Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: Examination of the intermediates involved in iron metabolism

Blood

Volumn 87, Issue 8, 1996, Pages 3477-3488

  Richardson, Des R ^a   Ponka, Prem ^b   Vyoral, Daniel ^b  

^a MCGILL UNIVERSITY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

SUCCINYLACETONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEME SYNTHESIS; IRON METABOLISM; IRON TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RABBIT; RETICULOCYTE;

EID: 0029865751     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.8.3477.bloodjournal8783477     Document Type: Article

References (77)

1. Jandl JH, Inman JK, Simmons RL, Allen DW: Transfer of iron from serum iron-binding protein to human reticulocytes. J Clin Invest 38:161, 1959
2. Jandl JH, Katz JH: The plasma-to-cell cycle of transferrin. J Clin Invest 42:314, 1963
3. Morgan EH: Transferrin biochemistry, physiology and clinical significance. Mol Aspects Med 4:1, 1981
4. Iacopetta BJ, Morgan EH: The kinetics of transferrin endocytosis and iron uptake from transferrin in rabbit reticulocytes. J Biol Chem 258:9108, 1983
5. Ponka P, Schulman HM, Cox TM: Iron metabolism in relation to heme synthesis, in Dailey HA (ed): Biosynthesis of Heme and Chlorophylls. New York, NY, McGraw-Hill, 1990, p 393
6. Kühn LC: mRNA-protein interactions regulate critical pathways in cellular iron metabolism. Brit J Haematol 79:1, 1991
7. Klausner RD, Rouault TA, Harford JB: Regulating the fate of mRNA: The control of cellular iron metabolism. Cell 72:19, 1993
8. Mazur A, Green S, Carleton A: Mechanism of plasma iron incorporation into hepatic ferritin. J Biol Chem 235:595, 1960
9. Wills ED: Mechanisms of lipid peroxide formation in animal tissues. Biochem J 99:667, 1966
10. 3+ among transferrin molecules. Biochem Biophys Res Commun 32:220, 1968
11. Konopka K, Leyko W, Gondko R, Sidorczyk Z, Fabjanowska Z, Swedowska M: Studies on the compounds of ATP and iron isolated from human erythrocytes. Clin Chim Acta 24:359, 1969
12. Morgan EH: A study of iron transfer from rabbit transferrin to reticulocytes using synthetic chelating agents. Biochim Biophys Acta 244:103, 1971
13. Borova J, Ponka P, Neuwirt J: Study of intracellular iron distribution in rabbit reticulocytes with normal and inhibited heme synthesis. Biochim Biophys Acta 320:143, 1973
14. Bartlett GR: Phosphate compounds in rat erythrocytes and reticulocytes. Biochem Biophys Res Commun 70:1055, 1976
15. Bartlett GR: Iron nucleotides in human and rat red cells. Biochem Biophys Res Commun 70:1063, 1976
16. Blackburn GW, Morgan EH: Factors affecting iron and transferrin release from rabbit reticulocyte ghosts to cytosol. Biochim Biophys Acta 497:728, 1977
17. Jacobs A: Low molecular weight intracellular iron transport compounds. Blood 50:433, 1977
18. r iron isolated from guinea pig reticulocytes as AMP-Fe and ATP-Fe complexes. Biochem J 261:787, 1989
19. Ebert P, Hess R, Frykholm B, Tschudy D: Succinylacetone, a potent inhibitor of heme synthesis: Effect on cell growth, heme content and aminolevulinic acid dehydratase activity of murine erythroleukemia cells. Biochem Biophys Res Commun 88:1382, 1979
20. Ponka P, Neuwirt J: Regulation of iron entry into reticulocytes. I. Feedback inhibitory effect of heme on iron entry into reticulocytes and on heme synthesis. Blood 33:690, 1969
21. Morgan EH: Chelator-mediated iron efflux from reticulocytes. Biochim Biophys Acta 733:39, 1983
22. Ponka P, Wilczynska A, Schulman HM: Iron utilization in rabbit reticulocytes. A study using succinylacetone as an inhibitor of heme synthesis. Biochim Biophys Acta 720:96, 1982
23. Bakkeren DL, de Jeu-Jaspars CM, van der Heul C, van Eijk HG: Analysis of iron-binding components in the low molecular weight fraction of rat reticulocyte cytosol. Int J Biochem 17:925, 1985
24. Adams ML, Ostapiuk I, Grasso JA: The effects of inhibition of heme synthesis on the intracellular localisation of iron in rat reticulocytes. Biochim Biophys Acta 1012:243, 1989
25. Garrick LM, Gniecko K, Liu Y, Cohan DS, Grasso JA, Garrick MD: Iron distribution in Belgrade rat reticulocytes after inhibition of heme synthesis with succinylacetone. Blood 81:3414, 1993
26. Watson A, Doherty FJ: Calcium promotes membrane association of reticulocyte 15-lipoxygenase. Biochem J 298:377, 1994
27. Richardson DR, Baker E: The uptake of iron and transferrin by the human melanoma cell. Biochim Biophys Acta 1053:1, 1990
28. Good NE, Winget GD, Winter W, Connolly TN, Izawa S, Singh MM: Hydrogen ion buffers for biological research. Biochemistry 5:467, 1966
29. Teale FWJ: Cleavage of the haem-protein link by acid methylethylketone. Biochim Biophys Acta 35:543, 1959
30. Bottomley SS, Wolfe LC, Bridges KR: Iron metabolism in K562 erythroleukemic cells. J Biol Chem 260:6811, 1985
31. Mengaud JM, Horwitz MA: The major iron-containing protein of Legionella pneumophila is an aconitase homologous with the human iron-responsive element-binding protein. J Bacteriol 175:5666, 1994
32. Vyoral D, Hradilek A, Neuwirt J: Transferrin and iron distribution in subcellular fractions of K562 cells in the early stages of transferrin endocytosis. Biochim Biophys Acta 137:148, 1992
33. Augustin W, Zborowski J, Baranska J, Wiswedel I, Wojtczak L: Synthesis of phospholipids in mitochondria and other membrane fractions of rabbit reticulocytes. Biochim Biophys Acta 489:298, 1977
34. Bessis MC, Brenton-Gorius J: Iron particles in normal erythroblasts and normal and pathological erythrocytes. J Biophys Biochem Cytol 3:503, 1957
35. Speyer BE, Fielding J: Ferritin as a cytosol iron transport intermediate in human reticulocytes. Br J Haematol 42:255, 1977
36. Mazur A, Carleton A: Relation of ferritin iron to heme synthesis in marrow and reticulocytes. J Biol Chem 238:1817, 1963
37. Neuwirt J, Ponka P, Borova J: Evidence for the presence of free and protein-bound nonhemoglobin heme in rabbit reticulocytes. Biochim Biophys Acta 264.235, 1972
38. Halliwell B, Gutteridge JMC: Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219:1, 1984
39. Halliwell B, Gutteridge JMC: Iron and free radical reactions: Two aspects of antioxidant protection. Trends Biochem Sci 11:372, 1986
40. Crichton RR: Iron uptake and utilization by mammalian cells. II. Intracellular iron utilization. Trends Biochem Sci 9:283, 1984
41. O'Halloran TV: Transition metals in the control of gene expression. Science 261:715, 1993
42. Bunn HF. Subunit assembly of hemoglobin: An important determinant of hematologic phenotype. Blood 69:1, 1987
43. Ponka P, Borova J, Neuwirt J: Accumulation of heme in mitochondria from rabbit reticulocytes with inhibited globin synthesis. Biochim Biophys Acta 304:715, 1973
44. Ketterer B, Srai KS, Christodoulides L: Haem-binding proteins in the rat liver cytosol. Biochim Biophys Acta 428:638, 1976
45. Harvey JW, Beutler E: Binding of heme by glutathione-S-transferase: A possible role of the erythrocyte enzyme. Blood 60:1227, 1982
46. Pollack S, Campana T: Low molecular weight non-heme iron and a highly labelled heme pool in the reticulocyte. Blood 56:564, 1980
47. Ponka P, Neuwirt J: Haem synthesis and iron uptake by reticulocytes. Br J Haematol 28:1, 1974
48. Schulman HM, Martinez-Medellin J, Sidloi R: The reticulocyte-mediated release of iron and bicarbonate from transferrin. Effect of metabolic inhibitors. Biochim Biophys Acta 343:529, 1974
49. Iacopetta B, Morgan E: Heme inhibits transferrin endocytosis in immature erythroid cells. Biochim Biophys Acta 805:211, 1984
50. Cox TM, O'Donnell MW, Aisen P, London IM: Hemin inhibits internalization of transferrin by reticulocytes and promotes phosphorylation of the membrane transferrin receptor. Proc Natl Acad Sci USA 82:5170, 1985
51. Ponka P, Schulman HM, Martinez-Medellin J: Haem inhibits iron uptake subsequent to endocytosis of transferrin in reticulocytes. Biochem J 251:105, 1988
52. Koller ME, Prante PH, Ulvik R, Romslo I: Effect of hemin and isonicotinic acid hydrazide on the uptake of iron from transferrin by isolated rat liver mitochondria. Biochem Biophys Res Commun 71.339, 1976
53. Kushner JP, Cartwright GE: Sideroblastic anaemia. Adv Intern Med 22:229, 1977
54. Harris JW: X-linked, pyridoxine-responsive sideroblastic anaemia. N Engl J Med 330:675, 1994
55. Martinez-Medellin J, Schulman HM: The kinetics of iron and transferrin incorporation into rabbit erythroid cells and the nature of stromal-bound Fe. Biochim Biophys Acta 264:272, 1972
56. Nunez MT, Cole ES, Glass J: Cytosol intermediates in the transport of iron. Blood 55:1051, 1980
57. Kohno H, Tokunaga R: Transferrin and iron uptake by rat reticulocytes. J Biochem 97:1181, 1985
58. Primosigh JV, Thomas ED: Studies on the partition of iron in bone marrow cells. J Clin Invest 47.1473, 1968
59. Stoning PL, Fatih S: Erythropoietin effects on iron metabolism in rat bone marrow cells. Biochim Biophys Acta 392:26, 1975
60. Pollack S, Campana T, Weaver J: Low molecular weight iron in guinea pig reticulocytes. Am J Hematol 19:75, 1985
61. Romslo I: Intracellular transport of iron, in Jacobs A, Worwood M (eds): Iron in Biochemistry and Medicine, volume 2. London, UK, Academic, 1980, p 325
62. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine (ed 2). Oxford, UK, Clarendon, 1989
63. Kuross SA, Hebbel RP: Non-heme iron in sickle erythrocyte membranes: Association with phospholipids and potential role in lipid peroxidation. Blood 72:1278, 1988
64. +-ATPase from reticulocyte endosomes reconstituted into liposomes acts as an iron transporter. J Biol Chem 269:10242, 1994
65. +-ATPase. Biochemistry 34:5130, 1995
66. Jamieson JD, Palade GE: Intracellular transport of secretory proteins in the pancreatic exocrine cell. Transport to condensing vacuoles and zymogen granules. J Cell Biol 34:597, 1967
67. Palade GE: Intracellular aspects of the process of protein synthesis. Science 189:347, 1975
68. Rothman JE: Mechanisms of intracellular protein transport. Nature 372:55, 1994
69. Voelker DR: Phosphatidylserine translocation to the mitochondrion is an ATP-dependent process in permeabilized animal cells. Proc Natl Acad Sci USA 86:9921, 1989
70. Voelker DR: Characterization of phosphatidylserine synthesis and translocation in permeabilized animal cells. J Biol Chem 265:14340, 1990
71. Voelker DR: The ATP-dependent translocation of phosphatidylserine to the mitochondria is a process that is restricted to the autologous organelle. J Biol Chem 268:7069, 1993
72. Vance JE: Phospholipid synthesis in a membrane fraction associated with the mitochondria. J Biol Chem 265:7248, 1990
73. Rusinol AE, Cui Z, Chen MH, Vance JE: A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins. J Biol Chem 269:27494, 1994
74. Martinez-Medellin J: Studies on transferrin and intracellular metabolism of iron in rabbit erythroid cells. Doctoral thesis, University of California, San Diego, CA, 1972
75. Neuwirt J, Borova J, Ponka P: Intracellular iron kinetics in erythroid cells, in Crichton RR (ed): Proteins of Iron Storage and Transport in Biochemistry and Medicine. Amsterdam, The Netherlands, North-Holland, 1975, p 161
76. Ponka P, Neuwirt J, Borova J, Fuchs O: Control of iron delivery to haemoglobin in erythroid cells, in Ciba Foundation Symposium 51 (new series): Iron Metabolism. Amsterdam, The Netherlands, Elsevier, 1977, p 167
77. Isobe K, Isobe Y, Sakurami T: Cytochemical demonstration of transferrin in the mitochondria of immature human erythroid cells. Acta Haematol 65:2, 1981