-
1
-
-
0035542970
-
AMP-activated protein kinase: The energy charge hypothesis revisited
-
Hardie DG, Hawley SA. AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 2001; 23:1112-9.
-
(2001)
Bioessays
, vol.23
, pp. 1112-1119
-
-
Hardie, D.G.1
Hawley, S.A.2
-
2
-
-
10944247187
-
The AMP-activated protein kinase pathway - New players upstream and downstream
-
Hardie DG. The AMP-activated protein kinase pathway - new players upstream and downstream. J Cell Science 2004; 117:5479-87.
-
(2004)
J Cell Science
, vol.117
, pp. 5479-5487
-
-
Hardie, D.G.1
-
3
-
-
34147152841
-
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
-
Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J 2007; 403:139-48.
-
(2007)
Biochem J
, vol.403
, pp. 139-148
-
-
Sanders, M.J.1
Grondin, P.O.2
Hegarty, B.D.3
Snowden, M.A.4
Carling, D.5
-
4
-
-
2342538485
-
Aberrant mRNA translation in cancer pathogenesis: An old concept revisited comes finally of age
-
Pandolfi PP. Aberrant mRNA translation in cancer pathogenesis: an old concept revisited comes finally of age. Oncogene 2004; 23:3134-7.
-
(2004)
Oncogene
, vol.23
, pp. 3134-3137
-
-
Pandolfi, P.P.1
-
5
-
-
2942544833
-
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells
-
Avdulov S, Li S, Michalek V, Burrichter D, Peterson M, Perlman DM, et al. Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 2004; 5:553-63.
-
(2004)
Cancer Cell
, vol.5
, pp. 553-563
-
-
Avdulov, S.1
Li, S.2
Michalek, V.3
Burrichter, D.4
Peterson, M.5
Perlman, D.M.6
-
6
-
-
20144387628
-
Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype
-
Swinnen JV, Beckers A, Brusselmans K, Organe S, Segers J, Timmermans L, et al. Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. Cancer Res 2005; 65:2441-8.
-
(2005)
Cancer Res
, vol.65
, pp. 2441-2448
-
-
Swinnen, J.V.1
Beckers, A.2
Brusselmans, K.3
Organe, S.4
Segers, J.5
Timmermans, L.6
-
7
-
-
85047689953
-
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
-
Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-aminoimidazole-4- carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 1995; 229:558-65.
-
(1995)
Eur J Biochem
, vol.229
, pp. 558-565
-
-
Corton, J.M.1
Gillespie, J.G.2
Hawley, S.A.3
Hardie, D.G.4
-
8
-
-
34250694982
-
5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- And TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling
-
Su RY, Chao Y, Chen TY, Huang DY, Lin WW. 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. Mol Cancer Ther 2007; 6:1562-71.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1562-1571
-
-
Su, R.Y.1
Chao, Y.2
Chen, T.Y.3
Huang, D.Y.4
Lin, W.W.5
-
9
-
-
34547981921
-
Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4- ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: Implication for targeted therapy
-
Sengupta TK, Leclerc GM, Hsieh-Kinser TT, Leclerc GJ, Singh I, Barredo JC. Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. Mol Cancer 2007; 6:46.
-
(2007)
Mol Cancer
, vol.6
, pp. 46
-
-
Sengupta, T.K.1
Leclerc, G.M.2
Hsieh-Kinser, T.T.3
Leclerc, G.J.4
Singh, I.5
Barredo, J.C.6
-
10
-
-
3543025724
-
AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms
-
Xiang X, Saha AK, Wen R, Ruderman NB, Luo Z. AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun 2004; 321:161-7.
-
(2004)
Biochem Biophys Res Commun
, vol.321
, pp. 161-167
-
-
Xiang, X.1
Saha, A.K.2
Wen, R.3
Ruderman, N.B.4
Luo, Z.5
-
11
-
-
24944480788
-
The Akt-mTOR tango and its relevance to cancer
-
Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005; 8:179-83.
-
(2005)
Cancer Cell
, vol.8
, pp. 179-183
-
-
Hay, N.1
-
12
-
-
34047095297
-
The two TORCs and Akt
-
Bhaskar PT, Hay N. The two TORCs and Akt. Dev Cell 2007; 12:487-502.
-
(2007)
Dev Cell
, vol.12
, pp. 487-502
-
-
Bhaskar, P.T.1
Hay, N.2
-
13
-
-
42949130656
-
AMPK and Raptor: Matching cell growth to energy supply
-
Hardie DG. AMPK and Raptor: matching cell growth to energy supply. Mol Cell 2008; 30:263-5.
-
(2008)
Mol Cell
, vol.30
, pp. 263-265
-
-
Hardie, D.G.1
-
14
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008; 30:214-26.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
-
15
-
-
25444524850
-
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
-
Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 2005; 280:32081-9.
-
(2005)
J Biol Chem
, vol.280
, pp. 32081-32089
-
-
Hahn-Windgassen, A.1
Nogueira, V.2
Chen, C.C.3
Skeen, J.E.4
Sonenberg, N.5
Hay, N.6
-
16
-
-
0141925771
-
Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
-
Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K, Dyck JR. Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biol Chem 2003; 278:39422-7.
-
(2003)
J Biol Chem
, vol.278
, pp. 39422-39427
-
-
Kovacic, S.1
Soltys, C.L.2
Barr, A.J.3
Shiojima, I.4
Walsh, K.5
Dyck, J.R.6
-
17
-
-
33646828975
-
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491
-
Horman S, Vertommen D, Heath R, Neumann D, Mouton V, Woods A, et al. Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem 2006; 281:5335-40.
-
(2006)
J Biol Chem
, vol.281
, pp. 5335-5340
-
-
Horman, S.1
Vertommen, D.2
Heath, R.3
Neumann, D.4
Mouton, V.5
Woods, A.6
-
18
-
-
28244466264
-
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase
-
Rattan R, Giri S, Singh AK, Singh I. 5-Aminoimidazole-4-carboxamide-1- beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem 2005; 280:39582-93.
-
(2005)
J Biol Chem
, vol.280
, pp. 39582-39593
-
-
Rattan, R.1
Giri, S.2
Singh, A.K.3
Singh, I.4
-
19
-
-
35748961731
-
Integrated therapy of kidney cancer
-
Longo R, D'Andrea MR, Sarmiento R, Salerno F, Gasparini G. Integrated therapy of kidney cancer. Ann Oncol 2007; 18:141-8.
-
(2007)
Ann Oncol
, vol.18
, pp. 141-148
-
-
Longo, R.1
D'Andrea, M.R.2
Sarmiento, R.3
Salerno, F.4
Gasparini, G.5
-
20
-
-
72949106926
-
Increased activated Akt expression in renal cell carcinomas and prognosis
-
Hager M, Haufe H, Kemmerling R, Hitzl W, Mikuz G, Moser PL, et al. Increased activated Akt expression in renal cell carcinomas and prognosis. J Cell Mol Med 2009; 13:2181-8.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 2181-2188
-
-
Hager, M.1
Haufe, H.2
Kemmerling, R.3
Hitzl, W.4
Mikuz, G.5
Moser, P.L.6
-
21
-
-
33846866035
-
The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer
-
Cho D, Signoretti S, Regan M, Mier JW, Atkins MB. The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer. Clin Cancer Res 2007; 13:758-63.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 758-763
-
-
Cho, D.1
Signoretti, S.2
Regan, M.3
Mier, J.W.4
Atkins, M.B.5
-
22
-
-
34249779568
-
Temsirolimus, interferonalpha or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, et al. Temsirolimus, interferonalpha or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356:2271-81.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
-
23
-
-
51649115883
-
Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 upregulation in renal cell carcinoma
-
Woodard J, Sassano A, Hay N, Platanias LC. Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 upregulation in renal cell carcinoma. Clin Cancer Res 2008; 14:4640-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4640-4649
-
-
Woodard, J.1
Sassano, A.2
Hay, N.3
Platanias, L.C.4
-
24
-
-
34548354859
-
Recent advances in targeted therapy for renal cell carcinoma
-
Clark PE. Recent advances in targeted therapy for renal cell carcinoma. Curr Opin Urol 2007; 17:331-6.
-
(2007)
Curr Opin Urol
, vol.17
, pp. 331-336
-
-
Clark, P.E.1
-
25
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108:1167-74.
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
-
26
-
-
0017785769
-
Primary bioassay of human tumor stem cells
-
Hamburger AW, Salmon SE. Primary bioassay of human tumor stem cells. Science 1977; 197:461-3.
-
(1977)
Science
, vol.197
, pp. 461-463
-
-
Hamburger, A.W.1
Salmon, S.E.2
-
27
-
-
69949116707
-
Role of Schlafen 2 (SLFN2) in the generation of IFNα-induced growth inhibitory responses
-
Katsoulidis E, Carayol N, Woodard J, Konieczna I, Majchrzak-Kita B, Jordan A, et al. Role of Schlafen 2 (SLFN2) in the generation of IFNα-induced growth inhibitory responses. J Biol Chem 2009; 284:25051-4.
-
(2009)
J Biol Chem
, vol.284
, pp. 25051-25054
-
-
Katsoulidis, E.1
Carayol, N.2
Woodard, J.3
Konieczna, I.4
Majchrzak-Kita, B.5
Jordan, A.6
-
29
-
-
0036216692
-
HIF-1 and tumor progression: Pathophysiology and therapeutics
-
Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 2002; 8:62-7.
-
(2002)
Trends Mol Med
, vol.8
, pp. 62-67
-
-
Semenza, G.L.1
-
30
-
-
68549096316
-
Targeted inhibition of mammalian target of rapamycin for the treatment of advanced renal cell carcinoma
-
Kapoor A, Figlin RA. Targeted inhibition of mammalian target of rapamycin for the treatment of advanced renal cell carcinoma. Cancer 2009; 115:3618-30.
-
(2009)
Cancer
, vol.115
, pp. 3618-3630
-
-
Kapoor, A.1
Figlin, R.A.2
-
32
-
-
0035843962
-
Structural mechanism for statin inhibition of HMG-CoA reductase
-
Istvan ES, Deisenhofer J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 2001; 292:1160-4.
-
(2001)
Science
, vol.292
, pp. 1160-1164
-
-
Istvan, E.S.1
Deisenhofer, J.2
-
33
-
-
0029665214
-
Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method
-
Ching YP, Davies SP, Hardie DG. Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method. Eur J Biochem 1996; 237:800-8.
-
(1996)
Eur J Biochem
, vol.237
, pp. 800-808
-
-
Ching, Y.P.1
Davies, S.P.2
Hardie, D.G.3
-
34
-
-
33845707278
-
Statins activate AMP-activated protein kinase in vitro and in vivo
-
Sun W, Lee TS, Zhu M, Gu C, Wang Y, Zhu Y, et al. Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation 2006; 14:2655-62.
-
(2006)
Circulation
, vol.14
, pp. 2655-2662
-
-
Sun, W.1
Lee, T.S.2
Zhu, M.3
Gu, C.4
Wang, Y.5
Zhu, Y.6
-
35
-
-
67649363839
-
Regulation of Rac1 by simvastatin in endothelial cells: Differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta
-
Kou R, Sartoretto J, Michel T. Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. J Biol Chem 2009; 284:14734-43.
-
(2009)
J Biol Chem
, vol.284
, pp. 14734-14743
-
-
Kou, R.1
Sartoretto, J.2
Michel, T.3
-
36
-
-
34547641739
-
Statin-induced breast cancer cell death: Role of inducible nitric oxide and arginase-dependent pathways
-
Kotamraju S, Williams CL, Kalyanaraman B. Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. Cancer Res 2007; 67:7386-94.
-
(2007)
Cancer Res
, vol.67
, pp. 7386-7394
-
-
Kotamraju, S.1
Williams, C.L.2
Kalyanaraman, B.3
-
37
-
-
44849099894
-
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
-
Sahra Ben I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008; 27:3576-86.
-
(2008)
Oncogene
, vol.27
, pp. 3576-3586
-
-
Sahra Ben, I.1
Laurent, K.2
Loubat, A.3
Giorgetti-Peraldi, S.4
Colosetti, P.5
Auberger, P.6
-
38
-
-
51249103805
-
Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients
-
Boon H, Bosselaar M, Praet SF, Blaak EE, Saris WH, Wagenmakers AJ, et al. Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients. Diabetologia 2008; 51:1893-900.
-
(2008)
Diabetologia
, vol.51
, pp. 1893-1900
-
-
Boon, H.1
Bosselaar, M.2
Praet, S.F.3
Blaak, E.E.4
Saris, W.H.5
Wagenmakers, A.J.6
-
39
-
-
0030904561
-
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
-
Kennedy SG, Wagner AJ, Conzen SD, Jordán J, Bellacosa A, Tsichlis PN, et al. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev 1997; 11:701-13.
-
(1997)
Genes Dev
, vol.11
, pp. 701-713
-
-
Kennedy, S.G.1
Wagner, A.J.2
Conzen, S.D.3
Jordán, J.4
Bellacosa, A.5
Tsichlis, P.N.6
-
40
-
-
33745840203
-
5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
-
Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J, et al. 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 2006; 26:5336-47.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5336-5347
-
-
Laderoute, K.R.1
Amin, K.2
Calaoagan, J.M.3
Knapp, M.4
Le, T.5
Orduna, J.6
-
41
-
-
0026654568
-
Correlation between interferon (IFN)α resistance and deletion of the IFNα/β genes in acute leukemia cell lines suggests selection against the IFN system
-
Colamonici OR, Domanski P, Platanias LC, Diaz MO. Correlation between interferon (IFN)α resistance and deletion of the IFNα/β genes in acute leukemia cell lines suggests selection against the IFN system. Blood 1992; 80:744-9.
-
(1992)
Blood
, vol.80
, pp. 744-749
-
-
Colamonici, O.R.1
Domanski, P.2
Platanias, L.C.3
Diaz, M.O.4
-
42
-
-
34249324822
-
Suppressive effects of statins on acute promyelocytic leukemia cells
-
Sassano A, Katsoulidis E, Antico G, Altman JK, Redig AJ, Minucci S, et al. Suppressive effects of statins on acute promyelocytic leukemia cells. Cancer Res 2007; 67:4524-32.
-
(2007)
Cancer Res
, vol.67
, pp. 4524-4532
-
-
Sassano, A.1
Katsoulidis, E.2
Antico, G.3
Altman, J.K.4
Redig, A.J.5
Minucci, S.6
-
43
-
-
33746178172
-
Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses
-
Giafis N, Katsoulidis E, Sassano A, Tallman MS, Higgins LS, Nebreda AR, et al. Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses. Cancer Res 2006; 66:6763-71.
-
(2006)
Cancer Res
, vol.66
, pp. 6763-6771
-
-
Giafis, N.1
Katsoulidis, E.2
Sassano, A.3
Tallman, M.S.4
Higgins, L.S.5
Nebreda, A.R.6
-
44
-
-
0029128365
-
Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase
-
Yetter A, Uddin S, Krolewski JJ, Jiao H, Yi T, Platanias LC. Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase. J Biol Chem 1995; 270:18179-82.
-
(1995)
J Biol Chem
, vol.270
, pp. 18179-18182
-
-
Yetter, A.1
Uddin, S.2
Krolewski, J.J.3
Jiao, H.4
Yi, T.5
Platanias, L.C.6
-
45
-
-
0037177813
-
Protein kinase C-delta (PKC-delta) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727
-
Uddin S, Sassano A, Deb DK, Verma A, Majchrzak B, Rahman A, et al. Protein kinase C-delta (PKC-delta) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J Biol Chem 2002; 277:14408-16.
-
(2002)
J Biol Chem
, vol.277
, pp. 14408-14416
-
-
Uddin, S.1
Sassano, A.2
Deb, D.K.3
Verma, A.4
Majchrzak, B.5
Rahman, A.6
|