Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells

Journal of Biological Chemistry

Volumn 285, Issue 34, 2010, Pages 26719-26726

  Solomon, Isaac H ^a   Huettner, James E ^a   Harris, David A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR PRION PROTEINS; CLAMPING TECHNIQUES; CULTURED CELL; DELETION MUTANTS; GLYCOSAMINOGLYCANS; IN-VIVO; ION CHANNEL; IONIC CURRENT; LIPID MEMBRANES; NEURODEGENERATIVE; NEUROTOXICITY; OVER-EXPRESSION; POINT MUTATIONS; PRION DISEASE; PRION PROTEIN; SYNTHETIC PEPTIDE; THERAPEUTIC AGENTS; TRANSFECTED CELLS; TRANSGENIC MICE; WILD TYPES;

AMINO ACIDS; CELL MEMBRANES; CYTOLOGY; ORGANIC ACIDS;

PROTEINS;

GLYCOSAMINOGLYCAN; ION CHANNEL; PRION PROTEIN;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ION CURRENT; LIPID MEMBRANE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE HOMOLOGY;

CELL LINE; ELECTROPHYSIOLOGICAL PHENOMENA; HUMANS; ION CHANNELS; ION TRANSPORT; NEUROTOXICITY SYNDROMES; PATCH-CLAMP TECHNIQUES; PRIONS;

MUS MUSCULUS;

EID: 77956220439     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.134619     Document Type: Article

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