Mechanisms of hypotonic inhibition of the sodium, proton exchanger type 1 (NHE1) in a biliary epithelial cell line (Mz-Cha-1)

Acta Physiologica

Volumn 190, Issue 3, 2007, Pages 199-208

  Elsing, C ^a   Gosch, I ^b   Hennings, J C ^c   Hubner C A ^c   Herrmann, T ^b  

^a St Elisabeth Hospital   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Bile formation; Cholangiocyte; Cytoskeleton; H+ exchanger type 1; Ion transport; Na+

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CALCIUM ION; CALMODULIN; COLCHICINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHALASIN; FLUORESCEIN DERIVATIVE; HYBRID PROTEIN; HYPOTONIC SOLUTION; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C; PROTEIN TYROSINE KINASE INHIBITOR; SODIUM CHLORIDE; SODIUM PROTON EXCHANGE PROTEIN 1;

ARTICLE; BILE DUCT; CELL LINE; CONFOCAL LASER MICROSCOPY; CYTOSKELETON; EPITHELIUM CELL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; SIGNAL TRANSDUCTION; SPECTROPHOTOMETER;

BILIARY TRACT; CALCIUM; CALMODULIN; CATION TRANSPORT PROTEINS; CELL LINE, TUMOR; CYTOSKELETON; EPITHELIAL CELLS; HUMANS; MEMBRANE PROTEINS; OSMOLAR CONCENTRATION; PHOSPHORYLATION; PROTEIN KINASE C; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

EID: 34250649802     PISSN: 17481708     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2007.01682.x     Document Type: Article

References (53)

1. Barfod, E.T., Moore, A.L., Melnick, R.F. Lidofsky, S.D. 2005. Src regulates distinct pathways for cell volume control through Vaν and phospholipase Cγ. J Biol Chem 280, 25548 25557.
2. Basavappa, S., Middleton, J., Mangel, A.W., McGill, J.M., Cohn, J.A. Fitz, J.G. 1993. Cl- and K+ transport in human biliary cell lines. Gastroenterology 104, 1796 1805.
3. Bertrand, B., Wakabayashi, S., Ikeda, T., Pouyssegur, J. Shigekawa, M. 1994. The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites. J Biol Chem 269, 13703 13709.
4. Biemesderfer, D., Rutherford, P.A., Nagy, T., Pizzonia, J.H., Abu-Alfa, A.K. Aronson, P.S. 1997. Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney. Am J Physiol 273, F289 F299.
5. Cohen, D.M. 2005. Src family kinases in cell volume regulation. Am J Physiol Cell Physiol 288, C483 C493.
6. Dascalu, A., Nevo, Z. Korenstein, R. 1992. Hyperosmotic activation of the Na(+)-H+ exchanger in a rat bone cell line: temperature dependence and activation pathways. J Physiol 456, 503 518.
7. Denker, S.P., Huang, D.C., Orlowski, J., Furthmayr, H. Barber, D.L. 2000. Direct binding of the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. Mol Cell 6, 1425 1436.
8. Ebner, H.L., Cordas, A., Pafundo, D.E., Schwarzbaum, P.J., Pelster, B. Krumschnabel, G. 2005. Importance of cytoskeletal elements in volume regulatory responses of trout hepatocytes. Am J Physiol Regul Integr Comp Physiol 289, 0R877 0R890.
9. Elsing, C. Huebner, C. 1997. Biliary tract physiology. Curr Opin Gastroenterol 13, 405 409.
10. Elsing, C., Reichen, J., Marti, U. Renner, E.L. 1994. Hepatocellular Na+/H+ exchange is activated at transcriptional and posttranscriptional levels in rat biliary cirrhosis. Gastroenterology 107, 468 478.
11. Elsing, C., Hirlinger, A., Renner, E.L., Lauterburg, B.H., Meier, P.J. Reichen, J. 1995. Solvent isotope effect on bile formation in the rat. Biochem J 307, 175 181.
12. Elsing, C., Kassner, A., Hubner, C., Buhli, H. Stremmel, W. 1996a. Absorptive and secretory mechanisms in biliary epithelial cells. J Hepatol 24 (Suppl. 1 121 127.
13. Elsing, C., Kassner, A. Stremmel, W. 1996b. Sodium, hydrogen antiporter activation by extracellular adenosine triphosphate in biliary epithelial cells. Gastroenterology 111, 1321 1332.
14. Fitz, J.G. 2002. Regulation of cholangiocyte secretion. Semin Liver Dis 22, 241 249.
15. Fliegel, L. 2005. The Na+/H+ exchanger isoform 1. Int J Biochem Cell Biol 37, 33 37.
16. Green, J., Yamaguchi, D.T., Kleeman, C.R. Muallem, S. 1988. Selective modification of the kinetic properties of Na+/H+ exchanger by cell shrinkage and swelling. J Biol Chem 263, 5012 5015.
17. Grinstein, S., Woodside, M., Sardet, C., Pouyssegur, J. Rotin, D. 1992. Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism. J Biol Chem 267, 23823 23828.
18. Grinstein, S., Woodside, M., Goss, G.G. Kapus, A. 1994. Osmotic activation of the Na+/H+ antiporter during volume regulation. Biochem Soc Trans 22, 512 516.
19. Haddad, P., Beck, J.S., Boyer, J.L. Graf, J. 1991. Role of chloride ions in liver cell volume regulation. Am J Physiol 261, G340 G348.
20. Hirata, K. Nathanson, M.H. 2001. Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver. Gastroenterology 121, 396 406.
21. Hoogerwerf, W.A., Tsao, S.C., Devuyst, O. et al. 1996. NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. Am J Physiol 270, G29 G41.
22. Hubner, C., Stremmel, W. Elsing, C. 2000. Sodium, hydrogen exchange type 1 and bile ductular secretory activity in the guinea pig. Hepatology 31, 562 571.
23. Janecki, A.J., Montrose, M.H., Zimniak, P. et al. 1998. Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco2. Protein kinase C-mediated inhibition of the exchanger. J Biol Chem 273, 8790 8798.
24. Kapus, A., Szaszi, K., Sun, J., Rizoli, S. Rotstein, O.D. 1999. Cell shrinkage regulates Src kinases and induces tyrosine phosphorylation of cortactin, independent of the osmotic regulation of Na+/H+ exchangers. J Biol Chem 274, 8093 8102.
25. Knuth, A., Gabbert, H., Dippold, W. et al. 1985. Biliary adenocarcinoma. Characterisation of three new human tumor cell lines. J Hepatol 1, 579 596.
26. Krump, E., Nikitas, K. Grinstein, S. 1997. Induction of tyrosine phosphorylation and Na+/H+ exchanger activation during shrinkage of human neutrophils. J Biol Chem 272, 17303 17311.
27. Kurashima, K., Yu, F.H., Cabado, A.G., Szabo, E.Z., Grinstein, S. Orlowski, J. 1997. Identification of sites required for down-regulation of Na+/H+ exchanger NHE3 activity by cAMP-dependent protein kinase, phosphorylation-dependent and -independent mechanisms. J Biol Chem 272, 28672 28679.
28. Lamprecht, G., Weinman, E.J. Yun, C.H. 1998. The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3. J Biol Chem 273, 29972 29978.
29. Lazaridis, K.N. LaRusso, N.F. 2003. Bile formation: do not ignore the role of plasma membrane-cytoskeleton linking proteins. Hepatology 37, 218 220.
30. Matthews, J.B., Smith, J.A., Mun, E.C. Sicklick, J.C. 1998. Osmotic regulation of intestinal epithelial Na+ K+ Cl- cotransport: role of Cl- and F-actin. Am J Physiol Cell Physiol 274, C697 C706.
31. McSwine, R.L., Li, J. Villereal, M.L. 1996. Examination of the role for Ca2+ in regulation and phosphorylation of the Na+/H+ antiporter NHE1 via mitogen and hypertonic stimulation. J Cell Physiol 168, 8 17.
32. Mennone, A., Biemesderfer, D., Negoianu, D. et al. 2001. Role of sodium/hydrogen exchanger isoform NHE3 in fluid secretion and absorption in mouse and rat cholangiocytes. Am J Physiol Gastrointest Liver Physiol 280, G247 G254.
33. Moe, O.W., Amemiya, M. Yamaji, Y. 1995. Activation of protein kinase A acutely inhibits and phosphorylates Na/H exchanger NHE-3. J Clin Invest 96, 2187 2194.
34. Moor, A.N. Fliegel, L. 1999. Protein kinase-mediated regulation of the Na(+)/H(+) exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways. J Biol Chem 274, 22985 22992.
35. Noel, J. Pouyssegur, J. 1995. Hormonal regulation, pharmacology, and membrane sorting of vertebrate Na+/H+ exchanger isoforms. Am J Physiol 268, C283 C296.
36. Orlowski, J. Grinstein, S. 1997. Na+/H+ exchangers of mammalian cells. J Biol Chem 272, 22373 22376.
37. Parker, J.C., Dunham, P.B. Minton, A.P. 1995. Effect of ionic strength on the regulation of Na/H exchange and KCl cotransport in dog red blood cells. J Gen Physiol 105, 677 699.
38. Putney, L.K., Denker, S.P. Barber, D.L. 2002. The changing face of the Na+/H+ exchanger NHE1: structure, regulation, and cellular actions. Annu Rev Pharmacol Toxicol 42, 527 552.
39. Reynoso-Paz, S., Coppel, R.L., Mackay, I.R., Bass, N.M., Ansari, A.A. Gershwin, M.E. 1999. The immunobiology of bile and biliary epithelium. Hepatology 30, 351 357.
40. Roberts, S.K., Ludwig, J. Larusso, N.F. 1997. The pathobiology of biliary epithelia. Gastroenterology 112, 269 279.
41. Schliess, F., Schreiber, R. Haussinger, D. 1995. Activation of extracellular signal-regulated kinases Erk-1 and Erk-2 by cell swelling in H4IIE hepatoma cells. Biochem J 309, 13 17.
42. Shrode, L.D., Klein, J.D., O'Neill, W.C. Putnam, R.W. 1995. Shrinkage-induced activation of Na+/H+ exchange in primary rat astrocytes: role of myosin light-chain kinase. Am J Physiol 269, C257 C266.
43. Shull, G.E., Miller, M.L. Schultheis, P.J. 2000. Lessons from genetically engineered animal models VIII. Absorption and secretion of ions in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 278, G185 G190.
44. Star, R.A., Zhang, B.X., Loessberg, P.A. Muallem, S. 1992. Regulatory volume decrease in the presence of HCO3- by single osteosarcoma cells UMR-106-01. J Biol Chem 267, 17665 17669.
45. Szaszi, K., Kurashima, K., Kaibuchi, K., Grinstein, S. Orlowski, J. 2001. Role of the cytoskeleton in mediating cAMP-dependent protein kinase inhibition of the epithelial Na+/H+ exchanger NHE3. J Biol Chem 276, 40761 40768.
46. Tietz, P.S. LaRusso, N.F. 2002. Focus on 'cholangiocytes exhibit dynamic, actin-dependent apical membrane turnover'. Am J Physiol Cell Physiol 282, C982 C983.
47. Tietz, P.S. LaRusso, N.F. 2004. Cholangiocyte biology. Curr Opin Gastroenterol 20, 270 274.
48. Wakabayashi, S., Bertrand, B., Ikeda, T., Pouyssegur, J. Shigekawa, M. 1994. Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective. J Biol Chem 269, 13710 13715.
49. Waldron, R.T. Rozengurt, E. 2000. Oxidative stress induces protein kinase D activation in intact cells. Involvement of Src and dependence on protein kinase C. J Biol Chem 275, 17114 17121.
50. Watson, A.J., Levine, S., Donowitz, M. Montrose, M.H. 1992. Serum regulates Na+/H+ exchange in Caco2 cells by a mechanism which is dependent on F-actin. J Biol Chem 267, 956 962.
51. Weinman, E.J., Steplock, D., Donowitz, M. Shenolikar, S. 2000. NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. Biochemistry (Mosc) 39, 6123 6129.
52. Wu, K.L., Khan, S., Lakhe-Reddy, S., Jarad, G., Mukherjee, A., Obejero-Paz, C.A., Konieckowski, M., Sedor, J.R. Schelling, J.R. 2004. The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival. J Biol Chem 279, 26280 26286.
53. Yun, C.H., Oh, S., Zizak, M., Steplock, D., Tsao, S., Tse, C.M., Weinman, E.J. Donowitz, M. 1997. cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein. Proc Natl Acad Sci USA 94, 3010 3015.