메뉴 건너뛰기




Volumn 40, Issue 10, 2009, Pages 1418-1426

Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis

Author keywords

4E BP1; Cell signaling; Endometrial cancer; Prognostic factors

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; INITIATION FACTOR 4E BINDING PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN P53;

EID: 69949156862     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2008.12.019     Document Type: Article
Times cited : (42)

References (38)
  • 2
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom T., Jones S., Wood L.D., et al. The consensus coding sequences of human breast and colorectal cancers. Science 314 (2006) 268-274
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1    Jones, S.2    Wood, L.D.3
  • 3
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • Bokhman J.V. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 15 (1983) 10-17
    • (1983) Gynecol Oncol , vol.15 , pp. 10-17
    • Bokhman, J.V.1
  • 6
    • 2942578078 scopus 로고    scopus 로고
    • Focus on endometrial and cervical cancer
    • Ellenson L.H., and Wu T.C. Focus on endometrial and cervical cancer. Cancer Cell 5 (2004) 533-538
    • (2004) Cancer Cell , vol.5 , pp. 533-538
    • Ellenson, L.H.1    Wu, T.C.2
  • 7
    • 1842506206 scopus 로고    scopus 로고
    • Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification
    • Lax S.F. Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. Virchows Arch 444 (2004) 213-223
    • (2004) Virchows Arch , vol.444 , pp. 213-223
    • Lax, S.F.1
  • 8
    • 2442701289 scopus 로고    scopus 로고
    • The ErbB/HER receptor protein-tyrosine kinases and cancer
    • Roskoski Jr. R. The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun 319 (2004) 1-11
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 1-11
    • Roskoski Jr., R.1
  • 9
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou C.M., Sorlie T., Eisen M.B., et al. Molecular portraits of human breast tumours. Nature 406 (2000) 747-752
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 10
    • 0242624620 scopus 로고    scopus 로고
    • Biologic and therapeutic role of HER2 in cancer
    • Menard S., Pupa S.M., Campiglio M., and Tagliabue E. Biologic and therapeutic role of HER2 in cancer. Oncogene 22 (2003) 6570-6578
    • (2003) Oncogene , vol.22 , pp. 6570-6578
    • Menard, S.1    Pupa, S.M.2    Campiglio, M.3    Tagliabue, E.4
  • 11
    • 7444228551 scopus 로고    scopus 로고
    • Analysis of HER-2/neu amplification in endometrial carcinoma by chromogenic in situ hybridization. Correlation with fluorescence in situ hybridization, HER-2/neu, p53 and Ki-67 protein expression, and outcome
    • Peiro G., Mayr D., Hillemanns P., Lohrs U., and Diebold J. Analysis of HER-2/neu amplification in endometrial carcinoma by chromogenic in situ hybridization. Correlation with fluorescence in situ hybridization, HER-2/neu, p53 and Ki-67 protein expression, and outcome. Mod Pathol 17 (2004) 227-287
    • (2004) Mod Pathol , vol.17 , pp. 227-287
    • Peiro, G.1    Mayr, D.2    Hillemanns, P.3    Lohrs, U.4    Diebold, J.5
  • 12
    • 25144510392 scopus 로고    scopus 로고
    • Amplification of c-erbB2 oncogene: a major prognostic indicator in uterine serous papillary carcinoma
    • Santin A.D., Bellone S., Van S.S., et al. Amplification of c-erbB2 oncogene: a major prognostic indicator in uterine serous papillary carcinoma. Cancer 104 (2005) 1391-1397
    • (2005) Cancer , vol.104 , pp. 1391-1397
    • Santin, A.D.1    Bellone, S.2    Van, S.S.3
  • 13
    • 27644575157 scopus 로고    scopus 로고
    • Coordinating ERK/MAPK signalling through scaffolds and inhibitors
    • Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 6 (2005) 827-837
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 827-837
    • Kolch, W.1
  • 14
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S., Loewith R., and Hall M.N. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 16
    • 33750044299 scopus 로고    scopus 로고
    • When translation meets transformation: the mTOR story
    • Averous J., and Proud C.G. When translation meets transformation: the mTOR story. Oncogene 25 (2006) 6423-6435
    • (2006) Oncogene , vol.25 , pp. 6423-6435
    • Averous, J.1    Proud, C.G.2
  • 17
    • 2942544833 scopus 로고    scopus 로고
    • Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells
    • Avdulov S., Li S., Michalek V., et al. Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 5 (2004) 553-563
    • (2004) Cancer Cell , vol.5 , pp. 553-563
    • Avdulov, S.1    Li, S.2    Michalek, V.3
  • 18
    • 33750089285 scopus 로고    scopus 로고
    • Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer
    • Castellvi J., Garcia A., Rojo F., et al. Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer. Cancer 107 (2006) 1801-1811
    • (2006) Cancer , vol.107 , pp. 1801-1811
    • Castellvi, J.1    Garcia, A.2    Rojo, F.3
  • 19
    • 33846276209 scopus 로고    scopus 로고
    • 4E-Binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis
    • Rojo F., Najera L., Lirola J., et al. 4E-Binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis. Clin Cancer Res 13 (2007) 81-89
    • (2007) Clin Cancer Res , vol.13 , pp. 81-89
    • Rojo, F.1    Najera, L.2    Lirola, J.3
  • 20
    • 34548028705 scopus 로고    scopus 로고
    • 4E-Binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications
    • Armengol G., Rojo F., Castellvi J., et al. 4E-Binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications. Cancer Res 67 (2007) 7551-7555
    • (2007) Cancer Res , vol.67 , pp. 7551-7555
    • Armengol, G.1    Rojo, F.2    Castellvi, J.3
  • 22
    • 0034616634 scopus 로고    scopus 로고
    • Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
    • Mutter G.L., Lin M.C., Fitzgerald J.T., et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 92 (2000) 924-930
    • (2000) J Natl Cancer Inst , vol.92 , pp. 924-930
    • Mutter, G.L.1    Lin, M.C.2    Fitzgerald, J.T.3
  • 23
    • 20144384275 scopus 로고    scopus 로고
    • Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression
    • Baak J.P., Van D.B., Steinbakk A., et al. Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression. Hum Pathol 36 (2005) 555-561
    • (2005) Hum Pathol , vol.36 , pp. 555-561
    • Baak, J.P.1    Van, D.B.2    Steinbakk, A.3
  • 24
    • 21044444976 scopus 로고    scopus 로고
    • Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities
    • Pallares J., Bussaglia E., Martinez-Guitarte J.L., et al. Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities. Mod Pathol 18 (2005) 719-727
    • (2005) Mod Pathol , vol.18 , pp. 719-727
    • Pallares, J.1    Bussaglia, E.2    Martinez-Guitarte, J.L.3
  • 25
    • 33750698981 scopus 로고    scopus 로고
    • PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia
    • Hayes M.P., Wang H., Espinal-Witter R., et al. PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia. Clin Cancer Res 12 20 Pt 1 (2006) 5932-5935
    • (2006) Clin Cancer Res , vol.12 , Issue.20 PART 1 , pp. 5932-5935
    • Hayes, M.P.1    Wang, H.2    Espinal-Witter, R.3
  • 26
    • 0026694997 scopus 로고
    • Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium
    • Mizuuchi H., Nasim S., Kudo R., Silverberg S.G., Greenhouse S., and Garrett C.T. Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium. Cancer Res 52 (1992) 2777-2781
    • (1992) Cancer Res , vol.52 , pp. 2777-2781
    • Mizuuchi, H.1    Nasim, S.2    Kudo, R.3    Silverberg, S.G.4    Greenhouse, S.5    Garrett, C.T.6
  • 27
    • 33846028791 scopus 로고    scopus 로고
    • Expression of the epidermal growth factor system in endometrioid endometrial cancer
    • Ejskjaer K., Sorensen B.S., Poulsen S.S., Forman A., Nexo E., and Mogensen O. Expression of the epidermal growth factor system in endometrioid endometrial cancer. Gynecol Oncol 104 (2007) 158-167
    • (2007) Gynecol Oncol , vol.104 , pp. 158-167
    • Ejskjaer, K.1    Sorensen, B.S.2    Poulsen, S.S.3    Forman, A.4    Nexo, E.5    Mogensen, O.6
  • 28
    • 33744828734 scopus 로고    scopus 로고
    • HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patients
    • Morrison C., Zanagnolo V., Ramirez N., et al. HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patients. J Clin Oncol 24 (2006) 2376-2385
    • (2006) J Clin Oncol , vol.24 , pp. 2376-2385
    • Morrison, C.1    Zanagnolo, V.2    Ramirez, N.3
  • 29
    • 27844445642 scopus 로고    scopus 로고
    • Perturbations of the AKT signaling pathway in human cancer
    • Altomare D.A., and Testa J.R. Perturbations of the AKT signaling pathway in human cancer. Oncogene 24 (2005) 7455-7464
    • (2005) Oncogene , vol.24 , pp. 7455-7464
    • Altomare, D.A.1    Testa, J.R.2
  • 30
    • 35549006238 scopus 로고    scopus 로고
    • Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosis
    • Mori N., Kyo S., Sakaguchi J., et al. Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosis. Cancer Sci 98 (2007) 1881-1888
    • (2007) Cancer Sci , vol.98 , pp. 1881-1888
    • Mori, N.1    Kyo, S.2    Sakaguchi, J.3
  • 31
    • 24744448247 scopus 로고    scopus 로고
    • PTEN-Positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma
    • Uegaki K., Kanamori Y., Kigawa J., et al. PTEN-Positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma. Oncol Rep 14 (2005) 389-392
    • (2005) Oncol Rep , vol.14 , pp. 389-392
    • Uegaki, K.1    Kanamori, Y.2    Kigawa, J.3
  • 32
    • 34547209343 scopus 로고    scopus 로고
    • Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
    • McCubrey J.A., Steelman L.S., Chappell W.H., et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 1773 (2007) 1263-1284
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1263-1284
    • McCubrey, J.A.1    Steelman, L.S.2    Chappell, W.H.3
  • 33
    • 34147133693 scopus 로고    scopus 로고
    • Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis
    • Mizumoto Y., Kyo S., Mori N., et al. Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis. Cancer Sci 98 (2007) 652-658
    • (2007) Cancer Sci , vol.98 , pp. 652-658
    • Mizumoto, Y.1    Kyo, S.2    Mori, N.3
  • 34
    • 0032520009 scopus 로고    scopus 로고
    • 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
    • Gingras A.C., Kennedy S.G., O'Leary M.A., Sonenberg N., and Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev 12 (1998) 502-513
    • (1998) Genes Dev , vol.12 , pp. 502-513
    • Gingras, A.C.1    Kennedy, S.G.2    O'Leary, M.A.3    Sonenberg, N.4    Hay, N.5
  • 35
    • 2342489456 scopus 로고    scopus 로고
    • eIF-4E Expression and its role in malignancies and metastases
    • De B.A., and Graff J.R. eIF-4E Expression and its role in malignancies and metastases. Oncogene 23 (2004) 3189-3199
    • (2004) Oncogene , vol.23 , pp. 3189-3199
    • De, B.A.1    Graff, J.R.2
  • 36
    • 33645881690 scopus 로고    scopus 로고
    • Biologic targets for therapeutic intervention in endometrioid endometrial adenocarcinoma and malignant mixed mullerian tumors
    • Rice L.W., Stone R.L., Xu M., et al. Biologic targets for therapeutic intervention in endometrioid endometrial adenocarcinoma and malignant mixed mullerian tumors. Am J Obstet Gynecol 194 (2006) 1119-1126
    • (2006) Am J Obstet Gynecol , vol.194 , pp. 1119-1126
    • Rice, L.W.1    Stone, R.L.2    Xu, M.3
  • 37
    • 23044449474 scopus 로고    scopus 로고
    • Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53
    • Constantinou C., and Clemens M.J. Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53. Oncogene (2005)
    • (2005) Oncogene
    • Constantinou, C.1    Clemens, M.J.2
  • 38
    • 45749141224 scopus 로고    scopus 로고
    • Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs
    • Rong L., Livingstone M., Sukarieh R., et al. Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA 14 (2008) 1318-1327
    • (2008) RNA , vol.14 , pp. 1318-1327
    • Rong, L.1    Livingstone, M.2    Sukarieh, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.