Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors

Journal of Medicinal Chemistry

Volumn 47, Issue 25, 2004, Pages 6349-6362

  Ma, Yongmin ^a   Luo, Wei ^a   Quinn, Peter J ^a   Liu, Zudong ^a   Hider, Robert C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 4 PYRIDONE DERIVATIVE; 3 HYDROXYPYRAN 4 ONE DERIVATIVE; 7 DIETHYLAMINO N [(5 HYDROXY 1 METHYL 4 OXO 1,4 DIHYDROPYRIDIN 2 YL)METHYL] 2 OXO 2H CHROMENE 3 CARBOXAMIDE; 7 DIETHYLAMINO N [(5 HYDROXY 6 METHYL 4 OXO 1,4 DIHYDROPYRIDIN 3 YL)METHYL] N METHYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; COUMARIN DERIVATIVE; FLUORESCENT DYE; HYDROXYPYRANONE DERIVATIVE; HYDROXYPYRIDINONE DERIVATIVE; IRON; IRON CHELATE; IRON CHELATING AGENT; N [(3 HYDROXY 1,6 DIMETHYL 4 OXO 1,4 DIHYDROPYRIDIN 2 YL)METHYL] 7 DIETHYLAMINO 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N [2 [3 HYDROXY 2 METHYL 4 OXOPYRIDIN 1(4H) YL]ETHYL] 2 (7 DIMETHYLAMINO 2 OXO 2H CHROMEN 4 YL)ACETAMIDE; N [2 [3 HYDROXY 2 METHYL 4 OXOPYRIDIN 1(4H) YL]ETHYL] 2 (7 METHOXY 2 OXO 2H CHROMEN 4 YL)ACETAMIDE; N [2 [3 HYDROXY 2 METHYL 4 OXOPYRIDIN 1(4H) YL]ETHYL] 7 DIETHYLAMINO 2 OXO 2H CHROMENE 3 CARBOXAMIDE; PYRAN DERIVATIVE; PYRIDONE DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOSENSOR; CELL LEVEL; CELL MEMBRANE PERMEABILITY; CHEMICAL REACTION; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROCYTE GHOST; ERYTHROCYTE MEMBRANE; FLUORESCENCE; HUMAN; HUMAN CELL; IRON CHELATION; LIGAND BINDING; METAL BINDING; MOLECULAR PROBE; NONPHOTOCHEMICAL QUENCHING; PH; PHYSICAL CHEMISTRY; QUANTITATIVE ANALYSIS; STOICHIOMETRY; STRUCTURE ANALYSIS; TECHNIQUE; TRANSPORT KINETICS; ULTRAVIOLET SPECTROSCOPY;

CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHYSICAL; COUMARINS; DRUG DESIGN; ERYTHROCYTE MEMBRANE; FLUORESCENT DYES; HUMANS; IRON CHELATING AGENTS; PYRANS; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9744251550     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049751s     Document Type: Article

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