Reactive oxygen species-mediated regulation of the Na+- H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers

Cell Death and Differentiation

Volumn 13, Issue 4, 2006, Pages 628-641

  Akram, S ^a   Teong, H F C ^a   Fliegel, L ^b   Pervaiz, S ^a   Clement M V ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cell death; Hydrogen peroxide; Na+ H+ exchanger NHE 1; Rac1; Superoxide

Indexed keywords

HYDROGEN PEROXIDE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SODIUM PROTON EXCHANGE PROTEIN 1; SUPEROXIDE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS;

ANIMALS; APOPTOSIS; CATION TRANSPORT PROTEINS; CELL LINE, TUMOR; DITIOCARB; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; MEMBRANE PROTEINS; MICE; NIH 3T3 CELLS; OXIDATION-REDUCTION; PROMOTER REGIONS (GENETICS); RAC1 GTP-BINDING PROTEIN; RNA INTERFERENCE; SODIUM-HYDROGEN ANTIPORTER; SUPEROXIDE DISMUTASE; SUPEROXIDES; TRANSFECTION;

ANIMALIA;

EID: 33644936885     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401775     Document Type: Article

References (40)

1. Pervaiz S and Clement MV (2004) Tumor intracellular redox status and drug resistance - serendipity or a causal relationship? Curr. Pharm. Des. 10: 1969-1977
2. Pervaiz S and Clement MV (2002) A permissive apoptotic environment: function of a decrease in intracellular superoxide anion and cytosolic acidification. Biochem. Biophys. Res. Commun. 290: 1145-1150
3. Clement MV and Pervaiz S (1999) Reactive oxygen intermediates regulate cellular response to apoptotic stimuli: An hypothesis. Free Radic. Res. 30: 247-252
4. Clement MV and Pervaiz S (2001) Intracellular superoxide and hydrogen peroxide concentrations: A critical balance that determines survival or death. Redox. Rep. 6: 211-214
5. Clement MV and Stamenkovic I (1996) Superoxide anion is a natural inhibitor of FAS-mediated cell death. EMBO J. 15: 216-225
6. Pervaiz S, Ramalingam JK, Hirpara JL and Clement MV (1999) Superoxide anion inhibits drug-induced tumor cell death. FEBS Lett. 459: 343-348
7. Ahmad KA, Clement MV, Hanif IM and Pervaiz S (2004) Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution. Cancer Res. 64: 1452-1459
8. Pervaiz S, Cao J, Chao OS, Chin YY and Clement MV (2001) Activation of the RacGTPase inhibits apoptosis in human tumor cells. Oncogene 20: 6263-6268
9. Hirpara JL, Clement MV and Pervaiz S (2001) Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells. J. Biol. Chem. 276: 514-521
10. Clement MV, Ponton A and Pervaiz S (1998) Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu. FEBS Lett. 440: 13-18
11. Hampton M and Orrenius S (1998) Redox regulation of apoptotic cell death. Biofactors 8: 1-5
12. Chandra J, Samali A and Orrenius S (2000) Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 29: 323-333
13. Brett CL, Wei Y, Donowitz M and Rao R (2002) Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. Am. J. Physiol. Cell Physiol. 282: C1031-C1041
14. + exchanger isoform NHE8. Am. J. Physiol. Renal Physiol. 284: F467-F473
15. + exchanger localized to the trans-Golgi network. J. Biol. Chem. 276: 17387-17394
16. + exchanger, NHE1: Structure, regulation, and cellular actions. Annu. Rev. Pharmacol. Toxicol. 42: 527-552
17. + exchanger gene expression: Mitogenic stimulation increases NHE1 promoter activity. Am. J. Physiol. 274: C831-C839
18. + exchanger. Am. J. Physiol. Renal. Physiol. 284: F829-F839
19. Cerutti PA (1985) Prooxidant states and tumor promotion. Science 227: 375-381
20. Sundaresan M, Yu Z-X, Ferrans VJ, Sulciner DJ, Gutkind JS, Iranis K, Goldschmidt-Clermont PJ and Finkel T (1996) Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem. J. 318: 379-382
21. Irani K and Goldschmidt-Clermont PJ (1998) Ras, superoxide and signal transduction. Biochem. Pharmacol. 55: 1339-1346
22. Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER, Sundaresan M, Finkel T and Goldschmidt-Clermont PJ (1997) Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275: 1649-1652
23. Yang W, Dyck JR and Fliegel L (1996) Regulation of NHE1 expression in L6 muscle cells. Biochim. Biophys. Acta. 1306: 107-113
24. Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ and Der CJ (1998) Increasing complexity of Ras signaling. Oncogene 17: 1395-1413
25. Joneson T and Bar-Sagi D (1998) A Rac1 effector site controlling mitogenesis through superoxide production. J. Biol. Chem. 273: 17991-17994
26. Toporik A, Gorzalczany Y, Hirshberg M, Pick E and Lotan O (1998) Mutational analysis of novel effector domains in Rac1 involved in the activation of nicotinamide adenine dinucleotide phosphate (reduced) oxidase. Biochemistry 37: 7147-7156
27. Hampton MB, Fadeel B and Orrenius S (1998) Redox regulation of the caspases during apoptosis. Ann. NY Acad. Sci. 854: 328-335
28. Baeuerle PA and Baltimore D (1996) NF-kappa B: Ten years after. Cell 87: 13-20
29. Bowie A and O'Neill LA (2000) Oxidative stress and nuclear factor-kappaB activation: A reassessment of the evidence in the light of recent discoveries. Biochem. Pharmacol. 59: 13-23
30. + exchange isoform 1 mRNA expression in isolated rat hearts. Am. J. Physiol. 277: H993-H998
31. Qiu RG, Chen J, Kim D, McCormick F and Symons M (1995) An essential role for Rac in Ras transformation. Nature 374: 457-459
32. + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes. FASEB J. 14: 2185-2197
33. Piwnica-Worms D, Jacob R, Horres CR and Lieberman M (1985) Na/H exchange in cultured chick heart cells. pHi regulation. J. Gen. Physiol. 85: 43-64
34. Moolenaar WH, Boonstra J, van der Saag PT and de Laat SW (1981) Sodium/ proton exchange in mouse neuroblastoma cells. J. Biol. Chem. 256: 12883-12887
35. + exchange at the apical membrane of Necturus gallbladder* Extracellular and intracellular pH studies. J. Gen. Physiol. 80: 299-321
36. + exchange system in skeletal muscle cells in culture. J. Biol. Chem. 257: 9394-9400
37. + antiport. J. Gen. Physiol. 83: 341-369
38. + exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival. J. Biol. Chem. 279: 26280-26286
39. Mukhin YV, Garnovskaya MN, Ullian ME and Raymond JR (2004) ERK is regulated by sodium-proton exchanger in rat aortic vascular smooth muscle cells. J. Biol. Chem. 279: 1845-1852
40. Pervaiz S and Clement MV (2002) Hydrogen peroxide-induced apoptosis: oxidative or reductive stress? Methods Enzymol. 352: 150-159