The common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism

Infection and Immunity

Volumn 69, Issue 2, 2001, Pages 1151-1159

  Ulanova, M ^a   Tarkowski, A ^a   Hahn Zoric, M ^a   Hanson, L A ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM HYDROXIDE; CD40 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 4; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MAJOR HISTOCOMPATIBILITY ANTIGEN; VACCINE;

ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD14; CYTOKINES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOGLOBULINS; INTERLEUKIN-4; MEMBRANE GLYCOPROTEINS; MONOCYTES; RNA, MESSENGER; UP-REGULATION;

EID: 0035144140     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.2.1151-1159.2001     Document Type: Article

References (49)

1. Biologic and clinical effects of granulocyte colony-stimulating factor in normal individuals
2. Tumor necrosis factor alpha is a critical eomponent of interleukin 13-mediated protective T helper cell type 2 responses ,luring helminth infection
3. Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling
4. In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to Freund's complete adjuvant, but continues to induce T helper 2 cytokine production
5. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells
6. Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes
7. Phenotypic characterization of dendritic cells
8. The selective induction of different immune responses by vaccine adjuvants
9. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation
10. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10
11. Molecular mechanisms regulating the expression of class II histocompatibility molecules on macrophages. Effects of inductive and suppressive signals on gene transcription
12. Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function
13. IL-4 and granulocyte-macrophage colony-stimulating factor selectively increase HLA-DR and HLA-DP antigens but not HLA-DQ antigens on human monocytes
14. Rate of disappearance of diphtheria toxoid injected into rabbits and guinea-pigs: Toxoid precipitated with alum
15. Local tissue irritating effects and adjuvant activities of calcium phosphate and aluminium hydroxide with different physical properties
16. Different T helper cell subsets elicited in mice utilising two different adjuvant vehicles: The role of endogenous IL-1 in proliferative responses
17. Adjuvant properties of aluminium and calcium compounds
18. Dendritic cells: Unique leucocyte populations which control the primary immune response
19. Augmentation of naive, Th1 and Th2 effector CD4 responses by IL-6, IL-1 and TNF
20. CD1 molecule expression on human monocytes induced by granulocyte-macrophage colony-stimulating factor
21. Retrovirally induced switch from production of IL-12 to IL-4 in dendritic cells
22. Induction of Ia and H-2 antigens on a macrophage cell line by immune interferon
23. Interleukin 4 down-regulates the expression of CD14 in normal human monocytes
24. Aluminium adjuvants,
25. Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: Effect on antigen uptake and antigen presentation
26. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
27. The IL-4 receptor: Signaling mechanisms and biologic functions
28. Aluminum salts
29. Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression
30. IL-4R alpha and gamma chain expression in LPS- and IL-4-stimulated MONO-MAC-6 cells
31. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells
32. Induction of TH1 and TH2 responses: A key role for the 'natural' immune response?
33. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability
34. Selective regulation of chemotactic lymphokine production. I. Selective potentiation of eosinophil chemotactic lymphokine production in alum hydroxy gel- and Bordetella pertussis vaccine-treated guinea pigs
35. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
36. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
37. Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4
38. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1)
39. Antigen-specific regulation of CD1 expression in humans
40. IFN-gamma and 1,25(OH)2D3 induce on THP-1 cells distinct patterns of cell surface antigen expression, cytokine production, and responsiveness to contact with activated T cells
41. Monocytes
42. Eosinophil response to alum adjuvants: Involvement of T cells in non-antigen dependent mechanisms
43. Regulation of interleukin-2 receptor gamma chain mRNA expression in human monocytic cell line THP-1
44. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
45. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells
46. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily
47. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes
48. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines