Chemical probes for biological systems

Drug Discovery Today

Volumn 16, Issue 3-4, 2011, Pages 99-106

  Garcia Serna, Ricard ^a   Mestres, Jordi ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; CIPRALISANT; CYPROHEPTADINE; DOPAMINE 2 RECEPTOR; ESCITALOPRAM; G PROTEIN COUPLED RECEPTOR; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; IMPROMIDINE; N METHYLHISTAMINE; NORADRENALIN TRANSPORTER; NORTRIPTYLINE; SEROTONIN 2A RECEPTOR; SEROTONIN TRANSPORTER; TIOTIDINE; TRIFLUPROMAZINE;

AFFINITY CHROMATOGRAPHY; BINDING AFFINITY; CHEMICAL PROBE; CHEMOMETRIC ANALYSIS; DRUG TARGETING; MOLECULAR PROBE; NATIONAL HEALTH ORGANIZATION; NUCLEIC ACID PROBE; PROCESS OPTIMIZATION; REVIEW;

EID: 79851508479     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2010.11.004     Document Type: Short Survey

References (25)

1. S.L. Schreiber Small molecules: the missing link in the central dogma Nat. Chem. Biol. 1 2005 64 66
2. M.F. Hibert French/European academic compound library initiative Drug Discov. Today 14 2009 723 725
3. C.P. Austin NIH molecular libraries initiative Science 306 2004 1138 1139 (Pubitemid 39488980)
4. J. Kaiser Industrial-style screening meets academic biology Science 321 2008 764 766
5. T.I. Oprea A crowdsourcing evaluation of the NIH chemical probes Nat. Chem. Biol. 5 2009 441 447
6. Y. Wang An overview of the PubChem BioAssay resource Nucleic Acids Res. 38 2010 D255 D266
7. J. Mestres Data completeness: the Achilles heel of drug-target networks Nat. Biotechnol. 26 2008 983 984
8. B.L. Roth Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia Nat. Rev. Drug Discov. 3 2004 353 359 (Pubitemid 38499762)
9. R. Morphy From magic bullets to designed multiple ligands Drug Discov. Today 9 2004 641 651 (Pubitemid 38981718)
10. A.L. Hopkins Can we rationally design promiscuous drugs? Curr. Opin. Struct. Biol. 16 2006 127 136 (Pubitemid 43221881)
11. A. Cavalli Multi-target-directed ligands to combat neurodegenerative diseases J. Med. Chem. 51 2008 347 372 (Pubitemid 351252260)
12. A.L. Hopkins Network pharmacology: the next paradigm in drug discovery Nat. Chem. Biol. 4 2008 682 690
13. N.H. Jensen, and B.L. Roth Massively parallel screening of the receptorome Comb. Chem. High Throughput Screen. 11 2008 420 427
14. T. Liu BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities Nucleic Acids Res. 35 2007 D198 D201 http://www.bindingdb.org
15. A.J. Harmar IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels Nucleic Acids Res. 37 2009 D680 D685 http://www.iuphar-db.org
16. S.J. Hill International Union of Pharmacology. XIII. Classification of histamine receptors Pharmacol. Rev. 49 1997 253 278 (Pubitemid 27414915)
17. R.L. Thurmond A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties J. Pharmacol. Exp. Ther. 309 2004 404 413 (Pubitemid 38393154)
18. F.M. Areias In silico directed chemical probing of the adenosine receptor family Bioorg. Med. Chem. 18 2010 3043 3052
19. S. Ekins In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling Br. J. Pharmacol. 152 2007 9 20 (Pubitemid 47339896)
20. J. Bajorath Computational analysis of ligand relationships within target families Curr. Opin. Chem. Biol. 12 2008 352 358
21. D. Rognan Structure-based approaches to target fishing and ligand profiling Mol. Inform. 29 2010 176 187
22. H. Kitano A robustness-based approach to systems-oriented drug design Nat. Rev. Drug Discov. 6 2007 202 210 (Pubitemid 46344624)
23. T. Kodadek Rethinking screening Nat. Chem. Biol. 6 2010 162 165
24. P. Workman, and I. Collins Probing the probes: fitness factors for small molecule tools Chem. Biol. 17 2010 561 577
25. S.V. Frye The art of the chemical probe Nat. Chem. Biol. 6 2010 159 161