Iron, oxidative stress and the example of solar ultraviolet A radiation

Photochemical and Photobiological Sciences

Volumn 11, Issue 1, 2012, Pages 118-134

  Aroun, Asma ^a   Zhong, Julia Li ^a   Tyrrell, Rex M ^a   Pourzand, Charareh ^a  

^a University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84255160826     PISSN: 1474905X     EISSN: 14749092     Source Type: Journal    
DOI: 10.1039/c1pp05204g     Document Type: Review

References (180)

1. G. Cairo F. Bernuzzi S. Recalcati A precious metal: Iron, an essential nutrient for all cells Genes Nutr. 2006 1 25 39
2. N. T. Le D. R. Richardson The role of iron in cell cycle progression and the proliferation of neoplastic cells Biochim. Biophys. Acta 2002 1603 31 46 (Pubitemid 35257983)
3. D. R. Richardson P. Ponka The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells Biochim. Biophys. Acta 1997 1331 1 40 (Pubitemid 27168147)
4. O. Kakhlon Z. I. Cabantchik The labile iron pool: Characterization, measurement and participation in cellular processes Free Radical Biol. Med. 2002 33 1037 1046
5. B. Halliwell J. M. C. Gutteridge Biologically relevant metal ion-dependent hydroxyl radical generation: An update FEBS Lett. 1992 307 108 112
6. R. M. Tyrrell The molecular and cellular pathology of solar ultraviolet radiation Mol. Aspects Med. 1994 15 1 77 (Pubitemid 24164703)
7. R. M. Tyrrell Activation of mammalian gene expression by the UV component of sunlight-from models to reality BioEssays 1996 18 139 148
8. H. J. Danpure R. M. Tyrrell Oxygen dependence of near-UV (365 nm) lethality and the interaction of near-UV and X-rays in two mammalian cell lines Photochem. Photobiol. 1976 23 171 177
9. R. M. Tyrrell, in Oxidative Stress: Oxidants and Antioxidants, ed., H. Sies, Academic Press, London, 1991, pp 57-83
10. C. Beauchamp I. A. Fridovich A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase J. Biol. Chem. 1970 245 4641 4646
11. J. A. Badwey M. L. Karnovsky Active oxygen species and the functions of phagocytic leukocytes Annu. Rev. Biochem. 1980 49 695 726
12. A. Valencia I. E. Kochevar Nox1-based NADPH oxidase is the major source of UVA-induced reactive oxygen species in human keratinocytes J. Invest. Dermatol. 2007 128 214 222
13. R. M. Tyrrell M. Pidoux Correlation between endogenous glutathione content and sensitivity of cultured human skin cells to radiation at defined wavelengths in the solar UV range Photochem. Photobiol. 1988 47 405 412
14. C. Pourzand R. D. Watkin J. E. Brown R. M. Tyrrell Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: The role of ferritin Proc. Natl. Acad. Sci. U. S. A. 1999 96 6751 6756 (Pubitemid 29274955)
15. E. Kvam A. Noel S. Basu-Modak R. M. Tyrrell Cyclooxygenase dependent release of heme from microsomal hemeproteins correlates with induction of heme oxygenase 1 transcription in human fibroblasts Free Radical Biol. Med. 1999 26 511 517 (Pubitemid 29146253)
16. R. M. Tyrrell Solar ultraviolet A radiation: An oxidizing skin carcinogen that activates heme oxygenase-1 Antioxid. Redox Signal. 2004 6 835 840 (Pubitemid 39237936)
17. G. F. Vile R. M. Tyrrell UVA radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen Free Radical Biol. Med. 1995 18 721 730
18. R. M. Tyrrell V. E. Reeve Potential protection of skin by acute UVA irradiation-from cellular to animal models Prog. Biophys. Mol. Biol. 2006 92 86 91 (Pubitemid 43831965)
19. C. J. Bertling F. Lin A. W. Girotti Role of hydrogen peroxide in the cytotoxic effects of UVA/B radiation on mammalian cells Photochem. Photobiol. 1996 64 137 142
20. G. T. Wondrak M. K. Jacobson E. L. Jacobson Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection Photochem. Photobiol. Sci. 2006 5 215 237 (Pubitemid 43228050)
21. P. Morliere A. Moysan R. Santus G. Huppe J-C Maziere L. Ertret UVA-induced lipid peroxidation in cultured human fibroblasts Biochim. Biophys. Acta 1991 1084 261 268
22. K. Punnonen C. T. Jansen A. Puntala M. Ahotoupa Effects of ultraviolet A and B irradiation on lipid peroxidation and activity of the antioxidant enzymes in keratinocytes in culture J. Invest. Dermatol. 1991 96 255 259
23. J. Dissemond L. A. Schneider P. Brenneisen K. Briviba J. Wenk M. Wlaschek K. Scharfetter-Kochanek Protective and determining factors for the overall lipid peroxidation in ultraviolet A1-irradiated fibroblasts: in vitro and in vivo investigations Br. J. Dermatol. 2003 149 341 349 (Pubitemid 37100261)
24. S. D. Aust L. A. Morehouse C. E. Thomas Role of metals in oxygen radical reactions J. Free Radicals Biol. Med. 1985 1 3 25 (Pubitemid 16104818)
25. A. W. Girotti Photosensitized oxidation of membrane lipids: reaction pathways, cytotoxic effects, and cytoprotective mechanisms J. Photochem. Photobiol., B 2001 63 103 113 (Pubitemid 33040728)
26. O. Reelfs I. M. Eggleston C. Pourzand Skin protection against UVA-induced iron damage by multiantioxidants and iron chelating drugs/prodrug Curr. Drug Metab. 2010 11 242 249
27. C. Pourzand R. M. Tyrrell Apoptosis, the role of oxidative stress and the example of solar ultraviolet radiation Photochem. Photobiol. 1999 70 380 391
28. J. L. Zhong A. Yiakouvaki P. Holley R. M. Tyrrell C. Pourzand Susceptibility of skin cells to UVA-induced necrotic cell death reflects the intracellular level of labile iron J. Invest. Dermatol. 2004 123 771 780 (Pubitemid 39281620)
29. K. Scharfetter-Kochanek M. Wlaschek P. Brenneisen M. Scauen R. Blaudschun J. Wenk UV-induced reactive oxygen species in photocarcinogenesis and photoaging Biol. Chem. 1997 378 1247 1257 (Pubitemid 27507540)
30. M. Shayeghi G. O. Latunde-Dada J. S. Oakhill A. H. Laftah K. Takeuchi N. Halliday Y. Khan A. Warley F. E. McCann R. C. Hider D. M. Frazer G. J. Anderson C. D. Vulpe R. J. Simpson A. T. McKie Identification of an intestinal heme transporter Cell 2005 122 789 801 (Pubitemid 41242642)
31. N. C. Andrews Molecular control of iron metabolism Best Pract. Res. Clin. Haematol. 2005 18 159 169 (Pubitemid 40298362)
32. C. W. Trenam D. R. Blake C. J. Morris Skin inflammation: Reactive oxygen species and the role of iron J. Invest. Dermatol. 1992 99 675 682 (Pubitemid 23002026)
33. L. C. Kuhn Molecular regulation of iron proteins Bailliere's Clin. Haematol. 1994 7 763 785
34. R. Crichton, B. Danielson and P. Geisser, in Iron therapy with special emphasis on intravenous administration (4th Edition), UNI-MED, Bremen, Germany, 2008, pp. 14-16
35. T. Ganz Molecular control of iron transport J. Am. Soc. Nephrol. 2007 18 394 400 (Pubitemid 46193304)
36. S. Epsztejn O. Kakhlon H. Glickstein W. Breuer Z. I. Cabantchik Fluorescence analysis of the labile iron pool of mammalian cells Anal. Biochem. 1997 248 31 40 (Pubitemid 27218221)
37. M. Kruszewski Labile iron pool: The main determinant of cellular response to oxidative stress Mut. Res. 2003 29 81 92 (Pubitemid 37456724)
38. B. P. Espósito S. Epsztejn W. Breuer Z. I. Cabantchik A review of fluorescence methods for assessing labile iron in cells and biological fluids Anal. Biochem. 2002 304 1 18 (Pubitemid 34492837)
39. C. Hershko G. Graham G. W. Bates E. A. Rachmilewitz Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity Br. J. Haematol. 1978 40 255 263 (Pubitemid 9040657)
40. T. Ganz E. Nemeth Hepcidin and disorders of iron metabolism Annu. Rev. Med. 2011 62 347 360
41. E. Nemeth M. S. Tuttle J. Powelson M. B. Vaughn A. Donovan D. M. Ward T. Ganz J. Kaplan Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 2004 306 2090 2093 (Pubitemid 40007660)
42. B. A. Syed P. J. Sargent S. Farnaud R. W. Evans An overview of molecular aspects of iron metabolism Hemoglobin 2006 30 69 80
43. L. Klautz E. Nemeth Novel tools for the evaluation of iron metabolism Haematologica 2010 95 1989 1991
44. M. W. Hentze L. C. Kuhn Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress Proc. Natl. Acad. Sci. U. S. A. 1996 93 8175 8182 (Pubitemid 26269529)
45. N. C. Andrews Forging a field: the golden age of iron biology Blood 2008 112 219 230
46. I. De Domenico D. McVey Ward J. Kaplan Regulation of iron acquisition and storage: consequences for iron-linked disorders Nat. Rev. Mol. Cell Biol. 2008 9 72 81
47. Z. D. Liu R. C. Hider Design of clinically useful iron(III)-selective chelators. Med. Res. Rev. 2002 22 26 64 (Pubitemid 34023572)
48. B. Halliwell and J. M. C. Gutteridge, Free radicals, ageing, and disease, in Free Radicals in Biology and Medicine, second edition, Clarendon, Oxford, 1989, pp 416-493
49. H. De Groot Reactive oxygen species in tissue injury. Hepato-Gastroenterology 1994 41 328 332
50. S. J. Stohs D. Bagchi Oxidative mechanisms in the toxicity of metal ions Free Radical Biol. Med. 1995 18 321 336
51. M. Tenopoulo P. T. Doulis A. Barbouti U. Brunk D. Galaris Role of compartmentalized redox active iron in hydrogen peroxide-induced DNA damage and apoptosis Biochem. J. 2005 387 703 710 (Pubitemid 40685704)
52. C. Pourzand O. Reelfs R. M. Tyrrell Approaches to define the involvement of reactive oxygen species and iron in ultraviolet-A inducible gene expression Methods Mol. Biol. 2000 99 257 276
53. G. Cairo A. Pietrangelo Iron regulatory proteins in pathobiology. Biochem. J. 2000 352 241 250 (Pubitemid 32011418)
54. B. G. Rosser G. J. Gores Liver cell necrosis: cellular mechanisms and clinical implications. Gastroenterology 1995 108 252 275
55. M. S. Sussman G. B. Bulkley Oxygen-derived free radicals in reperfusion injury Methods Enzymol. 1990 186 711 722
56. 2 liberated by sources other than xanthine oxidase Biol. Chem. Hoppe-Seyler 1991 372 35 41
57. L. Tacchini S. Recalcati A. Bernelli-Zazzera G. Cairo Induction of ferritin synthesis in ischemic-reperfused rat liver: analysis of the molecular mechanisms Gastroenterology 1997 113 946 953 (Pubitemid 27381156)
58. N. C. Andrews Disorders of iron metabolism N. Engl. J. Med. 1999 341 1986 1995 (Pubitemid 30010408)
59. A. Gaeta R. C. Hider The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy Br. J. Pharmacol. 2009 146 1041 1059 (Pubitemid 41786957)
60. S. Kalinowski D. R. Richardson The evolution of iron chelators for the treatment of iron overload disease and cancer Pharmacol. Rev. 2005 57 547 583 (Pubitemid 43036441)
61. M. Molina-Holgado R. C. Hider A. Gaeta R. Williams P. Francis Metals ions and neurodegeneration BioMetals 2007 20 639 654 (Pubitemid 46776561)
62. B. R. Bacon R. S. Britton The pathology of hepatic iron overload: a free radical-mediated process? Hepatology 1990 11 127 137 (Pubitemid 20075113)
63. J. P. Kehrer The Haber-Weiss reaction and mechanisms of toxicity Toxicology 2000 149 43 50 (Pubitemid 30645786)
64. K. V. Kowdley Iron, hemochromatosis, and hepatocellular carcinoma Gastroenterology 2004 127 S79 S86
65. M. Valko C. J. Rhodes J. Moncol M. Izakovic M. Mazur Free radicals, metals and antioxidants in oxidative stress-induced cancer Chem.-Biol. Interact. 2006 160 1 40 (Pubitemid 43227479)
66. M. Valko D. Leibfritz J. Moncol M. T. D. Cronin M. Mazur Free radicals and antioxidants in normal physiological functions and human diseases Int. J. Biochem. Cell Biol. 2007 39 44 84 (Pubitemid 44566469)
67. C. A. Swanson Iron intake and regulation: implications for iron deficiency and iron overload Alcohol 2003 30 99 102 (Pubitemid 37045368)
68. G. J. Brewer Risks of copper and iron toxicity during aging in humans Chem. Res. Toxicol. 2010 23 319 326
69. Y. Kongho T. Ohtake K. Ikuta Y. Suzuki Y. Hosoki H. Saito Iron accumulation in alcoholic liver diseases Alcohol.: Clin. Exp. Res. 2005 29 S189 S193
70. D. R. Petersen Alcohol, iron-associated oxidative stress, and cancer Alcohol 2005 35 243 249 (Pubitemid 41085802)
71. N. Imeryuz V. Tahan A. Sonsuz F. Eren S. Uraz M Yuksel Iron preloading aggravates nutritional steatohepatitis in rats by increasing apopotic cell death J. Hepatol. 2007 47 851 859 (Pubitemid 350051114)
72. S. Toyokuni Iron-induced carcinogenesis: the role of redox regulation Free Radical Biol. Med. 1996 20 553 566 (Pubitemid 26097272)
73. D. R. Richardson D. S. Kalinowski S. Lau P. J. Jansson D. B. Lovejoy Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents Biochim. Biophys. Acta 2009 1790 702 717
74. H. W. Hann M. W. Stahlhut B. S. Blumberg Iron nutrition and tumor growth: decreased tumor growth in iron-deficient mice Cancer Res. 1988 48 4168 4170
75. L. Molin P. O. Wester Iron content in normal and psoriatic epidermis Acta Derm. Venereol. 1973 53 473 476
76. Z. Ackerman M. Seidenbaum E. Loewenthal A. Rubinow Overload of iron in the skin of patients with varicose ulcers. Possible contributing role of iron accumulation in progression of the disease Arch. Dermatol. 1988 124 1376 1378
77. T. J. David F. E. Wells T. C. Sharpe A. C. Gibbs J. Devlin Serum levels of trace metals in children with atopic eczema Br. J. Dermatol. 1990 122 485 489 (Pubitemid 20137368)
78. J. L. Sullivan Iron and the sex difference in heart disease risk Lancet 1981 317 1293 1294 (Pubitemid 11111356)
79. J. Jian E. Pelle X. Huang Iron and menopause: does increased iron affect the health of postmenopausal women? Antioxid. Redox Signaling 2009 11 2939 2943
80. W. Y. Ong B. Halliwell Iron, atherosclerosis, and neurodegeneration: a key role for cholesterol in promoting iron-dependent oxidative damage? Ann. N. Y. Acad. Sci. 2004 1012 51 64 (Pubitemid 38453515)
81. M. W. Hentze T. A. Rouault J. B. Harford R. D. Klausner Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction Science 1989 244 357 359 (Pubitemid 19117876)
82. E. W. Müllner S. Rothenberger A. M. Müller L. C. Kühn In vivo and in vitro modulation of the mRNA-binding activity of iron-regulatory factor. Tissue distribution and effects of cell proliferation, iron levels and redox state Eur. J. Biochem. 1992 208 597 605
83. E. A. Martins R. L. Robalinho R. Meneghini Oxidative stress induces activation of a cytosolic protein responsible for control of iron uptake Arch. Biochem. Biophys. 1995 316 128 134
84. K. Pantopoulos M. W. Hentze Rapid responses to oxidative stress mediated by iron regulatory protein EMBO J. 1995 14 2917 2924
85. G. Cairo E. Castrusini G. Minotti A. Bernelli-Zazzera Superoxide and hydrogen peroxide-dependent inhibition of iron regulatory prtein activity : A protective stratagen against oxidative injury FASEB J. 1996 10 1326 1335 (Pubitemid 26313536)
86. G. Cairo L. Tacchini G. Pogliaghi E. Anzon A. Tomasi A. Bernelli-Zazzera Induction of ferritin synthesis by oxidative stress. Transcriptional and post-transcriptional regulation by expansion of the 'free' iron pool J. Biol. Chem. 1995 270 700 703
87. A. Yiakouvaki J. Savovic A. Al-Qenaei J. Dowden C. Pourzand Caged-Iron Chelators a novel approach towards protecting skin cells against UVA-induced necrotic cell death J. Invest. Dermatol. 2006 126 2287 2295 (Pubitemid 44413176)
88. S. Basu-Modak D. Ali M. Gordon T. Polte A. Yiakouvaki C. Pourzand C. Rice-Evans R. M. Tyrrell Suppression of UVA-mediated release of labile iron by epicathecin-A link to lysosomal protection Free Radical Biol. Med. 2006 41 1197 1204 (Pubitemid 44479826)
89. W. Breuer M. Shvartsman Z. I. Cabantchik Intracellular labile iron Int. J. Biochem. Cell Biol. 2008 40 350 354 (Pubitemid 351241220)
90. S. M. Keyse R. M. Tyrrell Heme oxygenase is the major 32 kDA stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. U. S. A. 1989 86 99 103 (Pubitemid 19036341)
91. C. Hanselmann C. Mauch S. Werner Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis? Biochem. J. 2001 353 459 466 (Pubitemid 32158313)
92. R. M. Tyrrell, in Heme-Oxygenase-The Elegant Orchestration of its Products in Medicine, ed., L. E. Otterbein, and, B. S. Zucherbraun, Nova, Science Publishers Inc, New York, 2005, pp. 333-350
93. E. Kvam V. Hejmadi S. Ryter C. Pourzand R. M. Tyrrell Heme oxygenase activity causes transient hypersensitivity to oxidative ultraviolet A radiation that depends on release of iron from heme Free Radical Biol. Med. 2000 28 1191 1196 (Pubitemid 30417461)
94. G. F. Vile R. M. Tyrrell Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin J. Biol. Chem. 1993 268 14678 14681 (Pubitemid 23206605)
95. G. F. Vile S. Basu-Modak C. Waltner R. M. Tyrrell Heme-oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts Proc. Natl. Acad. Sci. U. S. A. 1994 91 2607 2610 (Pubitemid 24139396)
96. F. Lin A. W. Girotti Elevated ferritin production, iron containment, and oxidant resistance in hemin-treated leukemia cells Biochem. Pharmacol. 1997 14 1361 1363
97. V. E. Reeve D. Domanski Refractoriness of UVA-induced protection from photo-immunosuppression correlates with heme oxygenase response to repeated UVA exposure Photochem. Photobiol. 2002 76 401 405
98. W. K. McCourbey M. D. Maines The structure, organisation and differential expression of the gene encoding rat heme-oxygenase-2 Gene 1994 139 155 161 (Pubitemid 24078716)
99. A. Noël R. M. Tyrrell Development of refractoriness of induced human heme oxygenase-1 gene expression to reinduction by UVA irradiation and hemin Photochem. Photobiol. 1997 66 456 463 (Pubitemid 127470190)
100. S. Fakih M. Podinovskaia X. Kong H. L. Collins U. E. Schaible R. C. Hider Targeting the lysosome: Fluorescent iron (III) chelators to selectively monitor endosomal/lysosomal labile iron pools J. Med. Chem. 2008 51 4539 4552
101. M. Tenopoulou T. Kurz P. T. Doulias D. Galaris U. T. Brunk Does the calcein-AM method assay the total cellular 'labile iron pool' or only a fraction of it? Biochem. J. 2007 403 261 266 (Pubitemid 46596581)
102. Y. Ma H. de Groot Z. Liu R. C. Hider F. Petrat Chelation and determination of labile iron in primary hepatocytes by pyridinone fluorescent probes Biochem. J. 2006 395 49 55
103. Y. Ma W. Luo P. J. Quinn Z. Liu R. C. Hider Design, Synthesis, Physicochemical properties and evaluation of novel iron chelators with fluorescent sensors J. Med. Chem. 2004 47 6349 6362 (Pubitemid 39587258)
104. F. Petrat U U. Rauen H. de Groot Determination of the chelatable iron pool of isolated rat hepatocytes by digital fluorescence microscopy using the fluorescent probe, phen green SK Hepatology 1999 29 1171 1179 (Pubitemid 29168752)
105. F. Petrat H. de Groot U. Rauen Determination of the chelatable iron pool of single intact cells by laser scanning microscopy Arch. Biochem. Biophys. 2000 376 74 81 (Pubitemid 30205116)
106. F. Petrat H. de Groot U. Rauen Subcellular distribution of chelatable iron: a laser scanning microscopic study in isolated hepatocytes and liver endothelial cells Biochem. J. 2001 356 61 69 (Pubitemid 34275706)
107. F. Petrat D. Weisheit M. Lensen H. de Groot R. Sustmann U. Rauen Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor Biochem. J. 2002 362 137 147 (Pubitemid 34174471)
108. O. Reelfs R. M. Tyrrell C. Pourzand Ultraviolet A radiation-induced immediate iron release is a key modulator of the activation of NF-kappaB in human skin fibroblasts J. Invest. Dermatol. 2004 122 1440 1447 (Pubitemid 38757226)
109. M. Shvartsman E. Fibach Z. I. Cabantchik Transferrin iron routing to the cytosol and mitochondria as studied by live and real-time fluorescence Biochem. J. 2010 429 185 193
110. W. Breuer M. Shvartsman Z. I. Cabantchik Intracellular labile iron Int. J. Biochem. Cell Biol. 2008 40 350 354 (Pubitemid 351241220)
111. Y. Yu Z. Kovacevic D. R. Richardson Tuning cell cycle regulation with an iron key Cell Cycle 2007 6 1982 1994 (Pubitemid 47327885)
112. R. S. Ohgami D. R. Campagna E. L. Greer B. Antiochos A. McDonald J. Chen J. J. Sharp Y. Fujiwara J. E. Barker M. D. Fleming Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells Nat. Genet. 2005 37 1264 1269 (Pubitemid 41568711)
113. H. Gunshin B. Mackenzie U. V. Berger Y. Gunshin M. F. Romero W. F. Boron S. Nussberger J. L. Gollan M. A. Hediger Cloning and characterization of a mammalian proton-coupled metal-ion transporter Nature 1997 388 482 488 (Pubitemid 27328927)
114. R. S. Eisenstein Iron regulatory proteins and the molecular control of mammalian iron metabolism Annu. Rev. Nutr. 2000 20 627 662
115. P. Arosio S. Levi Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage Biochim. Biophys. Acta 2010 1800 783 792
116. Y. Yu J. Wong D. B. Lovejoy D. S. Kalinowski D. R. Richardson Chelators at the cancer coalface: desferrioxamine to Triapine and beyond Clin. Cancer Res. 2006 12 6876 6883 (Pubitemid 44974479)
117. D. Darshan L. Vanoaica L. Richman F. Beerman L. C. Kühn Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage Hepatology 2009 50 852 860
118. S. Omiya S. Hikoso Y. Imanishi A. Saito O. Yamaguchi T. Takeda I. Mizote T. Oka M. Taneike Y. Nakano Y. Matsumura K. Nishida Y. Sawa M. Hori K. Otsu Downregulation of ferritin heavy chain decreases labile iron pool, oxidative stress and cell death in cardiomyocytes J. Mol. Cell. Cardiol. 2009 46 59 66
119. H. Shi K. Z. Bencze T. L. Stemmler C. C. Philpott A cytosolic iron chaperone that delivers iron to ferritin Science 2008 320 1207 1210 (Pubitemid 351929507)
120. H. Lange G. Kispal R. Lill Mechanism of iron transport to the site of heme synthesis inside yeast mitochondria J. Biol. Chem. 1999 274 18989 18996
121. L. M. Garrick K. Gniecko J. E. Hoke A. al-Nakeeb P. Ponka M. D. Garrick Ferric-salicylaldehyde isonicotinoyl hydrazone, a synthetic iron chelate, alleviates defective iron utilization by reticulocytes of the Belgrade rat J. Cell. Physiol. 1991 146 460 465 (Pubitemid 21910072)
122. A. S. Zhang A. D. Sheftel P. Ponka Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria Blood 2005 105 368 375 (Pubitemid 40053106)
123. A. D. Sheftel A. S. Zhang C. Brown O. S. Shirihai P. Ponka Direct intraorganellar transfer of iron from endosomes to mitochondria Blood 2007 110 125 132 (Pubitemid 47026827)
124. G. C. Shaw J. J. Cope I. Li K. Corson C. Hersey G. E. Ackermann B. Gwynn A. J. Lambert R. A. Wingert D. Traver N. S. Trede B. A. Barut Y. Zhou E. Minet A. Donovan A. Brownlie R. Balzan M. J. Weiss L. I. Peters J. Kaplan L. I. Zon B. H. Paw Mitoferrin is essential for erythroid iron assimilation Nature 2006 440 96 100 (Pubitemid 43336274)
125. W. Chen H. A. Dailey B. H. Paw Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme synthesis Blood 2010 116 628 630
126. P. Ponka Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells Blood 1997 89 1 25 (Pubitemid 26428173)
127. J. Borova P. Ponka J. Neuwirt Study of intracellular iron distribution in rabbit reticulocytes with normal and inhibited heme synthesis Biochim. Biophys. Acta 1973 320 143 156
128. P. Ponka A. Wilczynska H. M. Schulman Iron utilization in rabbit reticulocytes: a study using succinylacetone as an inhibitor of heme synthesis Biochim. Biophys. Acta, Mol. Cell Res. 1982 720 96 105 (Pubitemid 12110095)
129. D. R. Richardson P. Ponka D. Vyoral Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism. Blood 1996 87 3477 3488 (Pubitemid 26115381)
130. A. May E. Fitzsimons Sideroblastic anaemia Bailliere's Clin. Haematol. 1994 7 851 879
131. M. L. Adams I. Ostapiuk J. A. Grasso The effects of inhibition of heme synthesis on the intracellular localization of iron in rat reticulocytes Biochim. Biophys. Acta, Mol. Cell Res. 1989 1012 243 253 (Pubitemid 19193150)
132. T. K. Rostovtseva S. M. Bezrukov ATP transport through a single mitochondrial channel, VDAC, studied by current fluctuation analysis Biophys. J. 1998 74 2365 2373 (Pubitemid 28225233)
133. S. Levi E. Rovida The role of iron in mitochondria function Biochim. Biophys. Acta 2009 1790 629 636
134. F. Y. Li B. Leibiger I. Leibiger C. Larsson Characerisation of a putative murine mitochondrial transporter homology of hMRS3/4 Mamm. Genome 2002 13 20 23 (Pubitemid 34008420)
135. C. Pourzand O. Reelfs E. Kvam R. M. Tyrrell IRP can determine the effectiveness of δ-aminolevulinic acid in inducing protoporphyrin IX (PPIX) in primary human skin fibroblasts J. Invest. Dermatol. 1999 112 101 107
136. A. T. McKie P. Marciani A. Relfs K. Brennan K. Wehr D. Barrow S. Miret T. J. Bomford T. J. Peters F. Farzaneh M. A. Hediger M. W. Hentze R. J. Simpson A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation Mol. Cell 2000 5 299 309 (Pubitemid 30628088)
137. R. Lill Functions and biogenesis of iron sulfur proteins Nature 2009 460 831 888
138. I. J. Schultz C. Chen B. H. Paw I Hamza Iron and porphyrin trafficking in heme biogenesis J. Biol. Chem. 2010 285 26753 26759
139. U. Rauen A. Springer D. Weisheit F. Petrat H. G. Korth H. de Groot R. Sustmann Assessment of chelatable mitochondrial iron by using mitochondrion-selective fluorescent iron indicators with different iron-binding affinities ChemBioChem 2007 8 341 352 (Pubitemid 47194515)
140. B. Sturm U. Bistrich M. Schranzhofer J. P. Sarsero U. Rauen B. Scheiber-Mojdehkar H. de Groot P. Ioannou F. Petrat Friedreich's ataxia, no changes in mitochondrial labile iron in human lymphoblasts and fibroblasts: a decrease in antioxidative capacity? J. Biol. Chem. 2005 280 6701 6708 (Pubitemid 40341224)
141. T. Kurz A. Terman B. Gustafsson U. T. Brunk Lysosomes and oxidative stress in aging and apoptosis Biochim. Biophys. Acta 2008 1780 1291 1303
142. Z. Yu H. L. Persson J. W. Eaton U. T. Brunk Intralysosomal iron: a major determinant of oxidant-induced cell death Free Radical Biol. Med. 2003 34 1243 1252 (Pubitemid 36513967)
143. K. Kislyov J. J. Jennings Jr Y. Rbaibi C. T. Chu Autophagy, mitochondria and cell death in lysosomal storage diseases Autophagy 2007 3 259 262 (Pubitemid 46752692)
144. C. Settembre A. Fraldi L. Jahreiss C. Spampanato C. Venturi D. Medina R. D. Pablo C. Tacchetti D. C. Rubinsztein A. Ballabio A block of autophagy in lysosomal storage disorders Hum. Mol. Genet. 2007 17 119 129
145. H. Glickstein R. B. El G. Link W. Breuer A. M. Konijn C. Hershko H. Nick Z. I. Cabantchik Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences, Blood 2006 108 3195 3203
146. W. Breuer E. Greenberg Z. I. Cabantchik Newly delivered transferrin iron and oxidative cell injury FEBS Lett. 1997 403 213 219 (Pubitemid 27081497)
147. P. Morliere S. Salmon M. Aubailly A. Rister R. Santus Sensitization of skin fibroblasts to UVA by excess iron Biochim. Biophys. Acta 1997 1334 283 290 (Pubitemid 27117532)
148. A. M. Konijn H. Glickstein B. Vaisman E. G. Meyron-Holtz I. N. Slotki Z. I. Cabantchik The cellular labile iron pool and intracellular ferritin in K562 cells Blood 1999 94 2128 2134 (Pubitemid 29430430)
149. W. Breuer S. Epsztejn Z. I. Cabantchik Dynamics of the cytosolic chelatable iron pool of K562 cells FEBS Lett. 1996 382 304 308 (Pubitemid 26091450)
150. C. E. Thomas S. D. Aust Reductive release of iron from ferritin by cation free radicals of paraquat and other bipyridyls J. Biol. Chem. 1986 261 13064 13070 (Pubitemid 17006876)
151. B. J. Bolann R. J. Ulvik On the ability of superoxide to release iron from ferritin Eur. J. Biochem. 1990 193 899 904 (Pubitemid 20381724)
152. Y. Bando K. Aki Superoxide-mediated release of iron from feritin by some flavoenzymes Biochem. Biophys. Res. Commun. 1990 168 389 395 (Pubitemid 20164554)
153. F. Funk J. P. Lenders R. R. Crichton W. Schneider Reductive mobilisation of ferritin iron Eur. J. Biochem. 1985 152 167 172 (Pubitemid 16248779)
154. D. W. Reif Ferritin as a source of iron for oxidative damage Free Radical Biol. Med. 1992 12 417 427
155. S. D. Aust C. F. Chignell T. M. Bray B. Kalyanaraman R. P. Mason Free radicals in toxicology Toxicol. Appl. Pharmacol. 1993 120 168 178 (Pubitemid 23203320)
156. M. Aubailly R. Santus S. Salmon Ferrous iron release from ferritin by ultraviolet A radiation Photochem. Photobiol. 1991 54 769 773
157. P. I. Oteiza C. G. Kleinman M. Demasi E. J. H. Bechara 5-aminolevulinic acid induces iron release from ferritin Arch. Biochem. Biophys. 1995 316 607 611
158. B. Vaisman E. Fibach A. M. Konijn Utilization of intracellular ferritin iron for hemoglobin synthesis in developing human erythroid precursors Blood 1997 90 831 838 (Pubitemid 27299124)
159. 2 injury in adult cardiomyocytes Cardiovasc. Res. 2000 47 529 536 (Pubitemid 30646074)
160. T. Simunek C. Boer R. A. Bouwman R. Vasblom A. M. Versteilen M. Sterba V. Gersl R. Hrdina P. Ponka J. J. de Lange W. J. Paulus R. J. Musters SIH, a novel lipophilic iron chelator, protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death J. Mol. Cell. Cardiol. 2005 39 345 354 (Pubitemid 40995024)
161. T. Kurz A. Terman U. T. Brunk Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron Arch. Biochem. Biophys. 2007 462 220 230 (Pubitemid 46856317)
162. T. Kurz A. Leake T. Von Zglinicki U. T. Brunk Relocalized redox active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage Biochem. J. 2004 378 1039 1045 (Pubitemid 38406883)
163. M. Zhao F. Antunes J. W. Eaton U. T. Brunk Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis Eur. J. Biochem. 2003 270 3778 3786 (Pubitemid 37123249)
164. T. Kurz B. Gustafsson U. T. Brunk Intralysosomal iron chelation protects against oxidative stress-induced cellular damage FEBS J. 2006 273 3106 3117
165. H. L. Persson Z. Yu O. Tirosh J. W. Eaton U. T. Brunk Prevention of oxidant-induced cell death by lysosomotropic iron chelators Free Radical Biol. Med. 2003 34 1295 1305 (Pubitemid 36513971)
166. A. Cozzi B. Corsi s. Levi P. Santambrogio A. Albertini P. Arosio Overexpression of wild type and mutated human ferritin H-chain in Hela cels: in vivo role of ferroxidase activity J. Biol. Chem. 2000 275 25122 25129
167. S. Epsztejn H. Glickstein V. Piccard I. N. Slotki W. Breuer C. Beaumont Z. I. Cabantchik H-ferritin subunit Overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties Blood 1999 94 3593 3603 (Pubitemid 29536156)
168. H. Glickstein R. B. El M. Shvartsman Z. I. Cabantchik Intracellular
169. O. Kakhlon W. Breuer A. Munnich Z. I. Cabantchik Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulation Can. J. Physiol. Pharmacol. 2010 88 187 196
170. A. Wong J. Yang P. Cavadini C. Gellera B. Lonnerdal F. Taroni G. Cortopassi The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis Hum. Mol. Genet. 1999 8 425 430 (Pubitemid 29097330)
171. H. Itoh T. Shioda T. Matsura S. Koyama T. Nakanishi G. Kajiyama T. Kawasaki Iron ions induces mitochondrial DNA damage in HTC rat hepatoma cell culture- role of antioxidants in mitochondrial DNA protection from oxidative stresses Arch. Biochem. Biophys. 1994 313 120 125
172. C. K. Lim D. S. Kalinowski D. R. Richardson Protection against hydrogen peroxide-mediated cytotoxicity in Friedreich's ataxia fibroblasts using novel iron chelators of the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone class Mol. Pharmacol. 2008 74 225 235 (Pubitemid 351872173)
173. A. Uchiyama J-S. Kim K. Kon H. Jaeschke K. Ikejima S. Watanabe J. J. Lemasters Translocation of iron from lysosome into mitochondria is a key event during oxidative stress-induced hepatocellular injury Hepatology 2008 48 1644 1654
174. R. A. Swerlick N. J. Korman UVA and NF-kappaB activity: ironing out the details, Comment on: J. Invest. Dermatol. 2004 122:1440-1447 J. Invest. Dermatol. 2004 122 xi xii
175. E. Kvam R. M. Tyrrell Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation Carcinogenesis 1997 18 2379 2384 (Pubitemid 28134653)
176. S. Mecklenburg C. A. Collins M. Döring T. Burkholz M. Abbas F. H. Fry C. Pourzand C. Jacob The design of multifunctional antioxidants against the damaging ingredients of oxidative stress Phosphorus, Sulfur Silicon Relat. Elem. 2008 183 863 888
177. C. A. Collins F. H. Fry A. L. Holme S. Pariagh A. Yiakouvaki A. Al-Qenaei C. Pourzand C. Jacob Towards Multifunctional Antioxidants: Synthesis, Electrochemistry, in vitro and Cell Culture Evaluation of Compounds with Ligand/Catalytic Properties Org. Biomol. Chem. 2005 3 1541 1546 (Pubitemid 40644188)
178. L. A. Applegate A. Noel G. Vile E. Frenk R. M. Tyrrell Two genes contribute to different extents to the heme oxygenase enzyme activity measured in cultured human skin fibroblasts and keratinocytes: implications for protection against oxidant stress Photochem. Photobiol. 1995 61 285 291
179. M. J. Pygmalion L. Ruiz E. Popovic J. Gizard P. Portes X. Marat K. Lucet-Levannier B. Muller J. B. Galey MJ Pygmalion L Ruiz E Popovic J Gizard P Portes X Marat K Lucet-Levannier B Muller JB Galey Skin cell protection against UVA by Sideroxyl, a new antioxidant complementary to sunscreens Free Radical Biol. Med. 2010 49 1629 1637
180. M. Creighton-Gutteridge R. M. Tyrrell A novel iron chelator that does not induce HIF-1 activity Free Radical Biol. Med. 2002 33 356 363 (Pubitemid 34786274)