-
1
-
-
34248187981
-
Heat shock protein 90: The cancer chaperone
-
Neckers, L. Heat shock protein 90: the cancer chaperone. J. Biosci. 32, 517-530 (2007).
-
(2007)
J. Biosci.
, vol.32
, pp. 517-530
-
-
Neckers, L.1
-
2
-
-
49649117517
-
The Hsp90 chaperone machinery
-
Wandinger, S.K., Richter, K. & Buchner, J. The Hsp90 chaperone machinery. J. Biol. Chem. 283, 18473-18477 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 18473-18477
-
-
Wandinger, S.K.1
Richter, K.2
Buchner, J.3
-
3
-
-
0036494113
-
+ lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin
-
Bonvini, P., Gastaldi, T., Falini, B. & Rosolen, A. Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK+ CD30+ lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin. Cancer Res. 62, 1559-1566 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 1559-1566
-
-
Bonvini, P.1
Gastaldi, T.2
Falini, B.3
Rosolen, A.4
-
4
-
-
0035266132
-
Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts
-
Nimmanapalli, R., O'Bryan, E. & Bhalla, K. Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. Cancer Res. 61, 1799-1804 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 1799-1804
-
-
Nimmanapalli, R.1
O'Bryan, E.2
Bhalla, K.3
-
5
-
-
0035071607
-
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
-
Chiosis, G. et al. A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. Chem. Biol. 8, 289-299 (2001).
-
(2001)
Chem. Biol.
, vol.8
, pp. 289-299
-
-
Chiosis, G.1
-
6
-
-
66249138886
-
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
-
Caldas-Lopes, E. et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc. Natl. Acad. Sci. USA 106, 8368-8373 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 8368-8373
-
-
Caldas-Lopes, E.1
-
7
-
-
51449093764
-
Targeting Hsp90: Small-molecule inhibitors and their clinical development
-
Taldone, T., Gozman, A., Maharaj, R. & Chiosis, G. Targeting Hsp90: small-molecule inhibitors and their clinical development. Curr. Opin. Pharmacol. 8, 373-374 (2008).
-
(2008)
Curr. Opin. Pharmacol.
, vol.8
, pp. 373-374
-
-
Taldone, T.1
Gozman, A.2
Maharaj, R.3
Chiosis, G.4
-
8
-
-
33746365169
-
Discovery and development of purine-scaffold Hsp90 inhibitors
-
DOI 10.2174/156802606777812013
-
Chiosis, G. Discovery and development of purine-scaffold Hsp90 inhibitors. Curr. Top. Med. Chem. 6, 1183-1191 (2006) (Pubitemid 44110929).
-
(2006)
Current Topics in Medicinal Chemistry
, vol.6
, Issue.11
, pp. 1183-1191
-
-
Chiosis, G.1
-
9
-
-
0141485327
-
Development of purine-scaffold small molecule inhibitors of Hsp90
-
Chiosis, G. et al. Development of purine-scaffold small molecule inhibitors of Hsp90. Curr. Cancer Drug Targets 3, 371-376 (2003).
-
(2003)
Curr. Cancer Drug Targets
, vol.3
, pp. 371-376
-
-
Chiosis, G.1
-
10
-
-
0036836964
-
Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase
-
Chiosis, G., Lucas, B., Shtil, A., Huezo, H. & Rosen, N. Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase. Bioorg. Med. Chem. 10, 3555-3564 (2002).
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 3555-3564
-
-
Chiosis, G.1
Lucas, B.2
Shtil, A.3
Huezo, H.4
Rosen, N.5
-
11
-
-
30444447639
-
Identifcation of potent water soluble purine-scaffold inhibitors of the heat shock protein 90
-
He, H. et al. Identifcation of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. J. Med. Chem. 49, 381-390 (2006).
-
(2006)
J. Med. Chem.
, vol.49
, pp. 381-390
-
-
He, H.1
-
12
-
-
33645839336
-
Emerging Hsp90 inhibitors: From discovery to clinic
-
Chiosis, G., Rodina, A. & Moulick, K. Emerging Hsp90 inhibitors: from discovery to clinic. Anticancer. Agents Med. Chem. 6, 1-8 (2006) (Pubitemid 43796652).
-
(2006)
Anti-Cancer Agents in Medicinal Chemistry
, vol.6
, Issue.1
, pp. 1-8
-
-
Chiosis, G.1
Rodina, A.2
Moulick, K.3
-
13
-
-
37549015263
-
Germinal centres: Role in B cell physiology and malignancy
-
Klein, U. & Dalla-Favera, R. Germinal centres: role in B cell physiology and malignancy. Nat. Rev. Immunol. 8, 22-33 (2008).
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 22-33
-
-
Klein, U.1
Dalla-Favera, R.2
-
14
-
-
47149096182
-
B cell lymphoma 6 and the molecular pathogenesis of diffuse large B cell lymphoma
-
Ci, W., Polo, J.M. & Melnick, A. B cell lymphoma 6 and the molecular pathogenesis of diffuse large B cell lymphoma. Curr. Opin. Hematol. 15, 381-390 (2008).
-
(2008)
Curr. Opin. Hematol.
, vol.15
, pp. 381-390
-
-
Ci, W.1
Polo, J.M.2
Melnick, A.3
-
15
-
-
10344247666
-
The BCL-6 proto-oncogene suppresses p53 expression in germinal-centre B cells
-
Phan, R.T. & Dalla-Favera, R. The BCL-6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432, 635-639 (2004).
-
(2004)
Nature
, vol.432
, pp. 635-639
-
-
Phan, R.T.1
Dalla-Favera, R.2
-
16
-
-
34250762588
-
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR
-
Ranuncolo, S.M. et al. Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR. Nat. Immunol. 8, 705-714 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 705-714
-
-
Ranuncolo, S.M.1
-
17
-
-
65349119454
-
A peptomimetic inhibitor of BCL-6 with potent antilymphoma effects in vitro and in vivo
-
Cerchietti, L.C. et al. A peptomimetic inhibitor of BCL-6 with potent antilymphoma effects in vitro and in vivo. Blood 113, 3397-3405 (2009).
-
(2009)
Blood
, vol.113
, pp. 3397-3405
-
-
Cerchietti, L.C.1
-
18
-
-
11144277489
-
Specifc peptide interference reveals BCL-6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
-
Polo, J.M. et al. Specifc peptide interference reveals BCL-6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat. Med. 10, 1329-1335 (2004).
-
(2004)
Nat. Med.
, vol.10
, pp. 1329-1335
-
-
Polo, J.M.1
-
19
-
-
25144507241
-
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas
-
Valbuena, J.R. et al. Expression of heat-shock protein-90 in non-Hodgkin's lymphomas. Mod. Pathol. 18, 1343-1349 (2005).
-
(2005)
Mod. Pathol.
, vol.18
, pp. 1343-1349
-
-
Valbuena, J.R.1
-
20
-
-
20144382754
-
Molecular profling of diffuse large B cell lymphoma identifes robust subtypes including one characterized by host infammatory response
-
Monti, S. et al. Molecular profling of diffuse large B cell lymphoma identifes robust subtypes including one characterized by host infammatory response. Blood 105, 1851-1861 (2005).
-
(2005)
Blood
, vol.105
, pp. 1851-1861
-
-
Monti, S.1
-
21
-
-
33847674920
-
Transcriptional signature with differential expression of BCL-6 target genes accurately identifes BCL-6-dependent diffuse large B cell lymphomas
-
Polo, J.M. et al. Transcriptional signature with differential expression of BCL-6 target genes accurately identifes BCL-6-dependent diffuse large B cell lymphomas. Proc. Natl. Acad. Sci. USA 104, 3207-3212 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 3207-3212
-
-
Polo, J.M.1
-
22
-
-
0028786332
-
Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association
-
Schulte, T.W., Blagosklonny, M.V., Ingui, C. & Neckers, L. Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association. J. Biol. Chem. 270, 24585-24588 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 24585-24588
-
-
Schulte, T.W.1
Blagosklonny, M.V.2
Ingui, C.3
Neckers, L.4
-
23
-
-
0034718540
-
Modulation of Akt kinase activity by binding to Hsp90
-
Sato, S., Fujita, N. & Tsuruo, T. Modulation of Akt kinase activity by binding to Hsp90. Proc. Natl. Acad. Sci. USA 97, 10832-10837 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10832-10837
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
24
-
-
3142719113
-
Requirement of Hsp90 activity for IKB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-KB activation
-
Broemer, M., Krappmann, D. & Scheidereit, C. Requirement of Hsp90 activity for IKB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-KB activation. Oncogene 23, 5378-5386 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 5378-5386
-
-
Broemer, M.1
Krappmann, D.2
Scheidereit, C.3
-
25
-
-
0032128002
-
Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor
-
Niu, H., Ye, B.H. & Dalla-Favera, R. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 12, 1953-1961 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 1953-1961
-
-
Niu, H.1
Ye, B.H.2
Dalla-Favera, R.3
-
26
-
-
0033574789
-
Control of mRNA decay by heat shock-ubiquitin-proteasome pathway
-
DOI 10.1126/science.284.5413.499
-
Laroia, G., Cuesta, R., Brewer, G. & Schneider, R.J. Control of mRNA decay by heat shock-ubiquitin-proteasome pathway. Science 284, 499-502 (1999) (Pubitemid 29289625).
-
(1999)
Science
, vol.284
, Issue.5413
, pp. 499-502
-
-
Laroia, G.1
Cuesta, R.2
Brewer, G.3
Schneider, R.J.4
-
27
-
-
0037331203
-
Geldanamycin inhibits the production of infammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcripts
-
Wax, S., Piecyk, M., Maritim, B. & Anderson, P. Geldanamycin inhibits the production of infammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcripts. Arthritis Rheum. 48, 541-550 (2003).
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 541-550
-
-
Wax, S.1
Piecyk, M.2
Maritim, B.3
Anderson, P.4
-
28
-
-
50249096314
-
Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay
-
Sinsimer, K.S. et al. Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay. Mol. Cell. Biol. 28, 5223-5237 (2008).
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 5223-5237
-
-
Sinsimer, K.S.1
-
29
-
-
3142546235
-
The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation
-
Dean, J.L., Sully, G., Clark, A.R. & Saklatvala, J. The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. Cell. Signal. 16, 1113-1121 (2004).
-
(2004)
Cell. Signal.
, vol.16
, pp. 1113-1121
-
-
Dean, J.L.1
Sully, G.2
Clark, A.R.3
Saklatvala, J.4
-
30
-
-
38349175941
-
Estradiol up-regulates AUF1p45 binding to stabilizing regions within the 3'-untranslated region of estrogen receptor a mRNA
-
Ing, N.H., Massuto, D.A. & Jaeger, L.A. Estradiol up-regulates AUF1p45 binding to stabilizing regions within the 3'-untranslated region of estrogen receptor a mRNA. J. Biol. Chem. 283, 1764-1772 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 1764-1772
-
-
Ing, N.H.1
Massuto, D.A.2
Jaeger, L.A.3
-
31
-
-
0035162672
-
ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins
-
Bakheet, T., Frevel, M., Williams, B.R., Greer, W. & Khabar, K.S. ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins. Nucleic Acids Res. 29, 246-254 (2001).
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 246-254
-
-
Bakheet, T.1
Frevel, M.2
Williams, B.R.3
Greer, W.4
Khabar, K.S.5
-
32
-
-
0032915842
-
Chromatin recycling of glucocorticoid receptors: Implications for multiple roles of heat shock protein 90
-
Liu, J. & DeFranco, D.B. Chromatin recycling of glucocorticoid receptors: implications for multiple roles of heat shock protein 90. Mol. Endocrinol. 13, 355-365 (1999).
-
(1999)
Mol. Endocrinol.
, vol.13
, pp. 355-365
-
-
Liu, J.1
Defranco, D.B.2
-
33
-
-
41549133493
-
The tale of two domains: Proteomics and genomics analysis of SMYD2, a new histone methyltransferase
-
Abu-Farha, M. et al. The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase. Mol. Cell. Proteomics 7, 560-572 (2008).
-
(2008)
Mol. Cell. Proteomics
, vol.7
, pp. 560-572
-
-
Abu-Farha, M.1
-
34
-
-
32044436263
-
Hsp90: A chaperone for protein folding and gene regulation
-
Zhao, R. & Houry, W.A. Hsp90: a chaperone for protein folding and gene regulation. Biochem. Cell Biol. 83, 703-710 (2005).
-
(2005)
Biochem. Cell Biol.
, vol.83
, pp. 703-710
-
-
Zhao, R.1
Houry, W.A.2
-
35
-
-
33745197774
-
Depletion of hsp90beta induces multiple defects in B cell receptor signaling
-
Shinozaki, F. et al. Depletion of hsp90beta induces multiple defects in B cell receptor signaling. J. Biol. Chem. 281, 16361-16369 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 16361-16369
-
-
Shinozaki, F.1
-
36
-
-
58449136915
-
The heat shock protein 90 inhibitor IPI-504 induces apoptosis of AKT-dependent diffuse large B-cell lymphomas
-
Abramson, J.S. et al. The heat shock protein 90 inhibitor IPI-504 induces apoptosis of AKT-dependent diffuse large B-cell lymphomas. Br. J. Haematol. 144, 358-366 (2009).
-
(2009)
Br. J. Haematol.
, vol.144
, pp. 358-366
-
-
Abramson, J.S.1
-
37
-
-
33751258936
-
Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines
-
Robles, A.I. et al. Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines. Clin. Cancer Res. 12, 6547-6556 (2006)
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 6547-6556
-
-
Robles, A.I.1
|