A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein

Journal of Biological Chemistry

Volumn 285, Issue 10, 2010, Pages 7752-7765

  Massignan, Tania ^a,b   Stewart, Richard S ^a   Biasini, Emiliano ^a,b   Solomon, Isaac H ^a   Bonetto, Valentina ^b   Chiesa, Roberto ^b   Harris, David A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDES; BLEOMYCINS; CATIONIC COMPOUNDS; CELLULAR ASSAYS; CELLULAR PHENOTYPES; CO-EXPRESSION; DELETION MUTANTS; IN-VIVO; ISOFORMS; MUTANT PROTEINS; NEUROTOXIC EFFECTS; NORMAL FUNCTION; PATHOLOGICAL EFFECTS; PHYSIOLOGICAL ACTIVITY; PRION DISEASE; PRION PROTEIN; TOXIC EFFECT; TRANSFECTED CELLS; TRANSGENIC MICE; WILD TYPES;

CELL CULTURE; SCANDIUM; TOXICITY;

PROTEINS;

PRION PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; MUTANT; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WILD TYPE;

AMEBICIDES; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BIOLOGICAL ASSAY; BLEOMYCIN; CELL LINE; CELL SURVIVAL; CINNAMATES; DRUG EVALUATION, PRECLINICAL; GENTAMICINS; HUMANS; HYGROMYCIN B; MICE; MICE, TRANSGENIC; PHENOTYPE; PRION DISEASES; PRIONS; PROTEIN ISOFORMS; PRPC PROTEINS; PRPSC PROTEINS; STEM CELLS;

MUS MUSCULUS;

EID: 77951222072     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.064949     Document Type: Article

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