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Volumn 46, Issue 1, 2007, Pages 26-32

Molecular carcinogenesis of endometrial cancer

Author keywords

Carcinogenesis; Endometrial carcinoma; Genetic alteration

Indexed keywords

BETA CATENIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN MSH2; PROTEIN MSH6; PROTEIN P16; PROTEIN P53; UVOMORULIN;

EID: 34247513939     PISSN: 10284559     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1028-4559(08)60102-3     Document Type: Review
Times cited : (120)

References (73)
  • 1
    • 0029944173 scopus 로고    scopus 로고
    • A population-based study of endometrial cancer and familial risk in younger women: Cancer and Steroid Hormone Study Group
    • Gruber SB, Thompson WD. A population-based study of endometrial cancer and familial risk in younger women: Cancer and Steroid Hormone Study Group. Cancer Epidemiol Biomarkers Prev 1996;5:411-7.
    • (1996) Cancer Epidemiol Biomarkers Prev , vol.5 , pp. 411-417
    • Gruber, S.B.1    Thompson, W.D.2
  • 2
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983;15:10-7.
    • (1983) Gynecol Oncol , vol.15 , pp. 10-17
    • Bokhman, J.V.1
  • 3
    • 9444280099 scopus 로고    scopus 로고
    • Case-control study of endogenous steroid hormones and endometrial cancer
    • Potischman N, Hoover RN, Brinton LA, et al. Case-control study of endogenous steroid hormones and endometrial cancer. J Natl Cancer Inst 1996;88:1127-35.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1127-1135
    • Potischman, N.1    Hoover, R.N.2    Brinton, L.A.3
  • 4
    • 0031715566 scopus 로고    scopus 로고
    • Comparison of estrogen and progesterone receptor, Ki67, and p53 immunoreactivity in uterine endometrioid carcinoma and endometrioid carcinoma with squamous, mucinous, secretory, and ciliated cell differentiation
    • Lax SF, Pizer ES, Ronnett BM, Kurman RJ. Comparison of estrogen and progesterone receptor, Ki67, and p53 immunoreactivity in uterine endometrioid carcinoma and endometrioid carcinoma with squamous, mucinous, secretory, and ciliated cell differentiation. Hum Pathol 1998;29:924-31.
    • (1998) Hum Pathol , vol.29 , pp. 924-931
    • Lax, S.F.1    Pizer, E.S.2    Ronnett, B.M.3    Kurman, R.J.4
  • 5
    • 0028887101 scopus 로고
    • p53 in endometrial cancer and its putative precursors: Evidence for diverse pathways of tumorogenesis
    • Sherman ME, Bur ME, Kurman RJ. p53 in endometrial cancer and its putative precursors: evidence for diverse pathways of tumorogenesis. Hum Pathol 1995;26:1268-74.
    • (1995) Hum Pathol , vol.26 , pp. 1268-1274
    • Sherman, M.E.1    Bur, M.E.2    Kurman, R.J.3
  • 6
    • 0028829840 scopus 로고
    • Endometrial intraepithelial carcinoma: A distinctive lesion specifically associated with tumors displaying serous differentiation
    • Ambros RA, Sherman ME, Zahn CM, Bitterman P, Kurman RJ. Endometrial intraepithelial carcinoma: a distinctive lesion specifically associated with tumors displaying serous differentiation. Hum Pathol 1995;26:1260-7.
    • (1995) Hum Pathol , vol.26 , pp. 1260-1267
    • Ambros, R.A.1    Sherman, M.E.2    Zahn, C.M.3    Bitterman, P.4    Kurman, R.J.5
  • 7
    • 0031746796 scopus 로고    scopus 로고
    • Clear cell carcinoma of the endometrium is characterized by a distinctive profile of p53, Ki-67, estrogen, and progesterone receptor expression
    • Lax SF, Pizer ES, Ronnett BM, Kurman RJ. Clear cell carcinoma of the endometrium is characterized by a distinctive profile of p53, Ki-67, estrogen, and progesterone receptor expression. Hum Pathol 1998;29:551-8.
    • (1998) Hum Pathol , vol.29 , pp. 551-558
    • Lax, S.F.1    Pizer, E.S.2    Ronnett, B.M.3    Kurman, R.J.4
  • 8
    • 0034978311 scopus 로고    scopus 로고
    • Pten, a protean tumor suppressor
    • Mutter GL. Pten, a protean tumor suppressor. Am J Pathol 2001;158:1895-8.
    • (2001) Am J Pathol , vol.158 , pp. 1895-1898
    • Mutter, G.L.1
  • 9
    • 0038456399 scopus 로고    scopus 로고
    • PTEN signaling pathways in melanoma
    • Wu H, Goel V, Haluska FG. PTEN signaling pathways in melanoma. Oncogene 2003;22:3113-22.
    • (2003) Oncogene , vol.22 , pp. 3113-3122
    • Wu, H.1    Goel, V.2    Haluska, F.G.3
  • 10
    • 0034616634 scopus 로고    scopus 로고
    • Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
    • Mutter GL, Lin MC, Fitzgerald JT, et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 2000;92:924-30.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 924-930
    • Mutter, G.L.1    Lin, M.C.2    Fitzgerald, J.T.3
  • 11
    • 0035196043 scopus 로고    scopus 로고
    • PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma
    • Salvesen HB, MacDonald N, Ryan A, et al. PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma. Int J Cancer 2001;91:22-6.
    • (2001) Int J Cancer , vol.91 , pp. 22-26
    • Salvesen, H.B.1    MacDonald, N.2    Ryan, A.3
  • 12
    • 0032422644 scopus 로고    scopus 로고
    • PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics
    • Risinger JI, Hayes K, Maxwell GL, Carney ME, Barrett JC, Berchuck A. PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics. Clin Cancer Res 1998;4:3005-10.
    • (1998) Clin Cancer Res , vol.4 , pp. 3005-3010
    • Risinger, J.I.1    Hayes, K.2    Maxwell, G.L.3    Carney, M.E.4    Barrett, J.C.5    Berchuck, A.6
  • 13
    • 0028299319 scopus 로고
    • Microsatellite instability in endometrial carcinoma
    • Burks RT, Kessis TD, Cho KR, Hedrick L. Microsatellite instability in endometrial carcinoma. Oncogene 1994;9:1163-6.
    • (1994) Oncogene , vol.9 , pp. 1163-1166
    • Burks, R.T.1    Kessis, T.D.2    Cho, K.R.3    Hedrick, L.4
  • 15
    • 0034654642 scopus 로고    scopus 로고
    • Frequency and prognostic impact of microsatellite instability in a large population-based study of endometrial carcinomas
    • MacDonald ND, Salvesen HB, Ryan A, Iversen OE, Akslen LA, Jacobs IJ. Frequency and prognostic impact of microsatellite instability in a large population-based study of endometrial carcinomas. Cancer Res 2000;60:1750-2.
    • (2000) Cancer Res , vol.60 , pp. 1750-1752
    • MacDonald, N.D.1    Salvesen, H.B.2    Ryan, A.3    Iversen, O.E.4    Akslen, L.A.5    Jacobs, I.J.6
  • 16
    • 0032487831 scopus 로고    scopus 로고
    • MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas
    • Esteller M, Levine R, Baylin SB, Ellenson LH, Herman JG. MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene 1998;17:2413-7.
    • (1998) Oncogene , vol.17 , pp. 2413-2417
    • Esteller, M.1    Levine, R.2    Baylin, S.B.3    Ellenson, L.H.4    Herman, J.G.5
  • 17
    • 0033813298 scopus 로고    scopus 로고
    • Methylation of hMLH1 in a population-based series of endometrial carcinomas
    • Salvesen HB, MacDonald N, Ryan A, et al. Methylation of hMLH1 in a population-based series of endometrial carcinomas. Clin Cancer Res 2000;6:3607-13.
    • (2000) Clin Cancer Res , vol.6 , pp. 3607-3613
    • Salvesen, H.B.1    MacDonald, N.2    Ryan, A.3
  • 18
    • 0034020502 scopus 로고    scopus 로고
    • Altered expression of hMLH1 and hMSH2 protein in endometrial carcinomas with microsatellite instability
    • Staebler A, Lax SF, Ellenson LH. Altered expression of hMLH1 and hMSH2 protein in endometrial carcinomas with microsatellite instability. Hum Pathol 2000;31:354-8.
    • (2000) Hum Pathol , vol.31 , pp. 354-358
    • Staebler, A.1    Lax, S.F.2    Ellenson, L.H.3
  • 19
    • 0036152444 scopus 로고    scopus 로고
    • Loss of hMSH2 and hMSH6 expression is frequent in sporadic endometrial carcinomas with microsatellite instability: A population-based study
    • Stefansson I, Akslen LA, MacDonald N, et al. Loss of hMSH2 and hMSH6 expression is frequent in sporadic endometrial carcinomas with microsatellite instability: a population-based study. Clin Cancer Res 2002;8:138-43.
    • (2002) Clin Cancer Res , vol.8 , pp. 138-143
    • Stefansson, I.1    Akslen, L.A.2    MacDonald, N.3
  • 20
    • 0028883556 scopus 로고
    • Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas
    • Katabuchi H, van Rees B, Lambers AR, et al. Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas. Cancer Res 1995;55:5556-60.
    • (1995) Cancer Res , vol.55 , pp. 5556-5560
    • Katabuchi, H.1    van Rees, B.2    Lambers, A.R.3
  • 21
    • 0037609660 scopus 로고    scopus 로고
    • Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers
    • Goodfellow PJ, Buttin BM, Herzog TJ, et al. Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers. Proc Natl Acad Sci USA 2003;100:5908-13.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5908-5913
    • Goodfellow, P.J.1    Buttin, B.M.2    Herzog, T.J.3
  • 22
    • 0035120324 scopus 로고    scopus 로고
    • Favorable survival associated with microsatellite instability in endometrioid endometrial cancers
    • Maxwell GL, Risinger JI, Alvarez AA, Barrett JC, Berchuck A. Favorable survival associated with microsatellite instability in endometrioid endometrial cancers. Obstet Gynecol 2001;97:417-22.
    • (2001) Obstet Gynecol , vol.97 , pp. 417-422
    • Maxwell, G.L.1    Risinger, J.I.2    Alvarez, A.A.3    Barrett, J.C.4    Berchuck, A.5
  • 23
    • 0028872141 scopus 로고
    • Mutations of the Ki-ras oncogene in carcinoma of the endometrium
    • Caduff RF, Johnston CM, Frank TS. Mutations of the Ki-ras oncogene in carcinoma of the endometrium. Am J Pathol 1995;146:182-8.
    • (1995) Am J Pathol , vol.146 , pp. 182-188
    • Caduff, R.F.1    Johnston, C.M.2    Frank, T.S.3
  • 25
    • 0027157844 scopus 로고
    • Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma
    • Sasaki H, Nishii H, Takahashi H, et al. Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma. Cancer Res 1993;53:1906-10.
    • (1993) Cancer Res , vol.53 , pp. 1906-1910
    • Sasaki, H.1    Nishii, H.2    Takahashi, H.3
  • 26
    • 0035150494 scopus 로고    scopus 로고
    • K-ras mutation in endometrial carcinoma with microsatellite instability
    • Lagarda H, Catasus L, Arguelles R, Matias-Guiu X, Prat J. K-ras mutation in endometrial carcinoma with microsatellite instability. J Pathol 2001;193:193-9.
    • (2001) J Pathol , vol.193 , pp. 193-199
    • Lagarda, H.1    Catasus, L.2    Arguelles, R.3    Matias-Guiu, X.4    Prat, J.5
  • 27
    • 0034185044 scopus 로고    scopus 로고
    • Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer
    • Ikeda T, Yoshinaga K, Suzuki A, Sakurada A, Ohmori H, Horii A. Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer. Oncol Res 2000;7:567-70.
    • (2000) Oncol Res , vol.7 , pp. 567-570
    • Ikeda, T.1    Yoshinaga, K.2    Suzuki, A.3    Sakurada, A.4    Ohmori, H.5    Horii, A.6
  • 28
    • 0035153307 scopus 로고    scopus 로고
    • Beta-catenin mutations and aberrant nuclear expression during endometrial tumorigenesis
    • Saegusa M, Hashimura M, Yoshida T, Okayasu I. Beta-catenin mutations and aberrant nuclear expression during endometrial tumorigenesis. Br J Cancer 2001;84:209-17.
    • (2001) Br J Cancer , vol.84 , pp. 209-217
    • Saegusa, M.1    Hashimura, M.2    Yoshida, T.3    Okayasu, I.4
  • 29
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 30
    • 0035036476 scopus 로고    scopus 로고
    • Beta- and gamma-catenin expression in endometrial carcinoma. Relationship with clinicopathological features and microsatellite instability
    • Palacios J, Catasus L, Moreno Bueno G, Matias Guiu X, Prat J, Gamallo C. Beta- and gamma-catenin expression in endometrial carcinoma. Relationship with clinicopathological features and microsatellite instability. Virchows Arch 2001;438:464-9.
    • (2001) Virchows Arch , vol.438 , pp. 464-469
    • Palacios, J.1    Catasus, L.2    Moreno Bueno, G.3    Matias Guiu, X.4    Prat, J.5    Gamallo, C.6
  • 31
    • 0021119833 scopus 로고
    • The role of cancer cell motility in invasion
    • Strauli P, Haemmerli G. The role of cancer cell motility in invasion. Cancer Metastasis Rev 1984;3:127-41.
    • (1984) Cancer Metastasis Rev , vol.3 , pp. 127-141
    • Strauli, P.1    Haemmerli, G.2
  • 32
    • 0021329132 scopus 로고
    • Motility and adhesive properties of high and low-metastatic murine neoplastic cells
    • Volk T, Geiger B, Raz A. Motility and adhesive properties of high and low-metastatic murine neoplastic cells. Cancer Res 1984;44:811-24.
    • (1984) Cancer Res , vol.44 , pp. 811-824
    • Volk, T.1    Geiger, B.2    Raz, A.3
  • 33
    • 0036899153 scopus 로고    scopus 로고
    • E-cadherin expression in endometrioid, papillary serous, and clear cell carcinoma of the endometrium
    • Holcomb K, Delatorre R, Pedemonte B, McLeod C, Anderson L, Chambers J. E-cadherin expression in endometrioid, papillary serous, and clear cell carcinoma of the endometrium. Obstet Gynecol 2002;100:1290-5.
    • (2002) Obstet Gynecol , vol.100 , pp. 1290-1295
    • Holcomb, K.1    Delatorre, R.2    Pedemonte, B.3    McLeod, C.4    Anderson, L.5    Chambers, J.6
  • 34
    • 4143051355 scopus 로고    scopus 로고
    • Prognostic significance of E-cadherin protein expression in pathological stage I-III endometrial cancer
    • Mell LK, Meyer JJ, Tretiakova M, et al. Prognostic significance of E-cadherin protein expression in pathological stage I-III endometrial cancer. Clin Cancer Res 2004;10:5546-53.
    • (2004) Clin Cancer Res , vol.10 , pp. 5546-5553
    • Mell, L.K.1    Meyer, J.J.2    Tretiakova, M.3
  • 35
    • 33745103655 scopus 로고    scopus 로고
    • Combined E-cadherin, alpha-catenin, and beta-catenin expression is a favorable prognostic factor in endometrial carcinoma
    • Scholten AN, Aliredjo R, Creutzberg CL, Smit VT. Combined E-cadherin, alpha-catenin, and beta-catenin expression is a favorable prognostic factor in endometrial carcinoma. Int J Gynecol Cancer 2006;16:1379-85.
    • (2006) Int J Gynecol Cancer , vol.16 , pp. 1379-1385
    • Scholten, A.N.1    Aliredjo, R.2    Creutzberg, C.L.3    Smit, V.T.4
  • 36
    • 0033979559 scopus 로고    scopus 로고
    • Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis
    • Salvesen HB, Das S, Akslen LA. Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis. Clin Cancer Res 2000;6:153-9.
    • (2000) Clin Cancer Res , vol.6 , pp. 153-159
    • Salvesen, H.B.1    Das, S.2    Akslen, L.A.3
  • 38
    • 0033967724 scopus 로고    scopus 로고
    • The role of p16-cyclin d/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma
    • Tsuda H, Yamamoto K, Inoue T, Uchiyama I, Umesaki N. The role of p16-cyclin d/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma. Br J Cancer 2000;82:675-82.
    • (2000) Br J Cancer , vol.82 , pp. 675-682
    • Tsuda, H.1    Yamamoto, K.2    Inoue, T.3    Uchiyama, I.4    Umesaki, N.5
  • 39
    • 33645837682 scopus 로고    scopus 로고
    • Hypermethyltion in the p16 promoter region in the carcinogenesis of endometrial cancer in Japanese patients
    • Yanokura M, Banno K, Susumu N, et al. Hypermethyltion in the p16 promoter region in the carcinogenesis of endometrial cancer in Japanese patients. Anticancer Res 2006;26:851-6.
    • (2006) Anticancer Res , vol.26 , pp. 851-856
    • Yanokura, M.1    Banno, K.2    Susumu, N.3
  • 40
    • 20344395115 scopus 로고    scopus 로고
    • Low frequency of BRAF and CDKN2A mutations in endometrial cancer
    • Salvesen HB, Kumar R, Stefansson I, et al. Low frequency of BRAF and CDKN2A mutations in endometrial cancer. Int J Cancer 2005;115:930-4.
    • (2005) Int J Cancer , vol.115 , pp. 930-934
    • Salvesen, H.B.1    Kumar, R.2    Stefansson, I.3
  • 41
    • 0034651530 scopus 로고    scopus 로고
    • The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: Evidence of distinct molecular genetic pathways
    • Lax SF, Kendall B, Tashiro H, Slebos RJ, Hedrick L. The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways. Cancer 2000;88:814-24.
    • (2000) Cancer , vol.88 , pp. 814-824
    • Lax, S.F.1    Kendall, B.2    Tashiro, H.3    Slebos, R.J.4    Hedrick, L.5
  • 42
    • 0036569795 scopus 로고    scopus 로고
    • Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis
    • Koul A, Willen R, Bendahl PO, Nilbert M, Borg A. Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis. Cancer 2002;94:2369-79.
    • (2002) Cancer , vol.94 , pp. 2369-2379
    • Koul, A.1    Willen, R.2    Bendahl, P.O.3    Nilbert, M.4    Borg, A.5
  • 43
    • 0031670618 scopus 로고    scopus 로고
    • Correlation of proliferation indices, apoptosis, and related oncogene expression (bcl-2 and c-erbB-2) and p53 in proliferative, hyperplastic, and malignant endometrium
    • Ioffe OB, Papadimitriou JC, Drachenberg CB. Correlation of proliferation indices, apoptosis, and related oncogene expression (bcl-2 and c-erbB-2) and p53 in proliferative, hyperplastic, and malignant endometrium. Hum Pathol 1998;29:1150-9.
    • (1998) Hum Pathol , vol.29 , pp. 1150-1159
    • Ioffe, O.B.1    Papadimitriou, J.C.2    Drachenberg, C.B.3
  • 45
    • 0034950673 scopus 로고    scopus 로고
    • Molecular pathology of endometrial hyperplasia and carcinoma
    • Matias-Guiu X, Catasus L, Bussaglia E, et al. Molecular pathology of endometrial hyperplasia and carcinoma. Hum Pathol 2001;32:569-77.
    • (2001) Hum Pathol , vol.32 , pp. 569-577
    • Matias-Guiu, X.1    Catasus, L.2    Bussaglia, E.3
  • 46
    • 1842506206 scopus 로고    scopus 로고
    • Molecular genetic pathways in various types of endometrioid carcinoma: From a phenotypical to a molecular-based classification
    • Lax SF. Molecular genetic pathways in various types of endometrioid carcinoma: from a phenotypical to a molecular-based classification. Virchows Arch 2004;444:213-23.
    • (2004) Virchows Arch , vol.444 , pp. 213-223
    • Lax, S.F.1
  • 47
    • 0029048985 scopus 로고
    • KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2
    • Dong JT, Lamb PW, Rinker-Schaeffer CW, et al. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science (Washington DC) 1995;268:884-6.
    • (1995) Science (Washington DC) , vol.268 , pp. 884-886
    • Dong, J.T.1    Lamb, P.W.2    Rinker-Schaeffer, C.W.3
  • 48
    • 0037386824 scopus 로고    scopus 로고
    • KAI1 metastasis suppressor protein is down-regulated during the progression of human endometrial cancer
    • Liu FS, Dong JT, Chen JT, et al. KAI1 metastasis suppressor protein is down-regulated during the progression of human endometrial cancer. Clin Cancer Res 2003;9:1393-8.
    • (2003) Clin Cancer Res , vol.9 , pp. 1393-1398
    • Liu, F.S.1    Dong, J.T.2    Chen, J.T.3
  • 49
    • 0141569581 scopus 로고    scopus 로고
    • Loss of Smad4 protein expression occurs infrequently in endometrial carcinomas
    • Liu FS, Chen JT, Hsieh YT, et al. Loss of Smad4 protein expression occurs infrequently in endometrial carcinomas. Int J Gynecol Pathol 2003;22:347-52.
    • (2003) Int J Gynecol Pathol , vol.22 , pp. 347-352
    • Liu, F.S.1    Chen, J.T.2    Hsieh, Y.T.3
  • 51
    • 0031012928 scopus 로고    scopus 로고
    • p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis
    • Tashiro H, Isacson C, Levine R, Kurman RJ, Cho KR, Hedrick L. p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis. Am J Pathol 1997;150:177-85.
    • (1997) Am J Pathol , vol.150 , pp. 177-185
    • Tashiro, H.1    Isacson, C.2    Levine, R.3    Kurman, R.J.4    Cho, K.R.5    Hedrick, L.6
  • 52
    • 0030761409 scopus 로고    scopus 로고
    • Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
    • Tashiro H, Blazes MS, Wu R, et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 1997;57:3935-40.
    • (1997) Cancer Res , vol.57 , pp. 3935-3940
    • Tashiro, H.1    Blazes, M.S.2    Wu, R.3
  • 54
    • 0031690464 scopus 로고    scopus 로고
    • Microsatellite instability in endometrial carcinomas: Clinicopathologic correlations in a series of 42 cases
    • Catasus L, Machin P, Matias Guiu X, Prat J. Microsatellite instability in endometrial carcinomas: clinicopathologic correlations in a series of 42 cases. Hum Pathol 1998;29:1160-4.
    • (1998) Hum Pathol , vol.29 , pp. 1160-1164
    • Catasus, L.1    Machin, P.2    Matias Guiu, X.3    Prat, J.4
  • 55
    • 0034793145 scopus 로고    scopus 로고
    • Comparative immunohistochemical study of endometrioid and serous papillary carcinoma of endometrium
    • Halperin R, Zehavi S, Habler L, Hadas E, Bukovsky I, Schneider D. Comparative immunohistochemical study of endometrioid and serous papillary carcinoma of endometrium. Eur J Gynaecol Oncol 2001;22:122-6.
    • (2001) Eur J Gynaecol Oncol , vol.22 , pp. 122-126
    • Halperin, R.1    Zehavi, S.2    Habler, L.3    Hadas, E.4    Bukovsky, I.5    Schneider, D.6
  • 57
    • 0345269867 scopus 로고    scopus 로고
    • Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia
    • Moreno-Bueno G, Hardisson D, Sarrio D, et al. Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia. J Pathol 2003;199:471-8.
    • (2003) J Pathol , vol.199 , pp. 471-478
    • Moreno-Bueno, G.1    Hardisson, D.2    Sarrio, D.3
  • 58
    • 0036792576 scopus 로고    scopus 로고
    • Beta-catenin and E-cadherin expression patterns in high-grade endometrial carcinoma are associated with histological subtype
    • Schlosshauer PW, Ellenson LH, Soslow RA. Beta-catenin and E-cadherin expression patterns in high-grade endometrial carcinoma are associated with histological subtype. Mod Pathol 2002;15:1032-7.
    • (2002) Mod Pathol , vol.15 , pp. 1032-1037
    • Schlosshauer, P.W.1    Ellenson, L.H.2    Soslow, R.A.3
  • 59
    • 1842468101 scopus 로고    scopus 로고
    • Molecular genetic analysis of endometrial carcinoma: Evidence for 2 genetically distinctive entities
    • Lax SF, Abeler VM, Regitnig P. Molecular genetic analysis of endometrial carcinoma: evidence for 2 genetically distinctive entities. Virchows Arch 2001;439:247-52.
    • (2001) Virchows Arch , vol.439 , pp. 247-252
    • Lax, S.F.1    Abeler, V.M.2    Regitnig, P.3
  • 61
    • 25144523393 scopus 로고    scopus 로고
    • Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancer
    • Zorn KK, Bonome T, Gangi L, et al. Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancer. Clin Cancer Res 2005;11:6422-30.
    • (2005) Clin Cancer Res , vol.11 , pp. 6422-6430
    • Zorn, K.K.1    Bonome, T.2    Gangi, L.3
  • 62
    • 0038670783 scopus 로고    scopus 로고
    • Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers
    • Kanaya T, Kyo S, Maida Y, et al. Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers. Oncogene 2003;22:2352-60.
    • (2003) Oncogene , vol.22 , pp. 2352-2360
    • Kanaya, T.1    Kyo, S.2    Maida, Y.3
  • 63
    • 0027248156 scopus 로고
    • Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review
    • Lynch HT, Smyrk TC, Watson P, et al. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 1993;104:1535-49.
    • (1993) Gastroenterology , vol.104 , pp. 1535-1549
    • Lynch, H.T.1    Smyrk, T.C.2    Watson, P.3
  • 64
    • 0028229113 scopus 로고
    • The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer
    • Watson P, Vasen HF, Mecklin JP, Jarvinen H, Lynch HT. The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. Am J Med 1994;96:516-20.
    • (1994) Am J Med , vol.96 , pp. 516-520
    • Watson, P.1    Vasen, H.F.2    Mecklin, J.P.3    Jarvinen, H.4    Lynch, H.T.5
  • 65
    • 0028032493 scopus 로고
    • The epidemiology of endometrial cancer in hereditary nonpolyposis colorectal cancer
    • Vasen HF, Watson P, Mecklin JP, et al. The epidemiology of endometrial cancer in hereditary nonpolyposis colorectal cancer. Anticancer Res 1994;14:1675-8.
    • (1994) Anticancer Res , vol.14 , pp. 1675-1678
    • Vasen, H.F.1    Watson, P.2    Mecklin, J.P.3
  • 66
    • 0030882381 scopus 로고    scopus 로고
    • The International Collaborative Group on HNPCC. Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study
    • Peltomaki P, Vasen HF. The International Collaborative Group on HNPCC. Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. Gastroenterology 1997;113:1146-58.
    • (1997) Gastroenterology , vol.113 , pp. 1146-1158
    • Peltomaki, P.1    Vasen, H.F.2
  • 67
    • 0031278322 scopus 로고    scopus 로고
    • Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
    • Miyaki M, Konishi M, Tanaka K, et al. Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nat Genet 1997;17:271-2.
    • (1997) Nat Genet , vol.17 , pp. 271-272
    • Miyaki, M.1    Konishi, M.2    Tanaka, K.3
  • 68
    • 0035300475 scopus 로고    scopus 로고
    • Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer
    • Schweizer P, Moisio AL, Kuismanen SA, et al. Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer. Cancer Res 2001;61:2813-5.
    • (2001) Cancer Res , vol.61 , pp. 2813-2815
    • Schweizer, P.1    Moisio, A.L.2    Kuismanen, S.A.3
  • 69
    • 84988273336 scopus 로고    scopus 로고
    • Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: Association with family history and histopathology
    • Pare YR, Halling KC, Burgart LJ, et al. Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: association with family history and histopathology. Int J Cancer 2000;86:60-6.
    • (2000) Int J Cancer , vol.86 , pp. 60-66
    • Pare, Y.R.1    Halling, K.C.2    Burgart, L.J.3
  • 70
    • 0033645557 scopus 로고    scopus 로고
    • Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumors from HNPCC patients
    • de Leeuw WJ, Dierssen J, Vasen HF, et al. Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumors from HNPCC patients. J Pathol 2000;192:328-35.
    • (2000) J Pathol , vol.192 , pp. 328-335
    • de Leeuw, W.J.1    Dierssen, J.2    Vasen, H.F.3
  • 71
    • 0031893552 scopus 로고    scopus 로고
    • Familial endometrial adenocarcinoma
    • Sandles LG. Familial endometrial adenocarcinoma. Clin Obstet Gynecol 1998;41:167-71.
    • (1998) Clin Obstet Gynecol , vol.41 , pp. 167-171
    • Sandles, L.G.1
  • 72
    • 23044501891 scopus 로고    scopus 로고
    • Molecular analysis of familial endometrial carcinoma: A manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome?
    • Ollikainen M, Abdel-Rahman WM, Moisio AL, et al. Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? J Clin Oncol 2005;23:4609-16.
    • (2005) J Clin Oncol , vol.23 , pp. 4609-4616
    • Ollikainen, M.1    Abdel-Rahman, W.M.2    Moisio, A.L.3
  • 73
    • 0037226389 scopus 로고    scopus 로고
    • Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer
    • Risinger JI, Maxwell GL, Chandramouli GV, et al. Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer. Cancer Res 2003;63:6-11.
    • (2003) Cancer Res , vol.63 , pp. 6-11
    • Risinger, J.I.1    Maxwell, G.L.2    Chandramouli, G.V.3


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