Cell-based optimization of novel benzamides as potential antimalarial leads

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 24, 2009, Pages 6970-6974

  Wu, Tao ^a   Nagle, Advait ^a   Sakata, Tomoyo ^a   Henson, Kerstin ^a   Borboa, Rachel ^a   Chen, Zhong ^a   Kuhen, Kelli ^a   Plouffe, David ^a   Winzeler, Elizabeth ^a   Adrian, Francisco ^a   Tuntland, Tove ^a   Chang, Jonathan ^a   Simerson, Susan ^a   Howard, Steven ^a   Ek, Jared ^a   Isbell, John ^a   Deng, Xianming ^b   Gray, Nathanael S ^b   Tully, David C ^a   Chatterjee, Arnab K ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cellular assay; Cyclic amines; Kinase; Malaria; Pharmacokinetics; Resistant strains

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; BENZAMIDE DERIVATIVE; MEFLOQUINE; PHOSPHOTRANSFERASE; SULFADOXINE;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; CELL ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; FUNGAL STRAIN; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; BENZAMIDES; DIRECTED MOLECULAR EVOLUTION; ENZYME INHIBITORS; HUMANS; MICE; PHOSPHOTRANSFERASES; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 71849105991     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.050     Document Type: Article

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