Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin

Cell Death and Differentiation

Volumn 10, Issue 9, 2003, Pages 956-968

  Hentze, H ^a   Lin, X Y ^a,b   Choi, M S K ^a   Porter, A G ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Caspase; Interleukin; Lipopolysaccharide; Monocyte; Necrosis; Nigericin

Indexed keywords

BACTERIAL TOXIN; CATHEPSIN B; COMPLEMENTARY DNA; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; NIGERICIN; PROTEINASE INHIBITOR; STEFIN A;

ANIMAL CELL; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LEUKEMIA CELL LINE; LYSOSOME; MACROPHAGE ACTIVATION; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; REVIEW; WESTERN BLOTTING;

ANIMALS; BACTERIAL TOXINS; CALPAIN; CASPASE 1; CATHEPSIN B; CELL LINE; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; INTERLEUKIN-18; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MONOCYTES; NECROSIS; NIGERICIN; PROTEIN TRANSPORT;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0042914359     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401264     Document Type: Review

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