An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity

Journal of Biological Chemistry

Volumn 286, Issue 16, 2011, Pages 14724-14736

  Solomon, Isaac H ^a   Khatri, Natasha ^a   Biasini, Emiliano ^a   Massignan, Tania ^a   Huettner, James E ^b   Harris, David A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATIONIC DRUGS; CELL SURFACES; CELLULAR LOCALIZATION; FUNCTIONAL ACTIVITIES; IONIC CURRENT; N-TERMINALS; NEUROTOXICITY; NORMAL FUNCTION; PHYSIOLOGICAL ACTIVITY; PLASMA MEMBRANES; POINT MUTATIONS; PRION PROTEIN; STRUCTURAL FEATURE;

AMINO ACIDS; CELL MEMBRANES; IONIC DRUGS; SCANDIUM; TOXICITY;

CELL CULTURE;

PRION PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CELL CULTURE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY; ENDOCYTOSIS; GENE DELETION; GLYCOSYLATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIPID RAFT; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SITE DIRECTED MUTAGENESIS;

ANIMALS; CELL LINE; CELL MEMBRANE; CYTOPLASM; DETERGENTS; ELECTROPHYSIOLOGY; GENE DELETION; HUMANS; IONS; MICE; MUTATION; NEURODEGENERATIVE DISEASES; PRION DISEASES; PRIONS; PROTEIN STRUCTURE, TERTIARY;

EID: 79954607779     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.214973     Document Type: Article

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