Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1

Journal of Medicinal Chemistry

Volumn 44, Issue 20, 2001, Pages 3302-3310

  Ahmad, S ^a   Doweyko, L M ^a   Dugar, S ^a   Grazier, N ^a   Ngu, K ^a   Wu, S C ^a   Yost, K J ^a   Chen, B C ^a   Gougoutas, J Z ^a   DiMarco, J D ^a   Lan, S J ^a   Gavin, B J ^a   Chen, A Y ^a   Dorso, C R ^a   Serafino, R ^a   Kirby, M ^a   Atwal, K S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BMS 284640; CARIPORIDE; CYCLOPROPANE DERIVATIVE; ENIPORIDE; FURAN DERIVATIVE; GUANIDINE DERIVATIVE; ISOPROTEIN; SODIUM HYDROGEN EXCHANGER ISOFORM 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL LINE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PROTON SODIUM EXCHANGE; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CATION TRANSPORT PROTEINS; CELL LINE; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; CYCLOPROPANES; GUANIDINES; HUMANS; MEMBRANE PROTEINS; PROTEIN ISOFORMS; RATS; SODIUM-HYDROGEN ANTIPORTER; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035960055     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010100v     Document Type: Article

References (24)

1. + exchange structure, regulation, and its role in heart disease
2. Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger isoform
3. + exchanger isoform-2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion
4. Cloning, tissue distribution, and functional analysis of the human Na/H exchanger isoform, NHE-3
5. Molecular cloning of putative members of the Na/H exchanger gene family
6. A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity
7. + exchanger
8. Role of Na/H exchange in cardiac physiology and pathophysiology: Mediation of myocardial reperfusion injury by the pH paradox
9. + exchange inhibitor cariporide as a cardioprotective drug: From the laboratory to the GUARDIAN trial
10. Pharmacology and clinical assessment of cariporide for the treatment coronary artery diseases
11. + antiporter inhibitors
12. Preparation of acylguanidines as sodium/proton exchange inhibitors
13. New simple conversion of α, β-unsaturated carbonyl compounds into their corresponding cyclopropyl ketones and esters
14. The Wittig olefination reaction and modifications involving phosphoryl-stabilized carbanions. Stereochemistry, mechanism, and selected synthetic aspects
15. Construction of the gem-dimethyl-cyclopropane unit employing triphenylphosphonium isopropylide
16. Fluoride-mediated boronic acid coupling reactions
17. Palladium(0) catalyzed cross coupling reactions of hindered, double activated aryl halides with organozinc reagents - The effect of copper(I) cocatalysis
18. - exchange-deficient mutants
19. + exchange activity in cultured vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats
20. Sodium current in single rat heart muscle cells
21. + exchanger
22. Dichloro[1,1′-bis(diphenylphosphino)ferrocene] palladium(II): An effective catalyst for cross-coupling of secondary and primary alkyl Grignard and alkylzinc reagents with organic halides