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Volumn 17, Issue 24, 2011, Pages 7518-7528

Targeting the mTOR/4E-BP pathway in endometrial cancer

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; BEVACIZUMAB; BKM 120; CARBOPLATIN; CISPLATIN; DOXORUBICIN; ESTROGEN; EVEROLIMUS; INITIATION FACTOR 4E BINDING PROTEIN 1; K RAS PROTEIN; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MK 2206; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE LKB1; RAPAMYCIN; RIDAFOROLIMUS; SOMATOMEDIN C; TEMSIROLIMUS; TOPOTECAN; UNCLASSIFIED DRUG; XL 147;

EID: 84055176558     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-1664     Document Type: Review
Times cited : (32)

References (81)
  • 1
    • 79951575730 scopus 로고    scopus 로고
    • homepage on the Internet. Available from
    • American Cancer Society [homepage on the Internet]. Cancer Facts and Figures 2010. Available from: http://www.cancer.org/Research/CancerFactsFigures/ CancerFactsFigures/cancer-facts-and-figures-2010.
    • (2010) Cancer Facts and Figures
  • 2
    • 40749126861 scopus 로고    scopus 로고
    • Endometrial cancer
    • DOI 10.1097/AOG.0b013e318162f690, PII 0000625020080200000027
    • Sorosky JI. Endometrial cancer. Obstet Gynecol 2008;111:436-47. (Pubitemid 351653438)
    • (2008) Obstetrics and Gynecology , vol.111 , Issue.2 PART 1 , pp. 436-447
    • Sorosky, J.I.1
  • 3
    • 77949469320 scopus 로고    scopus 로고
    • Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
    • Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, et al. Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Model Mech 2010;3:181-93.
    • (2010) Dis Model Mech , vol.3 , pp. 181-193
    • Contreras, C.M.1    Akbay, E.A.2    Gallardo, T.D.3    Haynie, J.M.4    Sharma, S.5    Tagao, O.6
  • 4
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • DOI 10.1016/0090-8258(83)90111-7
    • Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983;15:10-7. (Pubitemid 13194678)
    • (1983) Gynecologic Oncology , vol.15 , Issue.1 , pp. 10-17
    • Bokhman, J.V.1
  • 5
    • 45949095023 scopus 로고    scopus 로고
    • Molecular target therapies in endometrial cancer: From the basic research to the clinic
    • DOI 10.1080/09513590801953556, PII 792375656
    • Gadducci A, Tana R, Cosio S, Fanucchi A, Genazzani AR. Molecular target therapies in endometrial cancer: from the basic research to the clinic. Gynecol Endocrinol 2008;24:239-49. (Pubitemid 351891652)
    • (2008) Gynecological Endocrinology , vol.24 , Issue.5 , pp. 239-249
    • Gadducci, A.1    Tana, R.2    Cosio, S.3    Fanucchi, A.4    Genazzani, A.R.5
  • 8
    • 33750576103 scopus 로고    scopus 로고
    • Molecular and pathologic aspects of endometrial carcinogenesis
    • DOI 10.1200/JCO.2006.06.7173
    • Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006;24:4783-91. (Pubitemid 46630943)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.29 , pp. 4783-4791
    • Hecht, J.L.1    Mutter, G.L.2
  • 9
    • 61449282506 scopus 로고    scopus 로고
    • The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies
    • Bansal N, Yendluri V, Wenham RM. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Cancer Contr 2009;16:8-13.
    • (2009) Cancer Contr , vol.16 , pp. 8-13
    • Bansal, N.1    Yendluri, V.2    Wenham, R.M.3
  • 10
    • 79953038262 scopus 로고    scopus 로고
    • PTEN loss in the continuum of common cancers, rare syndromes and mouse models
    • Hollander MC, BlumenthalGM,Dennis PA.PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer 2011;11:289-301.
    • (2011) Nat Rev Cancer , vol.11 , pp. 289-301
    • Hollander, M.C.1    Blumenthal, G.M.2    Dennis, P.A.3
  • 13
    • 0032904432 scopus 로고    scopus 로고
    • PTEN: A tumour suppressor that functions as a phospholipid phosphatase
    • DOI 10.1016/S0962-8924(99)01519-6, PII S0962892499015196
    • Maehama T, Dixon JE. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 1999;9:125-8. (Pubitemid 29161437)
    • (1999) Trends in Cell Biology , vol.9 , Issue.4 , pp. 125-128
    • Maehama, T.1    Dixon, J.E.2
  • 14
    • 0035361602 scopus 로고    scopus 로고
    • 1 cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells
    • Zhu X, Kwon CH, Schlosshauer PW, Ellenson LH, Baker SJ. PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells. Cancer Res 2001;61:4569-75. (Pubitemid 32685791)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4569-4575
    • Zhu, X.1    Kwon, C.-H.2    Schlosshauer, P.W.3    Ellenson, L.H.4    Baker, S.J.5
  • 15
    • 1242284600 scopus 로고    scopus 로고
    • Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN
    • DOI 10.1126/science.1092089
    • Raftopoulou M, Etienne-Manneville S, Self A, Nicholls S, Hall A. Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 2004;303:1179-81. (Pubitemid 38233580)
    • (2004) Science , vol.303 , Issue.5661 , pp. 1179-1181
    • Raftopoulou, M.1    Etienne-Manneville, S.2    Self, A.3    Nicholls, S.4    Hall, A.5
  • 16
    • 0034234268 scopus 로고    scopus 로고
    • High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten(+/-) mice
    • Stambolic V, Tsao MS, Macpherson D, Suzuki A, Chapman WB, Mak TW. High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res 2000;60: 3605-11. (Pubitemid 30482183)
    • (2000) Cancer Research , vol.60 , Issue.13 , pp. 3605-3611
    • Stambolic, V.1    Tsao, M.-S.2    Macpherson, D.3    Suzuki, A.4    Chapman, W.B.5    Mak, T.W.6
  • 17
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • DOI 10.1038/nrc1819, PII N1819
    • Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006;6:184-92. (Pubitemid 43292562)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.3 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 18
    • 28244490997 scopus 로고    scopus 로고
    • High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    • DOI 10.1158/0008-5472.CAN-05-2620
    • Oda K, Stokoe D, Taketani Y, McCormick F. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res 2005;65:10669-73. (Pubitemid 41713332)
    • (2005) Cancer Research , vol.65 , Issue.23 , pp. 10669-10673
    • Oda, K.1    Stokoe, D.2    Taketani, Y.3    McCormick, F.4
  • 19
    • 38649090091 scopus 로고    scopus 로고
    • PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters
    • DOI 10.1038/modpathol.3800992, PII 3800992
    • Catasus L, Gallardo A, Cuatrecasas M, Prat J. PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters. Mod Pathol 2008; 21:131-9. (Pubitemid 351172164)
    • (2008) Modern Pathology , vol.21 , Issue.2 , pp. 131-139
    • Catasus, L.1    Gallardo, A.2    Cuatrecasas, M.3    Prat, J.4
  • 20
    • 34247513939 scopus 로고    scopus 로고
    • Molecular carcinogenesis of endometrial cancer
    • Liu FS. Molecular carcinogenesis of endometrial cancer. Taiwan J Obstet Gynecol 2007;46:26-32.
    • (2007) Taiwan J Obstet Gynecol , vol.46 , pp. 26-32
    • Liu, F.S.1
  • 22
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
    • Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005;1:15-25. (Pubitemid 43960587)
    • (2005) Cell Metabolism , vol.1 , Issue.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 23
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
    • DOI 10.1016/S0092-8674(03)00929-2
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115:577-90. (Pubitemid 37506046)
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 25
    • 49849087494 scopus 로고    scopus 로고
    • Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
    • Lu KH, Wu W, Dave B, Slomovitz BM, Burke TW, Munsell MF, et al. Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma. Clin Cancer Res 2008;14:2543-50.
    • (2008) Clin Cancer Res , vol.14 , pp. 2543-2550
    • Lu, K.H.1    Wu, W.2    Dave, B.3    Slomovitz, B.M.4    Burke, T.W.5    Munsell, M.F.6
  • 26
    • 0032457024 scopus 로고    scopus 로고
    • Insulin-like growth factors in endometrial function
    • Rutanen EM. Insulin-like growth factors in endometrial function. Gynecol Endocrinol 1998;12:399-406.
    • (1998) Gynecol Endocrinol , vol.12 , pp. 399-406
    • Rutanen, E.M.1
  • 27
    • 0035863411 scopus 로고    scopus 로고
    • AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells
    • Tanno S, Tanno S, Mitsuuchi Y, Altomare DA, Xiao GH, Testa JR. AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res 2001;61:589-93. (Pubitemid 32128619)
    • (2001) Cancer Research , vol.61 , Issue.2 , pp. 589-593
    • Tanno, S.1    Tanno, S.2    Mitsuuchi, Y.3    Altomare, D.A.4    Xiao, G.-H.5    Testa, J.R.6
  • 28
    • 33751278008 scopus 로고    scopus 로고
    • Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium
    • DOI 10.1158/1078-0432.CCR-06-0912
    • McCampbell AS, Broaddus RR, Loose DS, Davies PJ. Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium. Clin Cancer Res 2006;12: 6373-8. (Pubitemid 44799707)
    • (2006) Clinical Cancer Research , vol.12 , Issue.21 , pp. 6373-6378
    • McCampbell, A.S.1    Broaddus, R.R.2    Loose, D.S.3    Davies, P.J.A.4
  • 29
    • 2142759556 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis
    • Brader S, Eccles SA. Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. Tumori 2004;90:2-8. (Pubitemid 38541717)
    • (2004) Tumori , vol.90 , Issue.1 , pp. 2-8
    • Brader, S.1    Eccles, S.A.2
  • 30
    • 79958696694 scopus 로고    scopus 로고
    • The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
    • Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 2011;332:1317-22.
    • (2011) Science , vol.332 , pp. 1317-1322
    • Hsu, P.P.1    Kang, S.A.2    Rameseder, J.3    Zhang, Y.4    Ottina, K.A.5    Lim, D.6
  • 31
    • 79958696336 scopus 로고    scopus 로고
    • Phosphoproteomic analysis identifies Grb10 as anmTORC1 substrate that negatively regulates insulin signaling
    • Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, et al. Phosphoproteomic analysis identifies Grb10 as anmTORC1 substrate that negatively regulates insulin signaling. Science 2011;332:1322-6.
    • (2011) Science , vol.332 , pp. 1322-1326
    • Yu, Y.1    Yoon, S.O.2    Poulogiannis, G.3    Yang, Q.4    Ma, X.M.5    Villén, J.6
  • 32
    • 1342300673 scopus 로고    scopus 로고
    • Involution of PTEN-null endometrial glands with progestin therapy
    • DOI 10.1016/j.ygyno.2003.11.026
    • Zheng W, Baker HE, Mutter GL. Involution of PTEN-null endometrial glands with progestin therapy. Gynecol Oncol 2004;92:1008-13. (Pubitemid 38251415)
    • (2004) Gynecologic Oncology , vol.92 , Issue.3 , pp. 1008-1013
    • Zheng, W.1    Baker, H.E.2    Mutter, G.L.3
  • 33
    • 34347220473 scopus 로고    scopus 로고
    • Defining the Role of mTOR in Cancer
    • DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007;12:9-22. (Pubitemid 47001784)
    • (2007) Cancer Cell , vol.12 , Issue.1 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 34
    • 77950516104 scopus 로고    scopus 로고
    • MTOR signaling and drug development in cancer
    • Dancey J. mTOR signaling and drug development in cancer. Nat Rev Clin Oncol 2010;7:209-19.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 209-219
    • Dancey, J.1
  • 35
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: Insights into a complex relationship
    • DOI 10.1038/nrc1974, PII NRC1974
    • Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 2006;6:729-34. (Pubitemid 44286004)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 729-734
    • Sabatini, D.M.1
  • 36
    • 70449900928 scopus 로고    scopus 로고
    • TOR complex 2: A signaling pathway of its own
    • Cybulski N, Hall MN. TOR complex 2: a signaling pathway of its own. Trends Biochem Sci 2009;34:620-7.
    • (2009) Trends Biochem Sci , vol.34 , pp. 620-627
    • Cybulski, N.1    Hall, M.N.2
  • 37
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-101. (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 38
    • 77954296394 scopus 로고    scopus 로고
    • 4EBP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors
    • She QB, Halilovic E, Ye Q, Zhen W, Shirasawa S, Sasazuki T, et al. 4EBP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. Cancer Cell 2010;18:39-51.
    • (2010) Cancer Cell , vol.18 , pp. 39-51
    • She, Q.B.1    Halilovic, E.2    Ye, Q.3    Zhen, W.4    Shirasawa, S.5    Sasazuki, T.6
  • 40
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008;118:3065-74.
    • (2008) J Clin Invest , vol.118 , pp. 3065-3074
    • Carracedo, A.1    Ma, L.2    Teruya-Feldstein, J.3    Rojo, F.4    Salmena, L.5    Alimonti, A.6
  • 43
    • 69949156862 scopus 로고    scopus 로고
    • Cell signaling in endometrial carcinoma: Phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis
    • Castellvi J, Garcia A, Ruiz-Marcellan C, Hernández-Losa J, Peg V, Salcedo M, et al. Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis. Hum Pathol 2009;40: 1418-26.
    • (2009) Hum Pathol , vol.40 , pp. 1418-1426
    • Castellvi, J.1    Garcia, A.2    Ruiz-Marcellan, C.3    Hernández-Losa, J.4    Peg, V.5    Salcedo, M.6
  • 44
    • 70349974719 scopus 로고    scopus 로고
    • Expression of mTOR protein and its clinical significance in endometrial cancer
    • No JH, Jeon YT, Park IA, Kang D, Kim JW, Park NH, et al. Expression of mTOR protein and its clinical significance in endometrial cancer. Med Sci Monit 2009;15:BR301-5.
    • (2009) Med Sci Monit , vol.15
    • No, J.H.1    Jeon, Y.T.2    Park, I.A.3    Kang, D.4    Kim, J.W.5    Park, N.H.6
  • 45
    • 0032834055 scopus 로고    scopus 로고
    • eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
    • DOI 10.1146/annurev.biochem.68.1.913
    • Gingras AC, Raught B, Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 1999;68:913-63. (Pubitemid 29449212)
    • (1999) Annual Review of Biochemistry , vol.68 , pp. 913-963
    • Gingras, A.-C.1    Raught, B.2    Sonenberg, N.3
  • 46
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5¢-cap function
    • Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC Jr, et al. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5¢-cap function. Nature 1994;371:762-7.
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.C.3    Donzé, O.4    Lin, T.A.5    Lawrence Jr., J.C.6
  • 52
    • 66949159435 scopus 로고    scopus 로고
    • Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: Association with stage and grade in vivo and link with response to rapamycin treatment in vitro
    • Darb-Esfahani S, Faggad A, Noske A, Weichert W, Buckendahl AC, Müller B, et al. Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to rapamycin treatment in vitro. J Cancer Res Clin Oncol 2009;135:933-41.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 933-941
    • Darb-Esfahani, S.1    Faggad, A.2    Noske, A.3    Weichert, W.4    Buckendahl, A.C.5    Müller, B.6
  • 53
    • 67349170390 scopus 로고    scopus 로고
    • Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma
    • Hayes MP, Douglas W, Ellenson LH. Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma. Gynecol Oncol 2009; 113:370-3.
    • (2009) Gynecol Oncol , vol.113 , pp. 370-373
    • Hayes, M.P.1    Douglas, W.2    Ellenson, L.H.3
  • 55
    • 38049085766 scopus 로고    scopus 로고
    • Loss of phosphatase and tensin homologue deleted on chromosome 10 and phosphorylation of mammalian target of rapamycin are associated with progesterone refractory endometrial hyperplasia
    • Milam MR, Soliman PT, Chung LH, Schmeler KM, Bassett RL Jr, Broaddus RR, et al. Loss of phosphatase and tensin homologue deleted on chromosome 10 and phosphorylation of mammalian target of rapamycin are associated with progesterone refractory endometrial hyperplasia. Int J Gynecol Cancer 2008;18:146-51.
    • (2008) Int J Gynecol Cancer , vol.18 , pp. 146-151
    • Milam, M.R.1    Soliman, P.T.2    Chung, L.H.3    Schmeler, K.M.4    Bassett Jr., R.L.5    Broaddus, R.R.6
  • 56
    • 35549006238 scopus 로고    scopus 로고
    • Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss
    • DOI 10.1111/j.1349-7006.2007.00630.x
    • Mori N, Kyo S, Sakaguchi J, Mizumoto Y, Ohno S, Maida Y, et al. Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss. Cancer Sci 2007;98:1881-8. (Pubitemid 350002193)
    • (2007) Cancer Science , vol.98 , Issue.12 , pp. 1881-1888
    • Mori, N.1    Kyo, S.2    Sakaguchi, J.3    Mizumoto, Y.4    Ohno, S.5    Maida, Y.6    Hashimoto, M.7    Takakura, M.8    Inoue, M.9
  • 58
    • 70749115376 scopus 로고    scopus 로고
    • Expression of metabolically targeted biomarkers in endometrial carcinoma
    • Wahl H, Daudi S, Kshirsagar M, Griffith K, Tan L, Rhode J, et al. Expression of metabolically targeted biomarkers in endometrial carcinoma. Gynecol Oncol 2010;116:21-7.
    • (2010) Gynecol Oncol , vol.116 , pp. 21-27
    • Wahl, H.1    Daudi, S.2    Kshirsagar, M.3    Griffith, K.4    Tan, L.5    Rhode, J.6
  • 59
    • 69249085764 scopus 로고    scopus 로고
    • Synergistic effect of rapamycin and cisplatin in endometrial cancer cells
    • Bae-Jump VL, Zhou C, Boggess JF, Gehrig PA. Synergistic effect of rapamycin and cisplatin in endometrial cancer cells. Cancer 2009;115: 3887-96.
    • (2009) Cancer , vol.115 , pp. 3887-3896
    • Bae-Jump, V.L.1    Zhou, C.2    Boggess, J.F.3    Gehrig, P.A.4
  • 60
    • 74049128836 scopus 로고    scopus 로고
    • Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis
    • Shafer A, Zhou C, Gehrig PA, Boggess JF, Bae-Jump VL. Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis. Int J Cancer 2010;126:1144-54.
    • (2010) Int J Cancer , vol.126 , pp. 1144-1154
    • Shafer, A.1    Zhou, C.2    Gehrig, P.A.3    Boggess, J.F.4    Bae-Jump, V.L.5
  • 61
    • 33745903146 scopus 로고    scopus 로고
    • Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells
    • DOI 10.1016/j.ygyno.2005.12.019, PII S0090825805011212
    • Treeck O, Wackwitz B, Haus U, Ortmann O. Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells. Gynecol Oncol 2006; 102:292-9. (Pubitemid 44041641)
    • (2006) Gynecologic Oncology , vol.102 , Issue.2 , pp. 292-299
    • Treeck, O.1    Wackwitz, B.2    Haus, U.3    Ortmann, O.4
  • 62
    • 2342483301 scopus 로고    scopus 로고
    • Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial cancer cells
    • Zhou C, Gehrig PA, Whang YE, Boggess JF. Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial cancer cells. Mol Cancer Ther 2003;2:789-95.
    • (2003) Mol Cancer Ther , vol.2 , pp. 789-795
    • Zhou, C.1    Gehrig, P.A.2    Whang, Y.E.3    Boggess, J.F.4
  • 63
    • 34249819647 scopus 로고    scopus 로고
    • Targeted RNA interference of phosphatidylinositol 3-kinase p110-beta induces apoptosis and proliferation arrest in endometrial carcinoma cells
    • DOI 10.1002/path.2158
    • An HJ, Cho NH, Yang HS, Kwak KB, Kim NK, Oh DY, et al. Targeted RNA interference of phosphatidylinositol 3-kinase p110-beta induces apoptosis and proliferation arrest in endometrial carcinoma cells. J Pathol 2007;212:161-9. (Pubitemid 46852094)
    • (2007) Journal of Pathology , vol.212 , Issue.2 , pp. 161-169
    • An, H.J.1    Cho, N.H.2    Yang, H.S.3    Kwak, K.B.4    Kim, N.K.5    Oh, D.Y.6    Lee, S.W.7    Kim, H.O.8    Koh, J.J.9
  • 64
    • 67650088379 scopus 로고    scopus 로고
    • Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia
    • Erdemoglu E, Güney M, Giray SG, Take G, Mungan T. Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia. Eur J Obstet Gynecol Reprod Biol 2009; 145:195-9.
    • (2009) Eur J Obstet Gynecol Reprod Biol , vol.145 , pp. 195-199
    • Erdemoglu, E.1    Güney, M.2    Giray, S.G.3    Take, G.4    Mungan, T.5
  • 65
    • 44349165577 scopus 로고    scopus 로고
    • Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat
    • DOI 10.1038/labinvest.2008.29, PII LABINVEST200829
    • McCampbell AS, Walker CL, Broaddus RR, Cook JD, Davies PJ. Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat. Lab Invest 2008;88:615-26. (Pubitemid 351733276)
    • (2008) Laboratory Investigation , vol.88 , Issue.6 , pp. 615-626
    • McCampbell, A.S.1    Walker, C.L.2    Broaddus, R.R.3    Cook, J.D.4    Davies, P.J.A.5
  • 66
    • 33847415365 scopus 로고    scopus 로고
    • Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model
    • Milam MR, Celestino J, Wu W, Broaddus RR, Schmeler KM, Slomovitz BM, et al. Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model. Am J Obstet Gynecol 2007;196:247, e1-5.
    • (2007) Am J Obstet Gynecol , vol.196 , Issue.247
    • Milam, M.R.1    Celestino, J.2    Wu, W.3    Broaddus, R.R.4    Schmeler, K.M.5    Slomovitz, B.M.6
  • 67
    • 33846869263 scopus 로고    scopus 로고
    • Resistance to endocrine therapy in breast cancer: Exploiting estrogen receptor/growth factor signaling crosstalk
    • DOI 10.1677/erc.1.01273
    • Massarweh S, Schiff R. Resistance to endocrine therapy in breast cancer: exploiting estrogen receptor/growth factor signaling crosstalk. Endocr Relat Cancer 2006;13[Suppl 1]:S15-24. (Pubitemid 46219245)
    • (2006) Endocrine-Related Cancer , vol.13 , Issue.SUPPL. 1
    • Massarweh, S.1    Schiff, R.2
  • 68
    • 33646934663 scopus 로고    scopus 로고
    • Old and new perspectives in the pharmacological treatment of advanced or recurrent endometrial cancer: Hormonal therapy, chemotherapy and molecularly targeted therapies
    • DOI 10.1016/j.critrevonc.2005.11.002, PII S104084280500226X
    • Gadducci A, Cosio S, Genazzani AR. Old and new perspectives in the pharmacological treatment of advanced or recurrent endometrial cancer: Hormonal therapy, chemotherapy and molecularly targeted therapies. Crit Rev Oncol Hematol 2006;58:242-56. (Pubitemid 43796082)
    • (2006) Critical Reviews in Oncology/Hematology , vol.58 , Issue.3 , pp. 242-256
    • Gadducci, A.1    Cosio, S.2    Genazzani, A.R.3
  • 69
    • 43249086546 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
    • O'Donnell A, Faivre S, Burris HA 3rd, Rea D, Papadimitrakopoulou V, Shand N, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J Clin Oncol 2008;26:1588-95.
    • (2008) J Clin Oncol , vol.26 , pp. 1588-1595
    • O'Donnell, A.1    Faivre, S.2    Burris III, H.A.3    Rea, D.4    Papadimitrakopoulou, V.5    Shand, N.6
  • 71
    • 33750271928 scopus 로고    scopus 로고
    • Molecular correlates associated with a phase II study of temsirolimus (CCI-779) in patients with metastatic or recurrent endometrial cancer-NCIC IND 160
    • Oza AM, Elit L, Biagi J, Chapman W, Tsao M, Hedley D, et al. Molecular correlates associated with a phase II study of temsirolimus (CCI-779) in patients with metastatic or recurrent endometrial cancer-NCIC IND 160. J Clin Oncol 2006;24:3003.
    • (2006) J Clin Oncol , vol.24 , pp. 3003
    • Oza, A.M.1    Elit, L.2    Biagi, J.3    Chapman, W.4    Tsao, M.5    Hedley, D.6
  • 72
    • 52049125733 scopus 로고    scopus 로고
    • Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148
    • Oza AM, Eisenhauer EA, Elit L, Cutz JC, Sakurada A, Tsao MS, et al. Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148. J Clin Oncol 2008;26:4319-25.
    • (2008) J Clin Oncol , vol.26 , pp. 4319-4325
    • Oza, A.M.1    Eisenhauer, E.A.2    Elit, L.3    Cutz, J.C.4    Sakurada, A.5    Tsao, M.S.6
  • 73
    • 37149010753 scopus 로고    scopus 로고
    • A phase II trial of the mTOR inhibitor AP23573 as a single agent in advanced endometrial cancer
    • Colombo N, McMeekin S, Schwartz P, Kostka J, Sessa C, Gehrig P, et al. A phase II trial of the mTOR inhibitor AP23573 as a single agent in advanced endometrial cancer. J Clin Oncol 2007;25:5516.
    • (2007) J Clin Oncol , vol.25 , pp. 5516
    • Colombo, N.1    McMeekin, S.2    Schwartz, P.3    Kostka, J.4    Sessa, C.5    Gehrig, P.6
  • 74
    • 78649592049 scopus 로고    scopus 로고
    • A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
    • Slomovitz BM, Lu KH, Johnston T, Coleman RL, Munsell M, Broaddus RR, et al. A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma. Cancer 2010;116:5415-9.
    • (2010) Cancer , vol.116 , pp. 5415-5419
    • Slomovitz, B.M.1    Lu, K.H.2    Johnston, T.3    Coleman, R.L.4    Munsell, M.5    Broaddus, R.R.6
  • 75
    • 80052010923 scopus 로고    scopus 로고
    • Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: A trial of the NCIC Clinical Trials Group
    • Oza AM, Elit L, Tsao MS, Kamel-Reid S, Biagi J, Provencher DM, et al. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group. J Clin Oncol 2011;29:3278-85.
    • (2011) J Clin Oncol , vol.29 , pp. 3278-3285
    • Oza, A.M.1    Elit, L.2    Tsao, M.S.3    Kamel-Reid, S.4    Biagi, J.5    Provencher, D.M.6
  • 76
    • 78149357205 scopus 로고    scopus 로고
    • Rapamycin inhibits cell proliferation in type I and type II endometrial carcinomas: A search for biomarkers of sensitivity to treatment
    • Bae-Jump VL, Zhou C, Boggess JF, Whang YE, Barroilhet L, Gehrig PA. Rapamycin inhibits cell proliferation in type I and type II endometrial carcinomas: a search for biomarkers of sensitivity to treatment. Gynecol Oncol 2010;119:579-85.
    • (2010) Gynecol Oncol , vol.119 , pp. 579-585
    • Bae-Jump, V.L.1    Zhou, C.2    Boggess, J.F.3    Whang, Y.E.4    Barroilhet, L.5    Gehrig, P.A.6
  • 77
    • 77951938324 scopus 로고    scopus 로고
    • A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies
    • Temkin SM, Yamada SD, Fleming GF. A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies. Gynecol Oncol 2010;117:473-6.
    • (2010) Gynecol Oncol , vol.117 , pp. 473-476
    • Temkin, S.M.1    Yamada, S.D.2    Fleming, G.F.3
  • 79
    • 77649286736 scopus 로고    scopus 로고
    • Genetic dissection of the oncogenicmTORpathway reveals druggable addiction to translational control via 4EBP-eIF4E
    • Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, et al. Genetic dissection of the oncogenicmTORpathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell 2010;17:249-61.
    • (2010) Cancer Cell , vol.17 , pp. 249-261
    • Hsieh, A.C.1    Costa, M.2    Zollo, O.3    Davis, C.4    Feldman, M.E.5    Testa, J.R.6
  • 80
    • 79952265072 scopus 로고    scopus 로고
    • 1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer
    • 1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J Med Chem 2011;54:1473-80.
    • (2011) J Med Chem , vol.54 , pp. 1473-1480
    • Liu, Q.1    Wang, J.2    Kang, S.A.3    Thoreen, C.C.4    Hur, W.5    Ahmed, T.6
  • 81
    • 0034667718 scopus 로고    scopus 로고
    • Clinical significance of microsatellite instability in endometrial carcinoma
    • Basil JB, Goodfellow PJ, Rader JS, Mutch DG, Herzog TJ. Clinical significance of microsatellite instability in endometrial carcinoma. Cancer 2000;89:1758-64.
    • (2000) Cancer , vol.89 , pp. 1758-1764
    • Basil, J.B.1    Goodfellow, P.J.2    Rader, J.S.3    Mutch, D.G.4    Herzog, T.J.5


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