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Volumn 2, Issue 8, 2003, Pages 789-795

Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; DNA BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN KINASE; RAPAMYCIN; TELOMERASE;

EID: 2342483301     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (72)

References (40)
  • 1
    • 0031833563 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: Immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling
    • DOI 10.1016/S0952-7915(98)80172-6
    • Abraham, R. T. Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling. Curr. Opin. Immunol., 10: 330-336, 1998. (Pubitemid 28286960)
    • (1998) Current Opinion in Immunology , vol.10 , Issue.3 , pp. 330-336
    • Abraham, R.T.1
  • 2
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle, T., and Hall, M. N. TOR, a central controller of cell growth. Cell, 103: 253-262, 2000.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 4
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • DOI 10.1038/sj.onc.1204091
    • Hidalgo, M., and Rowinsky, E. K. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene, 19: 6680-6686, 2000. (Pubitemid 32197708)
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 5
    • 0036225178 scopus 로고    scopus 로고
    • Inhibitors of mammalian target of rapamycin as novel antitumor agents: From bench to clinic
    • Huang, S., and Houghton, P. J. Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic. Curr. Opin. Investig. Drugs, 3: 295-304, 2002. (Pubitemid 34456089)
    • (2002) Current Opinion in Investigational Drugs , vol.3 , Issue.2 , pp. 295-304
    • Huang, S.1    Houghton, P.J.2
  • 6
    • 0035964367 scopus 로고    scopus 로고
    • Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
    • DOI 10.1073/pnas.191379498
    • Mills, G. B., Lu, Y., and Kohn, E. C. Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and invivo. Proc. Natl. Acad. Sci. USA, 98: 10031-10033, 2001. (Pubitemid 32802967)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.18 , pp. 10031-10033
    • Mills, G.B.1    Lu, Y.2    Kohn, E.C.3
  • 7
    • 0034472472 scopus 로고    scopus 로고
    • Telomerase and human tumorigenesis
    • DOI 10.1006/scbi.2000.0339
    • Stewart, S. A., and Weinberg, R. A. Telomerase and human tumorigenesis. Semin. Cancer Biol., 10: 399-406, 2000. (Pubitemid 32181910)
    • (2000) Seminars in Cancer Biology , vol.10 , Issue.6 , pp. 399-406
    • Stewart, S.A.1    Weinberg, R.A.2
  • 11
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • DOI 10.1073/pnas.96.8.4240
    • Cantley, L. C., and Neel, B. G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA, 96: 4240-4245, 1999. (Pubitemid 29190320)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.8 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 13
    • 0029856991 scopus 로고    scopus 로고
    • Comparison of the telomeric repeat amplification protocol (TRAP) to the new TRAP-eze telomerase detection kit
    • DOI 10.1007/BF00132889
    • Holt, S. E., Norton, J. C., Woodring, W. E., and Shay, J. W. Comparison of the telomeric repeat amplification protocol (TRAP) to the new TRAP-eze telomerase detection kit. Methods Cell Sci., 18: 237-248, 1996. (Pubitemid 26345354)
    • (1996) Methods in Cell Science , vol.18 , Issue.3 , pp. 237-248
    • Holt, S.E.1    Norton, J.C.2    Wright, W.E.3    Shay, J.W.4
  • 14
    • 0343415646 scopus 로고    scopus 로고
    • Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay
    • Bieche, I., Nogues, C., Paradis, V., Olivi, M., Bedossa, P., Lidereau, R., and Vidaud, M. Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay. Clin. Cancer Res., 6: 452-459, 2000. (Pubitemid 30111463)
    • (2000) Clinical Cancer Research , vol.6 , Issue.2 , pp. 452-459
    • Bieche, I.1    Nogues, C.2    Paradis, V.3    Olivi, M.4    Bedossa, P.5    Lidereau, R.6    Vidaud, M.7
  • 16
    • 0030915898 scopus 로고    scopus 로고
    • Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70(s6k)
    • DOI 10.1093/emboj/16.12.3693
    • Jefferies, H. B., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B., and Thomas, G. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k. EMBO J., 16: 3693-3704, 1997. (Pubitemid 27250062)
    • (1997) EMBO Journal , vol.16 , Issue.12 , pp. 3693-3704
    • Jefferies, H.B.J.1    Fumagalli, S.2    Dennis, P.B.3    Reinhard, C.4    Pearson, R.B.5    Thomas, G.6
  • 17
    • 0037174828 scopus 로고    scopus 로고
    • 389 in p70 S6 kinase 1
    • DOI 10.1074/jbc.M205168200
    • Romanelli, A., Dreisbach, V. C., and Blenis, J. Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr389 in p70 S6 kinase 1. J. Biol. Chem., 277: 40281-40289, 2002. (Pubitemid 35215600)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.43 , pp. 40281-40289
    • Romanelli, A.1    Dreisbach, V.C.2    Blenis, J.3
  • 18
    • 0025837327 scopus 로고
    • Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites
    • Ferrari, S., Bandi, H. R., Hofsteenge, J., Bussian, B. M., and Thomas, G. Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites. J. Biol. Chem., 266: 22770-22775, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22770-22775
    • Ferrari, S.1    Bandi, H.R.2    Hofsteenge, J.3    Bussian, B.M.4    Thomas, G.5
  • 19
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • DOI 10.1101/gad.887201
    • Gingras, A. C., Raught, B., and Sonenberg, N. Regulation of translation initiation by FRAP/mTOR. Genes Dev., 15: 807-826, 2001. (Pubitemid 32295062)
    • (2001) Genes and Development , vol.15 , Issue.7 , pp. 807-826
    • Gingras, A.-C.1    Raught, B.2    Sonenberg, N.3
  • 23
    • 0036735346 scopus 로고    scopus 로고
    • Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
    • Shi, Y., Gera, J., Hu, L., Hsu, J. H., Bookstein, R., Li, W., and Lichtenstein, A. Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res., 62: 5027-5034, 2002. (Pubitemid 34984430)
    • (2002) Cancer Research , vol.62 , Issue.17 , pp. 5027-5034
    • Shi, Y.1    Gera, J.2    Hu, L.3    Hsu, J.-H.4    Bookstein, R.5    Li, W.6    Lichtenstein, A.7
  • 24
    • 0036830256 scopus 로고    scopus 로고
    • Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells
    • Grunwald, V., DeGraffenried, L., Russel, D., Friedrichs, W. E., Ray, R. B., and Hidalgo, M. Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells. Cancer Res., 62:6141-6145, 2002. (Pubitemid 35244463)
    • (2002) Cancer Research , vol.62 , Issue.21 , pp. 6141-6145
    • Grunwald, V.1    DeGraffenried, L.2    Russel, D.3    Friedrichs, W.E.4    Ray, R.B.5    Hidalgo, M.6
  • 26
    • 0034790016 scopus 로고    scopus 로고
    • mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
    • DOI 10.1677/erc.0.0080249
    • Yu, K., Toral-Barza, L., Discafani, C., Zhang, W. G., Skotnicki, J., Frost, P., and Gibbons, J. J. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr. Relat. Cancer, 8: 249-258, 2001. (Pubitemid 32947647)
    • (2001) Endocrine-Related Cancer , vol.8 , Issue.3 , pp. 249-258
    • Yu, K.1    Toral-Barza, L.2    Discafani, C.3    Zhang, W.-G.4    Skotnicki, J.5    Frost, P.6    Gibbons, J.J.7
  • 29
    • 0033573016 scopus 로고    scopus 로고
    • The TOR signaling cascade regulates gene expression in response to nutrients
    • DOI 10.1101/gad.13.24.3271
    • Cardenas, M. E., Cutler, N. S., Lorenz, M. C., Di Como, C. J., and Heitman, J. The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev., 13: 3271-3279, 1999. (Pubitemid 30030448)
    • (1999) Genes and Development , vol.13 , Issue.24 , pp. 3271-3279
    • Cardenas, M.E.1    Cutler, N.S.2    Lorenz, M.C.3    Di, C.C.J.4    Heitman, J.5
  • 31
    • 0033540030 scopus 로고    scopus 로고
    • The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
    • Beck, T., and Hall, M. N. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature (Lond.), 402:689-692, 1999. (Pubitemid 129516342)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 689-692
    • Beck, T.1    Hall, M.N.2
  • 32
    • 0033968596 scopus 로고    scopus 로고
    • Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
    • DOI 10.1016/S0960-9822(99)00268-7
    • Yokogami, K., Wakisaka, S., Avruch, J., and Reeves, S. A. Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr. Biol., 10: 47-50, 2000. (Pubitemid 30057415)
    • (2000) Current Biology , vol.10 , Issue.1 , pp. 47-50
    • Yokogami, K.1    Wakisaka, S.2    Avruch, J.3    Reeves, S.A.4
  • 33
    • 0037470728 scopus 로고    scopus 로고
    • Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells
    • DOI 10.1016/S0006-291X(03)00343-7
    • Bruemmer, D., Yin, F., Liu, J., Kiyono, T., Fleck, E., Van Herle, A. J., and Law, R. E. Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 303: 251-258, 2003. (Pubitemid 36338233)
    • (2003) Biochemical and Biophysical Research Communications , vol.303 , Issue.1 , pp. 251-258
    • Bruemmer, D.1    Yin, F.2    Liu, J.3    Kiyono, T.4    Fleck, E.5    Van Herle, A.J.6    Law, R.E.7
  • 34
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • DOI 10.1128/MCB.21.12.3995-4004.2001
    • Laughner, E., Taghavi, P., Chiles, K., Mahon, P. C., and Semenza, G. L. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol. Cell. Biol., 21: 3995-4004, 2001. (Pubitemid 32476461)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.12 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 37
    • 0034234924 scopus 로고    scopus 로고
    • A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
    • Sekulic, A., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M., and Abraham, R. T. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res., 60: 3504-3513, 2000. (Pubitemid 30482170)
    • (2000) Cancer Research , vol.60 , Issue.13 , pp. 3504-3513
    • Sekulic, A.1    Hudson, C.C.2    Homme, J.L.3    Yin, P.4    Otterness, D.M.5    Karnitz, L.M.6    Abraham, R.T.7
  • 40
    • 0033178702 scopus 로고    scopus 로고
    • Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70(s6K) pathway in human pancreatic cancer cells
    • Grewe, M., Gansauge, F., Schmid, R. M., Adler, G., and Seufferlein, T. Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. Cancer Res., 59: 3581-3587, 1999. (Pubitemid 29381856)
    • (1999) Cancer Research , vol.59 , Issue.15 , pp. 3581-3587
    • Grewe, M.1    Gansauge, F.2    Schmid, R.M.3    Adler, G.4    Seufferlein, T.5


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