Determinants of Food Allergy

Immunology and Allergy Clinics of North America

Volumn 32, Issue 1, 2012, Pages 11-33

  Masilamani, Madhan ^a   Commins, Scott ^b   Shreffler, Wayne ^c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Allergen; Alpha gal; Animal food allergens; Cross reactive carbohydrate determinants; Food allergy; Peanut; Plant food allergens; Soy

Indexed keywords

CARBOHYDRATE DERIVATIVE; FOOD ALLERGEN; GALACTOSYLGALACTOSE; IMMUNOGLOBULIN E ANTIBODY; PROFILIN; VEGETABLE PROTEIN;

ALLERGENICITY; ALLERGY; ANTIBODY DETECTION; ANTIGEN STRUCTURE; CARBOHYDRATE ANALYSIS; CLINICAL FEATURE; CROSS REACTION; FOOD ALLERGY; HUMAN; IMMUNE RESPONSE; IMMUNOSTIMULATION; NONHUMAN; PEANUT ALLERGY; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW; SOY ALLERGY; STRUCTURE ANALYSIS; TICK BITE;

ALLERGENS; FOOD HYPERSENSITIVITY; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN E; MEAT; PEANUT HYPERSENSITIVITY; PLANTS; SOY FOODS;

EID: 84855842627     PISSN: 08898561     EISSN: 15578607     Source Type: Journal    
DOI: 10.1016/j.iac.2011.12.003     Document Type: Review

References (134)

1. Radauer C., Bublin M., Wagner S., et al. Allergens are distributed into few protein families and possess a restricted number of biochemical functions. JAllergy Clin Immunol 2008, 121(4):847-852. e7.
2. Aalberse R.C., Stadler B.M. In silico predictability of allergenicity: from amino acid sequence via 3-D structure to allergenicity. Mol Nutr Food Res 2006, 50(7):625-627.
3. Aalberse R.C. Structural biology of allergens. JAllergy Clin Immunol 2000, 106(2):228-238.
4. Astwood J.D., Leach J.N., Fuchs R.L. Stability of food allergens to digestion invitro. Nat Biotechnol 1996, 14(10):1269-1273.
5. Bannon G.A. What makes a food protein an allergen?. Curr Allergy Asthma Rep 2004, 4(1):43-46.
6. Fu T., Abbott U.R., Hatzos C. Digestibility of food allergens and nonallergenic proteins in simulated gastric fluid and simulated intestinal fluid-a comparative study. JAgric Food Chem 2002, 50(24):7154-7160.
7. Herman R.A., Woolhiser M.M., Ladics G.S., et al. Stability of a set of allergens and non-allergens in simulated gastric fluid. Int J Food Sci Nutr 2007, 58(2):125-141.
8. Pedrosa C., Felice F.G., Trisciuzzi C., et al. Selective neoglycosylation increases the structural stability of vicilin, the 7S storage globulin from pea seeds. Arch Biochem Biophys 2000, 382(2):203-210.
9. Wormald M.R., Dwek R.A. Glycoproteins: glycan presentation and protein-fold stability. Structure 1999, 7(7):R155-R160.
10. Bencúrová M., Hemmer W., Focke-Tejkl M., et al. Specificity of IgG and IgE antibodies against plant and insect glycoprotein glycans determined with artificial glycoforms of human transferrin. Glycobiology 2004, 14(5):457-466.
11. Altmann F. The role of protein glycosylation in allergy. Int Arch Allergy Immunol 2007, 142(2):99-115.
12. Faveeuw C., Mallevaey T., Paschinger K., et al. Schistosome N-glycans containing core α3-fucose and core β2-xylose epitopes are strong inducers of Th2 responses in mice. Eur J Immunol 2003, 33(5):1271-1281.
13. Wilson I.B., Zeleny R., Kolarich D., et al. Analysis of Asn-linked glycans from vegetable foodstuffs: widespread occurrence of Lewis a, core alpha1,3-linked fucose and xylose substitutions. Glycobiology 2001, 11(4):261-274.
14. Mills E.N., Jenkins J.A., Alcocer M.J.C., et al. Structural, biological, and evolutionary relationships of plant food allergens sensitizing via the gastrointestinal tract. Crit Rev Food Sci Nutr 2004, 44(5):379-407.
15. Considine T., Patel H.A., Singh H., et al. Influence of binding of sodium dodecyl sulfate, all-trans-retinol, palmitate, and 8-anilino-1-naphthalenesulfonate on the heat-induced unfolding and aggregation of beta-lactoglobulin B. JAgric Food Chem 2005, 53(8):3197-3205.
16. Roth-Walter F., Berin M.C., Arnaboldi P., et al. Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer's patches. Allergy 2008, 63(7):882-890.
17. Breiteneder H., Mills E.N. Molecular properties of food allergens. JAllergy Clin Immunol 2005, 115(1):14-23. [quiz: 24].
18. Barrett N.A., Rahman O.M., Fernandez J.M., et al. Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. JExp Med 2011, 208(3):593-604.
19. Royer P., Emara M., Yang C., et al. The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity. JImmunol 2010, 185(3):1522-1531.
20. Zhou Y., Kawasaki H., Hsu S., et al. Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1. Nat Med 2010, 16(10):1128-1133.
21. Reed C.E., Kita H. The role of protease activation of inflammation in allergic respiratory diseases. JAllergy Clin Immunol 2004, 114(5):997-1008. [quiz: 1009].
22. Trompette A., Divanovic S., Visintin A., et al. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2009, 457(7229):585-588.
23. Mills E., Madsen C., Shewry P. Food allergens of plant origin-their molecular and evolutionary relationships. Trends in Food Science and Technology 2003, (14):145-156.
24. Jenkins J.A., Breiteneder H., Mills E.N. Evolutionary distance from human homologs reflects allergenicity of animal food proteins. JAllergy Clin Immunol 2007, 120(6):1399-1405.
25. Hoffmann-Sommergruber K., Mills E.N. Food allergen protein families and their structural characteristics and application in component-resolved diagnosis: new data from the EuroPrevall project. Anal Bioanal Chem 2009, 395(1):25-35.
26. Dunwell J.M., Purvis A., Khuri S. Cupins: the most functionally diverse protein superfamily?. Phytochemistry 2004, 65(1):7-17.
27. Witke W. The role of profilin complexes in cell motility and other cellular processes. Trends Cell Biol 2004, 14(8):461-469.
28. Radauer C., Willerroider M., Fuchs H., et al. Cross-reactive and species-specific immunoglobulin E epitopes of plant profilins: an experimental and structure-based analysis. Clin Exp Allergy 2006, 36(7):920-929.
29. Ballmer-Weber B.K., Wangorsch A., Bohle B., et al. Component-resolved invitro diagnosis in carrot allergy: does the use of recombinant carrot allergens improve the reliability of the diagnostic procedure?. Clin Exp Allergy 2005, 35(7):970-978.
30. Lüttkopf D., Ballmer-Weber B.K., Wüthrich B., et al. Celery allergens in patients with positive double-blind placebo-controlled food challenge. JAllergy Clin Immunol 2000, 106(2):390-399.
31. Marković-Housley Z., Degano M., Lamba D., et al. Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v. 1 and its likely biological function as a plant steroid carrier. JMol Biol 2003, 325(1):123-133.
32. Spitzauer S. Allergy to mammalian proteins: at the borderline between foreign and self?. Int Arch Allergy Immunol 1999, 120(4):259-269.
33. Kanduc D., Lucchese A., Mittelman A. Individuation of monoclonal anti-HPV16 E7 antibody linear peptide epitope by computational biology. Peptides 2001, 22(12):1981-1985.
34. Ayuso R., Lehrer S.B., Tanaka L., et al. IgE antibody response to vertebrate meat proteins including tropomyosin. Ann Allergy Asthma Immunol 1999, 83(5):399-405.
35. Wild L.G., Lehrer S.B. Fish and shellfish allergy. Curr Allergy Asthma Rep 2005, 5(1):74-79.
36. Restani P., Beretta B., Fiocchi A., et al. Cross-reactivity between mammalian proteins. Ann Allergy Asthma Immunol 2002, 89(6 Suppl 1):11-15.
37. Fiocchi A., Restani P., Riva E., et al. Meat allergy: I-Specific IgE to BSA and OSA in atopic, beef sensitive children. JAm Coll Nutr 1995, 14(3):239-244.
38. Werfel S.J., Cooke S.K., Sampson H.A. Clinical reactivity to beef in children allergic to cow's milk. JAllergy Clin Immunol 1997, 99(3):293-300.
39. Liu A.H., Jaramillo R., Sicherer S.H., et al. National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006. JAllergy Clin Immunol 2010, 126(4):798-806. e13.
40. Sicherer S.H. Epidemiology of food allergy. JAllergy Clin Immunol 2011, 127(3):594-602.
41. Nicolaou N., Poorafshar M., Murray C., et al. Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. JAllergy Clin Immunol 2010, 125(1):191-197. e1-13.
42. Shreffler W.G., Castro R.R., Kucuk Z.Y., et al. The major glycoprotein allergen fromArachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant invitro. JImmunol 2006, 177(6):3677-3685.
43. Ilchmann A., Burgdorf S., Scheurer S., et al. Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II. JAllergy Clin Immunol 2010, 125(1):175-183. e1-11.
44. Hilmenyuk T., Bellinghausen I., Heydenreich B., et al. Effects of glycation of the model food allergen ovalbumin on antigen uptake and presentation by human dendritic cells. Immunology 2010, 129(3):437-445.
45. Hsu S., Tsai T., Kawasaki H., et al. Antigen coupled with Lewis-x trisaccharides elicits potent immune responses in mice. JAllergy Clin Immunol 2007, 119(6):1522-1528.
46. Khodoun M., Strait R., Orekov T., et al. Peanuts can contribute to anaphylactic shock by activating complement. JAllergy Clin Immunol 2009, 123(2):342-351.
47. Carroll M.C. The complement system in regulation of adaptive immunity. Nat Immunol 2004, 5(10):981-986.
48. Hawlisch H., Belkaid Y., Baelder R., et al. C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity 2005, 22(4):415-426.
49. Drouin S.M., Corry D.B., Hollman T.J., et al. Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. JImmunol 2002, 169(10):5926-5933.
50. Becker W., Brasseur D. Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission relating to the evaluation of allergenic foods for labeling purposes. The EFSA Journal 2004, 32:1-197.
51. Zuidmeer L., Goldhahn K., Rona R.J., et al. The prevalence of plant food allergies: a systematic review. JAllergy Clin Immunol 2008, 121(5):1210-1218. e4.
52. Savage J.H., Kaeding A.J., Matsui E.C., et al. The natural history of soy allergy. JAllergy Clin Immunol 2010, 125(3):683-686.
53. Kattan J.D., Cocco R.R., Järvinen K.M. Milk and soy allergy. Pediatr Clin North Am 2011, 58(2):407-426. x.
54. Sicherer S.H., Sampson H.A. Food allergy: recent advances in pathophysiology and treatment. Annu Rev Med 2009, 60:261-277.
55. Bruno G., Giampietro P.G., Guercio M.J.D., et al. Soy allergy is not common in atopic children: a multicenter study. Pediatr Allergy Immunol 1997, 8(4):190-193.
56. Mittag D., Vieths S., Vogel L., et al. Soybean allergy in patients allergic to birch pollen: clinical investigation and molecular characterization of allergens. JAllergy Clin Immunol 2004, 113(1):148-154.
57. Magnolfi C.F., Zani G., Lacava L., et al. Soy allergy in atopic children. Ann Allergy Asthma Immunol 1996, 77(3):197-201.
58. Bhatia J., Greer F., American Academy of Pediatrics Committee on Nutrition Use of soy protein-based formulas in infant feeding. Pediatrics 2008, 121(5):1062-1068.
59. Klemola T., Vanto T., Juntunen-Backman K., et al. Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow's milk allergy: a prospective, randomized study with a follow-up to the age of 2 years. JPediatr 2002, 140(2):219-224.
60. Zeiger R.S., Sampson H.A., Bock S.A., et al. Soy allergy in infants and children with IgE-associated cow's milk allergy. JPediatr 1999, 134(5):614-622.
61. David T.J. Anaphylactic shock during elimination diets for severe atopic eczema. Arch Dis Child 1984, 59(10):983-986.
62. Awazuhara H., Kawai H., Maruchi N. Major allergens in soybean and clinical significance of IgG4 antibodies investigated by IgE- and IgG4-immunoblotting with sera from soybean-sensitive patients. Clin Exp Allergy 1997, 27(3):325-332.
63. Shibasaki M., Suzuki S., Tajima S., et al. Allergenicity of major component proteins of soybean. Int Arch Allergy Appl Immunol 1980, 61(4):441-448.
64. Holzhauser T., Wackermann O., Ballmer-Weber B.K., et al. Soybean (glycine max) allergy in Europe: Gly m 5 (beta-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy. JAllergy Clin Immunol 2009, 123(2):452-458.
65. L'Hocine L., Boye J.I. Allergenicity of soybean: new developments in identification of allergenic proteins, cross-reactivities and hypoallergenization technologies. Crit Rev Food Sci Nutr 2007, 47(2):127-143.
66. González R., Polo F., Zapatero L., et al. Purification and characterization of major inhalant allergens from soybean hulls. Clin Exp Allergy 1992, 22(8):748-755.
67. Kalinski A., Weisemann J.M., Matthews B.F., et al. Molecular cloning of a protein associated with soybean seed oil bodies that is similar to thiol proteases of the papain family. JBiol Chem 1990, 265(23):13843-13848.
68. Kalinski A., Melroy D.L., Dwivedi R.S., et al. Asoybean vacuolar protein (P34) related to thiol proteases is synthesized as a glycoprotein precursor during seed maturation. JBiol Chem 1992, 267(17):12068-12076.
69. Rihs H.P., Chen Z., Ruëff F., et al. IgE binding of the recombinant allergen soybean profilin (rGly m 3) is mediated by conformational epitopes. JAllergy Clin Immunol 1999, 104(6):1293-1301.
70. van Zuuren E.J., Terreehorst I., Tupker R.A., et al. Anaphylaxis after consuming soy products in patients with birch pollinosis. Allergy 2010, 65(10):1348-1349.
71. Kleine-Tebbe J., Vogel L., Crowell D.N., et al. Severe oral allergy syndrome and anaphylactic reactions caused by a Bet v. 1- related PR-10 protein in soybean, SAM22. JAllergy Clin Immunol 2002, 110(5):797-804.
72. Vissers Y.M., Jansen A.P., Ruinemans-Koerts J., et al. IgE component-resolved allergen profile and clinical symptoms in soy and peanut allergic patients. Allergy 2011, 66(8):1125-1127.
73. Breiteneder H., Mills E.N. Plant food allergens-structural and functional aspects of allergenicity. Biotechnol Adv 2005, 23(6):395-399.
74. Burks A.W., Williams L.W., Helm R.M., et al. Identification of soy protein allergens in patients with atopic dermatitis and positive soy challenges; determination of change in allergenicity after heating or enzyme digestion. Adv Exp Med Biol 1991, 289:295-307.
75. Burks A.W., Cockrell G., Connaughton C., et al. Identification of peanut agglutinin and soybean trypsin inhibitor as minor legume allergens. Int Arch Allergy Immunol 1994, 105(2):143-149.
76. Ogawa T., Bando N., Tsuji H., et al. Alpha-subunit of beta-conglycinin, an allergenic protein recognized by IgE antibodies of soybean-sensitive patients with atopic dermatitis. Biosci Biotechnol Biochem 1995, 59(5):831-833.
77. Beardslee T.A., Zeece M.G., Sarath G., et al. Soybean glycinin G1 acidic chain shares IgE epitopes with peanut allergen Ara h 3. Int Arch Allergy Immunol 2000, 123(4):299-307.
78. L'Hocine L., Boye J.I., Jouve S. Ionic strength and pH-induced changes in the immunoreactivity of purified soybean glycinin and its relation to protein molecular structure. JAgric Food Chem 2007, 55(14):5819-5826.
79. Piacentini G.L., Benedetti M., Spezia E., et al. Anaphylactic sensitizing power of selected infant formulas. Ann Allergy 1991, 67(4):400-402.
80. Osterballe M., Mortz C.G., Hansen T.K., et al. The prevalence of food hypersensitivity in young adults. Pediatr Allergy Immunol 2009, 20(7):686-692.
81. Rozenfeld P., Docena G.H., Añón M.C., et al. Detection and identification of a soy protein component that cross-reacts with caseins from cow's milk. Clin Exp Immunol 2002, 130(1):49-58.
82. Chruszcz M., Maleki S.J., Majorek K.A., et al. Structural and immunologic characterization of Ara h 1, a major peanut allergen. JBiol Chem 2011, 286(45):39318-39327.
83. Sicherer S.H., Sampson H.A., Burks A.W. Peanut and soy allergy: a clinical and therapeutic dilemma. Allergy 2000, 55(6):515-521.
84. Foucard T., Yman I.M. Astudy on severe food reactions in Sweden-is soy protein an underestimated cause of food anaphylaxis?. Allergy 1999, 54(3):261-265.
85. Yunginger J.W., Nelson D.R., Squillace D.L., et al. Laboratory investigation of deaths due to anaphylaxis. JForensic Sci 1991, 36(3):857-865.
86. Ballmer-Weber B.K., Holzhauser T., Scibilia J., et al. Clinical characteristics of soybean allergy in Europe: a double-blind, placebo-controlled food challenge study. JAllergy Clin Immunol 2007, 119(6):1489-1496.
87. Pons L., Ponnappan U., Hall R.A., et al. Soy immunotherapy for peanut-allergic mice: modulation of the peanut-allergic response. JAllergy Clin Immunol 2004, 114(4):915-921.
88. Bindslev-Jensen C., Briggs D., Osterballe M. Can we determine a threshold level for allergenic foods by statistical analysis of published data in the literature?. Allergy 2002, 57(8):741-746.
89. Cordle C.T. Soy protein allergy: incidence and relative severity. JNutr 2004, 134(5):1213S-1219S.
90. Sicherer S.H., Morrow E.H., Sampson H.A. Dose-response in double-blind, placebo-controlled oral food challenges in children with atopic dermatitis. JAllergy Clin Immunol 2000, 105(3):582-586.
91. Amigo-Benavent M., Athanasopoulos V. Carbohydrate moieties on the invitro immunoreactivity of soy [beta]-conglycinin. Food Research International 2009, 42(7):819-825.
92. Bando N., Tsuji H., Yamanishi R., et al. Identification of the glycosylation site of a major soybean allergen, Gly m Bd 30K. Biosci Biotechnol Biochem 1996, 60(2):347-348.
93. Kroghsbo S., Bøgh K.L., Rigby N.M., et al. Sensitization with 7S globulins from peanut, hazelnut, soy or pea induces IgE with different biological activities which are modified by soy tolerance. Int Arch Allergy Immunol 2011, 155(3):212-224.
94. Müller U., Weber W., Hoffmann A., et al. Zschr für Lebensmittel-Untersuchung und -Forschung A 1998, 207:341-351.
95. Tsumura K., Kugimiya W., Bando N. Preparation of hypoallergenic soybean protein with processing functionality by selective enzymatic hydrolysis. Food Sci Tech Res 1999, 5(2):171-175.
96. Tsuji H., Okada N., Yamanishi R. Fate of a major soybean allergen, Gly m Bd 30K, in rice-, barley-and soybean-koji miso (fermented soybean paste) during fermentation. Food Sci Tech Res 1997, 3(2):145-149.
97. Kang J., Badger T.M., Ronis M.J., et al. Non-isoflavone phytochemicals in soy and their health effects. JAgric Food Chem 2010, 58(14):8119-8133.
98. Masilamani M., Wei J., Bhatt S., et al. Soybean isoflavones regulate dendritic cell function and suppress allergic sensitization to peanut. JAllergy Clin Immunol 2011, 128(6):1242-1250.
99. Messina M. Abrief historical overview of the past two decades of soy and isoflavone research. JNutr 2010, 140(7):1350S-1354S.
100. Kay A.B. Allergy and allergic diseases. Second of two parts. NEngl J Med 2001, 344(2):109-113.
101. Kay A.B. Allergy and allergic diseases. First of two parts. NEngl J Med 2001, 344(1):30-37.
102. Sampson H.A. Food allergy. Part 2: diagnosis and management. JAllergy Clin Immunol 1999, 103(6):981-989.
103. Sampson H.A. Food allergy. Part 1: immunopathogenesis and clinical disorders. JAllergy Clin Immunol 1999, 103(5 Pt 1):717-728.
104. Aalberse R.C., Koshte V., Clemens J.G. Immunoglobulin E antibodies that cross-react with vegetable foods, pollen, and Hymenoptera venom. JAllergy Clin Immunol 1981, 68(5):356-364.
105. Kochuyt A., Hoeyveld E.M., Stevens E.A. Prevalence and clinical relevance of specific immunoglobulin E to pollen caused by sting- induced specific immunoglobulin E to cross-reacting carbohydrate determinants in Hymenoptera venoms. Clin Exp Allergy 2005, 35(4):441-447.
106. van der Veen M.J., van Ree R., Aalberse R.C., et al. Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins. JAllergy Clin Immunol 1997, 100(3):327-334.
107. Ishihara H., Takahashi N., Oguri S., et al. Complete structure of the carbohydrate moiety of stem bromelain. An application of the almond glycopeptidase for structural studies of glycopeptides. JBiol Chem 1979, 254(21):10715-10719.
108. Bouwstra J.B., Spoelstra E.C., Waard P.D., et al. Conformational studies on the N-linked carbohydrate chain of bromelain. Eur J Biochem 1990, 190(1):113-122.
109. Wilson I.B., Altmann F. Structural analysis of N-glycans from allergenic grass, ragweed and tree pollens: core alpha1,3-linked fucose and xylose present in all pollens examined. Glycoconj J 1998, 15(11):1055-1070.
110. Weber A., Schröder H., Thalberg K., et al. Specific interaction of IgE antibodies with a carbohydrate epitope of honey bee venom phospholipase A2. Allergy 1987, 42(6):464-470.
111. Tretter V., Altmann F., Kubelka V., et al. Fucose alpha 1,3-linked to the core region of glycoprotein N-glycans creates an important epitope for IgE from honeybee venom allergic individuals. Int Arch Allergy Immunol 1993, 102(3):259-266.
112. Aalberse R.C., van Ree R. Cross-reactive carbohydrate determinants. Clin Rev Allergy Immunol 1997, 15(4):375-387.
113. Mari A. IgE to cross-reactive carbohydrate determinants: analysis of the distribution and appraisal of the invivo and invitro reactivity. Int Arch Allergy Immunol 2002, 129(4):286-295.
114. Commins S.P., Platts-Mills T.A. Anaphylaxis syndromes related to a new mammalian cross-reactive carbohydrate determinant. JAllergy Clin Immunol 2009, 124(4):652-657.
115. Foetisch K., Westphal S., Lauer I., et al. Biological activity of IgE specific for cross-reactive carbohydrate determinants. JAllergy Clin Immunol 2003, 111(4):889-896.
116. Fötisch K., Altmann F., Haustein D., et al. Involvement of carbohydrate epitopes in the IgE response of celery-allergic patients. Int Arch Allergy Immunol 1999, 120(1):30-42.
117. Iacovacci P., Afferni C., Butteroni C., et al. Comparison between the native glycosylated and the recombinant Cup a1 allergen: role of carbohydrates in the histamine release from basophils. Clin Exp Allergy 2002, 32(11):1620-1627.
118. van Ree R., Aalberse R.C. Specific IgE without clinical allergy. JAllergy Clin Immunol 1999, 103(6):1000-1001.
119. Lommerse J.P., Kroon-Batenburg L.M., Kamerling J.P., et al. Conformational analysis of the xylose-containing N-glycan of pineapple stem bromelain as part of the intact glycoprotein. Biochemistry 1995, 34(25):8196-8206.
120. Galili U. The alpha-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy. Immunol Cell Biol 2005, 83(6):674-686.
121. Jin C., Hantusch B., Hemmer W., et al. Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins. JAllergy Clin Immunol 2008, 121(1):185-190. e2.
122. Chung C.H., Mirakhur B., Chan E., et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. NEngl J Med 2008, 358(11):1109-1117.
123. Commins S.P., Satinover S.M., Hosen J., et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. JAllergy Clin Immunol 2009, 123(2):426-433.
124. Macher B.A., Galili U. The Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: a carbohydrate of unique evolution and clinical relevance. Biochim Biophys Acta 2008, 1780(2):75-88.
125. Spiro R.G., Bhoyroo V.D. Occurrence of alpha-D-galactosyl residues in the thyroglobulins from several species. Localization in the saccharide chains of the complex carbohydrate units. JBiol Chem 1984, 259(15):9858-9866.
126. Paschinger K., Fabini G., Schuster D., et al. Definition of immunogenic carbohydrate epitopes. Acta Biochim Pol 2005, 52(3):629-632.
127. Galili U., Mandrell R.E., Hamadeh R.M., et al. Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human flora. Infect Immun 1988, 56(7):1730-1737.
128. Springer G.F., Horton R.E. Blood group isoantibody stimulation in man by feeding blood group-active bacteria. JClin Invest 1969, 48(7):1280-1291.
129. Koike C., Fung J.J., Geller D.A., et al. Molecular basis of evolutionary loss of the alpha 1,3-galactosyltransferase gene in higher primates. JBiol Chem 2002, 277(12):10114-10120.
130. Larsen R.D., Rivera-Marrero C.A., Ernst L.K., et al. Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA. JBiol Chem 1990, 265(12):7055-7061.
131. Adédoyin J., Johansson S.G., Grönlund H., et al. Interference in immunoassays by human IgM with specificity for the carbohydrate moiety of animal proteins. JImmunol Methods 2006, 310(1-2):117-125.
132. Grönlund H., Adédoyin J., Commins S.P., et al. The carbohydrate galactose-alpha-1,3-galactose is a major IgE-binding epitope on cat IgA. JAllergy Clin Immunol 2009, 123(5):1189-1191.
133. Wong KN, Wang X, Lee W, etal. Deglycosylation of meat extracts reduced the binding of cross-reactive antibodies to meat. XXV Congress of the European Academy of Allergology and Clinical Immunology. Vienna (Austria), June 10-14, 2006.
134. Commins S.P., James H.R., Kelly L.A., et al. The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. JAllergy Clin Immunol 2011, 127(5):1286-1293. e6.