Neither interleukin-6 nor signalling via tumour necrosis factor receptor-1 contribute to the adjuvant activity of Alum and Freund's adjuvant

Immunology

Volumn 93, Issue 1, 1998, Pages 41-48

  Brewer, J M ^a,c   Conacher, M ^a   Gaffney, M ^a   Douglas, M ^a   Bluethmann, H ^b   Alexander, J ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FREUND ADJUVANT; INTERLEUKIN 6; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; GENE TARGETING; GRANULOMA; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LISTERIA MONOCYTOGENES; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANIMALS; ANTIGENS, CD; CELL CULTURE TECHNIQUES; FREUND'S ADJUVANT; IMMUNOGLOBULIN G; INTERLEUKIN-10; INTERLEUKIN-4; INTERLEUKIN-5; INTERLEUKIN-6; MICE; MICE, KNOCKOUT; OVALBUMIN; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; SPLEEN;

EID: 0031914326     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00399.x     Document Type: Article

References (31)

1. KERSTEN G.F.A. & CROMMELIN J.A. (1995) Liposomes and ISCOMS as vaccine formulations. Biochim Biophys Acta 1241, 117.
2. COX F.E.G. & LIEW F.Y. (1992) T-cell subsets and cytokines in parasitic infections. Immunol Today 13, 445.
3. BOMFORD R. (1980) The comparative selectivity of adjuvants for humoral and cell mediated immunity. Clin Exp Immunol 39, 435.
4. GRUN J.L. & MAURER P.H. (1989) Different T helper cell subsets elicited in mice utilising two different adjuvant vehicles: The role of endogenous IL-1 in proliferative responses. Cell Immunol 121, 134.
5. + cytotoxic responses is associated with up-regulation of IL-12 and supression of IL-10 production. Vaccine Res 5, 77.
6. BREWER J.M., CONACHER M., SATOSKAR A., BLUETHMANN H. & ALEXANDER J. (1996) In Interleukin-4 deficient mice. Alum not only generates T helper-1 responses equivalent to Freund's complete adjuvant, but continues to induce T helper-2 cytokine production. Eur J Immunol 26, 2062.
7. WORLD HEALTH ORGANIZATION (1976) WHO Technical Report Series 595 Immunological Adjuvants. WHO, Geneva.
8. BEUTLER B. & CERAMI A. (1989) The biology of cachectin/TNF A primary mediator of the host response. Annu Rev Immunol 7, 625.
9. VAN SNICK J. (1990) Interleukin-6: An overview. Annu Rev Immunol 8, 253.
10. THOMA B., GRELL M., PFIZENMAIER K. & SCHEURICH P. (1990) Identification of a 60-kD Tumor Necrosis Factor (TNF) Receptor as the major signal transducing component in TNF reponses. J Exp Med 172, 1019.
11. ERICKSON S.L., DESAUVAGE F.J., KIKLY K. et al. (1994) Decreased sensitivity to Tumor Necrosis Factor but normal T-cell development in TNF Receptor-2 deficient mice. Nature 372, 560.
12. ROTHE J., LESSLAUER W., LOTSCHER H. et al. (1993) Mice lacking the Tumor Necrosis Factor receptor 1 are resistant to TNF mediated toxicity but highly susceptible to infection with Listeria monocytogenes. Nature 364, 798.
13. KOPF M., BAUMANN H., FREER G. et al. (1994) Impaired immune and acute-phase responses in Interleukin-6-deficient mice. Nature 368, 339.
14. FATTORI E., CAPPELLETTI M., COSTA P. et al. (1994) Defective inflammatory response in Interleukin 6 deficient mice. J Exp Med 180, 1243.
15. BREWER J.M. & ALEXANDER J. (1992) The adjuvant activity of non-ionic surfactant vesicles (niosomes) on the BALB/c humoral response to bovine serum albumin. Immunology 75, 570.
16. LEHIR M., BLUETHMANN H., KOSCOVILBOIS M.H. et al. (1996) Differentiation of Follicular Dendritic Cells and full antibody responses require Tumor Necrosis Factor Receptor-1 signalling. J Exp Med 183, 2367.
17. KOPF M., LE GROS G., COYLE A.J., KOSCOVILBOIS M. & BROMBACHER F. (1995) Immune responses of IL-4, IL-5, IL-6 deficient mice. Immunol Rev 148, 45.
18. TEW J.G., PHIPPS R.P. & MANDEL T.E. (1980) The maintenance and regulation of the humoral immune response: Persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells. Immunol Rev 53, 175.
19. SNAPPER C.M. & PAUL W.E. (1987) Interferon-γ and B cell stimulatory factor-1 reciprocally regulate immunoglobulin isotype control. Science 239, 944.
20. FINKELMAN F.D., HOLMES J., KATONA I.M. et al. (1990) Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 8, 303.
21. PURKERSON J.M. & ISAKSON P.C. (1992) Interleukin-5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to Immunoglobulin (Ig) G1 and IgE. J Exp Med 175, 973.
22. + T cells: IL 5 is essential for induction of antigen-specific antibody responses by T (H)2 but not T (H) 1 clones. Eur J Immunol 20, 2219.
23. DALRYMPLE S.A., LUCIAN L.A., SLATTERY R. et al. (1995) Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: Correlation with inefficient neutrophilia. Infect Immun 63, 2262.
24. + T helper cell 1 development in Interleukin 6-deficient mice infected with Candida albicans. J Exp Med 183, 1345.
25. ROMANI L., PUCCETTI P. & BISTONI F. (1996) Biological role of Th cell subsets in candidiasis. Chem Immunol 63, 115.
26. TONNETTI L., SPACCAPELO R., CENCI E. et al. (1995) Interleukin-4 and -10 exacerbate candidiasis in mice. Eur J Immunol 25, 1559.
27. KELLY J.P. & BANCROFT G.J. (1996) Administration of Interleukin-10 abolishes innate resistance to Listeria monocytogenes. Eur J Immunol 26, 356.
28. ALEXANDER J. & HUNTER C.A. (1997) Immunoregulation During Toxoplasmosis. Chem Immunol, in press.
29. SUZUKI Y., CONELY F.K. & REMINGTON J.S. (1989) Importance of endogenous IFNγ for prevention of Toxoplasmic encephalitis in mice. J Immunol 143, 2045.
30. BOMFORD R. (1989) Adjuvants for anti-parasite vaccines. Parasitol Today 5, 41.
31. BANCROFT G.J., SCHREIBER R.D. & UNANUE E.R. (1991) Natural immunity: a T cell independent pathway of macrophage activation defined in the SCID mouse. Immunol Rev 124, 5.