-
2
-
-
78649417132
-
The prion hypothesis: from biological anomaly to basic regulatory mechanism
-
Tuite M.F., Serio T.R. The prion hypothesis: from biological anomaly to basic regulatory mechanism. Nat. Rev. Mol. Cell Biol. 2010, 11:823-833.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 823-833
-
-
Tuite, M.F.1
Serio, T.R.2
-
3
-
-
33646126278
-
New insights into prion structure and toxicity
-
Harris D.A., True H.L. New insights into prion structure and toxicity. Neuron 2006, 50:353-357.
-
(2006)
Neuron
, vol.50
, pp. 353-357
-
-
Harris, D.A.1
True, H.L.2
-
4
-
-
61349201380
-
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
-
Laurén J., et al. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 2009, 457:1128-1132.
-
(2009)
Nature
, vol.457
, pp. 1128-1132
-
-
Laurén, J.1
-
5
-
-
79956110918
-
The cellular prion protein mediates neurotoxic signalling of beta-sheet-rich conformers independent of prion replication
-
Resenberger U.K., et al. The cellular prion protein mediates neurotoxic signalling of beta-sheet-rich conformers independent of prion replication. EMBO J. 2011, 10:2057-2070.
-
(2011)
EMBO J.
, vol.10
, pp. 2057-2070
-
-
Resenberger, U.K.1
-
6
-
-
79952167224
-
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
-
Sandberg M.K., et al. Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Nature 2011, 470:540-542.
-
(2011)
Nature
, vol.470
, pp. 540-542
-
-
Sandberg, M.K.1
-
7
-
-
0242363656
-
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis
-
Mallucci G., et al. Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis. Science 2003, 302:871-874.
-
(2003)
Science
, vol.302
, pp. 871-874
-
-
Mallucci, G.1
-
8
-
-
0030054010
-
Normal host prion protein necessary for scrapie-induced neurotoxicity
-
Brandner S., et al. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 1996, 379:339-343.
-
(1996)
Nature
, vol.379
, pp. 339-343
-
-
Brandner, S.1
-
9
-
-
20344394154
-
Anchorless prion protein results in infectious amyloid disease without clinical scrapie
-
Chesebro B., et al. Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science 2005, 308:1435-1439.
-
(2005)
Science
, vol.308
, pp. 1435-1439
-
-
Chesebro, B.1
-
10
-
-
78951477465
-
Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection
-
Klingeborn M., et al. Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection. J. Virol. 2011, 85:1484-1494.
-
(2011)
J. Virol.
, vol.85
, pp. 1484-1494
-
-
Klingeborn, M.1
-
11
-
-
0022005315
-
A cellular gene encodes scrapie PrP 27-30 protein
-
Oesch B., et al. A cellular gene encodes scrapie PrP 27-30 protein. Cell 1985, 40:735-746.
-
(1985)
Cell
, vol.40
, pp. 735-746
-
-
Oesch, B.1
-
12
-
-
0026600865
-
Normal development and behavior of mice lacking the neuronal cell-surface PrP protein
-
Büeler H., et al. Normal development and behavior of mice lacking the neuronal cell-surface PrP protein. Nature 1992, 356:577-582.
-
(1992)
Nature
, vol.356
, pp. 577-582
-
-
Büeler, H.1
-
13
-
-
0028420937
-
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal
-
Manson J.C., et al. 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal. Mol. Neurobiol. 1994, 8:121-127.
-
(1994)
Mol. Neurobiol.
, vol.8
, pp. 121-127
-
-
Manson, J.C.1
-
14
-
-
0027319326
-
Mice devoid of PrP are resistant to scrapie
-
Büeler H., et al. Mice devoid of PrP are resistant to scrapie. Cell 1993, 73:1339-1347.
-
(1993)
Cell
, vol.73
, pp. 1339-1347
-
-
Büeler, H.1
-
15
-
-
0033215478
-
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel
-
Moore R.C., et al. Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J. Mol. Biol. 1999, 292:797-817.
-
(1999)
J. Mol. Biol.
, vol.292
, pp. 797-817
-
-
Moore, R.C.1
-
16
-
-
43149121009
-
The prion protein knockout mouse: a phenotype under challenge
-
Steele A.D., et al. The prion protein knockout mouse: a phenotype under challenge. Prion 2007, 1:83-93.
-
(2007)
Prion
, vol.1
, pp. 83-93
-
-
Steele, A.D.1
-
17
-
-
58149108891
-
Olfactory behavior and physiology are disrupted in prion protein knockout mice
-
Le Pichon C.E., et al. Olfactory behavior and physiology are disrupted in prion protein knockout mice. Nat. Neurosci. 2009, 12:60-69.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 60-69
-
-
Le Pichon, C.E.1
-
18
-
-
77649091387
-
Axonal prion protein is required for peripheral myelin maintenance
-
Bremer J., et al. Axonal prion protein is required for peripheral myelin maintenance. Nat. Neurosci. 2010, 13:310-318.
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 310-318
-
-
Bremer, J.1
-
19
-
-
42049099020
-
Physiology of the prion protein
-
Linden R., et al. Physiology of the prion protein. Physiol. Rev. 2008, 88:673-728.
-
(2008)
Physiol. Rev.
, vol.88
, pp. 673-728
-
-
Linden, R.1
-
20
-
-
0034628999
-
Cellular prion protein binds laminin and mediates neuritogenesis
-
Graner E., et al. Cellular prion protein binds laminin and mediates neuritogenesis. Mol. Brain Res. 2000, 76:85-92.
-
(2000)
Mol. Brain Res.
, vol.76
, pp. 85-92
-
-
Graner, E.1
-
21
-
-
0031436335
-
The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells
-
Rieger R., et al. The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells. Nat. Med. 1997, 3:1383-1388.
-
(1997)
Nat. Med.
, vol.3
, pp. 1383-1388
-
-
Rieger, R.1
-
22
-
-
17944363361
-
The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein
-
Gauczynski S., et al. The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein. EMBO J. 2001, 20:5863-5875.
-
(2001)
EMBO J.
, vol.20
, pp. 5863-5875
-
-
Gauczynski, S.1
-
23
-
-
0035861987
-
Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein
-
Schmitt-Ulms G., et al. Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. J. Mol. Biol. 2001, 314:1209-1225.
-
(2001)
J. Mol. Biol.
, vol.314
, pp. 1209-1225
-
-
Schmitt-Ulms, G.1
-
24
-
-
18544376071
-
Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth
-
Santuccione A., et al. Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. J. Cell Biol. 2005, 169:341-354.
-
(2005)
J. Cell Biol.
, vol.169
, pp. 341-354
-
-
Santuccione, A.1
-
25
-
-
77954497672
-
Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth
-
Devanathan V., et al. Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth. J. Neurosci. 2010, 30:9292-9305.
-
(2010)
J. Neurosci.
, vol.30
, pp. 9292-9305
-
-
Devanathan, V.1
-
26
-
-
65949115708
-
Regulation of embryonic cell adhesion by the prion protein
-
Malaga-Trillo E., et al. Regulation of embryonic cell adhesion by the prion protein. PLoS Biol. 2009, 7:e55.
-
(2009)
PLoS Biol.
, vol.7
-
-
Malaga-Trillo, E.1
-
27
-
-
0034235723
-
Immunolocalization of the cellular prion protein in normal brain
-
Moya K.L., et al. Immunolocalization of the cellular prion protein in normal brain. Microsc. Res. Tech. 2000, 50:58-65.
-
(2000)
Microsc. Res. Tech.
, vol.50
, pp. 58-65
-
-
Moya, K.L.1
-
28
-
-
28844477599
-
Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro
-
Kanaani J., et al. Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro. J. Neurochem. 2005, 95:1373-1386.
-
(2005)
J. Neurochem.
, vol.95
, pp. 1373-1386
-
-
Kanaani, J.1
-
29
-
-
0027997387
-
Prion protein is necessary for normal synaptic function
-
Collinge J., et al. Prion protein is necessary for normal synaptic function. Nature 1994, 370:295-297.
-
(1994)
Nature
, vol.370
, pp. 295-297
-
-
Collinge, J.1
-
30
-
-
0029265461
-
PrP gene dosage and long term potentiation
-
Manson J.C., et al. PrP gene dosage and long term potentiation. Neurodegeneration 1995, 4:113-114.
-
(1995)
Neurodegeneration
, vol.4
, pp. 113-114
-
-
Manson, J.C.1
-
31
-
-
0001473444
-
Dose-dependent, prion protein (PrP)-mediated facilitation of excitatory synaptic transmission in the mouse hippocampus
-
Carleton A., et al. Dose-dependent, prion protein (PrP)-mediated facilitation of excitatory synaptic transmission in the mouse hippocampus. Pflugers Arch. 2001, 442:223-229.
-
(2001)
Pflugers Arch.
, vol.442
, pp. 223-229
-
-
Carleton, A.1
-
32
-
-
7644224493
-
Hippocampal synaptic plasticity in mice devoid of cellular prion protein
-
Maglio L.E., et al. Hippocampal synaptic plasticity in mice devoid of cellular prion protein. Brain Res. 2004, 131:58-64.
-
(2004)
Brain Res.
, vol.131
, pp. 58-64
-
-
Maglio, L.E.1
-
34
-
-
0035033675
-
+ currents in cerebellar Purkinje cells
-
+ currents in cerebellar Purkinje cells. Neurobiol. Dis. 2001, 8:324-330.
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 324-330
-
-
Herms, J.W.1
-
35
-
-
0036470471
-
Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration
-
Mallucci G.R., et al. Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration. EMBO J. 2002, 21:202-210.
-
(2002)
EMBO J.
, vol.21
, pp. 202-210
-
-
Mallucci, G.R.1
-
36
-
-
33748029508
-
2+ homeostasis in hippocampal CA1 neurons
-
2+ homeostasis in hippocampal CA1 neurons. J. Neurochem. 2006, 98:1876-1885.
-
(2006)
J. Neurochem.
, vol.98
, pp. 1876-1885
-
-
Fuhrmann, M.1
-
37
-
-
79851481136
-
Cellular prion protein is implicated in the regulation of local Ca2+ movements in cerebellar granule neurons
-
Lazzari C., et al. Cellular prion protein is implicated in the regulation of local Ca2+ movements in cerebellar granule neurons. J. Neurochem. 2011, 116:881-890.
-
(2011)
J. Neurochem.
, vol.116
, pp. 881-890
-
-
Lazzari, C.1
-
38
-
-
49049112271
-
Altered neuron excitability and synaptic plasticity in the cerebellar granular layer of juvenile prion protein knock-out mice with impaired motor control
-
Prestori F., et al. Altered neuron excitability and synaptic plasticity in the cerebellar granular layer of juvenile prion protein knock-out mice with impaired motor control. J. Neurosci. 2008, 28:7091-7103.
-
(2008)
J. Neurosci.
, vol.28
, pp. 7091-7103
-
-
Prestori, F.1
-
39
-
-
0036944761
-
Excitatory amino acid neurotoxicity
-
Gillessen T., et al. Excitatory amino acid neurotoxicity. Adv. Exp. Med. Biol. 2002, 513:3-40.
-
(2002)
Adv. Exp. Med. Biol.
, vol.513
, pp. 3-40
-
-
Gillessen, T.1
-
40
-
-
43149109488
-
Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
-
Khosravani H., et al. Prion protein attenuates excitotoxicity by inhibiting NMDA receptors. J. Cell Biol. 2008, 181:551-565.
-
(2008)
J. Cell Biol.
, vol.181
, pp. 551-565
-
-
Khosravani, H.1
-
41
-
-
33846543360
-
Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125
-
Li A., et al. Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125. EMBO J. 2007, 26:548-558.
-
(2007)
EMBO J.
, vol.26
, pp. 548-558
-
-
Li, A.1
-
42
-
-
77953206169
-
A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death
-
Christensen H.M., et al. A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death. Am. J. Pathol. 2010, 176:2695-2706.
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 2695-2706
-
-
Christensen, H.M.1
-
43
-
-
34548331735
-
Enhanced susceptibility of Prnp-deficient mice to kainate-induced seizures, neuronal apoptosis, and death: role of AMPA/kainate receptors
-
Rangel A., et al. Enhanced susceptibility of Prnp-deficient mice to kainate-induced seizures, neuronal apoptosis, and death: role of AMPA/kainate receptors. J. Neurosci. Res. 2007, 85:2741-2755.
-
(2007)
J. Neurosci. Res.
, vol.85
, pp. 2741-2755
-
-
Rangel, A.1
-
44
-
-
79251552792
-
Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin gamma1 chain
-
Beraldo F.H., et al. Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin gamma1 chain. FASEB J. 2011, 25:265-279.
-
(2011)
FASEB J.
, vol.25
, pp. 265-279
-
-
Beraldo, F.H.1
-
45
-
-
77956220439
-
Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells
-
Solomon I.H., et al. Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells. J. Biol. Chem. 2010, 285:26719-26726.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 26719-26726
-
-
Solomon, I.H.1
-
46
-
-
79954607779
-
An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity
-
Solomon I.H., et al. An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity. J. Biol. Chem. 2011, 286:14724-14736.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 14724-14736
-
-
Solomon, I.H.1
-
47
-
-
25644433562
-
Overexpression of PrPC by adenovirus-mediated gene targeting reduces ischemic injury in a stroke rat model
-
Shyu W.C., et al. Overexpression of PrPC by adenovirus-mediated gene targeting reduces ischemic injury in a stroke rat model. J. Neurosci. 2005, 25:8967-8977.
-
(2005)
J. Neurosci.
, vol.25
, pp. 8967-8977
-
-
Shyu, W.C.1
-
48
-
-
0036124813
-
Oxidative stress and the prion protein in transmissible spongiform encephalopathies
-
Milhavet O., Lehmann S. Oxidative stress and the prion protein in transmissible spongiform encephalopathies. Brain Res. Rev. 2002, 38:328-339.
-
(2002)
Brain Res. Rev.
, vol.38
, pp. 328-339
-
-
Milhavet, O.1
Lehmann, S.2
-
49
-
-
1942485480
-
The cellular prion protein (PrPC) prevents apoptotic neuronal cell death and mitochondrial dysfunction induced by serum deprivation
-
Kim B.H., et al. The cellular prion protein (PrPC) prevents apoptotic neuronal cell death and mitochondrial dysfunction induced by serum deprivation. Brain Res. Mol. Brain Res. 2004, 124:40-50.
-
(2004)
Brain Res. Mol. Brain Res.
, vol.124
, pp. 40-50
-
-
Kim, B.H.1
-
50
-
-
0142135128
-
Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons
-
Roucou X., et al. Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons. J. Biol. Chem. 2003, 278:40877-40881.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40877-40881
-
-
Roucou, X.1
-
51
-
-
9144239220
-
Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death
-
Diarra-Mehrpour M., et al. Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death. Cancer Res. 2004, 64:719-727.
-
(2004)
Cancer Res.
, vol.64
, pp. 719-727
-
-
Diarra-Mehrpour, M.1
-
52
-
-
36248946665
-
New molecular insights into cellular survival and stress responses: neuroprotective role of cellular prion protein (PrPC)
-
Lo R.Y., et al. New molecular insights into cellular survival and stress responses: neuroprotective role of cellular prion protein (PrPC). Mol. Neurobiol. 2007, 35:236-244.
-
(2007)
Mol. Neurobiol.
, vol.35
, pp. 236-244
-
-
Lo, R.Y.1
-
53
-
-
67649963292
-
Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response
-
Haigh C.L., et al. Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response. J. Cell Sci. 2009, 122:1518-1528.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 1518-1528
-
-
Haigh, C.L.1
-
54
-
-
18444397736
-
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection
-
Zanata S.M., et al. Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. EMBO J. 2002, 21:3307-3316.
-
(2002)
EMBO J.
, vol.21
, pp. 3307-3316
-
-
Zanata, S.M.1
-
55
-
-
79960075550
-
Enhanced neural progenitor/stem cells self-renewal via the interaction of stress-inducible protein 1 with the prion protein
-
Santos T.G., et al. Enhanced neural progenitor/stem cells self-renewal via the interaction of stress-inducible protein 1 with the prion protein. Stem Cells 2011, 29:1126-1136.
-
(2011)
Stem Cells
, vol.29
, pp. 1126-1136
-
-
Santos, T.G.1
-
56
-
-
33644766915
-
Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis
-
Steele A.D., et al. Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:3416-3421.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 3416-3421
-
-
Steele, A.D.1
-
57
-
-
47949104726
-
Stress-protective signalling of prion protein is corrupted by scrapie prions
-
Rambold A.S., et al. Stress-protective signalling of prion protein is corrupted by scrapie prions. EMBO J. 2008, 27:1974-1984.
-
(2008)
EMBO J.
, vol.27
, pp. 1974-1984
-
-
Rambold, A.S.1
-
58
-
-
0001552281
-
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions
-
Shmerling D., et al. Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell 1998, 93:203-214.
-
(1998)
Cell
, vol.93
, pp. 203-214
-
-
Shmerling, D.1
-
59
-
-
33846498655
-
Lethal recessive myelin toxicity of prion protein lacking its central domain
-
Baumann F., et al. Lethal recessive myelin toxicity of prion protein lacking its central domain. EMBO J. 2007, 26:538-547.
-
(2007)
EMBO J.
, vol.26
, pp. 538-547
-
-
Baumann, F.1
-
60
-
-
77951222072
-
A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein
-
Massignan T., et al. A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein. J. Biol. Chem. 2010, 285:7752-7765.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 7752-7765
-
-
Massignan, T.1
-
61
-
-
79952188535
-
A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: a practical guide
-
Massignan T., et al. A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: a practical guide. Methods 2011, 53:214-219.
-
(2011)
Methods
, vol.53
, pp. 214-219
-
-
Massignan, T.1
-
62
-
-
0028305135
-
A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits
-
Shyng S.L., et al. A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits. J. Cell Biol. 1994, 125:1239-1250.
-
(1994)
J. Cell Biol.
, vol.125
, pp. 1239-1250
-
-
Shyng, S.L.1
-
63
-
-
0042313964
-
The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein
-
Sunyach C., et al. The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein. EMBO J. 2003, 22:3591-3601.
-
(2003)
EMBO J.
, vol.22
, pp. 3591-3601
-
-
Sunyach, C.1
-
64
-
-
0037113169
-
Cell-surface prion protein interacts with glycosaminoglycans
-
Pan T., et al. Cell-surface prion protein interacts with glycosaminoglycans. Biochem. J. 2002, 368:81-90.
-
(2002)
Biochem. J.
, vol.368
, pp. 81-90
-
-
Pan, T.1
-
65
-
-
80053228890
-
A nine amino acid domain is essential for mutant prion protein toxicity
-
Westergard L., et al. A nine amino acid domain is essential for mutant prion protein toxicity. J. Neurosci. 2011, 31:14005-14017.
-
(2011)
J. Neurosci.
, vol.31
, pp. 14005-14017
-
-
Westergard, L.1
-
66
-
-
80053330454
-
The N-terminal, polybasic region is critical for prion protein neuroprotective activity
-
Turnbaugh J.A., et al. The N-terminal, polybasic region is critical for prion protein neuroprotective activity. PLoS ONE 2011, 6:e25675.
-
(2011)
PLoS ONE
, vol.6
-
-
Turnbaugh, J.A.1
-
67
-
-
1642524321
-
Dual mechanisms for shedding of the cellular prion protein
-
Parkin E.T., et al. Dual mechanisms for shedding of the cellular prion protein. J. Biol. Chem. 2004, 279:11170-11178.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 11170-11178
-
-
Parkin, E.T.1
-
68
-
-
0141626391
-
Trafficking, turnover and membrane topology of PrP
-
Harris D.A. Trafficking, turnover and membrane topology of PrP. Br. Med. Bull. 2003, 66:71-85.
-
(2003)
Br. Med. Bull.
, vol.66
, pp. 71-85
-
-
Harris, D.A.1
-
69
-
-
0032488777
-
A transmembrane form of the prion protein in neurodegenerative disease
-
Hegde R.S., et al. A transmembrane form of the prion protein in neurodegenerative disease. Science 1998, 279:827-834.
-
(1998)
Science
, vol.279
, pp. 827-834
-
-
Hegde, R.S.1
-
70
-
-
0242412541
-
Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection
-
Stewart R.S., Harris D.A. Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection. J. Biol. Chem. 2003, 278:45960-45968.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 45960-45968
-
-
Stewart, R.S.1
Harris, D.A.2
-
71
-
-
51449098355
-
Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration
-
Rane N.S., et al. Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration. Dev. Cell 2008, 15:359-370.
-
(2008)
Dev. Cell
, vol.15
, pp. 359-370
-
-
Rane, N.S.1
-
72
-
-
16344384722
-
Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein
-
Stewart R.S., et al. Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein. J. Neurosci. 2005, 25:3469-3477.
-
(2005)
J. Neurosci.
, vol.25
, pp. 3469-3477
-
-
Stewart, R.S.1
-
73
-
-
0037195647
-
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol
-
Ma J., et al. Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science 2002, 298:1781-1785.
-
(2002)
Science
, vol.298
, pp. 1781-1785
-
-
Ma, J.1
-
74
-
-
66449124518
-
Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration
-
Chakrabarti O., Hegde R.S. Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. Cell 2009, 137:1136-1147.
-
(2009)
Cell
, vol.137
, pp. 1136-1147
-
-
Chakrabarti, O.1
Hegde, R.S.2
-
75
-
-
33746615107
-
Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP
-
Rambold A.S., et al. Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP. Mol. Biol. Cell 2006, 17:3356-3368.
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 3356-3368
-
-
Rambold, A.S.1
-
76
-
-
35248880092
-
TAT transduction: the molecular mechanism and therapeutic prospects
-
Gump J.M., Dowdy S.F. TAT transduction: the molecular mechanism and therapeutic prospects. Trends Mol. Med. 2007, 13:443-448.
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 443-448
-
-
Gump, J.M.1
Dowdy, S.F.2
-
77
-
-
70350215545
-
Antimicrobial activity of human prion protein is mediated by its N-terminal region
-
Pasupuleti M., et al. Antimicrobial activity of human prion protein is mediated by its N-terminal region. PLoS ONE 2009, 4:e7358.
-
(2009)
PLoS ONE
, vol.4
-
-
Pasupuleti, M.1
-
78
-
-
53749088102
-
Pathologic prion protein infects cells by lipid-raft dependent macropinocytosis
-
Wadia J.S., et al. Pathologic prion protein infects cells by lipid-raft dependent macropinocytosis. PLoS ONE 2008, 3:e3314.
-
(2008)
PLoS ONE
, vol.3
-
-
Wadia, J.S.1
-
79
-
-
0029933153
-
The role of APP processing and trafficking pathways in the formation of amyloid beta-protein
-
Selkoe D.J., et al. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Ann. N. Y. Acad. Sci. 1996, 777:57-64.
-
(1996)
Ann. N. Y. Acad. Sci.
, vol.777
, pp. 57-64
-
-
Selkoe, D.J.1
-
80
-
-
78650944520
-
APP processing in Alzheimer's disease
-
Zhang Y.W., et al. APP processing in Alzheimer's disease. Mol. Brain 2011, 4:3.
-
(2011)
Mol. Brain
, vol.4
, pp. 3
-
-
Zhang, Y.W.1
-
81
-
-
34248190279
-
A beta oligomers - a decade of discovery
-
Walsh D.M., Selkoe D.J. A beta oligomers - a decade of discovery. J. Neurochem. 2007, 101:1172-1184.
-
(2007)
J. Neurochem.
, vol.101
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
82
-
-
77951876319
-
Memory impairment in transgenic Alzheimer mice requires cellular prion protein
-
Gimbel D.A., et al. Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J. Neurosci. 2010, 30:6367-6374.
-
(2010)
J. Neurosci.
, vol.30
, pp. 6367-6374
-
-
Gimbel, D.A.1
-
83
-
-
80055071341
-
Amyloid-β-induced synapse damage Is mediated via cross-linkage of cellular prion proteins
-
Bate C., Williams A. Amyloid-β-induced synapse damage Is mediated via cross-linkage of cellular prion proteins. J. Biol. Chem. 2011, 286:37955-37963.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 37955-37963
-
-
Bate, C.1
Williams, A.2
-
84
-
-
77957778860
-
Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse
-
Chung E., et al. Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. BMC Neurosci. 2010, 11:130.
-
(2010)
BMC Neurosci.
, vol.11
, pp. 130
-
-
Chung, E.1
-
85
-
-
79958249995
-
Interaction between prion protein and toxic amyloid beta assemblies can be therapeutically targeted at multiple sites
-
Freir D.B., et al. Interaction between prion protein and toxic amyloid beta assemblies can be therapeutically targeted at multiple sites. Nat. Commun. 2011, 2:336.
-
(2011)
Nat. Commun.
, vol.2
, pp. 336
-
-
Freir, D.B.1
-
86
-
-
79956302348
-
Alzheimer's disease brain-derived amyloid-{beta}-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein
-
Barry A.E., et al. Alzheimer's disease brain-derived amyloid-{beta}-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. J. Neurosci. 2011, 31:7259-7263.
-
(2011)
J. Neurosci.
, vol.31
, pp. 7259-7263
-
-
Barry, A.E.1
-
87
-
-
76649093635
-
Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein
-
Balducci C., et al. Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:2295-2300.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 2295-2300
-
-
Balducci, C.1
-
88
-
-
77956165325
-
Prion protein and Abeta-related synaptic toxicity impairment
-
Calella A.M., et al. Prion protein and Abeta-related synaptic toxicity impairment. EMBO Mol. Med. 2010, 2:306-314.
-
(2010)
EMBO Mol. Med.
, vol.2
, pp. 306-314
-
-
Calella, A.M.1
-
89
-
-
79960660843
-
Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice
-
Cisse M., et al. Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice. J. Neurosci. 2011, 31:10427-10431.
-
(2011)
J. Neurosci.
, vol.31
, pp. 10427-10431
-
-
Cisse, M.1
-
90
-
-
77955617917
-
The prion protein as a receptor for amyloid-beta
-
discussion E4-5
-
Kessels H.W., et al. The prion protein as a receptor for amyloid-beta. Nature 2010, 466:E3-E4. discussion E4-5.
-
(2010)
Nature
, vol.466
-
-
Kessels, H.W.1
-
91
-
-
45249102680
-
Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders
-
Rahimi F., et al. Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders. Curr. Alzheimer Res. 2008, 5:319-341.
-
(2008)
Curr. Alzheimer Res.
, vol.5
, pp. 319-341
-
-
Rahimi, F.1
-
93
-
-
77956197815
-
Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role of N-terminal residues
-
Chen S., et al. Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role of N-terminal residues. J. Biol. Chem. 2010, 285:26377-26383.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 26377-26383
-
-
Chen, S.1
-
94
-
-
27944486535
-
Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis
-
Taylor D.R., et al. Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J. Cell Sci. 2005, 118:5141-5153.
-
(2005)
J. Cell Sci.
, vol.118
, pp. 5141-5153
-
-
Taylor, D.R.1
-
95
-
-
79954420180
-
Amyloid-beta oligomers increase the localization of prion protein at the cell surface
-
Caetano F.A., et al. Amyloid-beta oligomers increase the localization of prion protein at the cell surface. J. Neurochem. 2011, 117:538-553.
-
(2011)
J. Neurochem.
, vol.117
, pp. 538-553
-
-
Caetano, F.A.1
-
96
-
-
34547400403
-
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein
-
Parkin E.T., et al. Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:11062-11067.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 11062-11067
-
-
Parkin, E.T.1
-
97
-
-
80052979854
-
Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein
-
Griffiths H.H., et al. Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein. J. Biol. Chem. 2011, 286:33489-33500.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 33489-33500
-
-
Griffiths, H.H.1
-
98
-
-
0030836511
-
NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231)
-
Riek R., et al. NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231). FEBS Lett. 1997, 413:282-288.
-
(1997)
FEBS Lett.
, vol.413
, pp. 282-288
-
-
Riek, R.1
-
99
-
-
15844418768
-
Phylogenesis of prion protein
-
Krakauer D.C., et al. Phylogenesis of prion protein. Nature 1996, 380:675.
-
(1996)
Nature
, vol.380
, pp. 675
-
-
Krakauer, D.C.1
-
100
-
-
0026567814
-
Nearly ubiquitous tissue distribution of the scrapie agent precursor protein
-
Bendheim P.E., et al. Nearly ubiquitous tissue distribution of the scrapie agent precursor protein. Neurology 1992, 42:149-156.
-
(1992)
Neurology
, vol.42
, pp. 149-156
-
-
Bendheim, P.E.1
-
101
-
-
0025270288
-
The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells
-
Brown H.R., et al. The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells. Acta Neuropathol. 1990, 80:1-6.
-
(1990)
Acta Neuropathol.
, vol.80
, pp. 1-6
-
-
Brown, H.R.1
-
102
-
-
0034869693
-
Crystal structure of the human prion protein reveals a mechanism for oligomerization
-
Knaus K.J., et al. Crystal structure of the human prion protein reveals a mechanism for oligomerization. Nat. Struct. Biol. 2001, 8:770-774.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 770-774
-
-
Knaus, K.J.1
-
103
-
-
0037965529
-
Prion protein selectively binds copper(II) ions
-
Stöckel J., et al. Prion protein selectively binds copper(II) ions. Biochemistry 1998, 37:7185-7193.
-
(1998)
Biochemistry
, vol.37
, pp. 7185-7193
-
-
Stöckel, J.1
-
104
-
-
0023663071
-
Scrapie prion protein contains a phosphatidylinositol glycolipid
-
Stahl N., et al. Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell 1987, 51:229-249.
-
(1987)
Cell
, vol.51
, pp. 229-249
-
-
Stahl, N.1
-
105
-
-
0030799062
-
Blockade of glycosylation promotes acquisition of scrapie-like properties by the prion protein in cultured cells
-
Lehmann S., Harris D.A. Blockade of glycosylation promotes acquisition of scrapie-like properties by the prion protein in cultured cells. J. Biol. Chem. 1997, 272:21479-21487.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 21479-21487
-
-
Lehmann, S.1
Harris, D.A.2
-
106
-
-
0028926204
-
Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin
-
Gorodinsky A., Harris D.A. Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin. J. Cell Biol. 1995, 129:619-627.
-
(1995)
J. Cell Biol.
, vol.129
, pp. 619-627
-
-
Gorodinsky, A.1
Harris, D.A.2
-
107
-
-
0035851151
-
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein
-
Vincent B., et al. The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. J. Biol. Chem. 2001, 276:37743-37746.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37743-37746
-
-
Vincent, B.1
-
108
-
-
0029027854
-
Truncated forms of the human prion protein in normal brain and in prion diseases
-
Chen S.G., et al. Truncated forms of the human prion protein in normal brain and in prion diseases. J. Biol. Chem. 1995, 270:19173-19180.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19173-19180
-
-
Chen, S.G.1
-
109
-
-
0021752457
-
Purification and structural properties of a major scrapie prion protein
-
Prusiner S.B., et al. Purification and structural properties of a major scrapie prion protein. Cell 1984, 38:127-134.
-
(1984)
Cell
, vol.38
, pp. 127-134
-
-
Prusiner, S.B.1
-
110
-
-
80052800750
-
Prion diseases of yeast: amyloid structure and biology
-
Wickner R.B., et al. Prion diseases of yeast: amyloid structure and biology. Semin. Cell Dev. Biol. 2011, 22:469-475.
-
(2011)
Semin. Cell Dev. Biol.
, vol.22
, pp. 469-475
-
-
Wickner, R.B.1
-
111
-
-
78349247103
-
Prion amyloid structure explains templating: how proteins can be genes
-
Wickner R.B., et al. Prion amyloid structure explains templating: how proteins can be genes. FEMS Yeast Res. 2010, 10:980-991.
-
(2010)
FEMS Yeast Res.
, vol.10
, pp. 980-991
-
-
Wickner, R.B.1
-
112
-
-
77249133010
-
Prion-like mechanisms in neurodegenerative diseases
-
Frost B., Diamond M.I. Prion-like mechanisms in neurodegenerative diseases. Nat. Rev. Neurosci. 2010, 11:155-159.
-
(2010)
Nat. Rev. Neurosci.
, vol.11
, pp. 155-159
-
-
Frost, B.1
Diamond, M.I.2
-
113
-
-
1442330474
-
From conversion to aggregation: protofibril formation of the prion protein
-
DeMarco M.L., Daggett V. From conversion to aggregation: protofibril formation of the prion protein. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:2293-2298.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 2293-2298
-
-
DeMarco, M.L.1
Daggett, V.2
-
114
-
-
2942616602
-
Evidence for assembly of prions with left-handed beta-helices into trimers
-
Govaerts C., et al. Evidence for assembly of prions with left-handed beta-helices into trimers. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:8342-8347.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 8342-8347
-
-
Govaerts, C.1
-
115
-
-
84887212358
-
The comprehensive native interactome of a fully functional tagged prion protein
-
Rutishauser D., et al. The comprehensive native interactome of a fully functional tagged prion protein. PLoS ONE 2009, 4:e4446.
-
(2009)
PLoS ONE
, vol.4
-
-
Rutishauser, D.1
-
116
-
-
0028256222
-
Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red
-
Caughey B., et al. Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red. J. Virol. 1994, 68:2135-2141.
-
(1994)
J. Virol.
, vol.68
, pp. 2135-2141
-
-
Caughey, B.1
-
117
-
-
17944377091
-
Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor
-
Hundt C., et al. Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor. EMBO J. 2001, 20:5876-5886.
-
(2001)
EMBO J.
, vol.20
, pp. 5876-5886
-
-
Hundt, C.1
-
118
-
-
33846953615
-
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein
-
Taylor D.R., Hooper N.M. The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein. Biochem. J. 2007, 402:17-23.
-
(2007)
Biochem. J.
, vol.402
, pp. 17-23
-
-
Taylor, D.R.1
Hooper, N.M.2
-
119
-
-
36049043710
-
Prion protein regulates glutamate-dependent lactate transport of astrocytes
-
Kleene R., et al. Prion protein regulates glutamate-dependent lactate transport of astrocytes. J. Neurosci. 2007, 27:12331-12340.
-
(2007)
J. Neurosci.
, vol.27
, pp. 12331-12340
-
-
Kleene, R.1
-
120
-
-
0345505687
-
Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival
-
Chen S., et al. Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival. Mol. Cell. Neurosci. 2003, 22:227-233.
-
(2003)
Mol. Cell. Neurosci.
, vol.22
, pp. 227-233
-
-
Chen, S.1
-
121
-
-
0345687168
-
NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells
-
Schneider B., et al. NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:13326-13331.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 13326-13331
-
-
Schneider, B.1
-
122
-
-
19344370943
-
Activation of phosphatidylinositol 3-kinase by cellular prion protein and its role in cell survival
-
Vassallo N., et al. Activation of phosphatidylinositol 3-kinase by cellular prion protein and its role in cell survival. Biochem. Biophys. Res. Commun. 2005, 332:75-82.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.332
, pp. 75-82
-
-
Vassallo, N.1
-
123
-
-
0036176506
-
P38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells
-
Thellung S., et al. p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells. Neurobiol. Dis. 2002, 9:69-81.
-
(2002)
Neurobiol. Dis.
, vol.9
, pp. 69-81
-
-
Thellung, S.1
-
124
-
-
33748776269
-
C signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells
-
C signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. J. Biol. Chem. 2006, 281:28470-28479.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 28470-28479
-
-
Pietri, M.1
-
125
-
-
20444499045
-
Activation of the JNK-c-Jun pathway during the early phase of neuronal apoptosis induced by PrP106-126 and prion infection
-
Carimalo J., et al. Activation of the JNK-c-Jun pathway during the early phase of neuronal apoptosis induced by PrP106-126 and prion infection. Eur. J. Neurosci. 2005, 21:2311-2319.
-
(2005)
Eur. J. Neurosci.
, vol.21
, pp. 2311-2319
-
-
Carimalo, J.1
-
126
-
-
11844276068
-
Disassembling adherens junctions: breaking up is hard to do
-
D'Souza-Schorey C. Disassembling adherens junctions: breaking up is hard to do. Trends Cell Biol. 2005, 15:19-26.
-
(2005)
Trends Cell Biol.
, vol.15
, pp. 19-26
-
-
D'Souza-Schorey, C.1
-
127
-
-
34147128031
-
Sc interactions
-
Sc interactions. J. Biol. Chem. 2007, 282:7465-7471.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 7465-7471
-
-
Solforosi, L.1
-
128
-
-
0029054937
-
The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits
-
Shyng S.L., et al. The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits. J. Biol. Chem. 1995, 270:14793-14800.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 14793-14800
-
-
Shyng, S.L.1
|