Is the multifunctional Na +/H + exchanger isoform 1 a potential therapeutic target in cancer?

Current Medicinal Chemistry

Volumn 19, Issue 5, 2012, Pages 647-660

  Stock, C ^a   Ludwig, F T ^a   Schwab, A ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Cancer treatment; Cariporide (HOE642); Growth factors; Na + H + exchanger; NHE1; PH; Tumour microenvironment

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; 2 [2 METHYL 5 METHYLSULFONYL 4 (1 PYRROLYL)BENZOYL]GUANIDINE; 5 (N ETHYL N ISOPROPYL)AMILORIDE; [4 [4 (2 FUROYL) 1 PIPERAZINYL] 3 (METHYLSULFONYL)BENZOYL]GUANIDINE; AMILORIDE; ANTINEOPLASTIC AGENT; B RAF KINASE; BMS 284640; CARIPORIDE; CIMETIDINE; CLONIDINE; COMPOUND 9T; ENIPORIDE; GELATINASE B; HARMALINE; N AMIDINO 1,4 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; PLACEBO; PLASMINOGEN; PROTEIN BAX; PROTEIN INHIBITOR; PROTON; SABIPORIDE; SL 591227; SM 20220; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 1 INHIBITOR; T 162559; TY 12533; UNCLASSIFIED DRUG; UROKINASE; ZONIPORIDE;

ARTICLE; CELL FUNCTION; CELL MEMBRANE; CELL MOTILITY; CELL PH; CELL VOLUME; CHRONIC MYELOID LEUKEMIA; CYTOPLASM; CYTOSKELETON; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; EXTRACELLULAR MATRIX; FOCAL ADHESION; GENE EXPRESSION; HEART INFARCTION; HOMEOSTASIS; HUMAN; IC 50; ISCHEMIA; NEOPLASM; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REPERFUSION INJURY; TUMOR CELL; TUMOR MICROENVIRONMENT; UNSPECIFIED SIDE EFFECT; UNSTABLE ANGINA PECTORIS;

ANTINEOPLASTIC AGENTS; CATION TRANSPORT PROTEINS; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASMS; PROTEIN ISOFORMS; SODIUM-HYDROGEN ANTIPORTER;

EID: 84857750722     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712798992101     Document Type: Article

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