Migrastatin analogues target fascin to block tumour metastasis

Nature

Volumn 464, Issue 7291, 2010, Pages 1062-1066

  Chen, Lin ^a   Yang, Shengyu ^a   Jakoncic, Jean ^b   Zhang, J Jillian ^a   Huang, Xin Yun ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; ANTINEOPLASTIC AGENT; CYTOSKELETON PROTEIN; F ACTIN; FASCIN; MIGRASTATIN DERIVATIVE; MUTANT PROTEIN; TUBULIN; UNCLASSIFIED DRUG;

CAUSE OF DEATH; CHEMICAL BINDING; CYTOLOGY; DISEASE TREATMENT; MEDICINE; PROTEIN; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; BREAST METASTASIS; BREAST TUMOR; CELL MIGRATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; HUMAN; HUMAN CELL; METASTASIS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN TARGETING; STRUCTURE ANALYSIS; TUMOR CELL; X RAY ANALYSIS;

ACTINS; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; BREAST NEOPLASMS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; LUNG NEOPLASMS; MACROLIDES; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, SCID; MICROFILAMENT PROTEINS; MODELS, MOLECULAR; MUTATION; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PIPERIDONES; PROTEIN CONFORMATION;

STREPTOMYCES;

EID: 77951116071     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08978     Document Type: Article

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