Intralysosomal iron: A major determinant of oxidant-induced cell death

Free Radical Biology and Medicine

Volumn 34, Issue 10, 2003, Pages 1243-1252

  Yu, Zhengquan ^a,c   Persson, H Lennart ^a   Eaton, John W ^a,b   Brunk, Ulf T ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptosis; Autophagocytosis; Free radicals; Iron; Lysosomes; Oxidative stress

Indexed keywords

AMMONIUM CHLORIDE; DEFEROXAMINE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; IRON CHELATING AGENT; OXIDIZING AGENT; SILVER DERIVATIVE; SULFUR DERIVATIVE;

ALKALINITY; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ORGANELLE; CELL PH; CONTROLLED STUDY; CYTOCHEMISTRY; ELECTRON SPIN RESONANCE; INCUBATION TIME; LYSOSOME; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0037448105     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(03)00109-6     Document Type: Article

References (36)

1. Klionsky D.J., Emr S.D. Autophagy as a regulated pathway of cellular degradation. Science. 290:2000;1717-1721.
2. Dice J.F. Lysosomal pathways of protein degradation. 2000;Eurekah.com/Landes Bioscience, Georgetown, TX.
3. Radisky D.C., Kaplan J. Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts. Biochem. J. 336:1998;201-205.
4. Öllinger K., Brunk U.T. Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic. Biol. Med. 19:1995;565-574.
5. Brunk U.T., Zhang H., Dalen H., Öllinger K. Exposure of cells to non-lethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization. Free Radic. Biol. Med. 19:1995;813-822.
6. Persson H.L., Nilsson K.J., Brunk U.T. Novel cellular defenses against iron and oxidation ferritin and autophagocytosis preserve lysosomal stability in airway epithelium . Redox Rep. 6:2001;57-63.
7. Liu Z.D., Khodr H.H., Lu S.L., Hider R.C. Design, synthesis and evaluation of N-basic substituted 3-hydroxypyridin-4-ones orally active iron chelators with lysosomotrophic potential . J. Pharm. Pharmacol. 52:2000;263-272.
8. Konijn A.M., Glickstein H., Vaisman B., Meyron-Holtz E.G., Slotki I.N., Cabantchik Z.I. The cellular labile iron pool and intracellular ferritin in K562 cells. Blood. 94:1999;2128-2134.
9. Tabuchi M., Yoshimori T., Yamaguchi K., Yoshida T., Kishi F. Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells. J. Biol. Chem. 275:2000;22220-22228.
10. Starke P.E., Gilbertson J.D., Farber J.L. Lysosomal origin of the ferric iron required for cell killing by hydrogen peroxide. Biochem. Biophys. Res. Commun. 133:1985;371-379.
11. Garner B., Li W., Roberg K., Brunk U.T. On the cytoprotective role of ferritin in macrophages and its ability to enhance lysosomal stability. Free Radic. Res. 27:1997;487-500.
12. Garner B., Roberg K., Brunk U.T. Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress. Free Radic. Res. 29:1998;103-114.
13. Persson H.L., Svensson A.I., Brunk U.T. α-Lipoic acid and α-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. Redox Rep. 6:2001;327-334.
14. Brunk U.T., Neuzil J., Eaton J.W. Lysosomal involvement in apoptosis. Redox Rep. 6:2001;91-97.
15. Brunk U.T., Svensson I. Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak. Redox Rep. 4:1999;3-11.
16. Li W., Yuan X., Nordgren G., Dalen H., Dubowchik G.M., Firestone R.A., Brunk U.T. Induction of cell death by the lysosomotropic detergent MSDH. FEBS Lett. 470:2000;35-39.
17. Lloyd J.B., Cable H., Rice-Evans C. Evidence that desferrioxamine cannot enter cells by passive diffusion. Biochem. Pharmacol. 41:1991;1361-1363.
18. Cable H., Lloyd J.B. Cellular uptake and release of two contrasting iron chelators. J. Pharm. Pharmacol. 51:1999;131-134.
19. 2 release from vascular endothelial cells. Free Radic. Biol. Med. 14:1993;217-223.
20. Zdolsek J.M., Roberg K., Brunk U.T. Visualization of iron in cultured macrophages a cytochemical light and electron microscopic study using autometallography . Free Radic. Biol. Med. 15:1993;1-11.
21. Frankfurt O.S., Krishan A. Identification of apoptotic cells by formamide-induced DNA denaturation in condensed chromatin. J. Histochem. Cytochem. 49:2001;369-378.
22. Buettner G.R. Spin trapping ESR parameters of spin adducts . Free Radic. Biol. Med. 3:1987;259-303.
23. Antunes F., Cadenas E., Brunk U.T. Apoptosis, induced by the exposure to a low and steady state concentration of hydrogen peroxide, is a consequence of lysosomal rupture. Biochem J. 356:2001;549-555.
24. Petrat F., de Groot H., Rauen U. Subcellular distribution of chelatable iron a laser scanning microscopic study in isolated hepatocytes and liver endothelial cells . Biochem. J. 356:2001;61-69.
25. Ohkuma S., Poole B. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc. Natl. Acad. Sci. USA. 75:1978;3327-3331.
26. Franch H.A., Sooparb S., Du J., Brown N.S. A mechanism regulating proteolysis of specific proteins during renal tubular cell growth. J. Biol. Chem. 276:2001;19126-19131.
27. 125-labeled asialo-fetuin in isolated rat hepatocytes. Biochem. Pharmacol. 29:1979;917-925.
28. Brander C., Matter-Reissmann U.B., Jones N.G., Walker B.D., Sachs D.H., Seebach J.D. Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride. J. Immunol. Methods. 252:2001;1-14.
29. Hileti D., Panayiotidis P., Hoffbrand A.V. Iron chelators induce apoptosis in proliferating cells. Br. J. Haematol. 89:1995;181-187.
30. Nyholm S., Mann G.J., Johansson A.G., Bergeron R.J., Gräslund A., Thelander L. Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators. J. Biol. Chem. 268:1993;26200-26205.
31. Crichton R.R., Ward R.J. Iron species in iron homeostasis and toxicity. Analyst. 120:1995;693-697.
32. Schalinske K.L., Eisenstein R.S. Phosphorylation and activation of both iron regulatory proteins 1 and 2 in HL-60 cells. J. Biol. Chem. 271:1996;7168-7176.
33. Halliwell B., Gutteridge J.M. Role of free radicals and catalytic metal ions in human disease an overview . Methods Enzymol. 186:1990;1-85.
34. Breuer W., Epsztejn S., Cabantchik Z.I. Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II). J. Biol. Chem. 270:1995;24209-24215.
35. Epsztejn S., Kakhlon O., Glickstein H., Breuer W., Cabantchik I. Fluorescence analysis of the labile iron pool of mammalian cells. Anal. Biochem. 248:1997;31-40.
36. Breuer W., Greenberg E., Cabantchik Z.I. Newly delivered transferrin iron and oxidative injury. FEBS Lett. 403:1997;213-219.