1, 4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 16, 2001, Pages 2061-2065

  Heerding, Dirk A ^a   Chan, George ^a   DeWolf, Walter E ^a   Fosberry, Andrew P ^a   Janson, Cheryl A ^a   Jaworski, Deborah D ^a   McManus, Edward ^a   Miller, William H ^a   Moore, Terrance D ^a   Payne, David J ^a   Qiu, Xiayang ^a   Rittenhouse, Stephen F ^a   Slater Radosti, Courtney ^a   Smith, Ward ^a   Takata, Dennis T ^a   Vaidya, Kalindi S ^a   Yuan, Catherine C K ^a   Huffman, William F ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ENOYLACYL CARRIER PROTEIN REDUCTASE; IMIDAZOLE DERIVATIVE; OXIDOREDUCTASE; PROTEIN INHIBITOR; TRICLOSAN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; OXIDOREDUCTASES; STAPHYLOCOCCUS AUREUS;

EID: 17944376779     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00404-8     Document Type: Article

References (23)