Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells

American Journal of Pathology

Volumn 163, Issue 2, 2003, Pages 543-552

  Grzmil, Michal ^a   Thelen, Paul ^b   Hemmerlein, Bernhard ^b   Schweyer, Stefan ^b   Voigt, Silke ^a   Mury, Dina ^a   Burfeind, Peter ^a,b  

^a Institute of Human Genetics   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BAX INHIBITOR 1 PROTEIN; DOUBLE STRANDED RNA; PROTEIN BAX; PROTEIN INHIBITOR; RNA; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CELL DEATH; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 0042847060     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63682-6     Document Type: Article

References (29)

1. Greenlee RT, Murray T, Bolden S, Wingo, PA: Cancer statistics. CA Cancer J Clin 2000, 50:7-33
2. Asamoto M, Hokaiwado N, Cho YM, Takahashi S, Ikeda Y, Imaida K, Shirai T: Prostate carcinomas developing in transgenic rats with SV40 T Antigen expression under probasin promoter control are strictly androgen-dependent. Cancer Res 2001, 61:4693-4700
3. Welsh JB, Sapinoso LM, Su Al, Kern SG, Wang-Rodriguez J, Moskaluk CA, Frierson HF, Hampton GM: Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res 2001, 61:5974-5978
4. Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S: PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Cancer Res 2000, 60:6568-6572
5. Berges RR, Vucanovic J, Epstein JI, Walsh PC, Isaacs JT: Implication of cell cycle changes during the progression of human prostate cancer. Clin Cancer Res 1995, 1:473-480
6. Tu H, Borkowski A, Jacobs SC, Kyprianou N: Incidence of apoptosis and cell proliferation in prostate cancer: relationship with TGF-β and bcl-2 expression. Int J Cancer 1996, 69:357-363
7. Bruckheimer EM, Kyprianou N: Apoptosis in prostate carcinogenesis: a growth regulator and a therapeutic target: a review. Cell Tissue Res 2000, 301:153-162
8. Li X, Marani M, Yu J, Nan B, Roth JA, Kagawa S, Fang B, Denner L, Marcelli M: Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer. Cancer Res 2001, 61:186-191
9. Krajewska M, Krajewski S, Epstein JI, Shabaik A, Sauvageot J, Song K, Kitada S, Reed JC: Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers. Am J Pathol 1996, 148:1567-1576
10. Walter L, Marynen P, Szpirer J, Levan G, Günther E: Identification of a novel conserved human gene, TEGT. Genomics 1995, 28:301-304
11. Xu Q, Reed JC: Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol Cell 1998, 1:337-346
12. Morrison BW, Moorman JR, Kowdley GC, Kobayashi YM, Jones LR, Leder P: Mat-8, a novel phospholemnan-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. J Biol Chem 1995, 270:2176-2182
13. Schweyer S, Hemmerlein B, Radzun HJ, Fayyazi A: Continuous recruitment, co-expression of tumor necrosis factor-α and matrix metalloproteinases, and apoptosis of macrophages in gout tophi. Virchows Archiv 2000, 437:534-539
14. Van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH: Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002, 415:530-536
15. Schmits R, Cochlovius B, Treitz G, Regitz E, Ketter R, Preuss KD, Romeike BF, Pfreundschuh M: Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas. Int J Cancer 2002, 98:73-77
16. L underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells. Cancer Res 2001, 61:1699-1706
17. Villalva C, Trempat P, Greenland C, Thomas C, Girard JP, Moebius F, Delsol G, Brousset P: Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma. Br J Haematol 2002, 118:791-780
18. Hutvagner G, Zamore PD: RNAi: nature abhors a double-strand. Curr Opin Genet Dev 2002, 12:225-232
19. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411:494-498
20. Harborth J, Elbashir SM, Bechert K, Tuschl T, Weber K: Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci 2001, 114:4557-4565
21. Bolduc N, Brisson LF: Antisense down-regulation of NtBI-1 in tobacco BY-2 cells induces accelerated cell death upon carbon starvation. FEBS Lett 2002, 532:111-114
22. Bolduc N, Ouellett M, Pitre F, Brisson LF: Molecular characterization of two plant BI-1 homologues which suppress Bax-induced apoptosis in human 293 cells. Planta 2003, 216:377-386
23. Burns TF, El-Deiry WS: Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. J Biol Chem 2001, 276:37879-37886
24. Marcelli M, Marani M, Li X, Sturgis L, Haidacher SJ, Trial JA, Mannucci R, Nicoletti I, Denner L: Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activation. Prostate 2000, 42:260-273
25. Wang XZ, Beebe JR, Pwiti L, Bielawska A, Smyth MJ: Aberrant sphingolipid signaling is involved in the resistance of prostate cancer cell lines to chemotherapy. Cancer Res 1999, 59:5842-5848
26. Chen YR, Zhou G, Tan TH: c-Jun N-terminal kinase mediates apoptotic signaling induced by N-(4-hydroxyphenyl) retinamide. Mol Pharmacol 1999, 56:1271-1279
27. Mercatante DR, Mohler JL, Kole R: Cellular response to an antisense-mediated shift of Bcl-X pre-mRNA splicing and antineoplastic agents. J Biol Chem 277:49374-49382
28. Colombel M, Symmans F, Gil S, O'Toole KM, Chopin D, Benson M, Olsson CA, Korsmeyer S, Buttyan R: Detection of the apoptosis-suppressing oncoprotein bcl-2 in hormone-refractory human prostate cancers. Am J Pathol 1993, 143:390-400
29. McDonnel TJ, Troncoso P, Brisbay SM, Logothesis C, Chang LWK, Hsieh JT, Tu SM, Campbell ML: Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res 1992, 52:6940-6944