The pH difference between tumor and normal tissue offers a tumor specific target for the treatment of cancer

Drug Resistance Updates

Volumn 3, Issue 1, 2000, Pages 49-50

  Gerweck, L E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ACIDIFICATION; ANIMAL TISSUE; CANCER CHEMOTHERAPY; CELL COMPARTMENTALIZATION; CELL PH; CYTOARCHITECTURE; MAGNETIC RESONANCE ANGIOGRAPHY; NONHUMAN; NOTE; PKA; PRIORITY JOURNAL; TARGET CELL; TISSUE SPECIFICITY;

EID: 0034093495     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1054/drup.2000.0122     Document Type: Article

References (8)

1. J.L. Wike-Hooley J. Haveman H.S. Reinhold The relevance of pH in the treatment of malignant disease Radiother Oncol 2 1984 243 366
2. L.E. Gerweck K. Seetharaman Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer Cancer Res 56 1996 1194 1197
3. P. Vaupel F. Kallinowski P. Okunieff Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review Cancer Res 49 1989 6449 6465
4. G. Helmlinger F. Yuan M. Dellian R.K. Jain Interstitial pH and pO2 gradients in solid tumors in-vivo: High-resolution measurements reveal a lack of correlation Nat Med 3 1997 177 182
5. A.P. van den Berg J.L. Wike-Hooley A.E. van den Berg-Block Tumor pH in human mammary carcinoma Eur J Cancer Clin Oncol 18 1982 457 462
6. F. Pampus Die Wasserstoffionenkonzentration des Hirngewebes bei raumfordernden intracraniellen Prozessen Acta Neurochir 11 1963 305 318
7. J. Naeslund K.E. Swenson Investigations on the pH of malignant tumors in mice and humans after the administration of glucose Acta Obstet Gynecol Scand 32 1953 359 367
8. B.S. Ashby M.B. Cantab pH studies in human malignant tumors Lancet 2 1966 312 315