Utility of protein structures in overcoming ADMET-related issues of drug-like compounds

Drug Discovery Today

Volumn 16, Issue 11-12, 2011, Pages 530-538

  Stoll, Friederike ^a   Göller, Andreas H ^a   Hillisch, Alexander ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; GLYCOPROTEIN P; HUMAN SERUM ALBUMIN; POTASSIUM CHANNEL HERG; PREGNANE X RECEPTOR;

DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; HUMAN; NONHUMAN; PROTEIN STRUCTURE; QUANTITATIVE STRUCTURE PROPERTY RELATION; REVIEW;

ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; DRUG DISCOVERY; HUMANS; LIGANDS; MODELS, MOLECULAR; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS;

EID: 79958186689     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2011.04.008     Document Type: Review

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