Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage

Biochemical Journal

Volumn 378, Issue 3, 2004, Pages 1039-1045

  Kurz, Tino ^a,b   Leake, Alan ^b   Von Zglinicki, Thomas ^b   Brunk, Ulf T ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

DNA damage; Hydrogen peroxide; Lysosomal iron; Lysosome; Oxidative stress; Telomere

Indexed keywords

CELLS; CHELATION; DNA; IRON; REDOX REACTIONS; TRANSITION METALS;

MOLECULAR MASS; OXIDATIVE DAMAGE;

BIOCHEMISTRY;

DEFEROXAMINE; DODECYLAMINE; IRON; O METHYLSERINE DODECYLAMINE; SERINE; SINGLE STRANDED DNA; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; ENDOCYTOSIS; HUMAN; HUMAN CELL; IRON CHELATION; IRON TRANSPORT; LYSOSOME MEMBRANE; MOLECULAR WEIGHT; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

DEFEROXAMINE; DNA DAMAGE; IRON; IRON CHELATING AGENTS; LYSOSOMES; OXIDATION-REDUCTION; OXIDATIVE STRESS;

EID: 1642463971     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031029     Document Type: Article

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