Novel, non-acylguanidine-type Na+/H+ exchanger inhibitors: Synthesis and pharmacology of 5-tetrahydroquinolinylidene aminoguanidine derivatives

Journal of Medicinal Chemistry

Volumn 45, Issue 14, 2002, Pages 3009-3021

  Fukumoto, Shoji ^a   Imamiya, Eiko ^a   Kusumoto, Keiji ^a   Fujiwara, Shuji ^a   Watanabe, Toshifumi ^a   Shiraishi, Mitsuru ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 TETRAHYDROQUINOLINYLIDENE AMINOGUANIDINE DERIVATIVE; [[7 (5 FLUORO 2 METHYLPHENYL) 4 METHYL 7,8 DIHYDRO 5(6H) QUINOLINYLIDENE]AMINO]GUANIDINE DIMETHANESULFONATE; AMINOGUANIDINE; MEMBRANE PROTEIN; QUINOLINE DERIVATIVE; T 162559; TETRAHYDROQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL VOLUME; CORONARY ARTERY DISEASE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART INFARCTION; HUMAN; HUMAN CELL; NONHUMAN; RAT; REPERFUSION INJURY; STRUCTURE ACTIVITY RELATION; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; CARDIOVASCULAR AGENTS; CRYSTALLOGRAPHY, X-RAY; GUANIDINES; HUMANS; MALE; MOLECULAR STRUCTURE; MYOCARDIAL INFARCTION; QUINOLINES; RATS; RATS, WISTAR; SODIUM-HYDROGEN ANTIPORTER; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037019273     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0104567     Document Type: Article

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