Molecular control of iron metabolism

Best Practice and Research: Clinical Haematology

Volumn 18, Issue 2 SPEC. ISS., 2005, Pages 159-169

  Andrews, Nancy C ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Anemia; Ferritin; Hemochromatosis; Homeostasis; Iron; Metal transport; Transferrin

Indexed keywords

CARRIER PROTEIN; FERRIC HYDROXIDE SUCROSE; FERRITIN; FERROPORTIN; FERROUS GLUCONATE; HEMOSIDERIN; IRON; IRON DEXTRAN; METALLOPROTEIN; TRANSFERRIN; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

ANEMIA; ARTICLE; BIOCHEMISTRY; DISEASE CLASSIFICATION; ERYTHROPOIESIS; GENE MUTATION; GENETIC ANALYSIS; HEMOCHROMATOSIS; HOMEOSTASIS; HUMAN; INTESTINE ABSORPTION; IRON ABSORPTION; IRON DEFICIENCY; IRON METABOLISM; IRON OVERLOAD; IRON STORAGE; IRON TRANSPORT; JUVENILE; LIVER CELL; LYMPHOPOIESIS; MACROPHAGE; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; NONHUMAN; PLACENTA FUNCTION; PRIORITY JOURNAL;

EID: 14544268521     PISSN: 15216926     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beha.2004.10.004     Document Type: Review

References (69)

1. M.W. Hentze M.U. Muckenthaler & N.C. Andrews Balancing acts; molecular control of mammalian iron metabolism Cell 117 2004 285-297
2. M.D. Fleming M.A. Romano M.A. Su et al. Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport Proc Natl Acad Sci USA 95 1998 1148-1153
3. J.E. Levy O. Jin Y. Fujiwara et al. Transferrin receptor is necessary for development of erythrocytes and the nervous system Nat Genet 21 1999 396-399
4. R.M. Ned W. Swat & N.C. Andrews Transferrin receptor 1 is differentially required in lymphocyte development Blood 102 2003 3711-3718
5. E. Beutler T. Gelbart P. Lee et al. Molecular characterization of a case of atransferrinemia Blood 96 2000 4071-4074
6. S.E. Bernstein Hereditary hypotransferrinemia with hemosiderosis, a murine disorder resembling human atransferrinemia J Lab Clin Med 110 1987 690-705
7. M.F. Macedo M. de Sousa R.M. Ned et al. Transferrin is required for early T-cell differentiation Immunology 112 2004 543-549
8. T. Dickinson & J.R. Connor Histological analysis of selected brain regions of hypotransferrinemic mice Brain Res 635 1994 169-178
9. M.D. Fleming C.C. Trenor M.A. Su et al. Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter gene Nat Genet 16 1997 383-386
10. H. Gunshin B. Mackenzie U.V. Berger et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter Nature 388 1997 482-488
11. A.T. McKie D. Barrow G.O. Latunde-Dada et al. An iron-regulated ferric reductase associated with the absorption of dietary iron Science 291 2001 1755-1759
12. S. Abboud & D.J. Haile A novel mammalian iron-regulated protein involved in intracellular iron metabolism J Biol Chem 275 2000 19906-19912
13. A. Donovan A. Brownlie Y. Zhou et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter Nature 403 2000 776-781
14. A.T. McKie P. Marciani A. Rolfs et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation Mol Cell 5 2000 299-309
15. C.D. Vulpe Y.M. Kuo T.L. Murphy et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse Nat Genet 21 1999 195-199
16. D. Bratosin J. Mazurier J.P. Tissier et al. Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review Biochimie 80 1998 173-195
17. M.D. Knutson M.R. Vafa D.J. Haile & M. Wessling-Resnick Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages Blood 102 2003 4191-4197
18. Z.L. Harris A.P. Durley T.K. Man & J.D. Gitlin Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux Proc Natl Acad Sci USA 96 1999 10812-10817
19. J. Bradley E.A. Leibold Z.L. Harris et al. The influence of gestational age and fetal iron status on iron regulatory protein activity and iron transporter protein expression in third trimester human placenta Am J Physiol Regul Integr Comp Physiol 2004
20. G. Nicolas M. Bennoun A. Porteu et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin Proc Natl Acad Sci USA 99 2002 4596-4601
21. H. Kawabata R. Yang T. Hirama et al. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family J Biol Chem 274 1999 20826-20832
22. C. Camaschella A. Roetto A. Cali et al. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22 Nat Genet 25 2000 14-15
23. R.E. Fleming J.R. Ahmann M.C. Migas et al. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis Proc Natl Acad Sci USA 99 2002 10653-10658
24. C.M. Craven J. Alexander M. Eldridge et al. Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: A rodent model for hemochromatosis Proc Natl Acad Sci USA 84 1987 3457-3461
25. R.L. Hamill J.C. Woods & B.A. Cook Congenital atransferrinemia: A case report and review of the literature Am J Clin Pathol 96 1991 215-218
26. T.L. Wright P. Brissot W.L. Ma & R.A. Weisiger Characterization of non-transferrin-bound iron clearance by rat liver J Biol Chem 261 1986 10909-10914
27. P. Brissot T.L. Wright W.L. Ma & R.A. Weisiger Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states J Clin Invest 76 1985 1463-1470
28. G.Y. Oudit H. Sun M.G. Trivieri et al. L-type Ca(2+) channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy Nat Med 9 2003 1187-1194
29. E.C. Theil Ferritin: At the crossroads of iron and oxygen metabolism J Nutr 133 2003 1549S-1553S
30. J.V. Klavins J.P. Pickett & Z. Wessely Staining of minerals and solubility of iron in tissues Ann Clin Lab Sci 6 1976 214-222
31. A. Krause S. Neitz H.J. Magert et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity FEBS Lett 480 2000 147-150
32. G. Nicolas M. Bennoun I. Devaux et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice Proc Natl Acad Sci USA 98 2001 8780-8785
33. C.H. Park E.V. Valore A.J. Waring & T. Ganz Hepcidin, a urinary antimicrobial peptide synthesized in the liver J Biol Chem 276 2001 7806-7810
34. C. Pigeon G. Ilyin B. Courselaud et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload J Biol Chem 276 2001 7811-7819
35. M. Muckenthaler C.N. Roy A.O. Custodio et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis Nat Genet 34 2003 102-107
36. D.A. Weinstein C.N. Roy M.D. Fleming et al. Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease Blood 100 2002 3776-3781
37. G. Nicolas C. Chauvet L. Viatte et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation J Clin Invest 110 2002 1037-1044
38. E. Nemeth E.V. Valore M. Territo et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein Blood 101 2003 2461-2463
39. A. Roetto G. Papanikolaou M. Politou et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis Nat Genet 33 2003 21-22
40. E. Nemeth S. Rivera V. Gabayan et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin J Clin Invest 113 2004 1271-1276
41. D.E. Paglia, P. Dennis. Role of chronic iron overload in multiple disorders of captive black rhinoceroses (Diceros bicornis). In: Proceedings of the American Association of Zoo Veterinarians; 1999; Columbus, Ohio; p. 163-171.
42. J.N. Feder A. Gnirke W. Thomas et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis Nat Genet 13 1996 399-408
43. X.Y. Zhou S. Tomatsu R.E. Fleming et al. HFE gene knockout produces mouse model of hereditary hemochromatosis Proc Natl Acad Sci USA 95 1998 2492-2497
44. J.E. Levy L.K. Montross D.E. Cohen et al. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele Blood 94 1999 9-11
45. S. Bahram S. Gilfillan L.C. Kuhn et al. Experimental hemochromatosis due to MHC class I HFE deficiency: Immune status and iron metabolism Proc Natl Acad Sci USA 96 1999 13312-13317
46. M.J. Bennett J.A. Lebron & P.J. Bjorkman Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor Nature 403 2000 46-53
47. A.P. West Jr A.M. Giannetti A.B. Herr et al. Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites J Mol Biol 313 2001 385-397
48. A.M. Giannetti & P.J. Bjorkman HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface J Biol Chem 279 2004 25866-25875
49. C.N. Roy D.M. Penny J.N. Feder & C.A. Enns The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells J Biol Chem 274 1999 9022-9028
50. L. Salter-Cid A. Brunmark Y. Li et al. Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: Implications for cellular iron homeostasis Proc Natl Acad Sci USA 96 1999 5434-5439
51. A. Waheed J.H. Grubb X.Y. Zhou et al. Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis Proc Natl Acad Sci USA 99 2002 3117-3122
52. K.R. Bridle D.M. Frazer S.J. Wilkins et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis Lancet 361 2003 669-673
53. K.A. Ahmad J.R. Ahmann M.C. Migas et al. Decreased liver hepcidin expression in the hfe knockout mouse Blood Cells Mol Dis 29 2002 361-366
54. G. Nicolas L. Viatte D.Q. Lou et al. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis Nat Genet 34 2003 97-101
55. C.N. Roy A.O. Custodio J. De Graaf et al. An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice Nat Genet 36 2004 481-485
56. D.M. Frazer S.J. Wilkins K.N. Millard et al. Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE Br J Haematol 126 2004 434-436
57. P. Lee H. Peng T. Gelbart & E. Beutler The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes Proc Natl Acad Sci USA 101 2004 9263-9265
58. H. Kawabata R.S. Germain P.T. Vuong et al. Transferrin receptor 2-{alpha} supports cell growth both in iron-chelated cultured cells and in vivo J Biol Chem 275 2000 16618-16625
59. A.P. West Jr M.J. Bennett V.M. Sellers et al. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE J Biol Chem 275 2000 38135-38138
60. M.B. Johnson & C.A. Enns Regulation of transferrin receptor 2 by transferrin: Diferric transferrin regulates transferrin receptor 2 protein stability Blood 2004
61. A. Robb & M. Wessling-Resnick Regulation of transferrin receptor 2 protein levels by transferrin Blood 2004
62. G. Papanikolaou M.E. Samuels E.H. Ludwig et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis Nat Genet 36 2004 77-82
63. P.P. Monnier A. Sierra P. Macchi et al. RGM is a repulsive guidance molecule for retinal axons Nature 419 2002 392-395
64. J. Schmidtmer & D. Engelkamp Isolation and expression pattern of three mouse homologues of chick Rgm Gene Expr Patterns 4 2004 105-110
65. S. Jacolot G. Le Gac V. Scotet et al. HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype Blood 103 2004 2835-2840
66. A.T. Merryweather-Clarke E. Cadet A. Bomford et al. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis Hum Mol Genet 12 2003 2241-2247
67. O.T. Njajou N. Vaessen M. Joosse et al. A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis Nat Genet 28 2001 213-214
68. G. Montosi A. Donovan A. Totaro et al. Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene J Clin Invest 108 2001 619-623
69. A. Pietrangelo The ferroportin disease Blood Cells Mol Dis 32 2004 131-138