-
1
-
-
0020424378
-
Inhibition of cell growth by a hypothalamic peptide
-
Redding TW, Schally AV. Inhibition of cell growth by a hypothalamic peptide. Proc Natl Acad Sci U S A. 1982; 79:7014-7018.
-
(1982)
Proc Natl Acad Sci U S A.
, vol.79
, pp. 7014-7018
-
-
Redding, T.W.1
Schally, A.V.2
-
2
-
-
77958507818
-
Growth hormone-releasing hormone: extrapituitary effects in physiology and pathology
-
Barabutis N, Schally AV. Growth hormone-releasing hormone: extrapituitary effects in physiology and pathology. Cell Cycle. 2010; 9:4110-4116.
-
(2010)
Cell Cycle.
, vol.9
, pp. 4110-4116
-
-
Barabutis, N.1
Schally, A.V.2
-
3
-
-
37349032876
-
Antagonists of growthhormone-releasing hormone: an emerging new therapy for cancer
-
Schally AV, Varga JL, Engel JB. Antagonists of growthhormone-releasing hormone: an emerging new therapy for cancer. Nat Clin Pract Endocrinol Metab. 2008; 4:33-43.
-
(2008)
Nat Clin Pract Endocrinol Metab.
, vol.4
, pp. 33-43
-
-
Schally, A.V.1
Varga, J.L.2
Engel, J.B.3
-
4
-
-
77953555625
-
Targeting gastrin releasing peptide receptors: New options for the therapy and diagnosis of cancer
-
Hohla F, Schally AV. Targeting gastrin releasing peptide receptors: New options for the therapy and diagnosis of cancer. Cell Cycle. 2010; 9:1738-1741.
-
(2010)
Cell Cycle.
, vol.9
, pp. 1738-1741
-
-
Hohla, F.1
Schally, A.V.2
-
5
-
-
80655133978
-
GHRH antagonist MZ-5-156 increases the expression of AMPK in A549 lung cancer cells
-
Siejka A, Barabutis N, Schally AV. GHRH antagonist MZ-5-156 increases the expression of AMPK in A549 lung cancer cells. Cell Cycle. 2011; 10:3714-3718.
-
(2011)
Cell Cycle.
, vol.10
, pp. 3714-3718
-
-
Siejka, A.1
Barabutis, N.2
Schally, A.V.3
-
6
-
-
70349916272
-
GHRH antagonist causes DNA damage leading to p21 mediated cell cycle arrest and apoptosis in human colon cancer cells
-
Hohla F, Buchholz S, Schally AV, Seitz S, Rick FG, Szalontay L, Varga JL, Zarandi M, Halmos G, Vidaurre I, Krishan A, Kurtoglu M, Chandna S, Aigner E, Datz C. GHRH antagonist causes DNA damage leading to p21 mediated cell cycle arrest and apoptosis in human colon cancer cells. Cell Cycle. 2009; 8:3149-3156.
-
(2009)
Cell Cycle.
, vol.8
, pp. 3149-3156
-
-
Hohla, F.1
Buchholz, S.2
Schally, A.V.3
Seitz, S.4
Rick, F.G.5
Szalontay, L.6
Varga, J.L.7
Zarandi, M.8
Halmos, G.9
Vidaurre, I.10
Krishan, A.11
Kurtoglu, M.12
Chandna, S.13
Aigner, E.14
Datz, C.15
-
8
-
-
68049087751
-
RNAi screen for therapeutic target in leukemia
-
Tyner J, Druker BJ. RNAi screen for therapeutic target in leukemia. Cell Cycle. 2009; 8:2144.
-
(2009)
Cell Cycle.
, vol.8
, pp. 2144
-
-
Tyner, J.1
Druker, B.J.2
-
9
-
-
79957977839
-
The pursuit of oncotargets through understanding defective cell regulation
-
Qiao M, Shi Q, Pardee AB. The pursuit of oncotargets through understanding defective cell regulation. Oncotarget. 2010; 1:544-551.
-
(2010)
Oncotarget.
, vol.1
, pp. 544-551
-
-
Qiao, M.1
Shi, Q.2
Pardee, A.B.3
-
10
-
-
77956497712
-
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
-
Wang JB, Erickson JW, Fuji R, Ramachandran S, Gao P, Dinavahi R, Wilson KF, Ambrosio AL, Dias SM, Dang CV, Cerione RA. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2011; 18:207-219.
-
(2011)
Cancer Cell.
, vol.18
, pp. 207-219
-
-
Wang, J.B.1
Erickson, J.W.2
Fuji, R.3
Ramachandran, S.4
Gao, P.5
Dinavahi, R.6
Wilson, K.F.7
Ambrosio, A.L.8
Dias, S.M.9
Dang, C.V.10
Cerione, R.A.11
-
11
-
-
79957984650
-
Refractory chronic lymphocytic leukemia-new therapeutic strategies
-
Schnaiter A, Stilgenbauer S. Refractory chronic lymphocytic leukemia-new therapeutic strategies. Oncotarget. 2010; 1:472-482.
-
(2010)
Oncotarget.
, vol.1
, pp. 472-482
-
-
Schnaiter, A.1
Stilgenbauer, S.2
-
12
-
-
79957491278
-
NSP 5a3a: a potential novel cancer target in head and neck carcinoma
-
D'Agostino L, Giordano A. NSP 5a3a: a potential novel cancer target in head and neck carcinoma. Oncotarget. 2010; 1:423-435.
-
(2010)
Oncotarget.
, vol.1
, pp. 423-435
-
-
D'Agostino, L.1
Giordano, A.2
-
13
-
-
80052055075
-
A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs
-
Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S, Kawazoe Y, Hiraoka M, Uesugi M, Noda M. A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. Oncotarget. 2010; 1:252-264.
-
(2010)
Oncotarget.
, vol.1
, pp. 252-264
-
-
Murai, R.1
Yoshida, Y.2
Muraguchi, T.3
Nishimoto, E.4
Morioka, Y.5
Kitayama, H.6
Kondoh, S.7
Kawazoe, Y.8
Hiraoka, M.9
Uesugi, M.10
Noda, M.11
-
14
-
-
77951116071
-
Migrastatin analogues target fascin to block tumour metastasis
-
Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY. Migrastatin analogues target fascin to block tumour metastasis. Nature. 464:1062-1066.
-
Nature.
, vol.464
, pp. 1062-1066
-
-
Chen, L.1
Yang, S.2
Jakoncic, J.3
Zhang, J.J.4
Huang, X.Y.5
-
16
-
-
81255205373
-
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells
-
Anders L, Ke N, Hydbring P, Choi YJ, Widlund HR, Chick JM, Zhai H, Vidal M, Gygi SP, Braun P, Sicinski P. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell. 2011; 20:620-634.
-
(2011)
Cancer Cell.
, vol.20
, pp. 620-634
-
-
Anders, L.1
Ke, N.2
Hydbring, P.3
Choi, Y.J.4
Widlund, H.R.5
Chick, J.M.6
Zhai, H.7
Vidal, M.8
Gygi, S.P.9
Braun, P.10
Sicinski, P.11
-
17
-
-
80054692891
-
PEAK1, a novel kinase target in the fight against cancer
-
Kelber JA, Klemke RL. PEAK1, a novel kinase target in the fight against cancer. Oncotarget. 2010; 1:219-223.
-
(2010)
Oncotarget.
, vol.1
, pp. 219-223
-
-
Kelber, J.A.1
Klemke, R.L.2
-
18
-
-
79960635820
-
Role of Pten in leukemia stem cells
-
Peng C, Chen Y, Li D, Li S. Role of Pten in leukemia stem cells. Oncotarget. 2010; 1:156-160.
-
(2010)
Oncotarget.
, vol.1
, pp. 156-160
-
-
Peng, C.1
Chen, Y.2
Li, D.3
Li, S.4
-
19
-
-
77952105211
-
Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
-
Zhang B, Strauss AC, Chu S, Li M, Ho Y, Shiang KD, Snyder DS, Huettner CS, Shultz L, Holyoake T, Bhatia R. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell. 2010; 17:427-442.
-
(2010)
Cancer Cell.
, vol.17
, pp. 427-442
-
-
Zhang, B.1
Strauss, A.C.2
Chu, S.3
Li, M.4
Ho, Y.5
Shiang, K.D.6
Snyder, D.S.7
Huettner, C.S.8
Shultz, L.9
Holyoake, T.10
Bhatia, R.11
-
20
-
-
79960048519
-
BCL6: a novel target for therapy of Ph+B cell acute lymphoblastic leukemia
-
Van Etten RA. BCL6: a novel target for therapy of Ph+B cell acute lymphoblastic leukemia. Cancer Cell. 2011; 20:3-5.
-
(2011)
Cancer Cell.
, vol.20
, pp. 3-5
-
-
Van Etten, R.A.1
-
21
-
-
77950486830
-
A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo
-
Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Fares C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD, Jr., Prive GG, Melnick A. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell. 2010; 17:400-411.
-
(2010)
Cancer Cell.
, vol.17
, pp. 400-411
-
-
Cerchietti, L.C.1
Ghetu, A.F.2
Zhu, X.3
Da Silva, G.F.4
Zhong, S.5
Matthews, M.6
Bunting, K.L.7
Polo, J.M.8
Fares, C.9
Arrowsmith, C.H.10
Yang, S.N.11
Garcia, M.12
Coop, A.13
Mackerell Jr., A.D.14
Prive, G.G.15
Melnick, A.16
-
22
-
-
79952338410
-
Shape-shifting and tumor suppression by PLZF
-
Hobbs RM, Pandolfi PP. Shape-shifting and tumor suppression by PLZF. Oncotarget. 2010; 1:3-5.
-
(2010)
Oncotarget.
, vol.1
, pp. 3-5
-
-
Hobbs, R.M.1
Pandolfi, P.P.2
-
23
-
-
79957991472
-
Glutaminase: a hot spot for regulation of cancer cell metabolism?
-
Erickson JW, Cerione RA. Glutaminase: a hot spot for regulation of cancer cell metabolism? Oncotarget. 2010; 1:734-740.
-
(2010)
Oncotarget
, vol.1
, pp. 734-740
-
-
Erickson, J.W.1
Cerione, R.A.2
-
24
-
-
78650956336
-
Systemic combinatorial peptide selection yields a noncanonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma
-
Staquicini FI, Ozawa MG, Moya CA, Driessen WH, Barbu EM, Nishimori H, Soghomonyan S, Flores LG, 2nd, Liang X, Paolillo V, Alauddin MM, Basilion JP, Furnari FB, Bogler O, Lang FF, Aldape KD et al. Systemic combinatorial peptide selection yields a noncanonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma. J Clin Invest. 2011; 121:161-173.
-
(2011)
J Clin Invest.
, vol.121
, pp. 161-173
-
-
Staquicini, F.I.1
Ozawa, M.G.2
Moya, C.A.3
Driessen, W.H.4
Barbu, E.M.5
Nishimori, H.6
Soghomonyan, S.7
Flores II, L.G.8
Liang, X.9
Paolillo, V.10
Alauddin, M.M.11
Basilion, J.P.12
Furnari, F.B.13
Bogler, O.14
Lang, F.F.15
Aldape, K.D.16
-
25
-
-
78649823233
-
Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes
-
Duncan CG, Killela PJ, Payne CA, Lampson B, Chen WC, Liu J, Solomon D, Waldman T, Towers AJ, Gregory SG, McDonald KL, McLendon RE, Bigner DD, Yan H. Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. Oncotarget. 2010; 1:265-277.
-
(2010)
Oncotarget.
, vol.1
, pp. 265-277
-
-
Duncan, C.G.1
Killela, P.J.2
Payne, C.A.3
Lampson, B.4
Chen, W.C.5
Liu, J.6
Solomon, D.7
Waldman, T.8
Towers, A.J.9
Gregory, S.G.10
McDonald, K.L.11
McLendon, R.E.12
Bigner, D.D.13
Yan, H.14
-
26
-
-
80052580351
-
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
-
Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson IP, Pollard PJ, Watson DG, Deberardinis RJ, Shlomi T et al. Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature. 2011; 477:225-228.
-
(2011)
Nature.
, vol.477
, pp. 225-228
-
-
Frezza, C.1
Zheng, L.2
Folger, O.3
Rajagopalan, K.N.4
MacKenzie, E.D.5
Jerby, L.6
Micaroni, M.7
Chaneton, B.8
Adam, J.9
Hedley, A.10
Kalna, G.11
Tomlinson, I.P.12
Pollard, P.J.13
Watson, D.G.14
Deberardinis, R.J.15
Shlomi, T.16
-
27
-
-
79960624464
-
A high throughput method for identifying personalized tumor-associated antigens
-
Ionov Y. A high throughput method for identifying personalized tumor-associated antigens. Oncotarget. 2010; 1:148-155.
-
(2010)
Oncotarget.
, vol.1
, pp. 148-155
-
-
Ionov, Y.1
-
28
-
-
79251629946
-
The genetic landscape of the childhood cancer medulloblastoma
-
Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR et al. The genetic landscape of the childhood cancer medulloblastoma. Science. 2011; 331:435-439.
-
(2011)
Science.
, vol.331
, pp. 435-439
-
-
Parsons, D.W.1
Li, M.2
Zhang, X.3
Jones, S.4
Leary, R.J.5
Lin, J.C.6
Boca, S.M.7
Carter, H.8
Samayoa, J.9
Bettegowda, C.10
Gallia, G.L.11
Jallo, G.I.12
Binder, Z.A.13
Nikolsky, Y.14
Hartigan, J.15
Smith, D.R.16
-
29
-
-
77951707902
-
Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53
-
Heminger K, Markey M, Mpagi M, Berberich SJ. Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53. Aging (Albany NY). 2009; 1:89-108.
-
(2009)
Aging (Albany NY).
, vol.1
, pp. 89-108
-
-
Heminger, K.1
Markey, M.2
Mpagi, M.3
Berberich, S.J.4
-
30
-
-
80051734288
-
Curaxins: anticancer compounds that simultaneously suppress NF-kappaB and activate p53 by targeting FACT
-
Gasparian AV, Burkhart CA, Purmal AA, Brodsky L, Pal M, Saranadasa M, Bosykh DA, Commane M, Guryanova OA, Pal S, Safina A, Sviridov S, Koman IE, Veith J, Komar AA, Gudkov AV et al. Curaxins: anticancer compounds that simultaneously suppress NF-kappaB and activate p53 by targeting FACT. Sci Transl Med. 2011; 3:95ra74.
-
(2011)
Sci Transl Med.
, vol.3
-
-
Gasparian, A.V.1
Burkhart, C.A.2
Purmal, A.A.3
Brodsky, L.4
Pal, M.5
Saranadasa, M.6
Bosykh, D.A.7
Commane, M.8
Guryanova, O.A.9
Pal, S.10
Safina, A.11
Sviridov, S.12
Koman, I.E.13
Veith, J.14
Komar, A.A.15
Gudkov, A.V.16
-
31
-
-
80054716866
-
The metabolic regulator ERRalpha, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer
-
Chang CY, Kazmin D, Jasper JS, Kunder R, Zuercher WJ, McDonnell DP. The metabolic regulator ERRalpha, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell. 2011; 20:500-510.
-
(2011)
Cancer Cell.
, vol.20
, pp. 500-510
-
-
Chang, C.Y.1
Kazmin, D.2
Jasper, J.S.3
Kunder, R.4
Zuercher, W.J.5
McDonnell, D.P.6
-
32
-
-
80052595172
-
Short hairpin RNA screen reveals bromodomain proteins as novel targets in acute myeloid leukemia
-
Blobel GA, Kalota A, Sanchez PV, Carroll M. Short hairpin RNA screen reveals bromodomain proteins as novel targets in acute myeloid leukemia. Cancer Cell. 2011; 20:287-288.
-
(2011)
Cancer Cell.
, vol.20
, pp. 287-288
-
-
Blobel, G.A.1
Kalota, A.2
Sanchez, P.V.3
Carroll, M.4
-
33
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011; 478:524-528.
-
(2011)
Nature.
, vol.478
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
Rappaport, A.R.4
Herrmann, H.5
Sison, E.A.6
Magoon, D.7
Qi, J.8
Blatt, K.9
Wunderlich, M.10
Taylor, M.J.11
Johns, C.12
Chicas, A.13
Mulloy, J.C.14
Kogan, S.C.15
Brown, P.16
-
34
-
-
84856096764
-
Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules
-
Mitsunaga M, Ogawa M, Kosaka N, Rosenblum LT, Choyke PL, Kobayashi H. Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Nat Med. 2011; 17:1685-1691.
-
(2011)
Nat Med.
, vol.17
, pp. 1685-1691
-
-
Mitsunaga, M.1
Ogawa, M.2
Kosaka, N.3
Rosenblum, L.T.4
Choyke, P.L.5
Kobayashi, H.6
-
35
-
-
84856085129
-
Inhibition of proteasome deubiquitinating activity as a new cancer therapy
-
D'Arcy P, Brnjic S, Olofsson MH, Fryknas M, Lindsten K, De Cesare M, Perego P, Sadeghi B, Hassan M, Larsson R, Linder S. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011; 17:1636-1640.
-
(2011)
Nat Med.
, vol.17
, pp. 1636-1640
-
-
D'Arcy, P.1
Brnjic, S.2
Olofsson, M.H.3
Fryknas, M.4
Lindsten, K.5
De Cesare, M.6
Perego, P.7
Sadeghi, B.8
Hassan, M.9
Larsson, R.10
Linder, S.11
-
36
-
-
79958093406
-
Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer
-
Giamas G, Filipovic A, Jacob J, Messier W, Zhang H, Yang D, Zhang W, Shifa BA, Photiou A, Tralau-Stewart C, Castellano L, Green AR, Coombes RC, Ellis IO, Ali S, Lenz HJ et al. Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. Nat Med. 2011; 17:715-719.
-
(2011)
Nat Med.
, vol.17
, pp. 715-719
-
-
Giamas, G.1
Filipovic, A.2
Jacob, J.3
Messier, W.4
Zhang, H.5
Yang, D.6
Zhang, W.7
Shifa, B.A.8
Photiou, A.9
Tralau-Stewart, C.10
Castellano, L.11
Green, A.R.12
Coombes, R.C.13
Ellis, I.O.14
Ali, S.15
Lenz, H.J.16
-
37
-
-
79957920185
-
Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts
-
Ni X, Zhang Y, Ribas J, Chowdhury WH, Castanares M, Zhang Z, Laiho M, DeWeese TL, Lupold SE. Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts. J Clin Invest. 2011; 121:2383-2390.
-
(2011)
J Clin Invest.
, vol.121
, pp. 2383-2390
-
-
Ni, X.1
Zhang, Y.2
Ribas, J.3
Chowdhury, W.H.4
Castanares, M.5
Zhang, Z.6
Laiho, M.7
DeWeese, T.L.8
Lupold, S.E.9
-
38
-
-
79960428358
-
Targeting the inflammatory pathways to enhance chemotherapy of cancer
-
Zhu Z, Zhong S, Shen Z. Targeting the inflammatory pathways to enhance chemotherapy of cancer. Cancer Biol Ther. 2011; 12:95-105.
-
(2011)
Cancer Biol Ther.
, vol.12
, pp. 95-105
-
-
Zhu, Z.1
Zhong, S.2
Shen, Z.3
-
39
-
-
79957467315
-
Molecular identification and targeting of colorectal cancer stem cells
-
Kemper K, Grandela C, Medema JP. Molecular identification and targeting of colorectal cancer stem cells. Oncotarget. 2010; 1:387-395.
-
(2010)
Oncotarget.
, vol.1
, pp. 387-395
-
-
Kemper, K.1
Grandela, C.2
Medema, J.P.3
-
40
-
-
79957989939
-
Drug discovery approaches to target Wnt signaling in cancer stem cells
-
Curtin JC, Lorenzi MV. Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget. 2010; 1:563-577.
-
(2010)
Oncotarget.
, vol.1
, pp. 563-577
-
-
Curtin, J.C.1
Lorenzi, M.V.2
-
41
-
-
70449715255
-
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia
-
Chen Y, Li D, Li S. The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia. Cell Cycle. 2009; 8:3488-3492.
-
(2009)
Cell Cycle.
, vol.8
, pp. 3488-3492
-
-
Chen, Y.1
Li, D.2
Li, S.3
-
42
-
-
84859499054
-
Novel approaches to target cancer initiating cells-Eliminating the root of the cancer
-
McCubrey JA, Abrams SL, Umezawa K, Cocco L, Martelli AM, Franklin RA, Chappell WH, Steelman LS. Novel approaches to target cancer initiating cells-Eliminating the root of the cancer. Adv Enzyme Regul. 2011.
-
(2011)
Adv Enzyme Regul.
-
-
McCubrey, J.A.1
Abrams, S.L.2
Umezawa, K.3
Cocco, L.4
Martelli, A.M.5
Franklin, R.A.6
Chappell, W.H.7
Steelman, L.S.8
-
43
-
-
79957568143
-
miR-101 is downregulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis
-
Smits M, Nilsson J, Mir SE, van der Stoop PM, Hulleman E, Niers JM, de Witt Hamer PC, Marquez VE, Cloos J, Krichevsky AM, Noske DP, Tannous BA, Wurdinger T. miR-101 is downregulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis. Oncotarget. 2010; 1:710-720.
-
(2010)
Oncotarget.
, vol.1
, pp. 710-720
-
-
Smits, M.1
Nilsson, J.2
Mir, S.E.3
van der Stoop, P.M.4
Hulleman, E.5
Niers, J.M.6
de Witt Hamer, P.C.7
Marquez, V.E.8
Cloos, J.9
Krichevsky, A.M.10
Noske, D.P.11
Tannous, B.A.12
Wurdinger, T.13
-
44
-
-
79952092993
-
Leukemia stem cells and microenvironment: biology and therapeutic targeting
-
Konopleva MY, Jordan CT. Leukemia stem cells and microenvironment: biology and therapeutic targeting. J Clin Oncol. 2011; 29:591-599.
-
(2011)
J Clin Oncol.
, vol.29
, pp. 591-599
-
-
Konopleva, M.Y.1
Jordan, C.T.2
-
45
-
-
79954507936
-
miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells
-
Noonan EJ, Place RF, Basak S, Pookot D, Li LC. miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells. Oncotarget. 2010; 1:349-358.
-
(2010)
Oncotarget.
, vol.1
, pp. 349-358
-
-
Noonan, E.J.1
Place, R.F.2
Basak, S.3
Pookot, D.4
Li, L.C.5
-
46
-
-
77953565913
-
TargetScreen: an unbiased approach to identify functionally important microRNA targets
-
Mavrakis KJ, Wendel HG. TargetScreen: an unbiased approach to identify functionally important microRNA targets. Cell Cycle. 2010; 9:2080-2084.
-
(2010)
Cell Cycle.
, vol.9
, pp. 2080-2084
-
-
Mavrakis, K.J.1
Wendel, H.G.2
-
47
-
-
77953528169
-
A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLLAF4 acute lymphocytic leukemia cells
-
Kotani A, Ha D, Schotte D, den Boer ML, Armstrong SA, Lodish HF. A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLLAF4 acute lymphocytic leukemia cells. Cell Cycle. 2010; 9:1037-1042.
-
(2010)
Cell Cycle.
, vol.9
, pp. 1037-1042
-
-
Kotani, A.1
Ha, D.2
Schotte, D.3
den Boer, M.L.4
Armstrong, S.A.5
Lodish, H.F.6
-
48
-
-
77957361864
-
Targeting microRNAs in cancer: rationale, strategies and challenges
-
Garzon R, Marcucci G, Croce CM. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov. 2010; 9:775-789.
-
(2010)
Nat Rev Drug Discov.
, vol.9
, pp. 775-789
-
-
Garzon, R.1
Marcucci, G.2
Croce, C.M.3
-
49
-
-
79955070135
-
Is miR-29 an oncogene or tumor suppressor in CLL?
-
Pekarsky Y, Croce CM. Is miR-29 an oncogene or tumor suppressor in CLL? Oncotarget. 2010; 1:224-227.
-
(2010)
Oncotarget
, vol.1
, pp. 224-227
-
-
Pekarsky, Y.1
Croce, C.M.2
-
50
-
-
78650385772
-
MicroRNA-21: a novel therapeutic target in human cancer
-
Pan X, Wang ZX, Wang R. MicroRNA-21: a novel therapeutic target in human cancer. Cancer Biol Ther. 2011; 10:1224-1232.
-
(2011)
Cancer Biol Ther.
, vol.10
, pp. 1224-1232
-
-
Pan, X.1
Wang, Z.X.2
Wang, R.3
-
51
-
-
79958011128
-
Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia
-
Sacco A, Roccaro A, Ghobrial IM. Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia. Oncotarget. 2010; 1:578-582.
-
(2010)
Oncotarget.
, vol.1
, pp. 578-582
-
-
Sacco, A.1
Roccaro, A.2
Ghobrial, I.M.3
-
52
-
-
77957819681
-
The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
-
Martelli AM, Evangelisti C, Chiarini F, McCubrey JA. The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients. Oncotarget. 2010; 1:89-103.
-
(2010)
Oncotarget.
, vol.1
, pp. 89-103
-
-
Martelli, A.M.1
Evangelisti, C.2
Chiarini, F.3
McCubrey, J.A.4
-
53
-
-
79955818156
-
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia
-
Evangelisti C, Ricci F, Tazzari P, Tabellini G, Battistelli M, Falcieri E, Chiarini F, Bortul R, Melchionda F, Pagliaro P, Pession A, McCubrey JA, Martelli AM. Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia. Leukemia. 2011; 25:781-791.
-
(2011)
Leukemia.
, vol.25
, pp. 781-791
-
-
Evangelisti, C.1
Ricci, F.2
Tazzari, P.3
Tabellini, G.4
Battistelli, M.5
Falcieri, E.6
Chiarini, F.7
Bortul, R.8
Melchionda, F.9
Pagliaro, P.10
Pession, A.11
McCubrey, J.A.12
Martelli, A.M.13
-
55
-
-
59449092539
-
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma
-
Guillard S, Clarke PA, Te Poele R, Mohri Z, Bjerke L, Valenti M, Raynaud F, Eccles SA, Workman P. Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma. Cell Cycle. 2009; 8:443-453.
-
(2009)
Cell Cycle.
, vol.8
, pp. 443-453
-
-
Guillard, S.1
Clarke, P.A.2
Te Poele, R.3
Mohri, Z.4
Bjerke, L.5
Valenti, M.6
Raynaud, F.7
Eccles, S.A.8
Workman, P.9
-
56
-
-
78349261103
-
Targeting TOR dependence in cancer
-
Janes MR, Fruman DA. Targeting TOR dependence in cancer. Oncotarget. 2010; 1:69-76.
-
(2010)
Oncotarget.
, vol.1
, pp. 69-76
-
-
Janes, M.R.1
Fruman, D.A.2
-
57
-
-
79958016002
-
A beta version of life: p110beta takes center stage
-
Dbouk HA, Backer JM. A beta version of life: p110beta takes center stage. Oncotarget. 2010; 1:729-733.
-
(2010)
Oncotarget.
, vol.1
, pp. 729-733
-
-
Dbouk, H.A.1
Backer, J.M.2
-
58
-
-
79957983577
-
Targeting the PI3K/Akt/mTOR pathway-beyond rapalogs
-
Markman B, Dienstmann R, Tabernero J. Targeting the PI3K/Akt/mTOR pathway-beyond rapalogs. Oncotarget. 2010; 1:530-543.
-
(2010)
Oncotarget.
, vol.1
, pp. 530-543
-
-
Markman, B.1
Dienstmann, R.2
Tabernero, J.3
-
59
-
-
79957447410
-
P3Kalpha: a driver of tumor metastasis?
-
Zawel L. P3Kalpha: a driver of tumor metastasis? Oncotarget. 2010; 1:315-316.
-
(2010)
Oncotarget
, vol.1
, pp. 315-316
-
-
Zawel, L.1
-
60
-
-
74849124984
-
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy
-
Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging (Albany NY). 2009; 1:515-528.
-
(2009)
Aging (Albany NY).
, vol.1
, pp. 515-528
-
-
Armour, S.M.1
Baur, J.A.2
Hsieh, S.N.3
Land-Bracha, A.4
Thomas, S.M.5
Sinclair, D.A.6
-
61
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis M, Cipolla AK, Wubbenhorst B, Xu X, Gimotty PA, Kee D, Santiago-Walker AE, Letrero R, D'Andrea K, Pushparajan A, Hayden JE, Brown KD et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell. 2010; 18:683-695.
-
(2010)
Cancer Cell.
, vol.18
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
Somasundaram, R.4
Fukunaga-Kalabis, M.5
Cipolla, A.K.6
Wubbenhorst, B.7
Xu, X.8
Gimotty, P.A.9
Kee, D.10
Santiago-Walker, A.E.11
Letrero, R.12
D'Andrea, K.13
Pushparajan, A.14
Hayden, J.E.15
Brown, K.D.16
-
62
-
-
76349104427
-
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
-
Janes MR, Limon JJ, So L, Chen J, Lim RJ, Chavez MA, Vu C, Lilly MB, Mallya S, Ong ST, Konopleva M, Martin MB, Ren P, Liu Y, Rommel C, Fruman DA. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med. 2010; 16:205-213.
-
(2010)
Nat Med.
, vol.16
, pp. 205-213
-
-
Janes, M.R.1
Limon, J.J.2
So, L.3
Chen, J.4
Lim, R.J.5
Chavez, M.A.6
Vu, C.7
Lilly, M.B.8
Mallya, S.9
Ong, S.T.10
Konopleva, M.11
Martin, M.B.12
Ren, P.13
Liu, Y.14
Rommel, C.15
Fruman, D.A.16
-
63
-
-
79953298958
-
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
-
Wander SA, Hennessy BT, Slingerland JM. Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy. J Clin Invest. 2011; 121:1231-1241.
-
(2011)
J Clin Invest.
, vol.121
, pp. 1231-1241
-
-
Wander, S.A.1
Hennessy, B.T.2
Slingerland, J.M.3
-
64
-
-
78049434915
-
Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice
-
Chen C, Liu Y, Zheng P. Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice. J Clin Invest. 2010; 120:4091-4101.
-
(2010)
J Clin Invest.
, vol.120
, pp. 4091-4101
-
-
Chen, C.1
Liu, Y.2
Zheng, P.3
-
65
-
-
79958055230
-
The BRAFV600E mutation: what is it really orchestrating in thyroid cancer?
-
Nucera C, Lawler J, Hodin R, Parangi S. The BRAFV600E mutation: what is it really orchestrating in thyroid cancer? Oncotarget. 2010; 1:751-756.
-
(2010)
Oncotarget
, vol.1
, pp. 751-756
-
-
Nucera, C.1
Lawler, J.2
Hodin, R.3
Parangi, S.4
-
66
-
-
77957941316
-
BRAF inhibitor unveils its potential against advanced melanoma
-
Vultur A, Villanueva J, Herlyn M. BRAF inhibitor unveils its potential against advanced melanoma. Cancer Cell. 2010; 18:301-302.
-
(2010)
Cancer Cell.
, vol.18
, pp. 301-302
-
-
Vultur, A.1
Villanueva, J.2
Herlyn, M.3
-
67
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 2010; 467:596-599.
-
(2010)
Nature.
, vol.467
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
Zhang, J.4
Ibrahim, P.N.5
Cho, H.6
Spevak, W.7
Zhang, C.8
Zhang, Y.9
Habets, G.10
Burton, E.A.11
Wong, B.12
Tsang, G.13
West, B.L.14
Powell, B.15
Shellooe, R.16
-
68
-
-
80052887167
-
A critical role for the NFkB pathway in multiple myeloma
-
Demchenko YN, Kuehl WM. A critical role for the NFkB pathway in multiple myeloma. Oncotarget. 2010; 1:59-68.
-
(2010)
Oncotarget.
, vol.1
, pp. 59-68
-
-
Demchenko, Y.N.1
Kuehl, W.M.2
-
69
-
-
77953597349
-
A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways
-
Podar K, Anderson KC. A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways. Cell Cycle. 2010; 9:1722-1728.
-
(2010)
Cell Cycle.
, vol.9
, pp. 1722-1728
-
-
Podar, K.1
Anderson, K.C.2
-
70
-
-
79956027131
-
The Siah2-HIF-FoxA2 axis in prostate cancer-new markers and therapeutic opportunities
-
Qi J, Pellecchia M, Ronai ZA. The Siah2-HIF-FoxA2 axis in prostate cancer -new markers and therapeutic opportunities. Oncotarget. 2010; 1:379-385.
-
(2010)
Oncotarget.
, vol.1
, pp. 379-385
-
-
Qi, J.1
Pellecchia, M.2
Ronai, Z.A.3
-
71
-
-
74849127957
-
Antiangiogenic agents and HIF-1 inhibitors meet at the crossroads
-
Rapisarda A, Shoemaker RH, Melillo G. Antiangiogenic agents and HIF-1 inhibitors meet at the crossroads. Cell Cycle. 2009; 8:4040-4043.
-
(2009)
Cell Cycle.
, vol.8
, pp. 4040-4043
-
-
Rapisarda, A.1
Shoemaker, R.H.2
Melillo, G.3
-
72
-
-
79954775922
-
Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes
-
Kuo MT, Savaraj N, Feun LG. Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. Oncotarget. 2010; 1:246-251.
-
(2010)
Oncotarget.
, vol.1
, pp. 246-251
-
-
Kuo, M.T.1
Savaraj, N.2
Feun, L.G.3
-
73
-
-
77957003489
-
Therapeutic targeting of C-terminal binding protein in human cancer
-
Straza MW, Paliwal S, Kovi RC, Rajeshkumar B, Trenh P, Parker D, Whalen GF, Lyle S, Schiffer CA, Grossman SR. Therapeutic targeting of C-terminal binding protein in human cancer. Cell Cycle. 2010; 9:3740-3750.
-
(2010)
Cell Cycle.
, vol.9
, pp. 3740-3750
-
-
Straza, M.W.1
Paliwal, S.2
Kovi, R.C.3
Rajeshkumar, B.4
Trenh, P.5
Parker, D.6
Whalen, G.F.7
Lyle, S.8
Schiffer, C.A.9
Grossman, S.R.10
-
74
-
-
77955435095
-
The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors
-
Bommi PV, Dimri M, Sahasrabuddhe AA, Khandekar J, Dimri GP. The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors. Cell Cycle. 2010; 9:2663-2673.
-
(2010)
Cell Cycle.
, vol.9
, pp. 2663-2673
-
-
Bommi, P.V.1
Dimri, M.2
Sahasrabuddhe, A.A.3
Khandekar, J.4
Dimri, G.P.5
-
75
-
-
79959327789
-
VEGFindependent angiogenic pathways induced by PDGF-C
-
Li X, Kumar A, Zhang F, Lee C, Li Y, Tang Z, Arjuna P. VEGFindependent angiogenic pathways induced by PDGF-C. Oncotarget. 2010; 1:309-314.
-
(2010)
Oncotarget.
, vol.1
, pp. 309-314
-
-
Li, X.1
Kumar, A.2
Zhang, F.3
Lee, C.4
Li, Y.5
Tang, Z.6
Arjuna, P.7
-
76
-
-
77956402268
-
Targeting autophagy to fight hematopoietic malignancies
-
Puissant A, Robert G, Auberger P. Targeting autophagy to fight hematopoietic malignancies. Cell Cycle. 2010; 9:3470-3478.
-
(2010)
Cell Cycle.
, vol.9
, pp. 3470-3478
-
-
Puissant, A.1
Robert, G.2
Auberger, P.3
-
77
-
-
79952271270
-
Phospho-DeltaNp63alpha/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells
-
Huang Y, Ratovitski EA. Phospho-DeltaNp63alpha/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells. Aging (Albany NY). 2010; 2:959-968.
-
(2010)
Aging (Albany NY).
, vol.2
, pp. 959-968
-
-
Huang, Y.1
Ratovitski, E.A.2
-
78
-
-
79958008007
-
Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors
-
Taraboletti G, Rusnati M, Ragona L, Colombo G. Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors. Oncotarget. 2010; 1:662-673.
-
(2010)
Oncotarget.
, vol.1
, pp. 662-673
-
-
Taraboletti, G.1
Rusnati, M.2
Ragona, L.3
Colombo, G.4
-
79
-
-
77953576838
-
Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?
-
Powers MV, Jones K, Barillari C, Westwood I, van Montfort RL, Workman P. Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone? Cell Cycle. 2010; 9:1542-1550.
-
(2010)
Cell Cycle
, vol.9
, pp. 1542-1550
-
-
Powers, M.V.1
Jones, K.2
Barillari, C.3
Westwood, I.4
van Montfort, R.L.5
Workman, P.6
-
80
-
-
74849113809
-
Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications
-
Neznanov N, Gorbachev AV, Neznanova L, Komarov AP, Gurova KV, Gasparian AV, Banerjee AK, Almasan A, Fairchild RL, Gudkov AV. Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications. Cell Cycle. 2009; 8:3960-3970.
-
(2009)
Cell Cycle.
, vol.8
, pp. 3960-3970
-
-
Neznanov, N.1
Gorbachev, A.V.2
Neznanova, L.3
Komarov, A.P.4
Gurova, K.V.5
Gasparian, A.V.6
Banerjee, A.K.7
Almasan, A.8
Fairchild, R.L.9
Gudkov, A.V.10
-
81
-
-
71549121697
-
A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas
-
Cerchietti LC, Lopes EC, Yang SN, Hatzi K, Bunting KL, Tsikitas LA, Mallik A, Robles AI, Walling J, Varticovski L, Shaknovich R, Bhalla KN, Chiosis G, Melnick A. A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. Nat Med. 2009; 15:1369-1376.
-
(2009)
Nat Med.
, vol.15
, pp. 1369-1376
-
-
Cerchietti, L.C.1
Lopes, E.C.2
Yang, S.N.3
Hatzi, K.4
Bunting, K.L.5
Tsikitas, L.A.6
Mallik, A.7
Robles, A.I.8
Walling, J.9
Varticovski, L.10
Shaknovich, R.11
Bhalla, K.N.12
Chiosis, G.13
Melnick, A.14
-
82
-
-
79957483893
-
Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition
-
Beloueche-Babari M, Arunan V, Jackson LE, Perusinghe N, Sharp SY, Workman P, Leach MO. Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition. Oncotarget. 2010; 1:185-197.
-
(2010)
Oncotarget.
, vol.1
, pp. 185-197
-
-
Beloueche-Babari, M.1
Arunan, V.2
Jackson, L.E.3
Perusinghe, N.4
Sharp, S.Y.5
Workman, P.6
Leach, M.O.7
-
83
-
-
79961042759
-
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells
-
De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB et al. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2010; 108:11878-11883.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.108
, pp. 11878-11883
-
-
DeLeon, J.T.1
Iwai, A.2
Feau, C.3
Garcia, Y.4
Balsiger, H.A.5
Storer, C.L.6
Suro, R.M.7
Garza, K.M.8
Lee, S.9
Kim, Y.S.10
Chen, Y.11
Ning, Y.M.12
Riggs, D.L.13
Fletterick, R.J.14
Guy, R.K.15
Trepel, J.B.16
-
84
-
-
79951673830
-
Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease
-
Kang BH, Tavecchio M, Goel HL, Hsieh CC, Garlick DS, Raskett CM, Lian JB, Stein GS, Languino LR, Altieri DC. Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease. Br J Cancer. 2011; 104:629-634.
-
(2011)
Br J Cancer.
, vol.104
, pp. 629-634
-
-
Kang, B.H.1
Tavecchio, M.2
Goel, H.L.3
Hsieh, C.C.4
Garlick, D.S.5
Raskett, C.M.6
Lian, J.B.7
Stein, G.S.8
Languino, L.R.9
Altieri, D.C.10
-
85
-
-
77953533500
-
The AMPK-FoxO3A axis as a target for cancer treatment
-
Chiacchiera F, Simone C. The AMPK-FoxO3A axis as a target for cancer treatment. Cell Cycle. 2010; 9:1091-1096.
-
(2010)
Cell Cycle.
, vol.9
, pp. 1091-1096
-
-
Chiacchiera, F.1
Simone, C.2
-
86
-
-
84862833471
-
Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance
-
Shi L, Wang S, Zangari M, Xu H, Cao TM, Xu C, Wu Y, Xiao F, Liu Y, Yang Y, Salama M, Li G, Tricot G, Zhan F. Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance. Oncotarget. 2010; 1:22-33.
-
(2010)
Oncotarget.
, vol.1
, pp. 22-33
-
-
Shi, L.1
Wang, S.2
Zangari, M.3
Xu, H.4
Cao, T.M.5
Xu, C.6
Wu, Y.7
Xiao, F.8
Liu, Y.9
Yang, Y.10
Salama, M.11
Li, G.12
Tricot, G.13
Zhan, F.14
-
87
-
-
77956407620
-
Hedgehog pathway activation in chronic myeloid leukemia
-
Jagani Z, Dorsch M, Warmuth M. Hedgehog pathway activation in chronic myeloid leukemia. Cell Cycle. 2010; 9:3449-3456.
-
(2010)
Cell Cycle.
, vol.9
, pp. 3449-3456
-
-
Jagani, Z.1
Dorsch, M.2
Warmuth, M.3
-
88
-
-
77953589767
-
A growing family: adding mutated Erbb4 as a novel cancer target
-
Rudloff U, Samuels Y. A growing family: adding mutated Erbb4 as a novel cancer target. Cell Cycle. 2010; 9:1487-1503.
-
(2010)
Cell Cycle.
, vol.9
, pp. 1487-1503
-
-
Rudloff, U.1
Samuels, Y.2
-
89
-
-
80052065824
-
The anti-apoptotic members of the Bcl-2 family are attractive tumor-associated antigens
-
Straten P, Andersen MH. The anti-apoptotic members of the Bcl-2 family are attractive tumor-associated antigens. Oncotarget. 2010; 1:239-245.
-
(2010)
Oncotarget.
, vol.1
, pp. 239-245
-
-
Straten, P.1
Andersen, M.H.2
-
90
-
-
79957987225
-
Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype
-
Liu D, Martin V, Fueyo J, Lee OH, Xu J, Cortes-Santiago N, Alonso MM, Aldape K, Colman H, Gomez-Manzano C. Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype. Oncotarget. 2010; 1:700-709.
-
(2010)
Oncotarget.
, vol.1
, pp. 700-709
-
-
Liu, D.1
Martin, V.2
Fueyo, J.3
Lee, O.H.4
Xu, J.5
Cortes-Santiago, N.6
Alonso, M.M.7
Aldape, K.8
Colman, H.9
Gomez-Manzano, C.10
-
91
-
-
80053334425
-
Thioaptamer conjugated liposomes for tumor vasculature targeting
-
Mann AP, Bhavane RC, Somasunderam A, Liz Montalvo-Ortiz B, Ghaghada KB, Volk D, Nieves-Alicea R, Suh KS, Ferrari M, Annapragada A, Gorenstein DG, Tanaka T. Thioaptamer conjugated liposomes for tumor vasculature targeting. Oncotarget. 2011; 2:298-304.
-
(2011)
Oncotarget.
, vol.2
, pp. 298-304
-
-
Mann, A.P.1
Bhavane, R.C.2
Somasunderam, A.3
Liz Montalvo-Ortiz, B.4
Ghaghada, K.B.5
Volk, D.6
Nieves-Alicea, R.7
Suh, K.S.8
Ferrari, M.9
Annapragada, A.10
Gorenstein, D.G.11
Tanaka, T.12
-
92
-
-
81255188940
-
Tumor angiogenesis: molecular pathways and therapeutic targets
-
Weis SM, Cheresh DA. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med. 2011; 17:1359-1370.
-
(2011)
Nat Med.
, vol.17
, pp. 1359-1370
-
-
Weis, S.M.1
Cheresh, D.A.2
-
93
-
-
79958016793
-
Antiangiogenic agents in advanced gastrointestinal malignancies: past, present and a novel future
-
Mulder K, Koski S, Scarfe A, Chu Q, King K, Spratlin J. Antiangiogenic agents in advanced gastrointestinal malignancies: past, present and a novel future. Oncotarget. 2010; 1:515-529.
-
(2010)
Oncotarget.
, vol.1
, pp. 515-529
-
-
Mulder, K.1
Koski, S.2
Scarfe, A.3
Chu, Q.4
King, K.5
Spratlin, J.6
-
94
-
-
78649992510
-
Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization
-
Tvorogov D, Anisimov A, Zheng W, Leppanen VM, Tammela T, Laurinavicius S, Holnthoner W, Helotera H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell. 2010; 18:630-640.
-
(2010)
Cancer Cell.
, vol.18
, pp. 630-640
-
-
Tvorogov, D.1
Anisimov, A.2
Zheng, W.3
Leppanen, V.M.4
Tammela, T.5
Laurinavicius, S.6
Holnthoner, W.7
Helotera, H.8
Holopainen, T.9
Jeltsch, M.10
Kalkkinen, N.11
Lankinen, H.12
Ojala, P.M.13
Alitalo, K.14
-
95
-
-
65649108558
-
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival
-
Singh A, Greninger P, Rhodes D, Koopman L, Violette S, Bardeesy N, Settleman J. A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. Cancer Cell. 2009; 15:489-500.
-
(2009)
Cancer Cell.
, vol.15
, pp. 489-500
-
-
Singh, A.1
Greninger, P.2
Rhodes, D.3
Koopman, L.4
Violette, S.5
Bardeesy, N.6
Settleman, J.7
-
96
-
-
79958003343
-
Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget
-
Zlobec I, Lugli A. Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget. Oncotarget. 2010; 1:651-661.
-
(2010)
Oncotarget.
, vol.1
, pp. 651-661
-
-
Zlobec, I.1
Lugli, A.2
-
97
-
-
79957521262
-
Membrane lipids in invadopodia and podosomes: key structures for cancer invasion and metastasis
-
Yamaguchi H, Oikawa T. Membrane lipids in invadopodia and podosomes: key structures for cancer invasion and metastasis. Oncotarget. 2010; 1:320-328.
-
(2010)
Oncotarget.
, vol.1
, pp. 320-328
-
-
Yamaguchi, H.1
Oikawa, T.2
-
98
-
-
74949120328
-
Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes
-
Cubillos-Ruiz JR, Rutkowski M, Conejo-Garcia JR. Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes. Cell Cycle. 2010; 9:260-268.
-
(2010)
Cell Cycle.
, vol.9
, pp. 260-268
-
-
Cubillos-Ruiz, J.R.1
Rutkowski, M.2
Conejo-Garcia, J.R.3
-
99
-
-
77953553524
-
Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo
-
Hirai H, Shimomura T, Kobayashi M, Eguchi T, Taniguchi E, Fukasawa K, Machida T, Oki H, Arai T, Ichikawa K, Hasako S, Haze K, Kodera T, Kawanishi N, Takahashi-Suziki I, Nakatsuru Y et al. Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo. Cell Cycle. 2010; 9:1590-1600.
-
(2010)
Cell Cycle.
, vol.9
, pp. 1590-1600
-
-
Hirai, H.1
Shimomura, T.2
Kobayashi, M.3
Eguchi, T.4
Taniguchi, E.5
Fukasawa, K.6
Machida, T.7
Oki, H.8
Arai, T.9
Ichikawa, K.10
Hasako, S.11
Haze, K.12
Kodera, T.13
Kawanishi, N.14
Takahashi-Suziki, I.15
Nakatsuru, Y.16
-
100
-
-
36849067532
-
Prostate cancer cells tolerate a narrow range of androgen receptor expression and activity
-
Tararova ND, Narizhneva N, Krivokrisenko V, Gudkov AV, Gurova KV. Prostate cancer cells tolerate a narrow range of androgen receptor expression and activity. Prostate. 2007; 67:1801-1815.
-
(2007)
Prostate.
, vol.67
, pp. 1801-1815
-
-
Tararova, N.D.1
Narizhneva, N.2
Krivokrisenko, V.3
Gudkov, A.V.4
Gurova, K.V.5
-
101
-
-
77953252473
-
Grappling with the androgen receptor: a new approach for treating advanced prostate cancer
-
Thompson TC. Grappling with the androgen receptor: a new approach for treating advanced prostate cancer. Cancer Cell. 2010; 17:525-526.
-
(2010)
Cancer Cell.
, vol.17
, pp. 525-526
-
-
Thompson, T.C.1
-
102
-
-
77953578274
-
KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer
-
Rokhlin OW, Guseva NV, Taghiyev AF, Glover RA, Cohen MB. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer Biol Ther. 2010; 9:224-235.
-
(2010)
Cancer Biol Ther.
, vol.9
, pp. 224-235
-
-
Rokhlin, O.W.1
Guseva, N.V.2
Taghiyev, A.F.3
Glover, R.A.4
Cohen, M.B.5
-
103
-
-
73549104274
-
A genomic strategy for predicting androgen receptor activity in prostate tumors
-
Jonsson JG, Sissung TM, Figg WD. A genomic strategy for predicting androgen receptor activity in prostate tumors. Cancer Biol Ther. 2009; 8:2002-2003.
-
(2009)
Cancer Biol Ther.
, vol.8
, pp. 2002-2003
-
-
Jonsson, J.G.1
Sissung, T.M.2
Figg, W.D.3
-
104
-
-
79960050587
-
Targeting androgen receptor in estrogen receptor-negative breast cancer
-
Ni M, Chen Y, Lim E, Wimberly H, Bailey ST, Imai Y, Rimm DL, Liu XS, Brown M. Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell. 2011; 20:119-131.
-
(2011)
Cancer Cell.
, vol.20
, pp. 119-131
-
-
Ni, M.1
Chen, Y.2
Lim, E.3
Wimberly, H.4
Bailey, S.T.5
Imai, Y.6
Rimm, D.L.7
Liu, X.S.8
Brown, M.9
-
105
-
-
77953280591
-
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor
-
Andersen RJ, Mawji NR, Wang J, Wang G, Haile S, Myung JK, Watt K, Tam T, Yang YC, Banuelos CA, Williams DE, McEwan IJ, Wang Y, Sadar MD. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell. 2010; 17:535-546.
-
(2010)
Cancer Cell.
, vol.17
, pp. 535-546
-
-
Andersen, R.J.1
Mawji, N.R.2
Wang, J.3
Wang, G.4
Haile, S.5
Myung, J.K.6
Watt, K.7
Tam, T.8
Yang, Y.C.9
Banuelos, C.A.10
Williams, D.E.11
McEwan, I.J.12
Wang, Y.13
Sadar, M.D.14
-
106
-
-
77951903529
-
The promise of novel androgen receptor antagonists
-
Gioeli DG. The promise of novel androgen receptor antagonists. Cell Cycle. 2010; 9:440-441.
-
(2010)
Cell Cycle.
, vol.9
, pp. 440-441
-
-
Gioeli, D.G.1
-
107
-
-
74849083394
-
Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castrationresistant prostate cancer
-
Narizhneva NV, Tararova ND, Ryabokon P, Shyshynova I, Prokvolit A, Komarov PG, Purmal AA, Gudkov AV, Gurova KV. Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castrationresistant prostate cancer. Cell Cycle. 2009; 8:4155-4167.
-
(2009)
Cell Cycle.
, vol.8
, pp. 4155-4167
-
-
Narizhneva, N.V.1
Tararova, N.D.2
Ryabokon, P.3
Shyshynova, I.4
Prokvolit, A.5
Komarov, P.G.6
Purmal, A.A.7
Gudkov, A.V.8
Gurova, K.V.9
-
108
-
-
77955721945
-
Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy
-
Tovar C, Higgins B, Deo D, Kolinsky K, Liu JJ, Heimbrook DC, Vassilev LT. Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy. Cell Cycle. 2010; 9:3364-3375.
-
(2010)
Cell Cycle.
, vol.9
, pp. 3364-3375
-
-
Tovar, C.1
Higgins, B.2
Deo, D.3
Kolinsky, K.4
Liu, J.J.5
Heimbrook, D.C.6
Vassilev, L.T.7
-
109
-
-
79957974187
-
Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks
-
Hawtin RE, Stockett DE, Wong OK, Lundin C, Helleday T, Fox JA. Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks. Oncotarget. 2010; 1:606-619.
-
(2010)
Oncotarget.
, vol.1
, pp. 606-619
-
-
Hawtin, R.E.1
Stockett, D.E.2
Wong, O.K.3
Lundin, C.4
Helleday, T.5
Fox, J.A.6
-
110
-
-
79251525596
-
Overexpression of POLQ confers a poor prognosis in early breast cancer patients
-
Higgins GS, Harris AL, Prevo R, Helleday T, McKenna WG, Buffa FM. Overexpression of POLQ confers a poor prognosis in early breast cancer patients. Oncotarget. 2010; 1:175-184.
-
(2010)
Oncotarget.
, vol.1
, pp. 175-184
-
-
Higgins, G.S.1
Harris, A.L.2
Prevo, R.3
Helleday, T.4
McKenna, W.G.5
Buffa, F.M.6
-
111
-
-
80052973510
-
Association of Mycoplasma hominis infection with prostate cancer
-
Barykova YA, Logunov DY, Shmarov MM, Vinarov AZ, Fiev DN, Vinarova NA, Rakovskaya IV, Baker PS, Shyshynova I, Stephenson AJ, Klein EA, Naroditsky BS, Gintsburg AL, Gudkov AV. Association of Mycoplasma hominis infection with prostate cancer. Oncotarget. 2011; 2:289-297.
-
(2011)
Oncotarget.
, vol.2
, pp. 289-297
-
-
Barykova, Y.A.1
Logunov, D.Y.2
Shmarov, M.M.3
Vinarov, A.Z.4
Fiev, D.N.5
Vinarova, N.A.6
Rakovskaya, I.V.7
Baker, P.S.8
Shyshynova, I.9
Stephenson, A.J.10
Klein, E.A.11
Naroditsky, B.S.12
Gintsburg, A.L.13
Gudkov, A.V.14
-
112
-
-
66349097908
-
Improvement of purine and pyrimidine antimetabolite-based anticancer treatment by selective suppression of mycoplasma-encoded catabolic enzymes
-
Liekens S, Bronckaers A, Balzarini J. Improvement of purine and pyrimidine antimetabolite-based anticancer treatment by selective suppression of mycoplasma-encoded catabolic enzymes. Lancet Oncol. 2009; 10:628-635.
-
(2009)
Lancet Oncol.
, vol.10
, pp. 628-635
-
-
Liekens, S.1
Bronckaers, A.2
Balzarini, J.3
-
113
-
-
79957484677
-
An activating transcription factor 5-mediated survival pathway as a target for cancer therapy?
-
Sheng Z, Evans SK, Green MR. An activating transcription factor 5-mediated survival pathway as a target for cancer therapy? Oncotarget. 2010; 1:457-460.
-
(2010)
Oncotarget
, vol.1
, pp. 457-460
-
-
Sheng, Z.1
Evans, S.K.2
Green, M.R.3
-
114
-
-
77952543382
-
Therapeutic targeting of p53 by small molecules
-
Selivanova G. Therapeutic targeting of p53 by small molecules. Semin Cancer Biol. 2010; 20:46-56.
-
(2010)
Semin Cancer Biol.
, vol.20
, pp. 46-56
-
-
Selivanova, G.1
-
115
-
-
77953170345
-
p73 tumor suppressor protein: a close relative of p53 not only in structure but also in anti-cancer approach?
-
Zawacka-Pankau J, Kostecka A, Sznarkowska A, Hedstrom E, Kawiak A. p73 tumor suppressor protein: a close relative of p53 not only in structure but also in anti-cancer approach? Cell Cycle. 2010; 9:720-728.
-
(2010)
Cell Cycle
, vol.9
, pp. 720-728
-
-
Zawacka-Pankau, J.1
Kostecka, A.2
Sznarkowska, A.3
Hedstrom, E.4
Kawiak, A.5
-
116
-
-
82355164170
-
Inhibition of Glycolytic Enzymes Mediated by Pharmacologically Activated p53: TARGETING WARBURG EFFECT TO FIGHT CANCER
-
Zawacka-Pankau J, Grinkevich VV, Hunten S, Nikulenkov F, Gluch A, Li H, Enge M, Kel A, Selivanova G. Inhibition of Glycolytic Enzymes Mediated by Pharmacologically Activated p53: TARGETING WARBURG EFFECT TO FIGHT CANCER. J Biol Chem. 2011; 286:41600-41615.
-
(2011)
J Biol Chem.
, vol.286
, pp. 41600-41615
-
-
Zawacka-Pankau, J.1
Grinkevich, V.V.2
Hunten, S.3
Nikulenkov, F.4
Gluch, A.5
Li, H.6
Enge, M.7
Kel, A.8
Selivanova, G.9
-
117
-
-
65449154815
-
Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis
-
Grinkevich VV, Nikulenkov F, Shi Y, Enge M, Bao W, Maljukova A, Gluch A, Kel A, Sangfelt O, Selivanova G. Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis. Cancer Cell. 2009; 15:441-453.
-
(2009)
Cancer Cell.
, vol.15
, pp. 441-453
-
-
Grinkevich, V.V.1
Nikulenkov, F.2
Shi, Y.3
Enge, M.4
Bao, W.5
Maljukova, A.6
Gluch, A.7
Kel, A.8
Sangfelt, O.9
Selivanova, G.10
-
118
-
-
84859503234
-
Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma
-
de Lange J, Ly LV, Lodder K, Verlaan-de Vries M, Teunisse AF, Jager MJ, Jochemsen AG. Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma. Oncogene. 2011.
-
(2011)
Oncogene.
-
-
de Lange, J.1
Ly, L.V.2
Lodder, K.3
Verlaan-de Vries, M.4
Teunisse, A.F.5
Jager, M.J.6
Jochemsen, A.G.7
-
119
-
-
77953497421
-
Targeting the p53-family in cancer and chemosensitivity: triple threat
-
Chung J, Irwin MS. Targeting the p53-family in cancer and chemosensitivity: triple threat. Curr Drug Targets. 2010; 11:667-681.
-
(2010)
Curr Drug Targets.
, vol.11
, pp. 667-681
-
-
Chung, J.1
Irwin, M.S.2
-
121
-
-
81155134638
-
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis
-
Li D, Marchenko ND, Moll UM. SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. Cell Death Differ. 2011; 18:1904-1913.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 1904-1913
-
-
Li, D.1
Marchenko, N.D.2
Moll, U.M.3
-
122
-
-
66749128074
-
The transcriptionindependent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells
-
Vaseva AV, Marchenko ND, Moll UM. The transcriptionindependent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells. Cell Cycle. 2009; 8:1711-1719.
-
(2009)
Cell Cycle.
, vol.8
, pp. 1711-1719
-
-
Vaseva, A.V.1
Marchenko, N.D.2
Moll, U.M.3
-
123
-
-
70449730274
-
p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA
-
Hedstrom E, Eriksson S, Zawacka-Pankau J, Arner ES, Selivanova G. p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA. Cell Cycle. 2009; 8:3576-3583.
-
(2009)
Cell Cycle.
, vol.8
, pp. 3576-3583
-
-
Hedstrom, E.1
Eriksson, S.2
Zawacka-Pankau, J.3
Arner, E.S.4
Selivanova, G.5
-
124
-
-
79958011689
-
A new therapeutic basis for treating Li-Fraumeni Syndrome breast tumors expressing mutated TP53
-
Glazer RI. A new therapeutic basis for treating Li-Fraumeni Syndrome breast tumors expressing mutated TP53. Oncotarget. 2010; 1:470-471.
-
(2010)
Oncotarget.
, vol.1
, pp. 470-471
-
-
Glazer, R.I.1
-
125
-
-
84858414406
-
Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells
-
Garcia H, Fleyshman D, Kolesnikova K, Safina A, Commane M, Paszkiewicz G, Omelian A, Morrison C, Gurova K. Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells. Oncotarget. 2011; 2:783-796.
-
(2011)
Oncotarget.
, vol.2
, pp. 783-796
-
-
Garcia, H.1
Fleyshman, D.2
Kolesnikova, K.3
Safina, A.4
Commane, M.5
Paszkiewicz, G.6
Omelian, A.7
Morrison, C.8
Gurova, K.9
-
127
-
-
70449706006
-
Targeting oncogenic signaling pathways by exploiting nanotechnology
-
Basu S, Chaudhuri P, Sengupta S. Targeting oncogenic signaling pathways by exploiting nanotechnology. Cell Cycle. 2009; 8:3480-3487.
-
(2009)
Cell Cycle.
, vol.8
, pp. 3480-3487
-
-
Basu, S.1
Chaudhuri, P.2
Sengupta, S.3
-
128
-
-
79960876539
-
A robust approach to enhance tumor-selective accumulation of nanoparticles
-
Qiao Y, Huang X, Nimmagadda S, Bai R, Staedtke V, Foss CA, Cheong I, Holdhoff M, Kato Y, Pomper MG, Riggins GJ, Kinzler KW, Diaz LA, Jr., Vogelstein B, Zhou S. A robust approach to enhance tumor-selective accumulation of nanoparticles. Oncotarget. 2010; 2:59-68.
-
(2010)
Oncotarget.
, vol.2
, pp. 59-68
-
-
Qiao, Y.1
Huang, X.2
Nimmagadda, S.3
Bai, R.4
Staedtke, V.5
Foss, C.A.6
Cheong, I.7
Holdhoff, M.8
Kato, Y.9
Pomper, M.G.10
Riggins, G.J.11
Kinzler, K.W.12
Diaz Jr., L.A.13
Vogelstein, B.14
Zhou, S.15
-
129
-
-
70749103751
-
Tissuepenetrating delivery of compounds and nanoparticles into tumors
-
Sugahara KN, Teesalu T, Karmali PP, Kotamraju VR, Agemy L, Girard OM, Hanahan D, Mattrey RF, Ruoslahti E. Tissuepenetrating delivery of compounds and nanoparticles into tumors. Cancer Cell. 2009; 16:510-520.
-
(2009)
Cancer Cell.
, vol.16
, pp. 510-520
-
-
Sugahara, K.N.1
Teesalu, T.2
Karmali, P.P.3
Kotamraju, V.R.4
Agemy, L.5
Girard, O.M.6
Hanahan, D.7
Mattrey, R.F.8
Ruoslahti, E.9
-
130
-
-
79952341098
-
A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors
-
Lim KJ, Bisht S, Bar EE, Maitra A, Eberhart CG. A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer Biol Ther. 11:464-473.
-
Cancer Biol Ther.
, vol.11
, pp. 464-473
-
-
Lim, K.J.1
Bisht, S.2
Bar, E.E.3
Maitra, A.4
Eberhart, C.G.5
-
131
-
-
79957971764
-
Targeting tumors with salmonella Typhimurium-potential for therapy
-
Wall DM, Srikanth CV, McCormick BA. Targeting tumors with salmonella Typhimurium-potential for therapy. Oncotarget. 2010; 1:721-728.
-
(2010)
Oncotarget.
, vol.1
, pp. 721-728
-
-
Wall, D.M.1
Srikanth, C.V.2
McCormick, B.A.3
-
132
-
-
75149180026
-
Genetically engineered Salmonella typhimurium as an imageable therapeutic probe for cancer
-
Nguyen VH, Kim HS, Ha JM, Hong Y, Choy HE, Min JJ. Genetically engineered Salmonella typhimurium as an imageable therapeutic probe for cancer. Cancer Res. 2010; 70:18-23.
-
(2010)
Cancer Res.
, vol.70
, pp. 18-23
-
-
Nguyen, V.H.1
Kim, H.S.2
Ha, J.M.3
Hong, Y.4
Choy, H.E.5
Min, J.J.6
-
133
-
-
78649868164
-
Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity
-
Liu F, Zhang L, Hoffman RM, Zhao M. Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity. Cell Cycle. 2010; 9:4518-4524.
-
(2010)
Cell Cycle.
, vol.9
, pp. 4518-4524
-
-
Liu, F.1
Zhang, L.2
Hoffman, R.M.3
Zhao, M.4
-
134
-
-
80555149875
-
Strong inhibition of xenografted tumor growth by low-level doses of [(32)P]ATP
-
Cheng Y, Yang J, Agarwal R, Green GM, Mease RC, Pomper MG, Meltzer SJ, Abraham JM. Strong inhibition of xenografted tumor growth by low-level doses of [(32)P]ATP. Oncotarget. 2011; 2:461-466.
-
(2011)
Oncotarget.
, vol.2
, pp. 461-466
-
-
Cheng, Y.1
Yang, J.2
Agarwal, R.3
Green, G.M.4
Mease, R.C.5
Pomper, M.G.6
Meltzer, S.J.7
Abraham, J.M.8
-
135
-
-
61349141840
-
9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways
-
Guo C, Gasparian AV, Zhuang Z, Bosykh DA, Komar AA, Gudkov AV, Gurova KV. 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways. Oncogene. 2009; 28:1151-1161.
-
(2009)
Oncogene.
, vol.28
, pp. 1151-1161
-
-
Guo, C.1
Gasparian, A.V.2
Zhuang, Z.3
Bosykh, D.A.4
Komar, A.A.5
Gudkov, A.V.6
Gurova, K.V.7
-
136
-
-
77953533783
-
Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosisinducing ligand (TRAIL) or oxaliplatin
-
Jani TS, DeVecchio J, Mazumdar T, Agyeman A, Houghton JA. Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosisinducing ligand (TRAIL) or oxaliplatin. J Biol Chem. 2010; 285:19162-19172.
-
(2010)
J Biol Chem.
, vol.285
, pp. 19162-19172
-
-
Jani, T.S.1
DeVecchio, J.2
Mazumdar, T.3
Agyeman, A.4
Houghton, J.A.5
-
137
-
-
75149144542
-
New hopes from old drugs: revisiting DNAbinding small molecules as anticancer agents
-
Gurova K. New hopes from old drugs: revisiting DNAbinding small molecules as anticancer agents. Future Oncol. 2009; 5:1685-1704.
-
(2009)
Future Oncol.
, vol.5
, pp. 1685-1704
-
-
Gurova, K.1
-
138
-
-
80052066877
-
Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib
-
Neznanov N, Komarov AP, Neznanova L, Stanhope-Baker P, Gudkov AV. Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib. Oncotarget. 2011; 2:209-221.
-
(2011)
Oncotarget.
, vol.2
, pp. 209-221
-
-
Neznanov, N.1
Komarov, A.P.2
Neznanova, L.3
Stanhope-Baker, P.4
Gudkov, A.V.5
-
139
-
-
68049110425
-
Hypoxia enhances the replication of oncolytic herpes simplex virus in p53-breast cancer cells
-
Fasullo M, Burch AD, Britton A. Hypoxia enhances the replication of oncolytic herpes simplex virus in p53-breast cancer cells. Cell Cycle. 2009; 8:2194-2197.
-
(2009)
Cell Cycle.
, vol.8
, pp. 2194-2197
-
-
Fasullo, M.1
Burch, A.D.2
Britton, A.3
-
140
-
-
79958015593
-
Targeting metabolic remodeling in glioblastoma multiforme
-
Wolf A, Agnihotri S, Guha A. Targeting metabolic remodeling in glioblastoma multiforme. Oncotarget. 2010; 1:552-562.
-
(2010)
Oncotarget.
, vol.1
, pp. 552-562
-
-
Wolf, A.1
Agnihotri, S.2
Guha, A.3
-
141
-
-
79959861423
-
Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism
-
Zhao Y, Liu H, Liu Z, Ding Y, Ledoux SP, Wilson GL, Voellmy R, Lin Y, Lin W, Nahta R, Liu B, Fodstad O, Chen J, Wu Y, Price JE, Tan M. Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism. Cancer Res. 2011; 71:4585-4597.
-
(2011)
Cancer Res.
, vol.71
, pp. 4585-4597
-
-
Zhao, Y.1
Liu, H.2
Liu, Z.3
Ding, Y.4
Ledoux, S.P.5
Wilson, G.L.6
Voellmy, R.7
Lin, Y.8
Lin, W.9
Nahta, R.10
Liu, B.11
Fodstad, O.12
Chen, J.13
Wu, Y.14
Price, J.E.15
Tan, M.16
-
142
-
-
79952289342
-
Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency
-
Tandon P, Gallo CA, Khatri S, Barger JF, Yepiskoposyan H, Plas DR. Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. Proc Natl Acad Sci U S A. 2011; 108:2361-2365.
-
(2011)
Proc Natl Acad Sci U S A.
, vol.108
, pp. 2361-2365
-
-
Tandon, P.1
Gallo, C.A.2
Khatri, S.3
Barger, J.F.4
Yepiskoposyan, H.5
Plas, D.R.6
-
143
-
-
79951699777
-
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
-
Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, Hawkins C, Guha A. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med. 2011; 208:313-326.
-
(2011)
J Exp Med.
, vol.208
, pp. 313-326
-
-
Wolf, A.1
Agnihotri, S.2
Micallef, J.3
Mukherjee, J.4
Sabha, N.5
Cairns, R.6
Hawkins, C.7
Guha, A.8
-
144
-
-
77949967131
-
Targeting metabolic transformation for cancer therapy
-
Tennant DA, Duran RV, Gottlieb E. Targeting metabolic transformation for cancer therapy. Nat Rev Cancer. 2010; 10:267-277.
-
(2010)
Nat Rev Cancer.
, vol.10
, pp. 267-277
-
-
Tennant, D.A.1
Duran, R.V.2
Gottlieb, E.3
-
145
-
-
76649126249
-
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
-
Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A. 2010; 107:2037-2042.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, pp. 2037-2042
-
-
Le, A.1
Cooper, C.R.2
Gouw, A.M.3
Dinavahi, R.4
Maitra, A.5
Deck, L.M.6
Royer, R.E.7
Vander Jagt, D.L.8
Semenza, G.L.9
Dang, C.V.10
-
146
-
-
79954560252
-
Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations
-
Dedes KJ, Wilkerson PM, Wetterskog D, Weigelt B, Ashworth A, Reis-Filho JS. Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations. Cell Cycle. 2011; 10:1192-1199.
-
(2011)
Cell Cycle.
, vol.10
, pp. 1192-1199
-
-
Dedes, K.J.1
Wilkerson, P.M.2
Wetterskog, D.3
Weigelt, B.4
Ashworth, A.5
Reis-Filho, J.S.6
-
148
-
-
79955592811
-
Harnessing synthetic lethal interactions in anticancer drug discovery
-
Chan DA, Giaccia AJ. Harnessing synthetic lethal interactions in anticancer drug discovery. Nat Rev Drug Discov. 2011; 10:351-364.
-
(2011)
Nat Rev Drug Discov.
, vol.10
, pp. 351-364
-
-
Chan, D.A.1
Giaccia, A.J.2
-
149
-
-
83555174377
-
Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia
-
Packer LM, Rana S, Hayward R, O'Hare T, Eide CA, Rebocho A, Heidorn S, Zabriskie MS, Niculescu-Duvaz I, Druker BJ, Springer C, Marais R. Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia. Cancer Cell. 2011.
-
(2011)
Cancer Cell.
-
-
Packer, L.M.1
Rana, S.2
Hayward, R.3
O'Hare, T.4
Eide, C.A.5
Rebocho, A.6
Heidorn, S.7
Zabriskie, M.S.8
Niculescu-Duvaz, I.9
Druker, B.J.10
Springer, C.11
Marais, R.12
-
150
-
-
70349912096
-
Exploiting synthetic lethal interactions for targeted cancer therapy
-
Reinhardt HC, Jiang H, Hemann MT, Yaffe MB. Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle. 2009; 8:3112-3119.
-
(2009)
Cell Cycle.
, vol.8
, pp. 3112-3119
-
-
Reinhardt, H.C.1
Jiang, H.2
Hemann, M.T.3
Yaffe, M.B.4
-
151
-
-
80054711625
-
Targeting Rb mutant cancers by inactivating TSC2
-
Searle JS, Li B, Du W. Targeting Rb mutant cancers by inactivating TSC2. Oncotarget. 2010; 1:228-232.
-
(2010)
Oncotarget.
, vol.1
, pp. 228-232
-
-
Searle, J.S.1
Li, B.2
Du, W.3
-
152
-
-
77952101348
-
Specific killing of Rb mutant cancer cells by inactivating TSC2
-
Li B, Gordon GM, Du CH, Xu J, Du W. Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell. 2010; 17:469-480.
-
(2010)
Cancer Cell.
, vol.17
, pp. 469-480
-
-
Li, B.1
Gordon, G.M.2
Du, C.H.3
Xu, J.4
Du, W.5
-
154
-
-
77955747085
-
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
-
Korotchkina LG, Leontieva OV, Bukreeva EI, Demidenko ZN, Gudkov AV, Blagosklonny MV. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY). 2010; 2:344-352.
-
(2010)
Aging (Albany NY).
, vol.2
, pp. 344-352
-
-
Korotchkina, L.G.1
Leontieva, O.V.2
Bukreeva, E.I.3
Demidenko, Z.N.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
156
-
-
79952269372
-
DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
-
Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging (Albany NY). 2010; 2:924-935.
-
(2010)
Aging (Albany NY).
, vol.2
, pp. 924-935
-
-
Leontieva, O.V.1
Blagosklonny, M.V.2
-
157
-
-
67649347537
-
Growth and aging: a common molecular mechanism
-
Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging. 2009; 1:357-362.
-
(2009)
Aging.
, vol.1
, pp. 357-362
-
-
Blagosklonny, M.V.1
Hall, M.N.2
-
158
-
-
77953645579
-
Rapamycin and quasi-programmed aging: Four years later
-
Blagosklonny MV. Rapamycin and quasi-programmed aging: Four years later. Cell Cycle. 2010; 9:1859-1862.
-
(2010)
Cell Cycle.
, vol.9
, pp. 1859-1862
-
-
Blagosklonny, M.V.1
-
159
-
-
0035359505
-
Exploiting cancer cell cycling for selective protection of normal cells
-
Blagosklonny MV, Pardee AB. Exploiting cancer cell cycling for selective protection of normal cells. Cancer Res. 2001; 61:4301-4305.
-
(2001)
Cancer Res.
, vol.61
, pp. 4301-4305
-
-
Blagosklonny, M.V.1
Pardee, A.B.2
-
160
-
-
79956035239
-
Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy
-
Rao B, van Leeuwen IM, Higgins M, Campbel J, Thompson AM, Lane DP, Lain S. Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy. Oncotarget. 2010; 1:639-650.
-
(2010)
Oncotarget.
, vol.1
, pp. 639-650
-
-
Rao, B.1
van Leeuwen, I.M.2
Higgins, M.3
Campbel, J.4
Thompson, A.M.5
Lane, D.P.6
Lain, S.7
-
162
-
-
69749128490
-
Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy
-
Choong ML, Yang H, Lee MA, Lane DP. Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy. Cell Cycle. 2009; 8:2810-2818.
-
(2009)
Cell Cycle.
, vol.8
, pp. 2810-2818
-
-
Choong, M.L.1
Yang, H.2
Lee, M.A.3
Lane, D.P.4
-
163
-
-
79960464440
-
Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture
-
Apontes P, Leontieva OV, Demidenko ZN, Li F, Blagosklonny MV. Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture. Oncotarget. 2011; 2:222-233.
-
(2011)
Oncotarget.
, vol.2
, pp. 222-233
-
-
Apontes, P.1
Leontieva, O.V.2
Demidenko, Z.N.3
Li, F.4
Blagosklonny, M.V.5
-
164
-
-
77955001669
-
Radioprotection: smart games with death
-
Gudkov AV, Komarova EA. Radioprotection: smart games with death. J Clin Invest. 2010; 120:2270-2273.
-
(2010)
J Clin Invest.
, vol.120
, pp. 2270-2273
-
-
Gudkov, A.V.1
Komarova, E.A.2
-
165
-
-
79960845908
-
Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients
-
Lee C, Longo VD. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene. 2011; 30:3305-3316.
-
(2011)
Oncogene.
, vol.30
, pp. 3305-3316
-
-
Lee, C.1
Longo, V.D.2
-
166
-
-
78649882284
-
Fasting and differential chemotherapy protection in patients
-
Raffaghello L, Safdie F, Bianchi G, Dorff T, Fontana L, Longo VD. Fasting and differential chemotherapy protection in patients. Cell Cycle. 2010; 9:4474-4476.
-
(2010)
Cell Cycle.
, vol.9
, pp. 4474-4476
-
-
Raffaghello, L.1
Safdie, F.2
Bianchi, G.3
Dorff, T.4
Fontana, L.5
Longo, V.D.6
-
167
-
-
78149295964
-
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
-
Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, Venkatesh M, Jobin C, Yeh LA, Mani S, Redinbo MR. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 2010; 330:831-835.
-
(2010)
Science.
, vol.330
, pp. 831-835
-
-
Wallace, B.D.1
Wang, H.2
Lane, K.T.3
Scott, J.E.4
Orans, J.5
Koo, J.S.6
Venkatesh, M.7
Jobin, C.8
Yeh, L.A.9
Mani, S.10
Redinbo, M.R.11
-
168
-
-
75749114436
-
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis
-
Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK et al. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science. 2010; 327:593-596.
-
(2010)
Science.
, vol.327
, pp. 593-596
-
-
Kirsch, D.G.1
Santiago, P.M.2
di Tomaso, E.3
Sullivan, J.M.4
Hou, W.S.5
Dayton, T.6
Jeffords, L.B.7
Sodha, P.8
Mercer, K.L.9
Cohen, R.10
Takeuchi, O.11
Korsmeyer, S.J.12
Bronson, R.T.13
Kim, C.F.14
Haigis, K.M.15
Jain, R.K.16
-
169
-
-
77951139188
-
Therapeutic antibody targeting of individual Notch receptors
-
Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J et al. Therapeutic antibody targeting of individual Notch receptors. Nature. 2010; 464:1052-1057.
-
(2010)
Nature.
, vol.464
, pp. 1052-1057
-
-
Wu, Y.1
Cain-Hom, C.2
Choy, L.3
Hagenbeek, T.J.4
de Leon, G.P.5
Chen, Y.6
Finkle, D.7
Venook, R.8
Wu, X.9
Ridgway, J.10
Schahin-Reed, D.11
Dow, G.J.12
Shelton, A.13
Stawicki, S.14
Watts, R.J.15
Zhang, J.16
-
170
-
-
70350244838
-
Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy
-
McClelland SE, Burrell RA, Swanton C. Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy. Cell Cycle. 2009; 8:3262-3266.
-
(2009)
Cell Cycle.
, vol.8
, pp. 3262-3266
-
-
McClelland, S.E.1
Burrell, R.A.2
Swanton, C.3
-
171
-
-
60749108023
-
The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells
-
Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells. Cell Cycle. 2009; 8:88-96.
-
(2009)
Cell Cycle.
, vol.8
, pp. 88-96
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Menendez, J.A.3
-
172
-
-
79952538201
-
Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
-
Algire C, Amrein L, Bazile M, David S, Zakikhani M, Pollak M. Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. Oncogene. 2011; 30:1174-1182.
-
(2011)
Oncogene.
, vol.30
, pp. 1174-1182
-
-
Algire, C.1
Amrein, L.2
Bazile, M.3
David, S.4
Zakikhani, M.5
Pollak, M.6
-
173
-
-
78649858143
-
AMPK as a therapeutic target in renal cell carcinoma
-
Woodard J, Joshi S, Viollet B, Hay N, Platanias LC. AMPK as a therapeutic target in renal cell carcinoma. Cancer Biol Ther. 2010; 10:1168-1177.
-
(2010)
Cancer Biol Ther.
, vol.10
, pp. 1168-1177
-
-
Woodard, J.1
Joshi, S.2
Viollet, B.3
Hay, N.4
Platanias, L.C.5
-
174
-
-
77953527360
-
Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena
-
Martin-Castillo B, Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena. Cell Cycle. 2010; 9:1057-1064.
-
(2010)
Cell Cycle.
, vol.9
, pp. 1057-1064
-
-
Martin-Castillo, B.1
Vazquez-Martin, A.2
Oliveras-Ferraros, C.3
Menendez, J.A.4
-
175
-
-
78649872745
-
Metformin against TGFbetainduced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis
-
Cufi S, Vazquez-Martin A, Oliveras-Ferraros C, Martin-Castillo B, Joven J, Menendez JA. Metformin against TGFbetainduced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis. Cell Cycle. 2010; 9:4461-4468.
-
(2010)
Cell Cycle.
, vol.9
, pp. 4461-4468
-
-
Cufi, S.1
Vazquez-Martin, A.2
Oliveras-Ferraros, C.3
Martin-Castillo, B.4
Joven, J.5
Menendez, J.A.6
-
176
-
-
77957005703
-
Metformin and energy metabolism in breast cancer: from insulin physiology to tumour-initiating stem cells
-
Vazquez-Martin A, Oliveras-Ferraros C, Cufi S, Martin-Castillo B, Menendez JA. Metformin and energy metabolism in breast cancer: from insulin physiology to tumour-initiating stem cells. Curr Mol Med. 2010; 10:674-691.
-
(2010)
Curr Mol Med.
, vol.10
, pp. 674-691
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Cufi, S.3
Martin-Castillo, B.4
Menendez, J.A.5
-
177
-
-
84857752594
-
Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+breast cancer
-
He X, Esteva FJ, Ensor J, Hortobagyi GN, Lee MH, Yeung SC. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+breast cancer. Ann Oncol. 2011.
-
(2011)
Ann Oncol.
-
-
He, X.1
Esteva, F.J.2
Ensor, J.3
Hortobagyi, G.N.4
Lee, M.H.5
Yeung, S.C.6
-
178
-
-
77956401999
-
Metformin and other biguanides in oncology: advancing the research agenda
-
Pollak M. Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila). 2010; 3:1060-1065.
-
(2010)
Cancer Prev Res (Phila).
, vol.3
, pp. 1060-1065
-
-
Pollak, M.1
-
179
-
-
79959764729
-
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
-
Ben Sahra I, Regazzetti C, Robert G, Laurent K, Le Marchand-Brustel Y, Auberger P, Tanti JF, Giorgetti-Peraldi S, Bost F. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res. 2011; 71:4366-4372.
-
(2011)
Cancer Res.
, vol.71
, pp. 4366-4372
-
-
Ben Sahra, I.1
Regazzetti, C.2
Robert, G.3
Laurent, K.4
Le Marchand-Brustel, Y.5
Auberger, P.6
Tanti, J.F.7
Giorgetti-Peraldi, S.8
Bost, F.9
-
180
-
-
79955490053
-
Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
-
Iliopoulos D, Hirsch HA, Struhl K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res. 2011; 71:3196-3201.
-
(2011)
Cancer Res.
, vol.71
, pp. 3196-3201
-
-
Iliopoulos, D.1
Hirsch, H.A.2
Struhl, K.3
-
181
-
-
78650316639
-
Metformin for aging and cancer prevention
-
Anisimov VN. Metformin for aging and cancer prevention. Aging (Albany NY). 2010; 2:760-774.
-
(2010)
Aging (Albany NY).
, vol.2
, pp. 760-774
-
-
Anisimov, V.N.1
-
182
-
-
67650514082
-
Metformin induces unique biological and molecular responses in triple negative breast cancer cells
-
Liu B, Fan Z, Edgerton SM, Deng XS, Alimova IN, Lind SE, Thor AD. Metformin induces unique biological and molecular responses in triple negative breast cancer cells. Cell Cycle. 2009; 8:2031-2040.
-
(2009)
Cell Cycle.
, vol.8
, pp. 2031-2040
-
-
Liu, B.1
Fan, Z.2
Edgerton, S.M.3
Deng, X.S.4
Alimova, I.N.5
Lind, S.E.6
Thor, A.D.7
-
183
-
-
65349175605
-
Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
-
Alimova IN, Liu B, Fan Z, Edgerton SM, Dillon T, Lind SE, Thor AD. Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle. 2009; 8:909-915.
-
(2009)
Cell Cycle.
, vol.8
, pp. 909-915
-
-
Alimova, I.N.1
Liu, B.2
Fan, Z.3
Edgerton, S.M.4
Dillon, T.5
Lind, S.E.6
Thor, A.D.7
-
184
-
-
77957005003
-
Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status
-
Vazquez-Martin A, Oliveras-Ferraros C, Cufi S, Del Barco S, Martin-Castillo B, Menendez JA. Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status. Cell Cycle. 2010; 9:3807-3814.
-
(2010)
Cell Cycle.
, vol.9
, pp. 3807-3814
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Cufi, S.3
Del Barco, S.4
Martin-Castillo, B.5
Menendez, J.A.6
-
185
-
-
79951787451
-
Genomics: Drugs, diabetes and cancer
-
Birnbaum MJ, Shaw RJ. Genomics: Drugs, diabetes and cancer. Nature. 2011; 470:338-339.
-
(2011)
Nature.
, vol.470
, pp. 338-339
-
-
Birnbaum, M.J.1
Shaw, R.J.2
-
186
-
-
84858693012
-
Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis
-
Zhang ZJ, Zheng ZJ, Kan H, Song Y, Cui W, Zhao G, Kip KE. Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis. Diabetes Care. 2011; 34:2323-2328.
-
(2011)
Diabetes Care.
, vol.34
, pp. 2323-2328
-
-
Zhang, Z.J.1
Zheng, Z.J.2
Kan, H.3
Song, Y.4
Cui, W.5
Zhao, G.6
Kip, K.E.7
-
187
-
-
79953658412
-
Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival
-
Powe DG, Voss MJ, Zanker KS, Habashy HO, Green AR, Ellis IO, Entschladen F. Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival. Oncotarget. 2010; 1:628-638.
-
(2010)
Oncotarget.
, vol.1
, pp. 628-638
-
-
Powe, D.G.1
Voss, M.J.2
Zanker, K.S.3
Habashy, H.O.4
Green, A.R.5
Ellis, I.O.6
Entschladen, F.7
-
188
-
-
80052190882
-
Targeted therapies: Using betablockers to inhibit breast cancer progression
-
Powe DG, Entschladen F. Targeted therapies: Using betablockers to inhibit breast cancer progression. Nat Rev Clin Oncol. 2011; 8:511-512.
-
(2011)
Nat Rev Clin Oncol.
, vol.8
, pp. 511-512
-
-
Powe, D.G.1
Entschladen, F.2
-
189
-
-
79953647658
-
Beta-adrenergic signaling, a novel target for cancer therapy?
-
Schuller HM. Beta-adrenergic signaling, a novel target for cancer therapy? Oncotarget. 2010; 1:466-469.
-
(2010)
Oncotarget
, vol.1
, pp. 466-469
-
-
Schuller, H.M.1
-
190
-
-
79960141295
-
Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer
-
Melhem-Bertrandt A, Chavez-Macgregor M, Lei X, Brown EN, Lee RT, Meric-Bernstam F, Sood AK, Conzen SD, Hortobagyi GN, Gonzalez-Angulo AM. Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer. J Clin Oncol. 2011; 29:2645-2652.
-
(2011)
J Clin Oncol.
, vol.29
, pp. 2645-2652
-
-
Melhem-Bertrandt, A.1
Chavez-Macgregor, M.2
Lei, X.3
Brown, E.N.4
Lee, R.T.5
Meric-Bernstam, F.6
Sood, A.K.7
Conzen, S.D.8
Hortobagyi, G.N.9
Gonzalez-Angulo, A.M.10
-
191
-
-
79960138447
-
Beta blockers and breast cancer mortality: a population-based study
-
Barron TI, Connolly RM, Sharp L, Bennett K, Visvanathan K. Beta blockers and breast cancer mortality: a population-based study. J Clin Oncol. 2011; 29:2635-2644.
-
(2011)
J Clin Oncol.
, vol.29
, pp. 2635-2644
-
-
Barron, T.I.1
Connolly, R.M.2
Sharp, L.3
Bennett, K.4
Visvanathan, K.5
-
192
-
-
79960133993
-
Expanding our therapeutic options: Beta blockers for breast cancer?
-
Ganz PA, Cole SW. Expanding our therapeutic options: Beta blockers for breast cancer? J Clin Oncol. 2011; 29:2612-2616.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2612-2616
-
-
Ganz, P.A.1
Cole, S.W.2
-
193
-
-
74849123200
-
AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases
-
Ateeq B, Tomlins SA, Chinnaiyan AM. AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases. Cell Cycle. 2009; 8:3794-3795.
-
(2009)
Cell Cycle.
, vol.8
, pp. 3794-3795
-
-
Ateeq, B.1
Tomlins, S.A.2
Chinnaiyan, A.M.3
|