Amelioration of delayed-type hypersensitivity responses by IL-27 administration

Biochemical and Biophysical Research Communications

Volumn 373, Issue 3, 2008, Pages 397-402

  Miyazaki, Yoshiyuki ^a   Shimanoe, Yohei ^a   Wang, Seng ^a   Yoshida, Hiroki ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

Cytokine; Cytokine receptor; Delayed type hypersensitivity; IL 10; IL 27; Immune suppression; Inflammation; Knockout mice; T lymphocytes; Type II interferon; Type IV allergy

Indexed keywords

INTERLEUKIN 27;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; FOOTPAD SWELLING; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SWELLING; T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DERMATITIS, ALLERGIC CONTACT; DISEASE MODELS, ANIMAL; IMMUNOSUPPRESSION; INTERLEUKIN-10; INTERLEUKIN-17; MICE; MICE, MUTANT STRAINS; MUTATION; RECEPTORS, CYTOKINE; RECOMBINANT PROTEINS;

MUS;

EID: 47249144061     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.06.038     Document Type: Article

References (21)

1. Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., Hibbert L., Churakova T., Travis M., Vaisberg E., Blumenschein W.M., Mattson J.D., Wagner J.L., To W., Zurawski S., McClanahan T.K., Gorman D.M., Bazan J.F., de Waal Malefyt R., Rennick D., and Kastelein R.A. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16 (2002) 779-790
2. Yoshida H., Hamano S., Senaldi G., Covey T., Faggioni R., Mu S., Xia M., Wakeham A.C., Nishina H., Potter J., Saris C.J., and Mak T.W. WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15 (2001) 569-578
3. Takeda A., Hamano S., Yamanaka A., Hanada T., Ishibashi T., Mak T.W., Yoshimura A., and Yoshida H. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170 (2003) 4886-4890
4. Hamano S., Himeno K., Miyazaki Y., Ishii K., Yamanaka A., Takeda A., Zhang M., Hisaeda H., Mak T.W., Yoshimura A., and Yoshida H. WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity 19 (2003) 657-667
5. Villarino A., Hibbert L., Lieberman L., Wilson E., Mak T., Yoshida H., Kastelein R.A., Saris C., and Hunter C.A. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19 (2003) 645-655
6. Holscher C., Holscher A., Ruckerl D., Yoshimoto T., Yoshida H., Mak T., Saris C., and Ehlers S. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J. Immunol. 174 (2005) 3534-3544
7. Stumhofer J.S., Silver J.S., Laurence A., Porrett P.M., Harris T.H., Turka L.A., Ernst M., Saris C.J., O'Shea J.J., and Hunter C.A. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8 (2007) 1363-1371
8. Fitzgerald D.C., Zhang G.X., El-Behi M., Fonseca-Kelly Z., Li H., Yu S., Saris C.J., Gran B., Ciric B., and Rostami A. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8 (2007) 1372-1379
9. Awasthi A., Carrier Y., Peron J.P., Bettelli E., Kamanaka M., Flavell R.A., Kuchroo V.K., Oukka M., and Weiner H.L. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8 (2007) 1380-1389
10. Harrington L.E., Mangan P.R., and Weaver C.T. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr. Opin. Immunol. 18 (2006) 349-356
11. Stumhofer J.S., Laurence A., Wilson E.H., Huang E., Tato C.M., Johnson L.M., Villarino A.V., Huang Q., Yoshimura A., Sehy D., Saris C.J., O'Shea J.J., Hennighausen L., Ernst M., and Hunter C.A. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7 (2006) 937-945
12. Batten M., Li J., Yi S., Kljavin N.M., Danilenko D.M., Lucas S., Lee J., de Sauvage F.J., and Ghilardi N. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7 (2006) 929-936
13. + T cells partially through STAT3-dependent mechanism. J. Immunol. 177 (2006) 5377-5385
14. Nambu A., Nakae S., and Iwakura Y. IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses. Int. Immunol. 18 (2006) 701-712
15. Nakae S., Komiyama Y., Nambu A., Sudo K., Iwase M., Homma I., Sekikawa K., Asano M., and Iwakura Y. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17 (2002) 375-387
16. Mohan K., Cordeiro E., Vaci M., McMaster C., and Issekutz T.B. CXCR3 is required for migration to dermal inflammation by normal and in vivo activated T cells: differential requirements by CD4 and CD8 memory subsets. Eur. J. Immunol. 35 (2005) 1702-1711
17. Villarino A.V., Stumhofer J.S., Saris C.J., Kastelein R.A., de Sauvage F.J., and Hunter C.A. IL-27 limits IL-2 production during Th1 differentiation. J. Immunol. 176 (2006) 237-247
18. Owaki T., Asakawa M., Kamiya S., Takeda K., Fukai F., Mizuguchi J., and Yoshimoto T. IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3. J. Immunol. 176 (2006) 2773-2780
19. Wang S., Miyazaki Y., Shinozaki Y., and Yoshida H. Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiency. J. Immunol. 179 (2007) 6421-6428
20. Fitzgerald D.C., Ciric B., Touil T., Harle H., Grammatikopolou J., Das Sarma J., Gran B., Zhang G.X., and Rostami A. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 179 (2007) 3268-3275
21. Sugiyama N., Nakashima H., Yoshimura T., Sadanaga A., Shimizu S., Masutani K., Igawa T., Akahoshi M., Miyake K., Takeda A., Yoshimura A., Hamano S., and Yoshida H. Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of IL-27R{alpha} (WSX-1). Ann. Rheum. Dis. 1 (2007) 1-2