Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity

Journal of Biological Chemistry

Volumn 279, Issue 30, 2004, Pages 31429-31439

  Cameron, Angus ^a   Read, Jon ^a   Tranter, Rebecca ^a   Winter, Victoria J ^a   Sessions, Richard B ^a   Brady, Leo ^a   Vivas, Livia ^b   Easton, Anna ^b   Kendrick, Howard ^b   Croft, Simon L ^b   Barros, David ^c   Lavandera, Jose Luis ^c   Martin, José Julio ^c   Risco, Felix ^c   García Ochoa, Silvestre ^c   Gamo, Fracisco Javier ^c   Sanz, Laura ^c   Leon, Luisa ^c   Ruiz, Jose R ^c   Gabarró, Raquel ^c   Mallon, Araceli ^c   Gómez De Las Heras, Federico ^c   more..

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c GLAXOSMITHKLINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; ENZYME INHIBITION; FERMENTATION; MALARIA CONTROL; TOXICITY;

BIOAVAILABILITY; GLYCOLYSIS; HOMOLACTIC FERMENTATION; PARASITE LACTATE DEHYDROGENASE (LDH);

ENZYMES;

ANTIMALARIAL AGENT; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRROLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; ENERGY YIELD; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ERYTHROCYTE; FERMENTATION; GLYCOLYSIS; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; TOXICITY;

ANIMALS; ANTIMALARIALS; AZOLES; CATALYTIC DOMAIN; ENZYME INHIBITORS; HUMANS; L-LACTATE DEHYDROGENASE; MALARIA; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 3843112304     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402433200     Document Type: Article

References (35)

1. Lang-Unnasch, N., and Murphy, A. D. (1998) Annu. Rev. Microbiol. 52, 561-590
2. Scheibel, L. W., Adler, A., and Trager, W. (1979) Proc. Natl. Acad. Sci. U. S. A. 76, 5303-5307
3. Roth, E. F., Jr., Raventos-Suarez, C., Perkins, M., and Nagel, R. L. (1982) Biochem. Biophys. Res. Commun. 109, 355-362
4. Gomez, M. S., Piper, R. C., Hunsaker, L. A., Royer, R. E., Deck, L. M., Makler, M. T., and Vander Jagt, D. L. (1997) Mol. Biochem. Parasitol. 90, 235-246
5. Menting, J. G., Tilley, L., Deady, L. W., Ng, K., Simpson, R. J., Cowman, A. F., and Foley, M. (1997) Mol. Biochem. Parasitol. 88, 215-224
6. Ridley, R. G. (1997) Exp. Parasitol. 87, 293-304
7. Read, J. A., Winter, V. J., Eszes, C. M., Sessions, R. B., and Brady, R. L. (2001) Proteins 43, 175-185
8. Dunn, C. R., Banfield, M. J., Barker, J. J., Higham, C. W., Moreton, K. M., Turgut-Balik, D., Brady, R. L., and Holbrook, J. J. (1996) Nat. Struct. Biol. 3, 912-915
9. Makler, M. T., Ries, J. M., Williams, J. A., Bancroft, J. E., Piper, R. C., Gibbins, B. L., and Hinrichs, D. J. (1993) Am. J. Trop. Med. Hyg. 48, 739-741
10. Royer, R. E., Deck, L. M., Campos, N. M., Hunsaker, L. A., and Vander Jagt, D. L. (1986) J. Med. Chem. 29, 1799-1801
11. Deck, L. M., Royer, R. E., Chamblee, B. B., Hernandez, V. M., Malone, R. R., Torres, J. E., Hunsaker, L. A., Piper, R. C., Makler, M. T., and Vander Jagt, D. L. (1998) J. Med. Chem. 41, 3879-3887
12. Yu, Y., Deck, J. A., Hunsaker, L. A., Deck, L. M., Royer, R. E., Goldberg, E., and Vander Jagt, D. L. (2001) Biochem. Pharmacol. 62, 81-89
13. Dando, C., Schroeder, E. R., Hunsaker, L. A., Deck, L. M., Royer, R. E., Zhou, X., Parmley, S. F., and Vander Jagt, D. L. (2001) Mol. Biochem. Parasitol. 118, 23-32
14. Allain, C. C., Henson, C. P., Nadel, M. K., and Knoblesdorff, A. J. (1973) Clin. Chem. 19, 223-227
15. Wieland, H., Kitasato, Z., and Utzino, S. (1930) Liebigs Ann. Chem. 478, 43-54
16. Otwinowski, Z., and Minor, W. (1997) in Macromolecular Crystallography (Carter, J., C. W., and Sweet, R. M., eds) Part A, Vol. 276, pp. 307-326, Academic Press, New York
17. Collaborative Computational Project (1994) Acta Crystallogr. Sect. D. Biol. Crystallogr. 50, 760-763
18. Winter, V. J., Cameron, A., Tranter, R., Sessions, R. B., and Brady, R. L. (2004) Mo. Biochem. Parasitol. 131, 1-10
19. Kuzmic, P. (1996) Anal. Biochem. 237, 260-273
20. Barstow, D. A., Black, G. W., Sharman, A. F., Scawen, M. D., Atkinson, T., Li, S. S., Chia, W. N., Clarke, A. R., and Holbrook, J. J. (1990) Biochim. Biophys. Acta 1087, 73-79
21. Ponnudurai, T., Leeuwenberg, A. D., and Meuwissen, J. H. (1981) Trop. Geogr. Med. 33, 50-54
22. Trager, W., and Jensen, J. B. (1976) Science 193, 673-675
23. Desjardins, R. E., Canfield, C. J., Haynes, J. D., and Chulay, J. D. (1979) Antimicrob. Agents Chemother. 16, 710-718
24. Peters, W. (1975) Ann. Trop. Med. Parasitol. 69, 155-171
25. Palomino, J. C., and Portaels, F. (1999) Eur. J. Clin. Microbiol. Infect. Dis. 18, 380-383
26. Novoa, W. B., Winer, A. D., Glaid, A. J., and Schwert, G. W. (1959) J. Biol. Chem. 234, 1143-1148
27. Sessions, R. B., Dewar, V., Clarke, A. R., and Holbrook, J. J. (1997) Protein Eng. 10, 301-306
28. Vander Jagt, D. L., Caughey, W. S., Campos, N. M., Hunsaker, L. A., and Zanner, M. A. (1989) Prog. Clin. Biol. Res. 313, 105-118
29. Chapman, A. D., Cortes, A., Dafforn, T. R., Clarke, A. R., and Brady, R. L. (1999) J. Mol. Biol. 285, 703-712
30. Yuvaniyama, J., Chitnumsub, P., Kamchonwongpaisan, S., Vanichtanankul, J., Sirawaraporn, W., Taylor, P., Walkinshaw, M. D., and Yuthavong, Y. (2003) Nat. Struct. Biol. 10, 357-365
31. Perozzo, R., Kuo, M., Sidhu, A. B. S., Valiyaveettil, J. T., Bittman, R., Jacobs, W. R., Fidock, D. A., and Sacchettini, J. C. (2002) J. Biol. Chem. 277, 13106-13114
32. Hewitt, C. O., Eszes, C. M., Sessions, R. B., Moreton, K. M., Dafforn, T. R., Takei, J., Dempsey, C. E., Clarke, A. R., and Holbrook, J. J. (1999) Protein Eng. 12, 491-496
33. Eszes, C. M., Sessions, R. B., Clarke, A. R., Moreton, K. M., and Holbrook, J. J. (1996) FEBS Lett. 399, 193-197
34. Wilks, H. M., Hart, K. W., Feeney, R., Dunn, C. R., Muirhead, H., Chia, W. N., Barstow, D. A., Atkinson, T., Clarke, A. R., and Holbrook, J. J. (1988) Science 242, 1541-1544
35. Gardner, M. J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R. W., Carlton, J. M., Pain, A., Nelson, K. E., Bowman, S., Paulsen, I. T., James, K., Eisen, J. A., Rutherford, K., Salzberg, S. L., Craig, A., Kyes, S., Chan, M. S., Nene, V., Shallom, S. J., Suh, B., Peterson, J., Angiuoli, S., Pertea, M., Allen, J., Selengut, J., Haft, D., Mather, M. W., Vaidya, A. B., Martin, D. M., Fairlamb, A. H., Fraunholz, M. J., Roos, D. S., Ralph, S. A., McFadden, G. I., Cummings, L. M., Subramanian, G. M., Mungall, C., Venter, J. C., Carucci, D. J., Hoffman, S. L., Newbold, C., Davis, R. W., Fraser, C. M., and Barrell, B. (2002) Nature 419, 498-511