Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): Antiparasitic activity of a PKG inhibitor

Molecular and Biochemical Parasitology

Volumn 146, Issue 1, 2006, Pages 78-88

  Diaz, Carmen A ^a   Allocco, John ^a   Powles, Mary Ann ^a   Yeung, Lai ^a   Donald, Robert G K ^a   Anderson, Jennifer W ^a   Liberator, Paul A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

cGMP dependent protein kinase; Malaria; Plasmodium falciparum

Indexed keywords

COMPLEMENTARY DNA; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; PYRROLE 4 [2 (4 FLUOROPHENYL) 5 (1 METHYLPIPERIDINE 4 YL) 1H PYRROL 3 YL]PYRIDINE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CODON; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; ION EXCHANGE CHROMATOGRAPHY; MOUSE; NONHUMAN; PARASITOSIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ANIMALS; ANTIPARASITIC AGENTS; BASE SEQUENCE; CELLS, CULTURED; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; ERYTHROCYTES; FLUORESCEIN-5-ISOTHIOCYANATE; GENE EXPRESSION; LIFE CYCLE STAGES; MALARIA, FALCIPARUM; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; SEQUENCE ALIGNMENT; TRANSFECTION;

ANIMALIA; APICOMPLEXA; EIMERIA; EUKARYOTA; MURINAE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTOZOA; TOXOPLASMA GONDII;

EID: 31144470616     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2005.10.020     Document Type: Article

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