P53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

Science

Volumn 327, Issue 5965, 2010, Pages 593-596

  Kirsch, David G ^a,b,c   Santiago, Philip M ^a   Di Tomaso, Emmanuelle ^b   Sullivan, Julie M ^c   Hou, Wu Shiun ^a,g   Dayton, Talya ^a   Jeffords, Laura B ^c   Sodha, Pooja ^a   Mercer, Kim L ^a   Cohen, Rhianna ^a   Takeuchi, Osamu ^d   Korsmeyer, Stanley J ^d   Bronson, Roderick T ^e   Kim, Carla F ^a,h   Haigis, Kevin M ^a,i   Jain, Rakesh K ^b   Jacks, Tyler ^a,f  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^g GENOMICS RESEARCH CENTER   (Taiwan)

^h BOSTON CHILDREN S HOSPITAL   (United States)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEIN BAK1; PROTEIN BAX; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; CYTOLOGY; DIGESTIVE SYSTEM DISORDER; GENE EXPRESSION; GENETICALLY MODIFIED ORGANISM; IONIZATION; RADIATION EXPOSURE; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; GAMMA IRRADIATION; GASTROINTESTINAL DISEASE; GENE DELETION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INJURY;

ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL DEATH; EPITHELIAL CELLS; GAMMA RAYS; GENE DELETION; GENES, P53; INTESTINAL DISEASES; INTESTINAL MUCOSA; INTESTINE, SMALL; MESODERM; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; RADIATION DOSAGE; RADIATION INJURIES; TUMOR SUPPRESSOR PROTEIN P53;

MUS; MUS MUSCULUS;

EID: 75749114436     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1166202     Document Type: Article

References (35)

1. F. A. Mettler Jr., G. L. Voelz, N. Engl. J. Med. 346, 1554 (2002).
2. D. W. van Bekkum, E. Schotman, Int. J. Radiat Biol. 25, 361 (1974).
3. N. H. A. Terry, E. L. Travis, Int. J. Radiat. Oncol. Biol. Phys. 17, 569 (1989).
4. K. A. Mason, H. R. Withers, W. H. McBride, C. A. Davis, ]. B. Smathers, Radiat. Res. 117, 480 (1989).
5. M. Brown, Int. J. Radiat. Oncol. Biol. Phys. 70, 799 (2008).
6. A. J. Merritt et. al., Cancer Res. 54, 614 (1994).
7. C. S. Potten, Nature 269, 518 (1977).
8. J. R. Jeffers et al., Cancer Cell 4, 321 (2003).
9. A. Villunger et al., Science 302, 1036 (2003).
10. W. Qiu et al., Cell Stem Cell 2, 576 (2008).
11. F. Paris et al., Science 293, 293 (2001).
12. P. Santana et al., Cell 86, 189 (1996).
13. M. Garcia-Barros et al., Science 300, 1155 (2003).
14. J. A. Rotolo et al., Int. J. Radiat Oncol. Biol. Phys. 70, 804 (2008).
15. E. A. Komarova et al., Oncogene 23, 3265 (2004).
16. A. J. Merritt, T. D. Allen, C. S. Potten, J. A. Hickman, Oncogene 14, 2759 (1997).
17. J. H. Hendry, C. S. Potten, Int. J. Radiat. Biol. 42, 621 (1982).
18. J. Lesher, S. Lesher, Radiat. Res. 57, 148 (1974).
19. C. S. Potten, G. Owen, S. A. Roberts, Int. J. Radiat. Biol. 57, 185 (1990).
20. C. S. Branda, S. M. Dymecki, Dev. Cell 6, 7 (2004).
21. F. el Marjou et al., Genesis 39, 186 (2004).
22. P. A. Koni et al., J. Exp. Med. 193, 741 (2001).
23. O. Takeuchi et al., Proc. Natl. Acad. Sci. U.S.A. 102, 11272 (2005).
24. T. Lindsten et al., Mol. Cell 6, 1389 (2000).
25. See the supporting material on Science Online.
26. A. B. Salter et al., Blood 113, 2104 (2009).
27. P. A. Crawford, J. I. Gordon, Proc. Natl. Acad. Sci. U.S.A. 102, 13254 (2005).
28. G. Kroemer et al., Cell Death Differ. 12 (suppl. 2), 1463 (2005).
29. I. García-Cao et al., EMBO J. 21, 6225 (2002).
30. L. G. Burdelya et al., Science 320, 226 (2008).
31. P. G. Komarov et al., Science 285, 1733 (1999).
32. M. A. Christophorou, I. Ringshausen, A. J. Finch, L. B. Swigart, G. I. Evan, Nature 443, 214 (2006).
33. L. G. Burdelya et al., Cancer Res. 66, 9356 (2006).
34. J. A. Coderre et al., Radiat. Res. 166, 495 (2006).
35. FL mice; P. Crawford and J. Gordon for advice; E. Travis for providing a model jig; J. Down, C. Pope, and K. Doppke for performing dosimetry measurements; and K. Held for critically reading the manuscript. This work is funded by the Howard Hughes Medical Institute (T.J.), partially funded by Cancer Center Support (core) grant P30-CA14051 from the National Cancer Institute (NCI) (T.J.), NCI grant KO8 CA 114176 (D.G.K.), the pilot project from the Dana Farber Cancer Center for Medical Countermeasures Against Radiation U19-Al06775 (D.G.K.), grant RC1-Al078521 from the National Institute of Allergy and Infectious Diseases (D.G.K.), an American Society of Clinical Oncology Young Investigator Award (D.G.K.), and NCI grant P01 CA80124 (R.K.J.). T.J. is the David H. Koch Professor of Biology and a Daniel K. Ludwig Scholar.