Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage

Hepatology

Volumn 50, Issue 3, 2009, Pages 852-860

  Darshan, Deepak ^a,b   Vanoaica, Liviu ^a   Richman, Larry ^a   Beermann, Friedrich ^a   Kühn, Lukas C ^a  

^a EPFL   (Switzerland)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CERULOPLASMIN; FERRITIN; FERRITIN H; IRON; IRON SALT; MESSENGER RNA; PROTEIN DCYTB; TRANSCRIPTION FACTOR; TRANSFERRIN; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; APOFERRITIN; HEPCIDIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DEPOLARIZATION; EMBRYO; ENZYME ACTIVITY; EXON; GENE DELETION; HEMOSIDEROSIS; IRON BLOOD LEVEL; IRON INTAKE; IRON METABOLISM; IRON STORAGE; IRON TRANSPORT; LIVER; LIVER INJURY; LIVER MITOCHONDRION; LOXP SITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SPLEEN; SURVIVAL RATE; TISSUE DISTRIBUTION; ANIMAL; ANIMAL EMBRYO; BIOSYNTHESIS; DRUG EFFECT; GENETICS; LIVER DISEASE; MALE; METABOLISM;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; APOFERRITINS; CELL DEATH; EMBRYO, MAMMALIAN; IRON; LIVER; LIVER DISEASES; MALE; MICE; RNA, MESSENGER;

EID: 70349237065     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.23058     Document Type: Article

References (37)

1. Harrison PM, Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1996;1275:161-203. (Pubitemid 26248989)
2. Levi S, Luzzago A, Cesareni G, Cozzi A, Franceschinelli F, Albertini A, et al. Mechanism of ferritin uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site. A study of iron uptake and ferro-oxidase activity of human liver, recombinant H-chain ferritins, and of two H-chain deletion mutants. J Biol Chem 1988;263:18086-18092.
3. Lawson DM, Treffry A, Artymiuk PJ, Harrison PM, Yewdall SJ, Luzzago A, et al. Identification of the ferroxidase centre in ferritin. FEBS Lett 1989;254:207-210.
4. Hentze MW, Kühn LC. Molecular control of vertebrate iron metabolism - mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci U S A 1996;93:8175-8182. (Pubitemid 26269529)
5. De Domenico I, Vaughn MB, Li LT, Bagley D, Musci G, Ward DW, et al. Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome. EMBO J 2006;22:5396-5404. (Pubitemid 44764148)
6. Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, et al. Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species. Cell 2004;119:529-542. (Pubitemid 39482352)
7. Hussain SP, Hoseth LJ, Harris CC. Radical causes of cancer. Nat Rev Cancer 2003;3:276-285.
8. Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR. Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 2004;5:863-873. (Pubitemid 39482155)
9. Ferreira C, Bucchini D, Martin ME, Levi S, Arosio P, Grandchamp B, et al. Early embryonic lethality of H ferritin gene deletion in mice. J Biol Chem 2000;275:3021-3024. (Pubitemid 30082994)
10. Golding S, Young SP. Iron requirements of human-lymphocytes - relative contributions of intracellular and extracellular iron. Scand J Immunol 1995;41:229-236.
11. Ned RM, Swat W, Andrews NC. Transferrin receptor 1 is differentially required in lymphocyte development. Blood 2003;102:3711-3718. (Pubitemid 37409392)
12. Hahn PF, Bale WF, Ross JF, Balfour WM, Whipple GH. Radioactive iron absorption by gastro-intestinal tract. Influence of anemia, anoxia and antecedent feeding. Distribution in growing dogs. J Exp Med 1943;78:169-188.
13. Granick S. Ferritin IX. Increase of the protein apoferritin in the gastrointestinal mucosa as a direct response to iron feeding. The function of ferritin in the regulation of iron absorption. J Biol Chem 1946;164:737-746.
14. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-7819. (Pubitemid 37385574)
15. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A 2001;98:8780-8785.
16. Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33:21-22. (Pubitemid 36068676)
17. Zoller H, Koch RO, Theurl I, Obrist P, Pietrangelo A, Montosi G, et al. Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload. Gastroenterology 2001;120:1412-1419. (Pubitemid 32322315)
18. Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 2002;123:835-844. (Pubitemid 34977090)
19. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-2093. (Pubitemid 40007660)
20. Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002;100:3776-3781.
21. Vaisman B, Fibach E, Konijn AM. Utilization of intracellular ferritin iron for hemoglobin synthesis in developing human erythroid precursors. Blood 1997;90:831-838. (Pubitemid 27299124)
22. Ponka P, Richardson DR. Can ferritin provide iron for hemoglobin synthesis? Blood 1997;89:2611-2613.
23. Kühn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science 1995;269:1427-1429.
24. Dubois NC, Hofmann D, Kaloulis K, Bishop JM, Trumpp A. Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/IoxP mediated recombination in the nervous system, kidney, and somite-derived tissues. Genesis 2006;44:355-360. (Pubitemid 44384311)
25. Müllner EW, Neupert B, Kühn LC. A specific mRNA-binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA. Cell 1989;58:373-382.
26. Schuler M, Dierich A, Chambon P, Metzger D. Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse. Genesis 2004;39:167-172. (Pubitemid 39079514)
27. Santambrogio P, Levi S, Cozzi A, Corsi B, Arosio P. Evidence that the specificity of iron incorporation into homopolymers of human ferritin Land H-chains is conferred by the nucleation and ferroxidase centres. Biochem J 1996;314:139-144. (Pubitemid 26063842)
28. Cozzi A, Corsi B, Levi S, Santambrogio P, Biasiotto G, Arosio P. Analysis of the biologic functions of H- and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin. Blood 2004;103:2377-2383. (Pubitemid 38326261)
29. Drysdale JW, Munro HN. Regulation of synthesis and turnover of ferritin in rat liver. J Biol Chem 1966;241:3630-3637.
30. Kidane TZ, Sauble E, Linder MC. Release of iron from ferritin requires lysosomal activity. Am J Physiol Cell Physiol 2006;291:C445-C455. (Pubitemid 44343627)
31. Fleming RE, Holden CC, Tomatsu S, Waheed A, Brunt EM, Britton RS, et al. Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis. Proc Natl Acad Sci U S A 2001;98:2707-2711. (Pubitemid 32209547)
32. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabatan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood 2007;110:2182-2189. (Pubitemid 47443938)
33. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-2463. (Pubitemid 36857598)
34. Picard V, Epsztejn S, Santambrogio P, Cabantchik ZI, Beaumont C. Role of ferritin in the control of the labile iron pool in murine erythroleukemia cells. J Biol Chem 1998;273:15382-15386. (Pubitemid 28298142)
35. Kakhlon O, Gruenbaum Y, Cabantchik ZL. Repression of ferritin expression increases the labile iron pool, oxidative stress, and short-term growth of human erythroleukemia cells. Blood 2001;97:2863-2871.
36. Rauen U, Petrat F, Sustmann R, de Groot H. Iron-induced mitochondrial permeability transition in cultured hepatocytes. J Hepatol 2004;40:607-615. (Pubitemid 38367782)
37. Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 2007;787:99-163.