-
1
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathways in human cancer
-
Vivanco I, Sawyers CL: The phosphatidylinositol 3-kinase AKT pathways in human cancer. Nature Cancer Rev, 2: 489-501, 2002.
-
(2002)
Nature Cancer Rev
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
2
-
-
0033957661
-
The PTEN tumour suppressor protein: An antagonist of phosphoinositide 3-kinase signalling
-
Vazquez F, Sellers W: The PTEN tumour suppressor protein: an antagonist of phosphoinositide 3-kinase signalling. Biochem Biophys Acta, 1470: M21-35, 2000.
-
(2000)
Biochem Biophys Acta
, vol.1470
-
-
Vazquez, F.1
Sellers, W.2
-
3
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, Gray JW: PIK3CA is implicated as an oncogene in ovarian cancer. Nature Genet, 21: 99-102, 1999.
-
(1999)
Nature Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
Baldocchi, R.4
Godfrey, T.5
Collins, C.6
Pinkel, D.7
Powell, B.8
Mills, G.B.9
Gray, J.W.10
-
4
-
-
0035886016
-
The phosphatidylinositol 3'-kinase p85 alpha gene is an oncogene in human ovarian and colon tumours
-
Philp AJ, Campbell IG, Leet C, Vincan E, Rockman SP, Whitehead RH, Thomas RJ, Phillips WA: The phosphatidylinositol 3'-kinase p85 alpha gene is an oncogene in human ovarian and colon tumours. Cancer Res, 61: 7426-7429, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 7426-7429
-
-
Philp, A.J.1
Campbell, I.G.2
Leet, C.3
Vincan, E.4
Rockman, S.P.5
Whitehead, R.H.6
Thomas, R.J.7
Phillips, W.A.8
-
5
-
-
0034742120
-
Q: AKT1/PKB kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
-
Sun M, Wang G, Paciga JE, Feldman RI, Yuan ZQ, Ma X, Shelly SA, Jove R, Tsichlis PN, Nicosia SV, Cheng J, Q: AKT1/PKB kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol, 159: 431-437, 2001.
-
(2001)
Am J Pathol
, vol.159
, pp. 431-437
-
-
Sun, M.1
Wang, G.2
Paciga, J.E.3
Feldman, R.I.4
Yuan, Z.Q.5
Ma, X.6
Shelly, S.A.7
Jove, R.8
Tsichlis, P.N.9
Nicosia, S.V.10
Cheng, J.11
-
6
-
-
0029127042
-
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
-
Bellacosa A, de Feo D, Godwin AK, Bell DW, Cheng JQ, Altomare DA, Wan M, Dubeau L, Scambia G, Masciullo V: Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer, 64: 280-285, 1995.
-
(1995)
Int J Cancer
, vol.64
, pp. 280-285
-
-
Bellacosa, A.1
De Feo, D.2
Godwin, A.K.3
Bell, D.W.4
Cheng, J.Q.5
Altomare, D.A.6
Wan, M.7
Dubeau, L.8
Scambia, G.9
Masciullo, V.10
-
7
-
-
0033579163
-
Mutational spectra of PTEN/MMAC1 gene: A tumour suppressor with lipid phosphatase activity
-
Ali IU, Schriml LM, Dean M: Mutational spectra of PTEN/MMAC1 gene: a tumour suppressor with lipid phosphatase activity. J Natl Cancer Inst, 91: 1922-1932, 1999.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1922-1932
-
-
Ali, I.U.1
Schriml, L.M.2
Dean, M.3
-
8
-
-
0034650817
-
Allelic imbalance and mutations of the PTEN gene in ovarian cancer
-
Saito M, Okamoto A, Kohno T, Takakura S, Shinozaki H, Isonishi S, Yasuhara T, Yoshimura T, Ohtake Y, Ochiai K, Yokota J, Tanaka T: Allelic imbalance and mutations of the PTEN gene in ovarian cancer. Int J Cancer, 85: 160-165, 2000.
-
(2000)
Int J Cancer
, vol.85
, pp. 160-165
-
-
Saito, M.1
Okamoto, A.2
Kohno, T.3
Takakura, S.4
Shinozaki, H.5
Isonishi, S.6
Yasuhara, T.7
Yoshimura, T.8
Ohtake, Y.9
Ochiai, K.10
Yokota, J.11
Tanaka, T.12
-
9
-
-
0041672301
-
The oncogene phosphatidylinositol 3'-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma
-
Zhang L, Yang N, Katsaros D, Huang W, Park JW, Fracchioli S, Vezzani C, Rigault de la Longrais IA, Yao W, Rubin SC, Coukos G: The oncogene phosphatidylinositol 3'-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma. Cancer Res, 63: 4225-4231, 2003.
-
(2003)
Cancer Res
, vol.63
, pp. 4225-4231
-
-
Zhang, L.1
Yang, N.2
Katsaros, D.3
Huang, W.4
Park, J.W.5
Fracchioli, S.6
Vezzani, C.7
Rigault De La Longrais, I.A.8
Yao, W.9
Rubin, S.C.10
Coukos, G.11
-
10
-
-
0034713390
-
PIK3CA as an oncogene in cervical cancer
-
Ma YY, Wei SJ, Lin YC, Lung JC, Chang TC, Whang-Peng J, Liu JM, Yang DM, Yang WK, Shen CY: PIK3CA as an oncogene in cervical cancer. Oncogene, 19: 2739-2744, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 2739-2744
-
-
Ma, Y.Y.1
Wei, S.J.2
Lin, Y.C.3
Lung, J.C.4
Chang, T.C.5
Whang-Peng, J.6
Liu, J.M.7
Yang, D.M.8
Yang, W.K.9
Shen, C.Y.10
-
11
-
-
0032125580
-
Increased levels of phosphoinositol 3-Kinase activity in colorectal tumours
-
Phillips WA, St. Clair F, Munday AD, Thomas RJ, Mitchell CA: Increased levels of phosphoinositol 3-Kinase activity in colorectal tumours. Cancer, 83: 41-47, 1998.
-
(1998)
Cancer
, vol.83
, pp. 41-47
-
-
Phillips, W.A.1
St. Clair, F.2
Munday, A.D.3
Thomas, R.J.4
Mitchell, C.A.5
-
12
-
-
0033984095
-
Involvement of PTEN mutations in the genetic pathways of colorectal carcogenesis
-
Guanti G, Resta N, Simone C, Cariola F, Demma I, Fiorente P, Gentile M: Involvement of PTEN mutations in the genetic pathways of colorectal carcogenesis. Hum Mol Genet, 9: 283-287, 2000.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 283-287
-
-
Guanti, G.1
Resta, N.2
Simone, C.3
Cariola, F.4
Demma, I.5
Fiorente, P.6
Gentile, M.7
-
13
-
-
0032804162
-
Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype
-
Garcia JM, Silva JM, Dominguez G, Gonzalez R, Navarro A, Carretero L, Provencio M, Espana P, Bonilla F: Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype. Breast Cancer Res Treatment, 57: 237-243, 1999.
-
(1999)
Breast Cancer Res Treatment
, vol.57
, pp. 237-243
-
-
Garcia, J.M.1
Silva, J.M.2
Dominguez, G.3
Gonzalez, R.4
Navarro, A.5
Carretero, L.6
Provencio, M.7
Espana, P.8
Bonilla, F.9
-
14
-
-
0033618371
-
Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
-
Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, Weigel RJ, Roth RA: Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem, 274: 21528-21532, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 21528-21532
-
-
Nakatani, K.1
Thompson, D.A.2
Barthel, A.3
Sakaue, H.4
Liu, W.5
Weigel, R.J.6
Roth, R.A.7
-
15
-
-
0001457668
-
Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK, Testa JR: Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci, 93: 3636-3641, 1996.
-
(1996)
Proc Natl Acad Sci
, vol.93
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
Sonoda, G.4
Altomare, D.A.5
Watson, D.K.6
Testa, J.R.7
-
16
-
-
0030799909
-
Somatic mutations of PTEN in glioblastoma multiforme
-
Wang SI, Puc J, Li J, Bruce JN, Cairns P, Sidransky D, Parsons R: Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res, 57: 4183-4186, 1997.
-
(1997)
Cancer Res
, vol.57
, pp. 4183-4186
-
-
Wang, S.I.1
Puc, J.2
Li, J.3
Bruce, J.N.4
Cairns, P.5
Sidransky, D.6
Parsons, R.7
-
17
-
-
0030817576
-
PTEN gene mutations are seen in high-grade but not in low-grade gliomas
-
Rasheed BK, Stenzel TT, McLendon RE, Parsons R, Friedman AH, Friedman HS, Bigner DD, Bigner SH: PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res, 57: 4187-4190, 1997.
-
(1997)
Cancer Res
, vol.57
, pp. 4187-4190
-
-
Rasheed, B.K.1
Stenzel, T.T.2
McLendon, R.E.3
Parsons, R.4
Friedman, A.H.5
Friedman, H.S.6
Bigner, D.D.7
Bigner, S.H.8
-
18
-
-
0033833298
-
Identification of PTEN mutations in metastatic melanoma specimens
-
Celebi JT, Shendrik I, Silver DN, Peacocke M: Identification of PTEN mutations in metastatic melanoma specimens. J Med Genet, 37: 653-657, 2000.
-
(2000)
J Med Genet
, vol.37
, pp. 653-657
-
-
Celebi, J.T.1
Shendrik, I.2
Silver, D.N.3
Peacocke, M.4
-
19
-
-
0033819340
-
Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
-
Zhou XP, Gimm O, Hampel H, Niemann T, Walker MJ, Eng C: Epigenetic PTEN silencing in malignant melanomas without PTEN mutation. Am J Pathol, 157: 1123-1128, 2000.
-
(2000)
Am J Pathol
, vol.157
, pp. 1123-1128
-
-
Zhou, X.P.1
Gimm, O.2
Hampel, H.3
Niemann, T.4
Walker, M.J.5
Eng, C.6
-
20
-
-
0032574718
-
Inactivation of the tumour suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
-
Whang YE, Wu X, Suzuki H, Reiter RE, Tran C, Vessella RL, Said JW, Isaacs WB, Sawyers CL: Inactivation of the tumour suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci, 95: 5246-5250, 1998.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 5246-5250
-
-
Whang, Y.E.1
Wu, X.2
Suzuki, H.3
Reiter, R.E.4
Tran, C.5
Vessella, R.L.6
Said, J.W.7
Isaacs, W.B.8
Sawyers, C.L.9
-
21
-
-
0032898096
-
PTEN is inversely correlated with the cell survival factor akt/pkb and is inactivated via multiple mechanisms in haematological malignancies
-
Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C, Eng C: PTEN is inversely correlated with the cell survival factor akt/pkb and is inactivated via multiple mechanisms in haematological malignancies. Hum Mol Genet, 8: 185-193, 1999.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 185-193
-
-
Dahia, P.L.1
Aguiar, R.C.2
Alberta, J.3
Kum, J.B.4
Caron, S.5
Sill, H.6
Marsh, D.J.7
Ritz, J.8
Freedman, A.9
Stiles, C.10
Eng, C.11
-
22
-
-
0031855499
-
Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma
-
Nakahara Y, Nagai H, Kinoshita T, Uchida T, Hatano S, Murate T, Saito H: Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma. Leukaemia, 12: 1277-1280, 1998.
-
(1998)
Leukaemia
, vol.12
, pp. 1277-1280
-
-
Nakahara, Y.1
Nagai, H.2
Kinoshita, T.3
Uchida, T.4
Hatano, S.5
Murate, T.6
Saito, H.7
-
23
-
-
0001582482
-
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
Staal SP: Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Nat Acad Sci, 84: 5034-5037, 1987.
-
(1987)
Proc Nat Acad Sci
, vol.84
, pp. 5034-5037
-
-
Staal, S.P.1
-
24
-
-
0037422206
-
Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas
-
Kobayashi M, Iwamatsu A, Shinohara-Kanda A, Ihara S, Fukui Y: Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas. Oncogene, 22: 1294-1301, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 1294-1301
-
-
Kobayashi, M.1
Iwamatsu, A.2
Shinohara-Kanda, A.3
Ihara, S.4
Fukui, Y.5
-
25
-
-
7844247587
-
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
-
Forgacs E, Biesterveld EJ, Sekido Y, Fong K, Muneer S, Wistuba II, Milchgrub S, Brezinschek R, Virmani A, Gazdar AF, Minna JD: Mutation analysis of the PTEN/MMAC1 gene in lung cancer. Oncogene, 17: 1557-1565, 1998.
-
(1998)
Oncogene
, vol.17
, pp. 1557-1565
-
-
Forgacs, E.1
Biesterveld, E.J.2
Sekido, Y.3
Fong, K.4
Muneer, S.5
Wistuba, I.I.6
Milchgrub, S.7
Brezinschek, R.8
Virmani, A.9
Gazdar, A.F.10
Minna, J.D.11
-
26
-
-
0035008874
-
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
-
Hutchinson J, Jin J, Cardiff RD, Woodgett JR, Muller WJ: Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol, 21: 2203-12, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2203-2212
-
-
Hutchinson, J.1
Jin, J.2
Cardiff, R.D.3
Woodgett, J.R.4
Muller, W.J.5
-
27
-
-
0035235458
-
Phosphatidylinositol 3' kinase signalling in mammary tumori genesis
-
Scheid MP, Woodgett JR: Phosphatidylinositol 3' kinase signalling in mammary tumorigenesis. J Mammary Gland Biol Neoplasia, 6: 83-99, 2001.
-
(2001)
J Mammary Gland Biol Neoplasia
, vol.6
, pp. 83-99
-
-
Scheid, M.P.1
Woodgett, J.R.2
-
28
-
-
0035949588
-
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
-
Mayo LD, Donner DB: A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA, 98: 11598-11603, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 11598-11603
-
-
Mayo, L.D.1
Donner, D.B.2
-
29
-
-
0030869787
-
Induction of vascular endothelial growth factor by hypoxia is modulated by a PI3 kinase/Akt signalling pathway in Ha-ras transformed cells through a HIF-1 transcriptional element
-
Mazure NM, Chen EY, Laderoute KR, Giaccia AJ: Induction of vascular endothelial growth factor by hypoxia is modulated by a PI3 kinase/Akt signalling pathway in Ha-ras transformed cells through a HIF-1 transcriptional element. Blood, 90: 3322-3331, 1997.
-
(1997)
Blood
, vol.90
, pp. 3322-3331
-
-
Mazure, N.M.1
Chen, E.Y.2
Laderoute, K.R.3
Giaccia, A.J.4
-
30
-
-
0036731001
-
MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer
-
Koul D, Shen R, Garyali A, Ke LD, Liu TJ, Yung WK: MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer. Int J Oncol, 21: 469-475, 2002.
-
(2002)
Int J Oncol
, vol.21
, pp. 469-475
-
-
Koul, D.1
Shen, R.2
Garyali, A.3
Ke, L.D.4
Liu, T.J.5
Yung, W.K.6
-
31
-
-
0033119572
-
Induction of vascular endothelial growth factor expression in endothelial cells by platelet derived growth factor through the activation of PI3-kinase
-
Wang D, Huang H-J, Kazlauskas A, Cavanee WK: Induction of vascular endothelial growth factor expression in endothelial cells by platelet derived growth factor through the activation of PI3-kinase. Cancer Res, 59: 1464-1472, 1999.
-
(1999)
Cancer Res
, vol.59
, pp. 1464-1472
-
-
Wang, D.1
Huang, H.-J.2
Kazlauskas, A.3
Cavanee, W.K.4
-
32
-
-
0035116241
-
Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells
-
O-charoenrat P, Rhys-Evans P, Modjtahedi H, and Eccles SA. Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells. Clin Exp Metastasis 18: 155-161, 2000.
-
(2000)
Clin Exp Metastasis
, vol.18
, pp. 155-161
-
-
O-charoenrat, P.1
Rhys-Evans, P.2
Modjtahedi, H.3
Eccles, S.A.4
-
33
-
-
0035421326
-
Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma
-
Dong G, Chen Z, Li ZY, Yeh NT, Bancroft CC, Van Waes C: Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res, 61: 5911-5918, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 5911-5918
-
-
Dong, G.1
Chen, Z.2
Li, Z.Y.3
Yeh, N.T.4
Bancroft, C.C.5
Van Waes, C.6
-
34
-
-
0035447687
-
Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding
-
Yu Y, Hulmes JD, Herley MT, Whitney RG, Crabb JW, Sato JD: Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding. Biochem J, 358: 465-472, 2001.
-
(2001)
Biochem J
, vol.358
, pp. 465-472
-
-
Yu, Y.1
Hulmes, J.D.2
Herley, M.T.3
Whitney, R.G.4
Crabb, J.W.5
Sato, J.D.6
-
35
-
-
0033538057
-
The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling
-
Thakker GD, Hajjar DP, Muller WA, Rosengart TK: The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling. J Biol Chem, 274: 10002-10007, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 10002-10007
-
-
Thakker, G.D.1
Hajjar, D.P.2
Muller, W.A.3
Rosengart, T.K.4
-
36
-
-
0035242371
-
VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase
-
Qi JH, Claesson-Welsh L: VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase. Exp Cell Res, 263: 173-182, 2001.
-
(2001)
Exp Cell Res
, vol.263
, pp. 173-182
-
-
Qi, J.H.1
Claesson-Welsh, L.2
-
37
-
-
0033573099
-
Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells
-
Fujikawa K, de Aos Scherpenseel I, Jain SK, Presman E, Christensen RA, Varticovski L: Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells. Exp Cell Res, 253: 663-672, 1999.
-
(1999)
Exp Cell Res
, vol.253
, pp. 663-672
-
-
Fujikawa, K.1
De Aos Scherpenseel, I.2
Jain, S.K.3
Presman, E.4
Christensen, R.A.5
Varticovski, L.6
-
38
-
-
0036497905
-
Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathway
-
Nakashio A, Fujita N, Tsuruo T: Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathway. Int J Cancer, 98: 36-41, 2002.
-
(2002)
Int J Cancer
, vol.98
, pp. 36-41
-
-
Nakashio, A.1
Fujita, N.2
Tsuruo, T.3
-
39
-
-
0033542476
-
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
-
Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature, 399: 601-605, 1999.
-
(1999)
Nature
, vol.399
, pp. 601-605
-
-
Dimmeler, S.1
Fleming, I.2
Fisslthaler, B.3
Hermann, C.4
Busse, R.5
Zeiher, A.M.6
-
40
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangio genesis: Involvement of vascular endothelial growth factor
-
Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, Jauch KW, Geissler EK: Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Naure Med, 8: 128-135, 2002.
-
(2002)
Naure Med
, vol.8
, pp. 128-135
-
-
Guba, M.1
Von Breitenbuch, P.2
Steinbauer, M.3
Koehl, G.4
Flegel, S.5
Hornung, M.6
Bruns, C.J.7
Zuelke, C.8
Farkas, S.9
Anthuber, M.10
Jauch, K.W.11
Geissler, E.K.12
-
41
-
-
0030045346
-
Cell migration: A physically integrated molecular process
-
Lauffernburger DA, Horwitz AH: Cell migration: a physically integrated molecular process. Cell, 84: 359-369, 1996.
-
(1996)
Cell
, vol.84
, pp. 359-369
-
-
Lauffernburger, D.A.1
Horwitz, A.H.2
-
42
-
-
0036488589
-
Role of integrins in cell invasion and migration
-
Hood J, Cheresh D: Role of integrins in cell invasion and migration. Nature Cancer Reviews, 2: 91-100, 2002.
-
(2002)
Nature Cancer Reviews
, vol.2
, pp. 91-100
-
-
Hood, J.1
Cheresh, D.2
-
43
-
-
0037455576
-
Compensation mechanism in tumor cell migration: Mesenchymal-amoeboid transition after blocking of pericellular proteolysis
-
Wolf K, Mazo I, Leung H, Engelke K, von Andrian UH, Deryugina EI, Strongin AY, Brocker EB, Friedl P: Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol, 160: 267-277, 2003.
-
(2003)
J Cell Biol
, vol.160
, pp. 267-277
-
-
Wolf, K.1
Mazo, I.2
Leung, H.3
Engelke, K.4
Von Andrian, U.H.5
Deryugina, E.I.6
Strongin, A.Y.7
Brocker, E.B.8
Friedl, P.9
-
44
-
-
0035866381
-
Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-1 depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase
-
Dunn SE, Torres JV, Oh JS, Cykert DM, Barrett JC: Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-1 depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase. Cancer Res, 61: 1367-1374, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 1367-1374
-
-
Dunn, S.E.1
Torres, J.V.2
Oh, J.S.3
Cykert, D.M.4
Barrett, J.C.5
-
45
-
-
0035266290
-
Phosphatidylinositol 3-kinase activity in epithelial growth factor-stimulated matrix metalloproteinase-9 production and cell surface association
-
Ellerbroek SM, Halbleib JM, Benavidez M, Warmka JK, Wattenberg EV, Stack MS, Hudson LG: Phosphatidylinositol 3-kinase activity in epithelial growth factor-stimulated matrix metalloproteinase-9 production and cell surface association. Cancer Res, 61: 1855-1861, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 1855-1861
-
-
Ellerbroek, S.M.1
Halbleib, J.M.2
Benavidez, M.3
Warmka, J.K.4
Wattenberg, E.V.5
Stack, M.S.6
Hudson, L.G.7
-
46
-
-
0037455716
-
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signalling
-
Zhang D, Brodt P: Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signalling. Oncogene, 22: 974-982, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 974-982
-
-
Zhang, D.1
Brodt, P.2
-
47
-
-
0032586952
-
Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence 9 on phosphoinositide 3-OH kinase
-
Adelsman M, McCarthy J, Shimizu Y: Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence 9 on phosphoinositide 3-OH kinase. Mol Biol Cell, 10: 2861-2878, 1999.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 2861-2878
-
-
Adelsman, M.1
McCarthy, J.2
Shimizu, Y.3
-
48
-
-
0034615933
-
Cooperative signalling between alpha6beta4 integrin and erbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion
-
Gambaletta D, Marchetti A, Benedetti L, Mercurio A, Sacchi A, Falcioni R: Cooperative signalling between alpha6beta4 integrin and erbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion. J Biol Chem, 275: 10604-10610, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 10604-10610
-
-
Gambaletta, D.1
Marchetti, A.2
Benedetti, L.3
Mercurio, A.4
Sacchi, A.5
Falcioni, R.6
-
49
-
-
0034724443
-
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
-
Persad S, Attwell S, Virginia G, Delcommenne M, Troussard A, Sanghera J, Dedhar S: Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA, 97: 3201-3212, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3201-3212
-
-
Persad, S.1
Attwell, S.2
Virginia, G.3
Delcommenne, M.4
Troussard, A.5
Sanghera, J.6
Dedhar, S.7
-
50
-
-
0031740739
-
Cell interactions with collagen matrices in vivo and in vitro depend on phosphatidylinositol 3-kinase and free cytoplasmic calcium
-
Ahlen K, Berg A, Stiger F, Tengholm A, Siegbahn A, Gylfe E, Reed RK, Rubin K: Cell interactions with collagen matrices in vivo and in vitro depend on phosphatidylinositol 3-kinase and free cytoplasmic calcium. Cell Adhes Commun, 5: 461-473, 1998.
-
(1998)
Cell Adhes Commun
, vol.5
, pp. 461-473
-
-
Ahlen, K.1
Berg, A.2
Stiger, F.3
Tengholm, A.4
Siegbahn, A.5
Gylfe, E.6
Reed, R.K.7
Rubin, K.8
-
51
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumour suppressor PTEN
-
Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada K: Inhibition of cell migration, spreading, and focal adhesions by tumour suppressor PTEN. Science, 280: 1614-1617, 1998.
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
Aota, S.4
Parsons, R.5
Yamada, K.6
-
52
-
-
0343183328
-
Genetic deletion of the PTEN tumour suppressor gene promotes cell motility by activation of Rac1 and cdc42 GTPases
-
Liliental J, Moon SY, Lesche R, Mamillapalli R, Li D, Zheng Y, Sun H, Wu H: Genetic deletion of the PTEN tumour suppressor gene promotes cell motility by activation of Rac1 and cdc42 GTPases. Curr Biol, 10: 401-404, 2000.
-
(2000)
Curr Biol
, vol.10
, pp. 401-404
-
-
Liliental, J.1
Moon, S.Y.2
Lesche, R.3
Mamillapalli, R.4
Li, D.5
Zheng, Y.6
Sun, H.7
Wu, H.8
-
53
-
-
0033231070
-
Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'kinase and phospholipase C-dependent mechanism
-
Price JT, Tiganis T, Agarwal A, Djakiew D, Thompson EW: Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'kinase and phospholipase C-dependent mechanism. Cancer Res, 59: 5475-5478, 1999.
-
(1999)
Cancer Res
, vol.59
, pp. 5475-5478
-
-
Price, J.T.1
Tiganis, T.2
Agarwal, A.3
Djakiew, D.4
Thompson, E.W.5
-
54
-
-
0036056156
-
Cancer cell motility - One the road from c-erbB-2 receptor steered signaling to actin reorganization
-
Fledner JC, Brandt BH: Cancer cell motility - one the road from c-erbB-2 receptor steered signaling to actin reorganization. Exp Cell Res, 272: 93-108, 2002.
-
(2002)
Exp Cell Res
, vol.272
, pp. 93-108
-
-
Fledner, J.C.1
Brandt, B.H.2
-
55
-
-
0034676001
-
Role of PI3K regulatory subunit in the control of actin organization and cell migration
-
Jimenez C, Portela RA, Mellado M, Rodriguez-Frade JM, Collard J, Serrano A, Martinez AC, Avila J, Carrera AC: Role of PI3K regulatory subunit in the control of actin organization and cell migration. J Cell Biol, 151: 249-261, 2000.
-
(2000)
J Cell Biol
, vol.151
, pp. 249-261
-
-
Jimenez, C.1
Portela, R.A.2
Mellado, M.3
Rodriguez-Frade, J.M.4
Collard, J.5
Serrano, A.6
Martinez, A.C.7
Avila, J.8
Carrera, A.C.9
-
56
-
-
0028197377
-
A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase
-
Woscholski R, Kodaki T, McKinnon M, Waterfield MD, Parker PJ: A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase. FEBS Letters 342: 109-114, 1994.
-
(1994)
FEBS Letters
, vol.342
, pp. 109-114
-
-
Woscholski, R.1
Kodaki, T.2
McKinnon, M.3
Waterfield, M.D.4
Parker, P.J.5
-
57
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyrN - 4-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY, Brown RF: A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyrN - 4-one (LY294002). J Biol Chem, 269: 5241-5248, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
58
-
-
0028850452
-
Wortmannin and its structural homologue demethoxyviridin inhibit phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatylinositol 3-kinase
-
Cross MJ, Stewart A, Hodgkin MN, Kerr DJ, Wakelam MJ: Wortmannin and its structural homologue demethoxyviridin inhibit phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatylinositol 3-kinase. J Biol Chem, 270: 25352-25355, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 25352-25355
-
-
Cross, M.J.1
Stewart, A.2
Hodgkin, M.N.3
Kerr, D.J.4
Wakelam, M.J.5
-
59
-
-
0031458721
-
Inhibition of phospholipid signalling and proliferation of Swiss 3T3 cells by the wortmannin analogue demethoxyviridin
-
Cross MJ, Hodgkin MN, Plumb JA, Brunton VG, Stewart A, MacAully G, Hill R, Kerr DJ, Workman P, Wakelam MJ: Inhibition of phospholipid signalling and proliferation of Swiss 3T3 cells by the wortmannin analogue demethoxyviridin. Biochim Biophys Acta, 1362: 29-38, 1997.
-
(1997)
Biochim Biophys Acta
, vol.1362
, pp. 29-38
-
-
Cross, M.J.1
Hodgkin, M.N.2
Plumb, J.A.3
Brunton, V.G.4
Stewart, A.5
MacAully, G.6
Hill, R.7
Kerr, D.J.8
Workman, P.9
Wakelam, M.J.10
-
60
-
-
0034306450
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors
-
Davis SP, Reddy H, Caivano M, Cohen P: Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J, 351: 95-105, 2000.
-
(2000)
Biochem J
, vol.351
, pp. 95-105
-
-
Davis, S.P.1
Reddy, H.2
Caivano, M.3
Cohen, P.4
-
61
-
-
0034100051
-
In vivo and in vitro ovarian carcinoma growth inhibition by phosphatidylinositol 3-kinase inhibitor (LY294002)
-
Hu L, Zaloudek C, Mills GB, Gray J, Jaffee RB: In vivo and in vitro ovarian carcinoma growth inhibition by phosphatidylinositol 3-kinase inhibitor (LY294002). Clin Cancer Res, 6: 880-886, 2000.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 880-886
-
-
Hu, L.1
Zaloudek, C.2
Mills, G.B.3
Gray, J.4
Jaffee, R.B.5
-
62
-
-
0036278927
-
The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenylchromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells
-
Semba S, Itoh N, Ito M, Harada M, Yamakawa M: The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenylchromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells. Clin Cancer Res, 8: 1957-1963, 2002.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1957-1963
-
-
Semba, S.1
Itoh, N.2
Ito, M.3
Harada, M.4
Yamakawa, M.5
-
63
-
-
0041338049
-
Inhibition of the phosphatidylinositol 3'-kinase-Akt pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
-
Bondar V, Sweeny-Gotsch B, Andreeff M, Mills G, McConkey D: Inhibition of the phosphatidylinositol 3'-kinase-Akt pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Molec Cancer Therapeutics, 1: 989-997, 2002.
-
(2002)
Molec Cancer Therapeutics
, vol.1
, pp. 989-997
-
-
Bondar, V.1
Sweeny-Gotsch, B.2
Andreeff, M.3
Mills, G.4
McConkey, D.5
-
64
-
-
0036937229
-
Wortmannin inhibits growth of human non-small cell lung cancer in vitro and in vivo
-
Boehle AS, Kurdow R, Boenicke L, Schniewind B, Feandrich F, Dohrmann P, Kalthoff H: Wortmannin inhibits growth of human non-small cell lung cancer in vitro and in vivo. Langenbecks Arch Surg, 387: 234-239, 2002.
-
(2002)
Langenbecks Arch Surg
, vol.387
, pp. 234-239
-
-
Boehle, A.S.1
Kurdow, R.2
Boenicke, L.3
Schniewind, B.4
Feandrich, F.5
Dohrmann, P.6
Kalthoff, H.7
-
65
-
-
0036968347
-
Activation of the PI3K/Akt pathway and chemotherapeutic resistance
-
Kip A, West S, Sianna Castillo S, Dennis PA: Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Res Updates, 5: 234-248, 2002.
-
(2002)
Drug Res Updates
, vol.5
, pp. 234-248
-
-
Kip, A.1
West, S.2
Sianna Castillo, S.3
Dennis, P.A.4
-
66
-
-
2142842701
-
-
Therapeutic morpholino-subsituted compounds. US patent, 6, 403,588 B 1, 2002
-
Hayakaa M, Kaizawa H, Kawaguchi KI, Matsuda K, Ishikawa N, Koizumi T, Yamanao M, Ohta M: Therapeutic morpholino-subsituted compounds. US patent, 6, 403,588 B 1, 2002.
-
-
-
Hayakaa, M.1
Kaizawa, H.2
Kawaguchi, K.I.3
Matsuda, K.4
Ishikawa, N.5
Koizumi, T.6
Yamanao, M.7
Ohta, M.8
-
67
-
-
2142739291
-
-
Preparation and formulation of morpholino-subsituted heterocycles as phosphoinositide 3-kinase inhibitors for therapeutic use. International patent application, WO 0153266 A1: 2001
-
Robertson AJ, Jackson S, Kenche V, Yaip C, Parbaharan H, Thompson P: Preparation and formulation of morpholino-subsituted heterocycles as phosphoinositide 3-kinase inhibitors for therapeutic use. International patent application, WO 0153266 A1: 2001.
-
-
-
Robertson, A.J.1
Jackson, S.2
Kenche, V.3
Yaip, C.4
Parbaharan, H.5
Thompson, P.6
-
68
-
-
2142852177
-
-
Quinazolinone derivatives as inhibitors of human phosphatidylinositol 3-kinase delta. International patent application. WO 0181346 A2: 2001
-
Sadhu C, Dick K, Treiberg J, Sowell CG, Kesicki EA, Oliver A: Quinazolinone derivatives as inhibitors of human phosphatidylinositol 3-kinase delta. International patent application. WO 0181346 A2: 2001.
-
-
-
Sadhu, C.1
Dick, K.2
Treiberg, J.3
Sowell, C.G.4
Kesicki, E.A.5
Oliver, A.6
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