Signal transduction in cell-matrix interactions

International Review of Cytology

Volumn 168, Issue , 1996, Pages 81-121

  Guan, Jun Lin ^a   Chen, Hong Chen ^a  

^a Animal Health Diagnostic Center   (United States)

Author keywords

Cell adhesion; Cell migration; Crosstalk; Extracellular matrix; Focal adhesion kinase; Integrins; Second messenger; Signal transduction

Indexed keywords

CALCIUM ION; CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; GROWTH FACTOR RECEPTOR; INTEGRIN; PHOSPHATIDYLINOSITIDE; PHOSPHOPROTEIN; PHOSPHOTRANSFERASE; SCLEROPROTEIN;

APOPTOSIS; CALCIUM CELL LEVEL; CELL ADHESION; CELL DIFFERENTIATION; CELL MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; COMPLEX FORMATION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; ONCOGENE RAS; ONCOGENE SRC; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

EID: 0029856505     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0074-7696(08)60883-9     Document Type: Review

References (245)

1. Adams, J. C., and Watt, F. M. (1989). Fibronectin inhibits the terminal differentiation of human keratinocytes. Nature (London) 340, 307-309.
2. Adams, J. C., and Watt, F. M. (1993). Regulation of development and differentiation by the extracellular matrix. Development (Cambridge, U.K.) 117, 1183-1198.
3. Akiyama, S. K., Yamada, S. S., Yamada, K. M., and LaFlamme, S. E. (1994). Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras. J. Biol. Chem. 269, 15961-15964.
4. Andre, E., and Becker-Andre, M. (1993). Expression of an N-terminally truncated form of human focal adhesion kinase in brain. Biochetn. Biophys. Res. Commun. 190, 140-146.
5. Auger, K. R., Serunian, L. A., Soltoff, S. P., Libby, P., and Cantley, L. C. (1989). PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell (Cambridge, Mass.) 57, 167-175.
6. Battey, J. F., Way, J. M., Corjay, M. H., Shapira, H., Kusano, K., Harkins, R., Wu, J. M., Slattery, T., Mann, E., and Feldman, R. I. (1991). Molecular cloning of the bombesin/gastrinreleasing peptide receptor from Swiss 3T3 cells. Proc. Natl. Acad. Sci. U.S.A. 88, 395-399.
7. Benecke, B.-J., Ben-Ze'ev, A., and Penman, S. (1978). The control of mRNA production, translation and turnover in suspended and reattached anchorage-dependent fibroblasts. Cell (Cambridge, Mass.) 14, 931-939.
8. Ben-Ze'ev, A., Farmer, S., and Penman, S. (1980). Protein systhesis requires cell-surface contact while nuclear events respond to cell shape on anchorage dependent fibroblasts. Cell (Cambridge, Mass.) 21, 365-372.
9. Birge, R. B., Fajardo, J. E., Reichman, C., Shoelson, S. E., Songyang, Z., Cantley, L. C., and Hanafusa, H. (1993). Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CTlO-transformed fibroblasts. Mol. Cell. Biol. 13, 4648-4656.
10. Bissell, M. J., Hall, H. G., and Parry, G. (1982). How does the extracellular matrix direct gene expression? J. Theor. Biol. 99, 31-68.
11. Bockholt, S. M., and Burridge, K. (1993). Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin. J. Biol. Chem. 268, 14565-14567.
12. Boudreau, N., Sympson, C. J., Werb, Z., and Bissell, M. J. (1995). Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267, 891-893.
13. Brown, K. E., and Yamada, K. M. (1995). The role of integrins during vertebrate development. Semin. Dev. Biol. 6, 69-77.
14. Buday, L., and Downward, J. (1993). Epidermal growth factor regulates p21 ras through the formation of a complex of receptor, Grb2 adaptor protein, and Sos nucleotide exchange factor. Cell (Cambridge, Mass.) 73, 611-620.
15. Burgering, B. M. T., De Vries-Smits, A. M. M., Medema, R. H., Van Weeren, P. C., Tertoolen, L. G. J., and Bos, J. L. (1993). Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathway. Mol. Cell. Biol. 13, 7248-7256.
16. Burridge, K., Path, T., Nuckolls, G., and Turner, C. (1988). Focal adhesions: Transmembrane junction between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell. Biol. 4, 487-525.
17. Burridge, K., Turner, C. E., and Romer, L. H. (1992). Tyrosine phosphorylation of paxillin and pp!25FAK accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly. J. Cell Biol. 119, 893-903.
18. Calalb, M., Polte, T. R., and Hanks, S. K. (1995). Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases. Mol. Cell. Biol. 15, 954-963.
19. Carpenter, C. L., and Cantley, L. C. (1990). Phosphoinositide kinases. Biochemistry 29, 11147-11156.
20. Carpenter, C. L., Duckworth, B. C., Auger, K. R., Cohen, B., Schaffhausen, B. S., and Cantley, L. C. (1990). Purification and characterization of phosphoinositide 3-kinase from rat liver. /. Biol. Chem. 265, 19704-19711.
21. Cary, L. A., Chang, J. F., and Guan, J.-L. (1996). Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J. Cell Sci. in press.
22. Chan, P.-Y., Kanner, S. B., Whitney, G., and Aruffo, A. (1994). A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK. J. Biol. Chem. 269, 20567-20574.
23. Chardin, P., Camonis, J., Gale, W. L., Van Aelst, L., Schlessinger, J., Wigler, M. H., and Bar-Sagi, D. (1993). Human Sosl: A guanine nuleotide exchange factor for Ras that binds to Grb2. Science 260, 1338-1343.
24. Chen, H.-C, and Guan, J.-L. (1994a). Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. U.S.A. 91, 10148-10152.
25. Chen, H.-C., and Guan, J.-L. (1994b). Stimulation of phosphatidylinositol 3'-kinase associated with focal adhesion kinase by platelet-derived growth factor. J. Biol. Chem. 269, 31229-31233.
26. Chen, H.-C., Appeddu, P. A., Parsons, J. T., Hildebrand, J. D., Schaller, M. D., and Guan, J.-L. (1995). Interaction of Focal adhesion kinase with cytoskeletal protein talin. J. Biol. Chem. 270, 16995-16999.
27. Chen, Q., Kinch, M. S., Lin, T. H., Burridge, K., and Juliano, R. L. (1994). Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem. 269, 26602-26605.
28. Chong, L. D., Traynor-Kaplan, A., Bokoch, G. M-, and Schwartz, M. A. (1994). The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell (Cambridge, Mass.) 79, 507-513.
29. Chuang, J.-Z., Lin, D. C., and Lin, S. (1995). Molecular cloning, expression, and mapping of the high affinity act in-capping domain of chicken cardiac tensin. J. Cell Biol. 128, 1095-1109.
30. fyn. Mol. Cell. Biol. 14, 147-155.
31. Cooper, J. A., and Howell, B. (1993). The when and how of Src regulation. Cell (Cambridge, Mass.) 73, 1051-1054.
32. Cross, D. A. E., Alessi, D. R., Vandenheede, J. R., McDowell, H. E., and Cohen, P. (1994). The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamysin: Evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem. J. 303, 21-26.
33. Daniel, T. O., and Ives, H. (1987). Cyclosporin A inhibits kinase C-independent activation of the Na/H exchanger by PDGF and vanadate. Biochem. Biophys. Res. Commun. 145, 111-117.
34. Davis, S., Lu, M. L., Lo, S. H., Lin, S., Butler, J. A., Druker, B. J., Roberts, T. M., An, Q., and Chen, L. B. (1991). Presence of an SH2 domain in the actin-binding protein tensin. Science 252, 712-715.
35. DeCIue, J. E., and Martin, S. (1987). Phosphorylation of talin at tyrosine in Rous sarcoma virus-transformed cells. Mol. Cell. Biol. 14, 371-378.
36. Dejanna, E., Colella, S., Conforti, G., Abbadini, M., Gaboli, M., and Marchisio, P. C. (1988). Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells. J. Cell Biol. 107, 1215-1223.
37. Dhawan, J., and Farmer, S. R. (1990). Regulation of a (I)-collagen gene expression in response to cell adhesion in Swiss 3T3 fibroblasts. J. Biol. Chem. 265, 9015-9021.
38. Dhawan, J., Lichtler, A. C., Rowe, D. W., and Farmer, S. R. (1991). Cell adhesion regulates pro-a (I) collagen mRNA stability and transcription in mouse fibroblasts. J. Biol. Chem. 266, 8470-8475.
39. Dike, L. E., and Farmer, S. R. (1988). Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 85, 6792-6796.
40. Dipasquale, A. (1975). Locomotory activity of epithelial in culture. Exp. Cell Res. 94, 191-215.
41. Dustin, M. L., and Springer, T. A. (1991). Role of lymphocyte adhesion receptors in transient cell interactions and cell locomotion. Annu. Rev. Imimmol. 9, 2-66.
42. Egan, S. E., Giddings, B. W., Brooks, M. W., Buday, L., Sizeland, A. M., and Weinberg, R. (1993). Association of Ras exchange protein Sos with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (London) 363, 45-51.
43. Ferrell, J. E., and Martin, G. S. (1989). Tyrosine-specific protein phosphorylation is regulated by glycoprotein Ilb-IIIa in platelets. Proc. Natl. Acad. Sci. U.S.A. 86, 2234-2238.
44. Folkman, J., and Moscona, A. (1978). The role of cell shape in growth control. Nature (London) 273, 345-349.
45. Freedman, A. S., Rhynhart, K., Nojima, Y., Svahn, J., Eliseo, L., Benjamin, C. D., Morimoto, C., and Vivier, E. (1993). Stimulation of protein tyrosine phosphorylation in human B cells after ligation of the 01 integrin VLA-4. J. Immunol. ISO, 1645-1652.
46. Frisch, S. M., and Francis, H. (1994). Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626.
47. Fukami, K., Furuhashi, K., Inagaki, M., Endo, T., Hatano, S., and Takenawa, T. (1992). Requirement of phosphatidylinositol-4,5-bisphosphate for a-actinin function. Nature (London) 359, 150-152.
48. Fukami, K., Endo, T., Imamura, M., and Takenawa, T. (1994). a-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase. J. Biol. Client. 269, 1518-1522.
49. Fukui, Y., Kornbluth, S., Jong, S. M., Wang, L.-H., and Hanafusa, H. (1989). Phosphatidylinositol kinase type 1 activity associates with various oncogene products. Oncogens 4, 283-292.
50. Gates, R. E., King, L. E., Jr., Hanks, S. K., and Nanney, L. B. (1994). Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds and in culture. Cell Growth Differ. 5, 891-899.
51. Glenney, J. R., and Zokas, L. (1989). Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton. J. Cell Biol. 10C, 2401-2408.
52. Golden, A., Bruggr, J. S., and Shattil, S. J. (1990). Role of platelet membrane glycoprotein Ilb-IIIa in agonist-induced tyrosine phosphorylation of platelets proteins. J. Cell Biol. 111, 3117-3127.
53. Goshima, K. A., Masuda, A., and Owaribe, K. (1984). Insulin-induced formation of ruffling membrane of KB cells and its correlation with enhancement of amino acid transport. J. Cell Biol. 98, 801-809.
54. Grant, D. S., Tashiro, K.-L, Segui-Real, B., Yamada, Y., Martin, G. R., and Kleinman, H. K. (1989). Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structure. Cell (Cambridge, Mass.) 58, 933-943.
55. 1/S control of anchorage-independent growth in the fibroblast cell cycle. J. Cell Biol. 115, 1419-1425.
56. Guadagno, T. M., Ohtsubo, M., Roberts, J. M., and Assoain, R. K. (1993). A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262, 1572-1575.
57. Guan, J.-L., and Hynes, R. O. (1990). Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin 4β1. Cell (Cambridge, Mass.) 60, 51-63.
58. Guan, J.-L., and Shalloway, D. (1992). Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature (London) 358, 690-692.
59. Guan, J.-L., Trevithick, J. E., and Hynes, R. O. (1991). Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul. 2, 951-964.
60. Guinebault, C., Payrastre, B., Racaud-Sultan, C., Mazarguil, H., Breton, M., Mauco, G., Plantavid, M., and Chap, H. (1995). Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase. J. Cell Biol. 129, 831-842.
61. Hall, A. (1993). Ras related proteins. Curr. Opin. Cell Biol. 5, 265-268.
62. FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence. J. Biol. Chem. 268, 6851-6854.
63. Hamawy, M., Minoguchi, K., Swaim, W. D., Mergenhagen, S. E., and Siraganian, R. P. (1995). A 77-kDa protein associates with pp125FAK in mast cells and becomes tyrosinephosphorylated by high affinity IgE receptor aggregation. J. Biol. Chem. 270, 12305-12309.
64. Hanks, S. K., Calalb, M. B., Harper, M. C., and Patel, S. K. (1992). Focal adhesion protein tyrosine kinase phosphorylated in response to cell spreading on fibronectin. Proc. Natl. Acad. Sci. U.S.A. 89, 8487-8491.
65. Hansen, L. K., Mooney, D., Vacanti, J. P., and Ingber, D. E. (1994). Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepacyte growth. Mol. Biol. Cell 5, 967-975.
66. Haskill, S., Johnson, C., Eierman, D., Becker, S., and Warren, K. (1988). Adherence induce selective mRNA expression of monocyte mediators and proto-oncogenes. J. Immunol. 140, 1690-1694.
67. Haskill, S., Beg, A. A., Tompkins, S. M., Morris, J. S., Yurochko, A. D., Sampson-Johannes, A., Mondai, K., Ralph, P., and Baldwin, A. S., Jr. (1991). Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity. Cell (Cambridge, Mass.) 65, 1281-1289.
68. Hatai, M., Hashi, H., Mogi, A., Soga, H., Yokota, J., and Yaoi, Y. (1994). Stimulation of tyrosine -and serine-phosphorylation of focal adhesion kinase in mouse 3T3 cells by fibronectin and fibroblast growth factor. FEBS Lett. 350, 113-116.
69. 2 3-OH kinase. Nature (London) 358, 157-159.
70. Hay, E. D., ed. (1985). "Cell Biology of Extracellular Matrix." Plenum, New York.
71. Hayashi, Y., Haimovich, B., Reszka, A., Boettiger, D., and Horwitz, A. (1990). Expression and function of chicken integrin b1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells. J. Cell Biol. 110, 175-184.
72. Hemler, M. E. (1990). VLA proteins in the integrin family: Structures, functions and their roles in leucocytes. Annu. Rev. Immunol. 8, 365-400.
73. Hens, M. D., and DeSimone, D. W. (1995). Molecular analysis and developmental expression of the focal adhesion kinase pp125FAK in Xenopus laevis. Dev. Biol. 170, 274-288.
74. FAK, to cellular focal adhesions. J. Cell Biol. 123, 993-1005.
75. Hildebrand, J. D., Schaller, M. D., and Parsons, J. T. (1995). Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. Mol. Biol. Cell 6, 637-647.
76. Hordijk, P. L., Verlaan, I., van Corven, E. J., and Moolenaar, W. H. (1994). Protein tyrosine phosphorylation induced by lysophosphatidic acid in rat-1 fibroblasts. J. Biol. Chem. 269, 645-651.
77. Horwitz, A. F., Duggan, K., Buck, C., Beckerle, M. C., and Burridge, K. (1986). Interactions of plasma membrane fibronectin receptor with talin: A transmembrane linkage. Nature (London) 320, 531-533.
78. FAK. J. Cell Biol. 122, 473-483.
79. Huhtala, P., Humphries, M. J., McCarthy, J. B., Tremble, P. M., Werb, Z., and Damsky, C. H. (1995). Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates
80. metalloproteinase gene expression in fibroblasts adhering to fibronectin. J. Cell Biol. 129, 867-879.
81. Humphries, M. J., Akiyama, S. K., Komoriya, A., Olden, K., and Yamada, K. M. (1986). Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion. J. Cell Biol. 103, 2637-2647.
82. Hunter, T. (1989). Protein modification: Phosphorylation on tyrosine residues. Curr. Opin. Cell Biol. 1, 1168-1181.
83. Hynes, R. O. (1990). "Fibronectins." Springer-Verlag, New York.
84. Hynes, R. O. (1992). Integrins: Versatility, modulation and signaling in cell adhesion. Cell (Cambridge, Mass.) 69, 11-25.
85. Hynes, R. O., and Lander, A. D. (1992). Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell (Cambridge, Mass.) 68, 303-322.
86. Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., Yamamoto, T., and Aizawa, S. (1995). Reduced cell motility and enhanced focal contact formation in cells from FAK-deficient mice. Nature (London) 377, 539-544.
87. Ingber, D. E., Prusty, D., Frangioni, J. V., Cragoe, E. J., Jr., Lechene, C., and Schwartz, M. A. (1990). Control of intracellular pH and growth by fibronectin in capillary endothelial cells. J. Cell Biol. 110, 1803-1811.
88. Izumi, T., Saeki, Y., Akanuma, Y., Takaku, F., and Kasuga, M. (1988). Requirement for receptor-intrinsic tyrosine kinase activities during ligand-induced membrane ruflling of KB cells: Essential sites of src-related growth factor receptor kinases. J. Biol. Chem. 263, 10386-10393.
89. Jaconi, M. E. E., Theler, J. M., Schlegel, W., Appel, R. D., Wright, S. D., and Lew, P. D. (1991). Multiple elevations of cytosolic-free calcium in human neutrophils: Initiation by adherence receptors of the integrin family. J. Cell Biol. 112, 1249-1257.
90. Janmey, P. A., and Stossel, T. P. (1987). Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature (London) 325, 362-364.
91. Johansson, M. W., Larsson, E., Liming, B., Pasquale, E., and Ruoslahti, E. (1994). Altered localization and cytoplasmic domain-binding properties of tyrosine-phosphorylated bl integrin. J. Cell Biol. 126, 1299-1309.
92. Johnson, R. P., and Craig, S. W. (1995). F-actin binding site masked by the intramolecular association of vinculin head and tail domains. Nature (London) 373, 261-264.
93. Juliano, R. L., and Haskill, S. (1993). Signal transduction from the extracellular matrix. J. Cell Biol 120, 577-585.
94. Kadowaki, T., Koyasu, S., Nishida, E., Sakai, H., Takaku, F., Yahara, I., and Kasuga, M. (1986). Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells: Clarification of the roles of type 1 insulin-like growth factor receptors and insulin receptors. J. Biol. Chem. 261, 16141-16147.
95. Kanner, S. B., Reynolds, A. B., Vines, R. R., and Parsons, J. T. (1990). Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 87, 3328-3332.
96. Kanner, S. B., Grosmaire, L. S., Ledbetter, J. A., and Damle, N. K. (1993). 02 integrin LFA-1 signaling through phospholipase C-yl activation. Proc. Natl. Acad. Sci. U.S.A. 90, 7099-7103.
97. ras upon antibodymediated a2b1 integrin activation in T-lymphoblastic cells. J. Biol. Chem. 268, 20701-20704.
98. Kornberg, L., Earp, S. E., Turner, C. E., Procktop, C., and Juliano, R. L. (1991). Signal transduction by integrins: Increased protein tyrosine phosphorylation caused by clustering of bl integrins. Proc. Natl. Acad. Sci. U.S.A. 88, 8392-8396.
99. Kornberg, L., Earp, H. S., Parsons, J. T., Schaller, M., and Juliano, R. L. (1992). Cell adhesion or integrin clustering increase phosphorylation of a focal adhesion-associated tyrosine kinase. J. Biol. Chem. 267, 23439-23442.
100. Kornblihtt, A. R., Vibe-Pedersen, K., and Baralle, F. E. (1985). Human fibronectin: Cell specific alternative mRNA splicing generates polypeptide chains differing in the number of internal repeats. Nucleic Acids Res. 12, 5853-5868.
101. Kubota, Y., Kleinman, H. K., Martin, G. R., and Lawley, T. J. (1988). Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structure. J. Cell Biol. 107, 1589-1598.
102. Kumagai, N., Morii, N., Fujisawa, K., Nemoto, Y., and Narumiya, S. (1993a). ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J. Biol. Chem. 268, 24535-24538.
103. Kumagai, N., Morii, N., Fujisawa, K., Yoshimasa, T., Nakao, K., and Narumiya, S. (1993b). Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP-kinase and focal adhesion kinase in cultured Swiss 3T3 cells. FEBS Lett. 329, 273-276.
104. Lassing, I., and Lindberg, U. (1985). Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin. Nature (London) 314, 472-474.
105. Leavesley, D. I., Schwartz, M. A., Rosenfeld, M., and Cheresh, D. A. (1993). Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J. Cell Biol. 121, 163-170.
106. Lee, S., Christakos, S., and Small, M. (1993). Apoptosis and signal transduction: Clues to a molecular mechanism. Curr. Opin. Cell Biol. 5, 286-294.
107. Leevers, S. J., and Marshall, C. J. (1992). Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. EMBO J. 11, 569-574.
108. Lev, S., Moreno, H., Martinez, R., Canoll, P., Peles, E., Musacchio, J. M., Plowman, G. D., Rudy, B., and Schlessinger, J. (1995). Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature (London) 376, 737-745.
109. Lewis, J. M., and Schwartz, M. A. (1995). Mapping in vivo association of cytoplasmic proteins with integrin b1 cytoplasmic domain mutants. Mol. Biol. Cell 6, 151-160.
110. Lin, T. H., Urochko, A., Kornberg, L., Morris, J., Walker, J. J., Haskill, S., and Juliano, R. L. (1994). The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes. J. Cell Biol. 126, 1585-1593.
111. Lindberg, F. P., Gresham, H. D., Schwarz, E., and Brown, E. J. (1993). Molecular cloning of integrin-associated protein: An immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. J. Cell Biol. 123, 485-496.
112. Lindberg, F. P., Lublin, D. M., Telen, M. J., Veile, R. A., Miller, Y. E., Donis-Keller, H., and Brown, E. J. (1994). Rh-related antigen CD47 is the signal-transducer integrin-associated protein. J. Biol. Chem. 269, 1567-1570.
113. FAK in platelets. J. Cell Biol. 119, 905-912.
114. Lo, S. H., Janmey, P. A., Hartwig, J. H., and Chen, L. B. (1994). Interactions of tensin with actin and identification of its three distinct actin-binding domains. J. Cell Biol. 125, 1067-1075.
115. + exchange by phorbol esters and growth factors. J. Biol. Chem. 265, 7188-7194.
116. Lukashev, M. E., Sheppard, D., and Pytela, R. (1994). Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain. J. Biol. Chem. 269, 18311-18314.
117. + exchange by platelet-derived growth factor involves phosphatidylinositol 3′-kinase and phospholipase Cg. J. Biol. Chem. 269, 30734-30739.
118. Mackie, E. J., Thesleff, I., and Chiquet-Ehrismann, R. (1987). Tenascin is associated with chondrogenic and osteogenic differentiation in vivo and promotes chondrogenesis in vitro. J. Cell Biol. 105, 2569-2579.
119. Maeyama, K., Hohman, R. J., Metzger, H., and Beaven, M. A. (1986). Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. J. Biol. Chem. 261, 2583-2592.
120. Maher, P. A., Pasquale, E. B., Wang, J. Y. J., and Singer, S. J. (1985). Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells. Proc. Natl. Acad. Sei. U.S.A. 82, 6576-6580.
121. Marcantonio, E. E., Guan, J.-L., Trevithick, J. E., and Hynes, R. O. (1990). Mapping of the functional determinants of the integrin b cytoplasmic domain by site-directed mutagenesis. Cell Regul. 1, 597-604.
122. Marx, J. (1993). Cell death studies yield cancer clues. Science 259, 760-761.
123. Matsuda, M., Hashimoto, Y., Muroya, K., Hasegawa, H., Kurata, T., Tanaka, S., Nakamura, S., and Hattori, S. (1994). CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells. Mol. Cell. Biol. 14, 5495-5500.
124. FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J. Biol. Chem. 269, 31807-31813.
125. McConkey, D., and Orrenius, S. (1994). Signal transduction pathways to apoptosis. Trends Cell Biol. 4, 370-375.
126. McNamee, H. P., Ingber, D. E., and Schwartz, M. A. (1993). Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J. Cell Biol. 121, 673-678.
127. Mellström, K., Heldin, C.-H., and Westermark, B. (1988). Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor. Exp. Cell Res. 177, 347-359.
128. Meredith, J. E., Fazeli, B., and Schwartz, M. A. (1993). The extracellular matrix as a cell survival factor. Mol. Biol. Cell 4, 953-961.
129. Middlemas, D. S., Meisenhelder, J., and Hunter, T. (1994). Identication of TrkB autophosphorylation sites and evidence that phospholipase C-g1 is a substrate for the TrkB receptor. J. Biol. Chem. 269, 5458-5466.
130. Miura, M., Zhu, H., Rotello, R., Hartwieg, E. A., and Yuan, J. (1993). Induction of apoptosis in fibroblasts by IL-lb-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell (Cambridge, Mass.) 75, 653-660.
131. Miyamoto, S., Akiyama, S., and Yamada, K. M. (1995). Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267, 883-885.
132. Miyata, Y., Nishida, E., and Sakai, H. (1988). Growth factor- and phorbol ester-induced changes in cell morpholog analyzed by digital image processing. Exp. Cell Res. 175, 286-297.
133. Moolenaar, W. H. (1994). LPA: A novel lipid mediator with diverse biological actions. Trends Cell Biol. 4, 218-219.
134. Moolenaar, W. H. (1995). Lysophosphatidic acid signalling. Curr. Opin. Cell Biol. 1, 203-210.
135. Morgan, S. J., Smith, A. D., and Parker, P. J. (1990). Purification and characterization of bovine brain type 1 phosphatidylinositol kinase. Eur. J. Biochem. 191, 761-767.
136. Mosher, D. F., ed. (1989). "Fibronectin." Academic Press, San Diego, CA
137. Mould, A. P., Wheldon, L. A., Komoriya, A., Wayner, E. A., Yamada, K. M., and Humphries, M. J. (1990). Affinity Chromatographie isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin 4β1. J. Biol. Chem. 265, 4020-4024.
138. Nermut, M. V., Green, N. M., Eason, P., Yamada, S. S., and Yamada, K. M. (1988). Electron microscopy and structural model of human fibronectin receptor. EMBO J. 7, 4093-4099.
139. Neugebauer, K. M., and Reichardt, L. F. (1991). Cell-surface regulation of b1 integrin activity on developing retinal neurons. Nature (London) 221, 521-549.
140. Neugebauer, K. M., Emmett, C. J., Venström, K. A., and Reichardt, L. F. (1991). Vitronectin and thrombospondin promote retinal neurite outgrowth: Developmental regulation and role of integrins. Neuron 6, 345-358.
141. Ng-Sikorski, J., Andersson, R., Patarroyo, M., and Andersson, T. (1991). Calcium signaling capacity of the CD11b/CD18 integrin on human neutrophils. Exp. Cell Res. 195, 504-508.
142. Nishiyama, T., Sasaki, T., Takaishi, K., Kato, M., Yaku, H., Araki, K., Matsuura, Y., and Takai, Y. (1994). Rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. Mol. Cell. Biol. 14, 2447-2456.
143. Nojima, B. Y., Rothstein, D. M., Sugita, K., Schlossman, S. F., and Morimoto, C. (1992). Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein. J. Exp. Med. 175, 1045-1053.
144. Nojima, Y., Morino, N., Mimura, T., Hamasaki, K., Furuya, H., Sakai, R., Sato, T., Tachibana, K., Morimoto, C., Yazaki, Y., and Hirai, H. (1995). Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J. Biol. Chem. 270, 15398-15402.
145. Obara, M., Kang, M. S., and Yamada, K. M. (1988). Site-directed mutagenesis of the cell-binding domain of human fibronectin: Separable, synergistic sites mediate adhesive function. Cell (Cambridge, Mass.) 53, 649-657.
146. Osborne, B., and Schwartz, L. M. (1994). Essential genes that regulate apoptosis. Trends Cell Biol. 4, 394-399.
147. Otey, C., Pavalko, F., and Burridge, K. (1990). An interaction between a-actinin and the integrin subunit in vitro. J. Cell Biol. Ill, 721-729.
148. Pardi, R., Bender, J. R., Dettori, C., Giannazza, E., and Engleman, E. G. (1989). Heterologous distribution and transmembrane signalling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets. J. Iminonol. 143, 3157-3166.
149. Pasqauale, E. B., Maher, P. A., and Singer, S. J. (1986). Talin is phosphorylated on tyrosine in chicken embroy fibroblasts transformed by Rous sarcoma virs. Proc. Natl. Acad. Sei. U.S.A. 83, 5507-5511.
150. Pawson, T., and Schlessinger, J. (1993). SH2 and SH3 domains. Curr. Opin. Cell Biol. 3, 434-442.
151. Pelletier, A. J., Bodary, S. C., and Levinson, A. D. (1992). Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells. Mol. Biol. Cell 3, 989-998.
152. Perona, R., and Serrano, R. (1988). Increased pH and tumorigenicity of fibroblasts expressing a yeast proton pump. Nature (London) 334, 438-440.
153. Polte, T. R., and Hanks, S. K. (1995). Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130cas. Proc. Natl. Acad. Sei. U.S.A. 92, 10678-10682.
154. Polte, T. R., Naftilan, A. J., and Hanks, S. K. (1994). Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II. J. Cell. Biochem. 55, 106-119.
155. Qian, F., Vaux, D. L., and Weissman, I. L. (1994). Expression of the integrin a4b1 on melanoma cells can inhibit the invasive stage of metastasis formation. Cell (Cambridge, Mass.) 77, 335-347.
156. Raff, M. (1992). Social controls on cell survival and cell death. Nature (London) 356, 397-400.
157. Rana, R. S., and Hokin, L. E. (1990). Role of phosphoinositides in transmembrane signaling. Physiol. Rev. 70, 115-164.
158. Rankin, B. M., and Rozengurt, E. (1994). Platelet-derived growth factor modulation of focal adhesion kinase and paxillin tyrosine phosphorylation in Swiss 3T3 cells. J. Biol. Chem. 269, 704-710.
159. Rankin, S., Morii, N. Narumiya, S., and Rozengurt, E. (1994). Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin. FEBS Lett. 354, 315-319.
160. + antiporter gene expression during monocytic differentiation of HL-60. J. Biol. Chem. 266, 13485-13488.
161. Re, F., Zanetti, A., Sironi, M., Polentarutti, N., Lanfrancone, L., Dejana, E., and Colotta, F. (1994). Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J. Cell Biol. 127, 537-546.
162. Richter, J., Ng-Sikorski, J., Olsson, I., and Andersson, T. (1990). Tumor necrosis factorinduced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2+. Proc. Natl. Acad. Sei. U.S.A. 87, 9472-9476.
163. Ridley, A. J., and Hall, A. (1992). The small binding protein Rho regulates the assembly of focal adhesion and actin stress fibers in response to growth factors. Cell (Cambridge, Mass.) 70, 389-399.
164. Ridley, A. J., and Hall, A. (1994). Signal transduction pathways regulating Rho-mediated stress fibre formation: Requirement for a tyrosine kinase. EMBO J. 13, 2600-2610.
165. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., and Hall, A. (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell (Cambridge, Mass.) 70, 401-410.
166. Roche, S., Koegl, M., and Courtneidge, S. A. (1994). The phosphatidylinositol 3-kinase a is required for DNA synthesis induced by some, but not all, growth factors. Proc. Natl. Acad. Sei. U.S.A. 91, 9185-9189.
167. Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., and Downward, J. (1994). Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature (London) 370, 527-532.
168. src localization in cells infected with partial transformation mutant of Rous sarcoma virus. Mol. Cell. Biol. 3, 731-746.
169. Romer, L. H., Mclean, N., Turner, C. E., and Burridge, K. (1994). Tyrosine kinase activity, cytoskeleton organization, and motility in human vascular endothelial cells. Mol. Biol. Cell 5, 349-361.
170. Roskelley, C. D., Desprez, P. Y., and Bissell, M. J. (1994). Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proc. Natl. Acad. Sei. U.S.A. 91, 12378-12383.
171. Rozengurt, E. (1986). Early signals in the mitogenic response. Science 234, 161-166.
172. Ruoslahti, .E. (1991). Integrins.y. Clin. Invest. 87, 1-5.
173. Ruoslahti, E., and Pierschbacher, M. D. (1986). Arg-Gly-Asp: A versatile cell recognition signal. Cell (Cambridge, Mass.) 44, 517-518.
174. Ruoslahti, E., and Reed, J. (1994). Anchorage dependence, integrin, and apoptosis. Cell (Cambridge, Mass.) 77, 477-478.
175. Sabe, H., Hata, A., Okada, M., Nakagawa, H., and Hanafusa, H. (1994). Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src. Proc. Natl. Acad. Sei. U.S.A. 91, 3984-3988.
176. Sakai, R., Iwamatsu, A., Hirano, N., Ogawa, S., Tanaka, T., Mano, H., Yazaki, Y., and Hirai, H. (1994). A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 13, 3748-3756.
177. FAK) in rat-1 fibroblasts. Biochetn. J. 301, 407-414.
178. FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol. Cell. Biol. 15, 2635-2645.
179. FAK, a structurally distinctive protein tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sei. U.S.A. 89, 5192-5196.
180. src. Mol. Cell. Biol. 14, 1680-1688.
181. Schaller, M. D., Otey, C. A., Hildebrand, J. D., and Parsons, J. T. (1995). Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J. Cell Biol. 130, 1181-1187.
182. Schlaepfer, D. D., Hanks, S. K., Hunter, T., and van der Geer, P. (1994). Integrin-mediated signal transduction linked to ras pathway by Grb2 binding to focal adhesion kinase. Nature (London) 372, 786-791.
183. Schmidhauser, C., Bissell, M. J., Myers, C. A., and Casperson, G. F. (1990). Extracellular matrix and hormones transcriptionally regulate bovine b-casein 5′ sequences in stably transfected mouse mammary cells. Proc. Nail. Acad. Sei. U.S.A. 87, 9118-9122.
184. Schmidhauser, C., Casperson, G. F., Mayer, C. A., Sanzo, K. T., Bollen, S., and Bissell, M. J. (1992). A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of b-casein gene expression. Mol. Biol. Cell 3, 699-709.
185. + antiporter by PDGF. Proc. Natl. Acad. Sei. U.S.A. 89, 6138-6141.
186. Schwartz, M. A., Lechene, C., and Ingber, D. E. (1991a). Insoluble flbronectin activates the Na/H antiporter by clustering and immobilizing integrin a5/b1, independent of cell shape. Proc. Natl. Acad. Sei. U.S.A. 88, 7849-7853.
187. Schwartz, M. A., Ingber, D. E., Lawrence, M., Springer, T. A., and Lechene, C. (1991b). Multiple integrins share the ability to induce elevation of intracellular pH. Exp. Cell Res. 195, 533-535.
188. Schwartz, M. A., Brown, E. J., and Fazeli, B. (1993). A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells. J. Biol. Chem. 268, 19931-19934.
189. Schwarzbauer, J. E., Tamkun, J. W., Lemischka, I. R., and Hynes, R. O. (1983). Three different fibronectin mRNAs arise by alternative splicing within the coding region. Cell (Cambridge, Mass.) 35, 421-431.
190. Schwarzbauer, J. E., Patel, R. S., Fonda, D., and Hynes, R. O. (1987). Multiple sites of alternative splicing of the rat fibronectin gene transcript. EMBO J. 6, 2573-2580.
191. Sefton, B. M., Hunter, T., Ball, E. H., and Singer, S. J. (1981). Vinculin: A cytoskeletal target of the transforming protein of Rous sarcoma virus. Cell (Cambridge, Mass.) 24, 165-174.
192. Serve, H., Yee, N. S., Stella, G., Sepp-Lorenzino, L., Tan, J. C., and Besmer, P. (1995). Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J. 14, 473-483.
193. Seufferlein, T., and Rozengurt, E. (1994). Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. J. Biol. Chem. 268, 14261-14268.
194. FAK in platelets requires coordinated signaling through integrin and agonist receptors. J. Biol. Chem. 269, 14738-14745.
195. Shaw, R. J., Doherty, D. E., Ritter, A. G., Benedict, S. H., and Clark, R. A. F. (1990). Adhesion-dependent increase in human monocyte PDGF(B) mRNA is associated with increase in c-fos, c-jun, and EFR2 mRNA. J. Cell Biol. Ill, 2139-2148.
196. Shin, S., Freedman, V. H., Risser, R., and Pollack, R. (1975). Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage-independent growth in vitro. Proc. Natl. Acad. Sei. U.S.A. 72, 4435-4439.
197. Singer, I. I., Scott, S., Kawka, D. W., Kazazis, D. M., Gailit, J., and Ruoslahti, E. (1988). Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation. J. Cell Biol. 106, 2127-2182.
198. Sinnett-Smith, J., Zachary, I., Valverde, A. M., and Rozengurt, E. (1993). Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. J. Biol. Client. 268, 14261-14268.
199. Solowska, J., Guan, J.-L., Marcantonio, E. E., Trevithick, J. E., Buck, C. A., and Hynes, R. O. (1989). Expression of normal and mutant avian integrin subunits in rodent cells. J. Cell Biol. 109, 853-861.
200. Somogyi, L., Lasic, Z., Vukicevic, S., and Banfic, H. (1994). Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C. Biochem. J. 299, 603-611.
201. Songyang, Z., Shoelson, S. E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W. G., King, F., Roberts, T., Ratnofsky, S., Lechleider, R. J., Neel, B. G., Birge, R. B., Fajardo, J. E., Chou, M. M., Hanafusa, H., Schaffhausen, B., and Cantley, L. C. (1993). SH2 domains recognize specific phosphopeptide sequences. Cell (Cambridge, Mass.) 72, 767-778.
202. Sporn, S. A., Eirman, D. F., Johnson, C. E., Morris, J., Martin, G., Ladner, M., and Haskill, D. F. (1990). Monocyte adherence results in selective induction of novel genes sharing homology with mediators of inflammation and tissue repair. J. Immunol. 144, 4434-4444.
203. Stoker, M., O'Neill, C., Berryman, S., and Waxman, V. (1968). Anchorage and growth regulation in normal and virus transformed cells. Int. J. Cancer 3, 683-693.
204. Stossel, T. P. (1989). From signal to pseudopod. J. Biol. Chem. 264, 18261-18264.
205. Stossel, T. P. (1993). On the crawling of animal cell. Science 260, 1086-1094.
206. Streuli, C. H., Bailey, N., and Bissell, M. J. (1991). Control of mammary epithelial differentiation: Basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity. J. Cell Biol. 115, 1385-1395.
207. 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3′,4′-biphosphate. J. Biol. Chem. 266, 23554-23557.
208. Sun, X. J., Miralpeix, M., Myers, M. G., Glasheen, E. M., Backer, J. M., Kahn, C. R., and White, M. F. (1992). Expression and function of IRS-1 in insulin signal transmission. J. Biol. Chem. 267, 22662-22672.
209. Tanaka, S., Morishita, T., Hashimoto, Y., Hattori, S., Nakamura, S., Shibuya, M., Matuoka, K., Takenawa, T., Kurata, T., Nagashima, K., and Matsuda, M. (1994). C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc. Natl. Acad. Sei. U.S.A. 91, 3443-3447.
210. Tapley, P., Horwitz, A., Buck, C., Duggan, K., and Rohrschneider, L. (1989). Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts. Oncogene 4, 325-333.
211. Taylor, S. J., Chae, H. Z., Rhee, S. G., and Exton, J. (1991). Activation of the bl isozyme of phospholipase C by a subunits of the Gq class of G proteins. Nature (London) 350, 516-518.
212. Thomas, S. M., DeMarco, M., D'Arcangelo, G., Halegoua, S., and Brugge, J. S. (1992). Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinase. Cell (Cambridge, Mass.) 68, 1031-1040.
213. 3. J. Biol. Chem. 269, 32358-32367.
214. Tremble, P., Damsky, C. H., and Werb, Z. (1995). Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals. J. Cell Biol. 129, 1707-1720.
215. Tsuda, L., Inoue, Y., Yoo, M.-A., Mizuno, M., Hata, M., Lim, Y.-M., Adachi-Yamada, T., Ryo, H., Masamune, Y., and Nishida, Y. (1993). A protein kinase similar to MAP kinase activator acts downstream of the Raf kinase in Drosophila. Cell (Cambridge, Mass.) 72, 407-414.
216. Tsutami, K., and Saavedra, J. M. (1992). Heterogeneity of angiotensin II AT2 receptors in the rat brain. Mol. Pharmacol. 41, 290-297.
217. FAK binding region. J. Cell Sei. 107, 1583-1591.
218. Turner, C. E., Glenney, J. R., and Burridge, K. (1990). Paxillin. A new vinculin-binding protein in focal adhesions. J. Cell Biol. Ill, 1059-1068.
219. FAK during development: Relation to paxillin. J. Cell Sei. 105, 637-645.
220. + exchange involvement in colony stimulating factor-1 stimulated macrophage proliferation. Evidence for a requirement during late Gl of the cell cycle but not for early growth factor response. J. Biol. Chem. 265, 16929-16939.
221. Valius, M., and Kazlauskas, A. (1993). Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell (Cambridge, Mass.) 73, 321-334.
222. van Corven, E. J., Groenink, A., Jalink, K., Eichholtz, T., and Moolenaar, W. H. (1989). Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins. Cell (Cambridge, Mass.) 59, 45-54.
223. van der Bend, F. L., Brunner, J., Jalink, K., van Corven, E. J., Moolenaar, W. H., and van Blitterswijk, W. J. (1992). Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid. EMBO J. 11, 2495-2501.
224. Varticovski, L., Daley, G. Q., Jackson, P., Baltimore, D., and Cantley, L. (1991). Activation of phosphatidylinositol 3′-kinase in cells expressing abl oncogene variants. Mol. Cell. Biol. 11, 1107-1113.
225. Vaux, M. (1993). Toward an understanding of the molecular mechanisms of physiological cell death. Proc. Nail. Acad. Sei. U.S.A. 90, 786-789.
226. von der Mark, K., and Ocalan, M. (1989). Antagonistic effects of laminin and fibronectin on the expression of the myogenic phenotype. Differentiation (Berlin) 40, 150-157.
227. Vukicevic, S., Luyten, F. P., Kleinman, H. K., and Reddi, A. H. (1990). Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: Regulation by discrete domains of laminin. Cell (Cambridge, Mass.) 63, 437-445.
228. Vuori, K., and Ruoslahti, E. (1993). Activation of protein kinase C preceds a5b1 integrin-mediated cell spreading on fibronectin. J. Biol. Chem. 268, 21459-21462.
229. Vuori, K., and Ruoslahti, E. (1994). Association of insulin receptor substrate-1 with integrins. Science 266, 1576-1578.
230. Vuori, K., and Ruoslahti, E. (1995). Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix. J. Biol. Chem. 270, 22259-22262.
231. Watt, F. M. (1991). Cell culture models of differentiation. FASEB J. 5, 287-294.
232. Wayner, E. A., Garcia-Pardo, A., Humphries, M. J., McDonald, J. A., and Carter, W. G. (1989). Identification and characterization of the lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J. Cell Biol. 109, 1321-1330.
233. Welsh, G. I., Foulstone, E. J., Young, S. W., Tavare, J. M., and Proud, C. G. (1994). Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem. J. 303, 15-20.
234. Weng, Z., Taylor, J. A. Turner, C. E., Burgge, J. S., and Seidel-Dugan, C. (1993). Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed balb/c 3T3 cells. J. Biol. Chem. 268, 14956-14963.
235. Werb, Z., Tremble, P. M., Behrendtsen, O., Crowlcy, E., and Damsky, C. H. (1989). Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J. Cell Biol. 109, 877-889.
236. FAK. DNA Cell Blol. 12, 823-830.
237. Wood, C. K., Turner, C. E., Jackson, P., and Critchley, D. R. (1994). Characterization of the paxillin-binding site and the C-terminal focal adhesion targeting sequence in vinculin. J. Cell Sei. 107, 709-717.
238. Wood, K. W., Sarnecki, C., Roberts, T. M., and Blenis, J. (1992). Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1 and RSK. Cell (Cambridge, Mass.) 68, 1041-1050.
239. King, Z., Chen, H.-C., Nowlen, J. K., Taylor, S. J., Shalloway, D., and Guan, J.-L. (1994). Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol. Biol. Cell 5, 413-421.
240. Yamauchi, K., Holt, K., and Pessin, J. E. (1993). PhosphatidylinositoB-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription. J. Biol. Chem. 268, 14597-14600.
241. Yaun, J., Shaham, S., Ledoux, S., Ellis, H. M., and Horvitz, H. R. (1993). The C. elegan cell death gene ced-3 encodes a protein similar to mammalian interleukin-1b-converting enzyme. Cell (Cambridge, Mass.) 75, 641-652.
242. Yurochko, A. D., Liu, D. Y., Eierman, D., and Haskill, S. (1992). Integrin as a primary signal transduction molecule regulating monocyte immediate-early gene induction. Proc. Natl. Acad. Sci. U.S.A. 89, 9034-9038.
243. Zachary, I., Sinnett-Smith, J., and Rozengurt, E. (1992). Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. J. Biol. Chem. 267, 19031-19034.
244. Zachary, I., Sinnett-Smith, J., Turner, C. E., and Rozengurt, E. (1993). Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion kinase. J. Biol. Chem. 268, 22060-22065.
245. Zhang, J., Fry, M. J., Waterfield, M. D., Jaken, S., Liao, L., Fox, J. E. B., and Rittenhouse, S. E. (1992). Activated phosphoinositide-3-kinase associated with membrane cytoskeleton in thrombin exposed platelets. J. Biol. Chem. 267, 4686-4692.