PTEN induces G1 cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells

Cancer Research

Volumn 61, Issue 11, 2001, Pages 4569-4575

  Zhu, Xiaoyan ^a   Kwon, Chang Hyuk ^b   Schlosshauer, Peter W ^c   Ellenson, Lora Hedrick ^c   Baker, Suzanne J ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D3; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ARTICLE; CELL CYCLE G1 PHASE; COMPLEX FORMATION; ENDOMETRIUM CARCINOMA; GENE MUTATION; GROWTH REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; STOICHIOMETRY; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; ENDOMETRIAL NEOPLASMS; ENZYME ACTIVATION; FEMALE; G1 PHASE; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0035361602     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

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3. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
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6. Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers
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9. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
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14. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies
15. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
16. Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
17. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAG13, a novel membrane-associated guanylate kinase
18. The C. Elegans PTEN homolog. DAF-18, acts in the insulin receptor-like metabolic signaling pathway
19. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
20. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
21. Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN
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23. Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer
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30. 1 growth arrest in glioma cells
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34. 1 arrest followed by cell death
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54. Phosphorylation of the PTEN tail regulates protein stability and function
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61. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
62. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
63. D-type cyclins
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68. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β