The N-terminal, polybasic region is critical for prion protein neuroprotective activity

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Turnbaugh, Jessie A ^a,b   Westergard, Laura ^b   Unterberger, Ursula ^a   Biasini, Emiliano ^a   Harris, David A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL LOSS; DELETION MUTANT; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE; ANIMAL; BRAIN; CELL LINE; CHEMISTRY; GENE DELETION; GENETICS; METABOLISM; PATHOLOGY; PH; PHENOTYPE; PRION; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT;

MUS; MUS MUSCULUS;

ANIMALS; BRAIN; CELL LINE; HYDROGEN-ION CONCENTRATION; MICE; MICE, TRANSGENIC; PHENOTYPE; PRIONS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SEQUENCE DELETION;

EID: 80053330454     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025675     Document Type: Article

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