (2006) Nature , vol.440 , Issue.7081 , pp. 237-241
    • Martinon, F.1    Pétrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 117
    • 0034687696 scopus 로고    scopus 로고
    • Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses
    • Shi Y, Zheng W, Rock KL (2000). Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc Natl Acad Sci USA 97(26): 14590-14595.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.26 , pp. 14590-14595
    • Shi, Y.1    Zheng, W.2    Rock, K.L.3
  • 118
    • 61449116809 scopus 로고    scopus 로고
    • A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity
    • Kanevets U, Sharma K, Dresser K, Shi Y (2009). A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity. J Immunol 182 (4): 1912-1918.
    • (2009) J Immunol , vol.182 , Issue.4 , pp. 1912-1918
    • Kanevets, U.1    Sharma, K.2    Dresser, K.3    Shi, Y.4


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