Discovery of zoniporide: A potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 6, 2001, Pages 803-807

  Guzman Perez, Angel ^a   Wester, Ronald T ^a   Allen, Mary C ^a   Brown, Janice A ^a   Buchholz, Allan R ^a   Cook, Ewell R ^a   Day, Wesley W ^a   Hamanaka, Ernest S ^a   Kennedy, Scott P ^a   Knight, Delvin R ^a   Kowalczyk, Paul J ^a   Marala, Ravi B ^a   Mularski, Christian J ^a   Novomisle, William A ^a   Ruggeri, Roger B ^a   Tracey, W Ross ^a   Hill, Roger J ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARIPORIDE; CARRIER PROTEIN; ENIPORIDE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONFORMATIONAL TRANSITION; DOG; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; PLASMA PROTEIN BINDING; PROTON SODIUM EXCHANGE; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; DOGS; GUANIDINES; INJECTIONS, INTRAVENOUS; MOLECULAR CONFORMATION; PROTECTIVE AGENTS; PYRAZOLES; RATS; SODIUM-HYDROGEN ANTIPORTER; SOLUBILITY; WATER;

CANIS FAMILIARIS;

EID: 0035953078     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00059-2     Document Type: Article

References (44)