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Volumn 457, Issue 7229, 2009, Pages 585-588

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

Author keywords

[No Author keywords available]

Indexed keywords

DER P 2 ALLERGEN; HOUSE DUST ALLERGEN; LIPOPOLYSACCHARIDE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

EID: 59049100417     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07548     Document Type: Article
Times cited : (642)

References (30)
  • 1
    • 0032968706 scopus 로고    scopus 로고
    • Immunologic basis of antigen-induced airway hyperresponsiveness
    • Wills-Karp, M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17, 255-281 (1999).
    • (1999) Annu. Rev. Immunol , vol.17 , pp. 255-281
    • Wills-Karp, M.1
  • 2
    • 34250813748 scopus 로고    scopus 로고
    • Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa
    • Ohto, U. et al. Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science 316, 1632-1634 (2007).
    • (2007) Science , vol.316 , pp. 1632-1634
    • Ohto, U.1
  • 3
    • 0036307905 scopus 로고    scopus 로고
    • The crystal structure of a major dust mite allergen Der p 2, and its biological implications
    • Derewenda, U. et al. The crystal structure of a major dust mite allergen Der p 2, and its biological implications. J. Mol. Biol. 318, 189-197 (2002).
    • (2002) J. Mol. Biol , vol.318 , pp. 189-197
    • Derewenda, U.1
  • 4
    • 34548222514 scopus 로고    scopus 로고
    • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran
    • Kim, H. M. et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran. Cell 130, 906-917 (2007).
    • (2007) Cell , vol.130 , pp. 906-917
    • Kim, H.M.1
  • 5
    • 27144432361 scopus 로고    scopus 로고
    • Structural biology of allergens
    • Thomas, W. R. et al. Structural biology of allergens. Curr. Allergy Asthma Rep. 5, 388-393 (2005).
    • (2005) Curr. Allergy Asthma Rep , vol.5 , pp. 388-393
    • Thomas, W.R.1
  • 6
    • 39449133957 scopus 로고    scopus 로고
    • Amechanism for the initiation of allergen-induced T helper type 2 responses
    • Sokol, C. L. et al. Amechanism for the initiation of allergen-induced T helper type 2 responses. Nature Immunol. 9, 310-318 (2008).
    • (2008) Nature Immunol , vol.9 , pp. 310-318
    • Sokol, C.L.1
  • 7
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki, A. & Medzhitov, R. Toll-like receptor control of the adaptive immune responses. Nature Immunol. 5, 987-995 (2004).
    • (2004) Nature Immunol , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 8
    • 13944260898 scopus 로고    scopus 로고
    • + T cell populations lacking helper function. Nature Immunol. 6, 163-170 (2005).
    • + T cell populations lacking helper function. Nature Immunol. 6, 163-170 (2005).
  • 9
    • 33645734929 scopus 로고    scopus 로고
    • Toll dependent selection of microbial antigens for presentation by dendritic cells
    • Blander, J. M. & Medzhitov, R. Toll dependent selection of microbial antigens for presentation by dendritic cells. Nature 440, 808-812 (2006).
    • (2006) Nature , vol.440 , pp. 808-812
    • Blander, J.M.1    Medzhitov, R.2
  • 10
    • 0014417112 scopus 로고
    • Mites and house-dust allergy in bronchial asthma
    • Maunsell, K. et al. Mites and house-dust allergy in bronchial asthma. Lancet 291, 1267-1270 (1968).
    • (1968) Lancet , vol.291 , pp. 1267-1270
    • Maunsell, K.1
  • 11
    • 0033863960 scopus 로고    scopus 로고
    • Localization of a major allergen, Der p 2, in the gut and faecal pellets of Dermatophagoides pteronyssinus
    • Park, G. M. et al. Localization of a major allergen, Der p 2, in the gut and faecal pellets of Dermatophagoides pteronyssinus. Clin. Exp. Allergy 30, 1293-1297 (2000).
    • (2000) Clin. Exp. Allergy , vol.30 , pp. 1293-1297
    • Park, G.M.1
  • 12
    • 0024382841 scopus 로고
    • Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp)
    • Heymann, P. W. et al. Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp). J. Allergy Clin. Immunol. 83, 1055-1067 (1989).
    • (1989) J. Allergy Clin. Immunol , vol.83 , pp. 1055-1067
    • Heymann, P.W.1
  • 13
    • 0036558018 scopus 로고    scopus 로고
    • Inohara, N. & Nunez, G. ML - a conserved domain involved in innate immunity and lipid metabolism. Trends Biochem. Sci. 27, 219-221 (2002).
    • Inohara, N. & Nunez, G. ML - a conserved domain involved in innate immunity and lipid metabolism. Trends Biochem. Sci. 27, 219-221 (2002).
  • 14
    • 3142546368 scopus 로고    scopus 로고
    • Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition
    • Gruber, A. et al. Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition. J. Biol. Chem. 279, 28475-28482 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 28475-28482
    • Gruber, A.1
  • 15
    • 15444374455 scopus 로고    scopus 로고
    • The role of endotoxin and its receptors in allergic disease
    • Williams, L. K. et al. The role of endotoxin and its receptors in allergic disease. Ann. Allergy Asthma Immunol. 94, 323-332 (2005).
    • (2005) Ann. Allergy Asthma Immunol , vol.94 , pp. 323-332
    • Williams, L.K.1
  • 16
    • 20644450101 scopus 로고    scopus 로고
    • Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105
    • Divanovic, S. et al. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nature Immunol. 6, 571-578 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 571-578
    • Divanovic, S.1
  • 17
    • 0037220924 scopus 로고    scopus 로고
    • Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis
    • Kawasaki, K. et al. Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis. J. Immunol. 170, 413-420 (2003).
    • (2003) J. Immunol , vol.170 , pp. 413-420
    • Kawasaki, K.1
  • 18
    • 4544250809 scopus 로고    scopus 로고
    • A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4
    • Kennedy, M. N. et al. A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4. J. Biol. Chem. 279, 34698-34704 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 34698-34704
    • Kennedy, M.N.1
  • 19
    • 1642529500 scopus 로고    scopus 로고
    • Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations
    • Gioannini, T. L. et al. Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations. Proc. Natl Acad. Sci. USA 101, 4186-4191 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 4186-4191
    • Gioannini, T.L.1
  • 20
    • 0037136585 scopus 로고    scopus 로고
    • Environmental exposure to endotoxin and its relation to asthma in school-age children
    • Braun-Fahrlander, C. et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N. Engl. J. Med. 347, 869-877 (2002).
    • (2002) N. Engl. J. Med , vol.347 , pp. 869-877
    • Braun-Fahrlander, C.1
  • 21
    • 0036800204 scopus 로고    scopus 로고
    • House dust endotoxin and allergic sensitization in children
    • Gehring, U. et al. House dust endotoxin and allergic sensitization in children. Am. J. Respir. Crit. Care Med. 166, 939-944 (2002).
    • (2002) Am. J. Respir. Crit. Care Med , vol.166 , pp. 939-944
    • Gehring, U.1
  • 22
    • 0035818268 scopus 로고    scopus 로고
    • Exposure to farming in early life and development of asthma and allergy: A cross-sectional survey
    • Riedler, J. et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 358, 1129-1133 (2001).
    • (2001) Lancet , vol.358 , pp. 1129-1133
    • Riedler, J.1
  • 23
    • 0035495857 scopus 로고    scopus 로고
    • The germless theory of allergic disease: Revisiting the hygiene hypothesis
    • Wills-Karp, M. et al. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nature Rev. Immunol. 1, 69-75 (2001).
    • (2001) Nature Rev. Immunol , vol.1 , pp. 69-75
    • Wills-Karp, M.1
  • 24
    • 0024542885 scopus 로고
    • Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects
    • Michel, O. et al. Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects. J. Appl. Physiol. 66, 1059-1064 (1989).
    • (1989) J. Appl. Physiol , vol.66 , pp. 1059-1064
    • Michel, O.1
  • 25
    • 0034069884 scopus 로고    scopus 로고
    • Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide
    • Tulic, M. K. et al. Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide. Am. J. Respir. Cell Mol. Biol. 22, 604-612 (2000).
    • (2000) Am. J. Respir. Cell Mol. Biol , vol.22 , pp. 604-612
    • Tulic, M.K.1
  • 26
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • Eisenbarth, S. C. et al. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196, 1645-1651 (2002).
    • (2002) J. Exp. Med , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1
  • 27
    • 0038387445 scopus 로고    scopus 로고
    • To respond or not to respond: T cells in allergic asthma
    • Herrick, C. A. & Bottomly, K. To respond or not to respond: T cells in allergic asthma. Nature Rev. Immunol. 3, 405-412 (2003).
    • (2003) Nature Rev. Immunol , vol.3 , pp. 405-412
    • Herrick, C.A.1    Bottomly, K.2
  • 28
    • 3242708716 scopus 로고    scopus 로고
    • Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2
    • Jia, H. P. et al. Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2. Am. J. Physiol. Lung Cell. Mol. Physiol. 287, L428-L437 (2004).
    • (2004) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.287
    • Jia, H.P.1
  • 29
    • 37549001771 scopus 로고    scopus 로고
    • Transfer of monomeric endotoxin from MD-2 to CD14: Characterization and functional consequences
    • Teghanemt, A. et al. Transfer of monomeric endotoxin from MD-2 to CD14: characterization and functional consequences. J. Biol. Chem. 282, 36250-36256 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 36250-36256
    • Teghanemt, A.1
  • 30
    • 0032545213 scopus 로고    scopus 로고
    • Interleukin-13: Central mediator of allergic asthma
    • Wills-Karp, M. et al. Interleukin-13: central mediator of allergic asthma. Science 282, 2258-2261 (1998).
    • (1998) Science , vol.282 , pp. 2258-2261
    • Wills-Karp, M.1


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