Prion protein affects Ca2+-activated K+ currents in cerebellar Purkinje cells

Neurobiology of Disease

Volumn 8, Issue 2, 2001, Pages 324-330

  Herms, J W ^a,b   Tings, T ^a   Dunker, S ^b   Kretzschmar, H A ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; PRION PROTEIN;

AFTERHYPERPOLARIZATION; ARTICLE; CALCIUM HOMEOSTASIS; HIPPOCAMPUS; NONHUMAN; PATHOGENESIS; PHENOTYPE; POTASSIUM CURRENT; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PURKINJE CELL; SCRAPIE; TRANSGENIC MOUSE; VOLTAGE CLAMP;

EID: 0035033675     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0369     Document Type: Article

References (35)

1. Prion research: The next frontiers
2. Intrinsic physiological and morphological properties of principal cells of the hippocampus and neocortex in hamsters infected with scrapie
3. The cellular prion protein binds copper in vivo
4. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
5. Hippocampal slices from prion protein null mice: Disrupted Ca2+ activated K+ currents
6. Prion protein is necessary for normal synaptic function
7. Suppression of long-term potentiation in hippocampal slices by copper
8. A thin slice preparation for patch-clamp recordings from neurones of the mammalian central nervous system
9. Patch clamp and calcium imaging in brain slices
10. Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie
11. A new generation of Ca2+ indicators with greatly improved fluorescence properties
12. The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricular myocytes
13. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches
14. Evidence for release of copper in the brain: Depolarisation-induced release of newly taken-up 67copper
15. Patch-clamp analysis of synaptic transmission to cerebellar Purkinje cells of prion protein knockout mice
16. Evidence of presynaptic location and function of the prion protein
17. Altered intracellular calcium hoemostasis in cerebellar granule cells of prion protein deficient mice
18. Alterations in potasium currents may trigger neurodegeneration in murine scrapie
19. Scrapie prion proteins are synthesized in neurons
20. Diagnostic criteria for sporadic Creutzfeldt-Jakob disease
21. Calcium-dependent current generating the afterhyperpolarization of hippocampal neurons
22. Calcium-induced calcium release in cerebellar Purkinje cells
23. PrP gene dosage and long term potentiation
24. Developmental expression of the prion protein gene in glial cells
25. Divalent ions released from stainless steel hypodermic needles reduce neuronal calcium currents
26. Combined fura-2 and patch clamp measurements in rat peritoneal mast cells
27. The prion diseases
28. Cellular prion protein localization in rodent and primate brain
29. High-affinity copper block of GABAA-receptor-mediated currents in acutely isolated cerebellar Purkinje cells of the rat
30. Scrapie prion protein contains a phospatidylinositol glycolipid
31. An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neurons
32. An after-hyperpolarization of medium duration in rat hippocampal pyramidal cells
33. Copper binding to the prion protein: Structural implications of four identical cooperative binding sites
34. The role of PrP in pathogenesis of experimental scrapie
35. Regulation of intracellular free calcium levels by the cellular prion protein